Measurement of the top quark mass in the dileptonic tt¯ decay channel using the mass observables Mbℓ , MT2 , and Mbℓν in pp collisions at s=8 TeV

Sirunyan, A. M.,Tumasyan, A.,Adam, W.,Asilar, E.,Bergauer, T.,Brandstetter, J.,Brondolin, E.,Dragicevic, M.,Erö,, J.,Flechl, M.,Friedl, M.,Frü,hwirth, R.,Ghete, V. M.,Hartl, C.,Hö,rmann, N American Physical Society 2017 Physical Review D Vol.96 No.3

<P>A measurement of the top quark mass (M-t) in the dileptonic t (t) over bar decay channel is performed using data from proton-proton collisions at a center-of-mass energy of 8 TeV. The data was recorded by the CMS experiment at the LHC and corresponds to an integrated luminosity of 19.7 +/- 0.5 fb(-1). Events are selected with two oppositely charged leptons (l = e, mu) and two jets identified as originating from b quarks. The analysis is based on three kinematic observables whose distributions are sensitive to the value of Mt. An invariant mass observable, M-bl, and a 'stransverse mass' observable, M-T2, are employed in a simultaneous fit to determine the value of M-t and an overall jet energy scale factor (JSF). A complementary approach is used to construct an invariant mass observable, M-blv, that is combined with M-T2 to measure M-t. The shapes of the observables, along with their evolutions in M-t and JSF, are modeled by a nonparametric Gaussian process regression technique. The sensitivity of the observables to the value of M-t is investigated using a Fisher information density method. The top quark mass is measured to be 172.22 +/- 0.18(stat)(-0.93)(+0.89) (syst) GeV.</P>

Anisotropic Magnetization and Charge Density Wave in a Na0.78CoO2 Single Crystal

이종수,J. B. Peng,S. M. Lee,C. T. Lin 한국물리학회 2008 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.52 No.2

Single crystals of γ-Na0.78CoO2 were grown using the floating zone method. The static magnetic susceptibility M/H(T) of Na0.78CoO2 showed significant anisotropic behavior for different crystal orientations of H ∥ (ab) and H ∥ (c). While (M/H)ab(T) for a magnetic field H= 1 T in an ab-plane followed the Curie-Weiss law at high temperatures (T ≥ 100 K), (M/H)c(T) for H ∥ c-axis deviated from Curie-Weiss behavior, which may be understood by using phonon localization from strong electron-phonon coupling. The impurity spin-1/2 effect, dressed by spin fluctuation, was significant at low temperatures (T ≤ 30 K) for both field orientations of H ∥ (ab) and H ∥ (c). The electrical resistivity ρ(T) of Na0.78CoO2 showed a clear metallic character down to 16 K, with a weak increase in the resistivity ρ(T) at low temperatures T ≤ 16 K). The gap-like behavior of ρ(T) was insensitive to applied magnetic fields up to 7 T, which indicates a non-degenerate charge gap. The electrical conductivity σ(T) followed the density wave behavior with a small energy gap (0.64 meV) at low temperatures. We discussed the electrical resistivity ρ(T)$ and the anisotropic M/H(T) behavior of Na0.78CoO2 in terms of the charge density wave and a strong electron-phonon interaction. Single crystals of γ-Na0.78CoO2 were grown using the floating zone method. The static magnetic susceptibility M/H(T) of Na0.78CoO2 showed significant anisotropic behavior for different crystal orientations of H ∥ (ab) and H ∥ (c). While (M/H)ab(T) for a magnetic field H= 1 T in an ab-plane followed the Curie-Weiss law at high temperatures (T ≥ 100 K), (M/H)c(T) for H ∥ c-axis deviated from Curie-Weiss behavior, which may be understood by using phonon localization from strong electron-phonon coupling. The impurity spin-1/2 effect, dressed by spin fluctuation, was significant at low temperatures (T ≤ 30 K) for both field orientations of H ∥ (ab) and H ∥ (c). The electrical resistivity ρ(T) of Na0.78CoO2 showed a clear metallic character down to 16 K, with a weak increase in the resistivity ρ(T) at low temperatures T ≤ 16 K). The gap-like behavior of ρ(T) was insensitive to applied magnetic fields up to 7 T, which indicates a non-degenerate charge gap. The electrical conductivity σ(T) followed the density wave behavior with a small energy gap (0.64 meV) at low temperatures. We discussed the electrical resistivity ρ(T)$ and the anisotropic M/H(T) behavior of Na0.78CoO2 in terms of the charge density wave and a strong electron-phonon interaction.

