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A Different Perspective on Macroscopic Sampling of Cholecystectomy Specimens
Asuman Argon,Ayşe Yağcı,Funda Taşlı,Tulu Kebat,Senem Deniz,Nazif Erkan,Gül Kitapçıoğlu,Enver Vardar 대한병리학회 2013 Journal of Pathology and Translational Medicine Vol.47 No.6
Background: Because there may be interdepartmental differences in macroscopic sampling of cholecystectomy specimens, we aimed to investigate differences between the longitudinal sampling technique and our classical sampling technique in cholecystectomy specimens in which there was no obvious malignancy. Methods: Six hundred eight cholecystectomy specimens that were collected between 2011 and 2012 were included in this study. The first group included 273 specimens for which one sample was taken from each of the fundus, body, and neck regions (our classical technique). The second group included 335 specimens for which samples taken from the neck region and lengthwise from the fundus toward the neck were placed together in one cassette (longitudinal sampling). The Pearson chi-square, Fisher exact, and ANOVA tests were used and differences were considered significant at p<.05. Results: In the statistical analysis, although gallbladders in the first group were bigger, the average length of the samples taken in the second group was greater. Inflammatory cells, pyloric metaplasia, intestinal metaplasia, low grade dysplasia, and invasive carcinoma were seen more often in the second group. Conclusions: In our study, the use of a longitudinal sampling technique enabled us to examine a longer mucosa and to detect more mucosal lesions than did our classical technique. Thus, longitudinal sampling can be an effective technique in detecting preinvasive lesions.
Dielectron production in Au + Au collisions at<sub>sNN</sub>=200GeV
Adare, A.,Aidala, C.,Ajitanand, N. N.,Akiba, Y.,Akimoto, R.,Alexander, J.,Alfred, M.,Al-Ta'ani, H.,Angerami, A.,Aoki, K.,Apadula, N.,Aramaki, Y.,Asano, H.,Aschenauer, E. C.,Atomssa, E. T.,Averbeck, R. American Physical Society 2016 Physical review. C Vol.93 No.1
Lévy-stable two-pion Bose-Einstein correlations in sNN=200 GeV Au+Au collisions
Adare, A.,Aidala, C.,Ajitanand, N. N.,Akiba, Y.,Akimoto, R.,Alexander, J.,Alfred, M.,Al-Ta'ani, H.,Angerami, A.,Aoki, K.,Apadula, N.,Aramaki, Y.,Asano, H.,Aschenauer, E. C.,Atomssa, E. T.,Awes, T. C. American Physical Society 2018 Physical Review C Vol.97 No.6
Adare, A.,Afanasiev, S.,Aidala, C.,Ajitanand, N. N.,Akiba, Y.,Akimoto, R.,Al-Bataineh, H.,Alexander, J.,Alfred, M.,Al-Ta'ani, H.,Angerami, A.,Aoki, K.,Apadula, N.,Aramaki, Y.,Asano, H.,Aschenauer, E. American Physical Society 2016 Physical Review C Vol.94 No.6
<P>The PHENIX experiment at the BNL Relativistic Heavy Ion Collider has measured second- and third-order Fourier coefficients of the azimuthal distributions of direct photons emitted at midrapidity in Au + Au collisions at root S-NN = 200 GeV for various collision centralities. Combining two different analysis techniques, results were obtained in the transverse momentum range of 0.4 < p(T) < 4.0 GeV/c. At low p(T) the second-order coefficients, nu(2), are similar to the ones observed in hadrons. Third-order coefficients, nu(3), are nonzero and almost independent of centrality. These new results on nu(2) and nu(3), combined with previously published results on yields, are compared to model calculations that provide yields and asymmetries in the same framework. Those models are challenged to explain simultaneously the observed large yield and large azimuthal anisotropies.</P>
Warfarin pharmacogenetics: a single VKORC1 polymorphism is predictive of dose across 3 racial groups
Limdi, Nita A.,Wadelius, Mia,Cavallari, Larisa,Eriksson, Niclas,Crawford, Dana C.,Lee, Ming-Ta M.,Chen, Chien-Hsiun,Motsinger-Reif, Alison,Sagreiya, Hersh,Liu, Nianjun,Wu, Alan H. B.,Gage, Brian F.,Jo American Society of Hematology 2010 Blood Vol.115 No.18
