Chemopreventive potential of kimchi, an ethnic food from Korea, against colorectal carcinogenesis associated with red meat intake

Surya Reggie,Surya Ervan,Nugroho David,Romulo Andreas,Kamal Nurkhalida,Rahayu Winiati Pudji,Benchawattananon Rachadaporn,Jin‑Seok Oh 한국식품연구원 2023 Journal of Ethnic Foods Vol.10 No.10

Kimchi, the traditional fermented vegetables with seasonings from Korea, is globally renowned as healthy food with anticancer properties. Colorectal cancer is the world’s third leading cancer with an increasing incidence rate over the past years. High red meat intake is strongly associated with colorectal cancer, and the World Health Organization has identified red meat as probably carcinogenic to humans (Group 2A). This study aimed to investigate the chemopreventive potential of cabbage kimchi against the promotion of colorectal cancer by red meat in vivo using carcinogen-injected rats. Rats were fed by AIN-76 diet enriched in freeze-dried beef sirloin supplemented or not with kimchi powder for 120 days prior to killing. Kimchi supplementation at moderate (5%) and high (10%) concentration significantly suppressed the formation of precancerous lesions in the colon of red meat-fed rats. Using fecal water, the aqueous extract of feces, we found out that kimchi supplementation limited iron-mediated oxidation and reduced lipid peroxidation in the feces of rats. Furthermore, kimchi supplementation reduced the toxicity of fecal water of red meat-fed rats toward human colonic epithelial cells in vitro by suppressing the formation of cellular reactive oxygen species (ROS). The chemopreventive effects of kimchi were associated with the acidification of fecal matrix and increase in fecal lactic acid bacteria (LAB). Gene expression analysis in the colon of rats demonstrated that kimchi supplementation prevented colorectal carcinogenesis by up-regulating the expression of tumor-suppressor genes and antioxidant enzymes, as well as by down-regulating the expression of proinflammatory proteins. Taken together, our findings suggested that kimchi consumption is correlated with lower promotion of colorectal cancer associated with red meat intake.

Chemopreventive potential of kimchi, an ethnic food from Korea, against colorectal carcinogenesis associated with red meat intake

Surya Reggie,Surya Ervan,Nugroho David,Romulo Andreas,Kamal Nurkhalida,Rahayu Winiati Pudji,Benchawattananon Rachadaporn,Jin‑Seok Oh 한국식품연구원 2023 Journal of Ethnic Foods Vol.10 No.-

Kimchi, the traditional fermented vegetables with seasonings from Korea, is globally renowned as healthy food with anticancer properties. Colorectal cancer is the world’s third leading cancer with an increasing incidence rate over the past years. High red meat intake is strongly associated with colorectal cancer, and the World Health Organization has identified red meat as probably carcinogenic to humans (Group 2A). This study aimed to investigate the chemopreventive potential of cabbage kimchi against the promotion of colorectal cancer by red meat in vivo using carcinogen-injected rats. Rats were fed by AIN-76 diet enriched in freeze-dried beef sirloin supplemented or not with kimchi powder for 120 days prior to killing. Kimchi supplementation at moderate (5%) and high (10%) concentration significantly suppressed the formation of precancerous lesions in the colon of red meat-fed rats. Using fecal water, the aqueous extract of feces, we found out that kimchi supplementation limited iron-mediated oxidation and reduced lipid peroxidation in the feces of rats. Furthermore, kimchi supplementation reduced the toxicity of fecal water of red meat-fed rats toward human colonic epithelial cells in vitro by suppressing the formation of cellular reactive oxygen species (ROS). The chemopreventive effects of kimchi were associated with the acidification of fecal matrix and increase in fecal lactic acid bacteria (LAB). Gene expression analysis in the colon of rats demonstrated that kimchi supplementation prevented colorectal carcinogenesis by up-regulating the expression of tumor-suppressor genes and antioxidant enzymes, as well as by down-regulating the expression of proinflammatory proteins. Taken together, our findings suggested that kimchi consumption is correlated with lower promotion of colorectal cancer associated with red meat intake.