Measurement of the t-channel single-top-quark production cross section and of the |V tb| CKM matrix element in pp collisions at $ \sqrt{s} $ = 8 TeV

Khachatryan, V.,Sirunyan, A. M.,Tumasyan, A.,Adam, W.,Bergauer, T.,Dragicevic, M.,Erö,, J.,Fabjan, C.,Friedl, M.,Frü,hwirth, R.,Ghete, V. M.,Hartl, C.,Hö,rmann, N.,Hrubec, J.,Jeitler, M.,K Springer-Verlag 2014 Journal of high energy physics Vol.2014 No.6

<P>Measurements are presented of the t-channel single-top-quark production cross section in proton-proton collisions at root s = 8 TeV. The results are based on a data sample corresponding to an integrated luminosity of 19.7 fb(-1) recorded with the CMS detector at the LHC. The cross section is measured inclusively, as well as separately for top (t) and antitop (t) over bar, in final states with a muon or an electron. The measured inclusive t-channel cross section is sigma(t-ch.) = 83.6 +/- 2.3 (stat.) +/- 7.4 (syst.) pb. The single t and (t) cross sections are measured to be sigma(t-ch.)(t) = 53.8 +/- 1.5 (stat.) +/- 4.4 (syst.) pb and sigma(t-ch.)(t) over bar = 27.6 +/- 1.3 (stat.) +/- 3.7 (syst.) pb, respectively. The measured ratio of cross sections is Rt-ch. = sigma(t-ch.)(t)/sigma(t-ch.)(t) over bar = 1.95 +/- 0.10 (stat.) +/- 0.19 (syst.), in agreement with the standard model prediction. The modulus of the Cabibbo-Kobayashi-Maskawa matrix element V-tb is extracted and, in combination with a previous CMS result at root s = 7 TeV, a value vertical bar V-tb vertical bar = 0.998 +/- 0.038 (exp.) +/- 0.016 (theo.) is obtained.</P>

임신 및 각종 갑상선질환에서 갑상선 기능 판정에 관한 연구 : 혈청유리 T4의 진단적 의의에 관한 고찰 The diagnostic value of free thyroxine by RIA

이종철,유명희,윤휘중,신영태,정순일,조보연,이문호,이명철 대한핵의학회 1981 핵의학 분자영상 Vol.15 No.1

To evaluate the diagnostic accuracy of the measurement of free thyroxine(FT4) by radioimmunoassay, we measured free T4 and T4, T3, T3RU, TSH and TBG serum levels by radioimmunoassay in 18 healthy persons and 52 patients with various thyroid diseases and 11 normal pregnant women. The results are as follows. 1) In 19 cases of overt hyperthyroidism, T3, free T4 and FTI, T4/TBG ratio reflect hyperfunction in all cases. T4 is increased in 94%(18/19) and TBG and TSH are decreased in 79%(15/19). 2) In 8 patients with overt hypothyroidism, TSH is increased in all cases and free T4 and FTI is decreased in all cases. T4 is decreased in 87.5%(7/8), T3 is decreased in 75%(6/8) and T4/TBG ratio is decreased in 62.5%(5/8). 3) In 5 patients who are clinically in euthyroid state after treatment of hyperthyroidism, T4 free T4, FTI and TSH are in the normal range in all cases and T3 is normal in 60%(3/5) and slightly increased in 40%(2/5). 4) In 10 patients who showed clinically borderline hypothyroidism after treatment of hyperthyroidism, TSH is increased in all cases and free T4 and FTI are decreased in all cases, but T4 and T3, T4/TBG ratio are in the normal limit in all cases. So after treatment of hyperthyroidism, TSH, free T4 or FTI are recommended as optimal function test. 5) In normal pregnancy, free T4, FTI and T4/TBG ratio reflect normal function, but the other parameters unreliable due to the influence of increased TBG. Also TBG and TSH level in pregnancy is increased significantly compared with normal healthy control group. 6) The coefficients of correlation between T4 and FTI were 0.862(p〈0.001) and 0.685(p〈0.001) between free T4 and T4/TBG ratio. In most patients, diagnostic value of free T4 was comparable and even superior to FTI, so free T4 measurement can be used routinely with thyrotropin assay in the diagnosis of hypothyrodism or with T3 for the diagnosis of hyperthyroidism.