<B>Abstract</B><P>Warfarin-dosing algorithms incorporating CYP2C9 and VKORC1 −1639G>A improve dose prediction compared with algorithms based solely on clinical and demographic factors. However, these algorithms better capture dose variability among whites than Asians or blacks. Herein, we evaluate whether other VKORC1 polymorphisms and haplotypes explain additional variation in warfarin dose beyond that explained by VKORC1 −1639G>A among Asians (n = 1103), blacks (n = 670), and whites (n = 3113). Participants were recruited from 11 countries as part of the International Warfarin Pharmacogenetics Consortium effort. Evaluation of the effects of individual VKORC1 single nucleotide polymorphisms (SNPs) and haplotypes on warfarin dose used both univariate and multi variable linear regression. VKORC1 −1639G>A and 1173C>T individually explained the greatest variance in dose in all 3 racial groups. Incorporation of additional VKORC1 SNPs or haplotypes did not further improve dose prediction. VKORC1 explained greater variability in dose among whites than blacks and Asians. Differences in the percentage of variance in dose explained by VKORC1 across race were largely accounted for by the frequency of the −1639A (or 1173T) allele. Thus, clinicians should recognize that, although at a population level, the contribution of VKORC1 toward dose requirements is higher in whites than in nonwhites; genotype predicts similar dose requirements across racial groups.</P>
Pollack, Samuela,Igo Jr., Robert P.,Jensen, Richard A.,Christiansen, Mark,Li, Xiaohui,Cheng, Ching-Yu,Ng, Maggie C.Y.,Smith, Albert V.,Rossin, Elizabeth J.,Segrè,, Ayellet V.,Davoudi, Samaneh,Ta American Diabetes Association 2019 Diabetes Vol.68 No.2
<P>To identify genetic variants associated with diabetic retinopathy (DR), we performed a large multiethnic genome-wide association study. Discovery included eight European cohorts (<I>n</I> = 3,246) and seven African American cohorts (<I>n</I> = 2,611). We meta-analyzed across cohorts using inverse-variance weighting, with and without liability threshold modeling of glycemic control and duration of diabetes. Variants with a <I>P</I> value <1 × 10<SUP>−5</SUP> were investigated in replication cohorts that included 18,545 European, 16,453 Asian, and 2,710 Hispanic subjects. After correction for multiple testing, the C allele of rs142293996 in an intron of nuclear VCP-like (<I>NVL</I>) was associated with DR in European discovery cohorts (<I>P</I> = 2.1 × 10<SUP>−9</SUP>), but did not reach genome-wide significance after meta-analysis with replication cohorts. We applied the Disease Association Protein-Protein Link Evaluator (DAPPLE) to our discovery results to test for evidence of risk being spread across underlying molecular pathways. One protein–protein interaction network built from genes in regions associated with proliferative DR was found to have significant connectivity (<I>P</I> = 0.0009) and corroborated with gene set enrichment analyses. These findings suggest that genetic variation in <I>NVL,</I> as well as variation within a protein–protein interaction network that includes genes implicated in inflammation, may influence risk for DR.</P>
Development of targeted oncolytic virotherapeutics through translational research
Liu, Ta-Chiang,Hwang, Tae-Ho,Bell, John C,Kirn, David H Informa UK (Ashley Publications) 2008 Expert opinion on biological therapy Vol.8 No.9
<P>BACKGROUND: Oncolytic virotherapeutics is a promising platform for cancer treatment but the product class has yet been successful. The key to success is integration of bidirectional translational research to rapidly address issues encountered in the laboratory and the clinics. OBJECTIVE: We highlight the hurdles identified for the targeted oncolytic virotherapy approach, specifically those identified in clinical trials with wild-type viruses and first-generation targeted agents. We also analyze the translational research and development that has been applied to overcome these hurdles, including virus engineering and design improvements for next-generation virotherapeutics. RESULTS/CONCLUSION: The iterative loop between the clinic and the lab can function as a major driving force to optimize products from this platform.</P>
Measurement ofΥ(1S+2S+3S)production inp+pand Au + Au collisions at<sub>sNN</sub>=200GeV
Adare, A.,Afanasiev, S.,Aidala, C.,Ajitanand, N. N.,Akiba, Y.,Akimoto, R.,Al-Bataineh, H.,Al-Ta'ani, H.,Alexander, J.,Angerami, A.,Aoki, K.,Apadula, N.,Aphecetche, L.,Aramaki, Y.,Asai, J.,Asano, H.,As American Physical Society 2015 PHYSICAL REVIEW C - Vol.91 No.2