Effects of alcohol consumption on circulating lipid in fatty liver disease and Represent Potential cardio metabolic risk markers in Kathmandu

Surya ram DUWAL,Urusha MAHARJAN 한국간담췌외과학회 2021 Annals of hepato-biliary-pancreatic surgery Vol.25 No.-

Drug Target Identification and Elucidation of Natural Inhibitors for Bordetella petrii: An In Silico Study

Surya Narayan Rath,Manisha Ray,Animesh Pattnaik,Sukanta Kumar Pradhan 한국유전체학회 2016 Genomics & informatics Vol.14 No.4

Environmental microbes like Bordetella petrii has been established as a causative agent for various infectious diseases in human. Again, development of drug resistance in B. petrii challenged to combat against the infection. Identification of potential drug target and proposing a novel lead compound against the pathogen has a great aid and value. In this study, bioinformatics tools and technology have been applied to suggest a potential drug target by screening the proteome information of B. petrii DSM 12804 (accession No. PRJNA28135) from genome database of National Centre for Biotechnology information. In this regards, the inhibitory effect of nine natural compounds like ajoene (Allium sativum), allicin (A. sativum), cinnamaldehyde (Cinnamomum cassia), curcumin (Curcuma longa), gallotannin (active component of green tea and red wine), isoorientin (Anthopterus wardii), isovitexin (A. wardii), neral (Melissa officinalis), and vitexin (A. wardii) have been acknowledged with anti-bacterial properties and hence tested against identified drug target of B. petrii by implicating computational approach. The in silico studies revealed the hypothesis that lpxD could be a potential drug target and with recommendation of a strong inhibitory effect of selected natural compounds against infection caused due to B. petrii, would be further validated through in vitro experiments.

Synthesis of high porous electrospun hollow TiO2 nanofibers for bone tissue engineering application

Surya Prasad Adhikari,Hem Raj Pant,Hamouda M. Mousa,조슈아 리,kim han joo,박찬희,김철생 한국공업화학회 2016 Journal of Industrial and Engineering Chemistry Vol.35 No.-

Highly porous, hollow TiO2 nanofibers (NFs) were fabricated through coaxial nozzle electrospinning usinga polymer sol–gel solution of CaCO3 and TiO2 precursor. Hollow and porous TiO2 NFs were obtained byetching CaCO3 on calcined TiO2 fibers using dilute HCl. Characterization of the as-synthesized materialswere performed using FE-SEM and XRD before and after 24 h of bio-mineralization. The in vitro cellculture test was performed using MC3T3-E1 osteoblast cells to assess cell response of the differentNFs. The results suggested that as-synthesized porous nanotubes have better biocompatibility forbone regeneration and implantations compared to other nonporous TiO2 nanorods or NFs.

Plumbagin engenders apoptosis in lung cancer cells via caspase-9 activation and targeting mitochondrial-mediated ROS induction

Surya Kant Tripathi,Kannan R. R. Rengasamy,Bijesh Kumar Biswal 대한약학회 2020 Archives of Pharmacal Research Vol.43 No.2