조사료원과 급여수준이 한우의 비육능력 (肥育能力) 및 도체성적에 (屠體成績) 미치는 영향

정태영(T . Y . Chung),김종민(C . M . Kim),이왕열(W . Y . Lee),선우훈희(H . H . Sunwoo) 한국영양사료학회 1994 韓國營養飼料學會誌 Vol.18 No.1

Nasal-type NK/T-cell lymphomas are more frequently T rather than NK lineage based on T-cell receptor gene, RNA, and protein studies: lineage does not predict clinical behavior

Hong, M.,Lee, T.,Young Kang, S.,Kim, S. J.,Kim, W.,Ko, Y. H. Nature Publishing Group 2016 Modern pathology Vol.29 No.5

<P>Extranodal natural killer (NK)/T-cell lymphoma (ENKTL), nasal type, comprises NK or cytotoxic T cells. We evaluated the clinical impact of cell type and the usefulness of T-cell receptor (TCR) gene transcripts in distinguishing cell lineage. One hundred and eight cases of ENKTL were analyzed for TCR gene rearrangements using the BIOMED-2 protocol and for TCR gene expression using immunohistochemistry for TCR-beta F1 and TCR-c gamma M1, and RNA in situ hybridization for TCR gene transcripts. Prognostic factors were analyzed. Among the 108 cases, 44 were monoclonal for a TCR rearrangement (40%) while 64 (60%) were undefinable. The monoclonal cases expressed TCR-beta F1 in 14 out of 40 cases (35%) and TCR-c gamma M1 in 1 out of 44 cases (2%). The 64 undetermined cases expressed TCR-beta F1 in 15 cases (23%) and TCR-c gamma M1 in 1 (2%). Thirteen of 40 TCR-beta constant gene transcript-positive cases (33%) expressed TCR-beta F1 and one of nine TCR-gamma constant gene transcript-positive cases (11%) expressed TCR-c gamma M1. TCR gene transcripts were not useful in the distinction of cell lineages. TCR gene transcripts were positive in ENKTLs as well as in normal B cells and aggressive NK-cell leukemia. Based on gene rearrangements and immunohistochemistry for TCR, there were 60 T-cell type cases (56%), 32 NK-cell type cases (30%), and 16 cases with an undetermined cell type (14%). TCR protein was expressed in 30/60 T-ENKTLs (50%) in a variable fraction of tumor cells. There were no significant differences in clinical findings or overall patient survival between T-or NK-cell types of ENKTL, although those with a T-cell type tended to show a better prognosis for those with localized nasal lymphomas. Univariate and multivariate analysis showed that a non-nasal ENKTL, age 460 years, high level of lactate dehydrogenase, bone marrow involvement, and the absence of radiotherapy were independent prognostic factors.</P>

Metabolic characterization of (1-(5-fluoropentyl)-1H-indol-3-yl)(4-methyl-1-naphthalenyl)-methanone (MAM-2201) using human liver microsomes and cDNA-overexpressed cytochrome P450 enzymes

Kong, T. Y.,Kim, J. H.,Choi, W. G.,Lee, J. Y.,Kim, H. S.,Kim, J. Y.,In, M. K.,Lee, H. S. Springer Science + Business Media 2017 Analytical and bioanalytical chemistry Vol.409 No.6

<P>MAM-2201 is a synthetic cannabinoid that is increasingly found in recreational drug abusers and cases of severe intoxication. Thus, characterization of the metabolic pathways of MAM-2201 is necessary to predict individual pharmacokinetics and toxicity differences, and to avoid toxic drug-drug interactions. Collectively, 19 phase 1 metabolites of MAM-2201 were identified using liquid chromatography-Orbitrap mass spectrometry following human liver microsomal incubations in the presence of NADPH: 7 hydroxy-MAM-2201 (M1-M7), 4 dihydroxy-MAM-2201 (M8-M11), dihydrodiol-MAM-2201 (M12), N-(5-hydroxypentyl)-MAM-2201 (M13), hydroxy-M13 (M14), N-dealkyl-MAM-2201 (M15), 2 hydroxy-M15 (M16, M17), MAM-2201 N-pentanoic acid (M18), and hydroxy-M18 (M19). On the basis of intrinsic clearance values in human liver microsomes, hydroxy-MAM-2201 (M1), N-(5-hydroxypentyl)-MAM-2201 (M13), and hydroxy-M13 (M14) were the major metabolites. Based on an enzyme kinetics study using human cDNA-expressed cytochrome P450 (CYP) enzymes and an immunoinhibition study using selective CYP antibodies in human liver microsomes, CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, and CYP3A4 enzymes were responsible for MAM-2201 metabolism. The CYP3A4 enzyme played a prominent role in MAM-2201 metabolism, and CYP1A2, CYP2B6, CYP2C8, and CYP2C9 enzymes played major roles in the formation of some metabolites. MAM-2201 is extensively metabolized by multiple CYP enzymes, indicating that MAM-2201 and its metabolites should be used as markers of MAM-2201 abuse and toxicity.</P>

Two-stage partial melting and contrasting cooling history within the Higher Himalayan Crystalline Sequence in the far-eastern Nepal Himalaya

Imayama, T.,Takeshita, T.,Yi, K.,Cho, D.L.,Kitajima, K.,Tsutsumi, Y.,Kayama, M.,Nishido, H.,Okumura, T.,Yagi, K.,Itaya, T.,Sano, Y. Universitetsforlaget ; Elsevier Science Ltd 2012 Lithos Vol.134 No.-

The timing of partial melting and the pressure-temperature (P-T) paths in the High Himalayan Crystalline Sequence (HHCS) in far-eastern Nepal has been investigated using zircon chronology, rare earth element (REE) compositions, and P-T pseudosection analysis. Zircon from migmatites formed during Himalayan thermal events displays inherited magmatic core overgrown by two generations of metamorphic rims. The new rims are distinguished on the basis of their Tertiary ages, low MREE contents, and low Th/U ratios. The inner zircon rims from Sil+Grt+Bt+Kfs+Pl+Qtz and Ky+Sil+Grt+Bt+Ms+Pl+Qtz migmatites at different structural level of the HHCS display ages of c. 33-28Ma (Early Oligocene) and c. 21-18Ma (Early Miocene): these rims are characterized by flat MREE to HREE patterns and were overgrown by partial melt through muscovite dehydration melting under the stability of garnet, which occurred at P=c. 7-10kbar and T=c. 730-780<SUP>o</SUP>C, and at P=c. 8-14kbar and T=c. 720-770<SUP>o</SUP>C, respectively. The outer zircon rims are relatively enriched in HREE with respect to the inner rims and were overgrown at c. 27-23Ma (Late Oligocene) and at c. 18-16Ma (Early Miocene) during melt crystallization accompanying breakdown of garnet at P=c. 4-7kbar and T=c. 650-725<SUP>o</SUP>C. Early Miocene Ms-Bt leucogranites with two successively overgrown zircon rims at c. 18.3+/-0.3Ma and c. 16.3+/-0.2Ma were intruded into Early Oligocene migmatite hosts. Microstructural observations and the corresponding P-T conditions associated with the two generations of zircon rims indicate that the Early Oligocene and Early Miocene migmatites show relatively isobaric and nearly isothermal P-T paths during exhumation, respectively. The inferences are consistent with higher average cooling rates for the Early Miocene (c. 30-40<SUP>o</SUP>C/My) than the Early Oligocene (c. 15-25<SUP>o</SUP>C/My) migmatites, inferred from peak-T conditions and FT (c. 6Ma for both migmatites) and U-Pb zircon ages. The P-T-t paths of the two migmatites indicate that burial of the Early Miocene migmatites has been coeval with exhumation of the Early Oligocene migmatites, implying the formation of large-scale thrust within the HHCS.

Anomalous flux jump and supercooling phenomenon around the order-disorder transition in MgB₂ single crystals

Chotoku, M.,Nojima, T.,Ochiai, A.,Aoki, H.,Lee, H.G.,Lee, S.I. North-Holland 2009 Physica. C, Superconductivity Vol.469 No.15

We have performed the detailed measurements of temperature dependence of magnetization M(T) on MgB<SUB>2</SUB> single crystals in a wide range of field H using torque magnetometry. In a field region, where the peak effect in M(H) is observed, we find that M(T) of the warming branch increases monotonously with T and exhibits a small step-like increase at T<SUB>1</SUB><SUP>*</SUP>, which is related to the order-disorder transition, while M(T) of the cooling branch, showing the larger values than that in warming branch below T<SUB>1</SUB><SUP>*</SUP>, drops suddenly toward the warming branch at T<SUB>2</SUB><SUP>*</SUP>. We ascribe this anomalous behavior of M(T) of the cooling branch to a supercooling phenomenon of disordered phase, which transforms to the ordered state at T<SUB>2</SUB><SUP>*</SUP>.

Effect of Slaughter Age on Beef Color Stability during Display of Four Muscles from Japanese Black Steers

Muramoto, T.,Shibata, M.,Nakanishi, N. Asian Australasian Association of Animal Productio 2003 Animal Bioscience Vol.16 No.9

Effect of slaughter age (24, 28 and 38 months of age) on beef color stability during display of m. serratus ventralis, m. psoas major, m. semitendinosus and m. longissimus thoracis from Japanese Black steers was studied. Steak samples from muscles were over-wrapped with PVC film and displayed under fluorescent lights at $4^{\circ}C$ for 12 days. Percentages of metmyoglobin of steak samples were determined at days 0, 3, 6, 9 and 12. The percentage of metmyoglobin of m. psoas major at day 3 of display in the 24 months group was lower (p<0.05) than that in the 38 months group. The percentage of metmyoglobin of m. semitendinosus at day 6 of display in the 38 months group was higher (p<0.05) than that in the other groups. The percentage of metmyoglobin of m. longissimus thoracis at day 3 of display in the 24 months group was lower (p<0.01) than that in the other groups. The percentage of metmyoglobin of m. longissimus thoracis at day 6 (p<0.01), 9 (p<0.01) and 12 (p<0.05) of display in the 38 months group were higher than those in the other groups. Crude fat concentration in m. longissimus thoracis increased (p<0.05) after 28 months of age. $\alpha$-Tocopherol concentration in m. serratus ventralis in the 38 months group was higher (p<0.001) than that in the other groups. In m. psoas major the $\alpha$-tocopherol concentration in the 38 months group was higher (p<0.05) than that in the 24 months group. The $\alpha$-tocopherol concentration in m. longissimus thoracis increased (p<0.001) with age. These results suggested that in spite of increase in both the crude fat and the $\alpha$-tocopherol concentrations in m. longissimus thoracis, the beef color stability during display became short with age.