Plumbagin is a naturally-derived phytochemicalwhich exhibits promising medicinal properties, includinganticancer activities. In the present study, the anticancerpotential of plumbagin has been demonstrated in lungcancer cells by targeting reactive oxygen species (ROS)and the intrinsic mitochondrial apoptotic pathway. Plumbaginshowed impressive cytotoxic, anti-proliferative,and anti-migratory activities with IC503.10 ± 0.5 μM and4.10 ± 0.5 μM in A549 and NCI-H522 cells, respectively. Plumbagin treatment significantly reduced the size of A549tumor spheroids in a concentration-dependent manner. Plumbagin enhanced ROS production and arrested lung cancercells in S and G2/M phase. Expression of antioxidantgenes such as glutathione S-transferase P1 and superoxidedismutase-2 were found to be upregulated with plumbagintreatment in A549 cells. Plumbagin induced dissipation inmitochondrial membrane potential and affected the expressionof intrinsic apoptotic pathway proteins. Increasedexpression of cytochrome c promotes the activation of proapoptoticprotein Bax with decreased expression of antiapoptoticprotein Bcl-2. Further, plumbagin activated themitochondrial downstream pathway protein caspase-9 andcaspase-3 leading to apoptosis of A549 cells. Collectively,plumbagin could be a promising future phytotherapeuticcandidate for lung cancer treatment via targeting intrinsicmitochondrial apoptotic pathway and ROS.

Sharp bounds of fifth coefficient and Hermitian-Toeplitz determinants for Sakaguchi classes

Surya Giri,S. SIVAPRASAD KUMAR 대한수학회 2024 대한수학회보 Vol.61 No.2

For the classes of analytic functions $f$ defined on the unit disk satisfying $$\frac{2 z {f}'(z)}{f(z) - f(-z)} \prec \varphi(z) \quad \text{and} \quad \frac{(2 z {f}'(z))'}{(f(z) - f(-z))'} \prec \varphi(z) , $$ denoted by $\mathcal{S}^*_s(\varphi)$ and $\mathcal{C}_s(\varphi)$, respectively, the sharp bound of the $n^{th}$ Taylor coefficients are known for $n=2$, $3$ and $4$. In this paper, we obtain the sharp bound of the fifth coefficient. Additionally, the sharp lower and upper estimates of the third order Hermitian Toeplitz determinant for the functions belonging to these classes are determined. The applications of our results lead to the establishment of certain new and previously known results.

The Actuation Performance of Ionic Polymer Metal Composites with Mixtures of Ethylene Glycol and Hydrophobic Ionic Liquids as an Inner Solvent

Surya Pandita,박훈철,Hyoung Tae Lim,Young Tai Yoo 한국물리학회 2006 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.49 No.3

A mixture of 1-ethyl-3methylimidazolim trifluoromethanesulfonate ionic liquid and ethylene glycol was investigated as an inner solvent of ionic polymer metal composites (IPMC). The surface resistances of the IPMCs with the mixed solvents were 15 times higher than those of the water-based IPMCs, but they were 2 times lower than those of IPMCs with ethylene glycol. The increase in the surface resistance of non-water based IPMCs was triggered by electrode damage due to polymer swelling during the solvent exchanger process from water to the mixed solvent or to ethylene glycol. The actuation performance of the IPMC with the mixed solvent was significantly increased compared to that of the IPMC containing only ethylene glycol. This must be attributed to the high conductivity of the ionic liquid and to less electrode damage.

Education for democracy to Build a Global Common Society for Peace

Surya Nath Prasad 경희대학교 인류사회재건연구원 2003 OUGHTOPIA Vol.18 No.1

Mathematical analysis for Brownian motion of nonlinear thermal bioconvective stagnation point flow in a nanofluid using DTM and RKF method

Surya Kanta Mondal,Dulal Pal 한국CDE학회 2020 Journal of computational design and engineering Vol.7 No.3

In the present paper, bioconvective stagnation point flow of nanofluid containing gyrotactic microorganisms over a nonlinearly stretching sheet embedded in a porous medium is considered. The scaling group transformation method is introduced to obtain the similarity transformation to convert the governing partial differential equations to a set of ordinary differential equations. The reduced governing nonlinear differential equations are then solved numerically with Runge–Kutta–Fehlberg method. Differential transform method is employed to justify the results obtained by the numerical method. It is found that both the results matched nicely. It is noticed that the density of motile microorganism distribution grows high with an increase in the values of the bioconvection Peclet number. Further, the rate of heat transfer and the rate of mass transfer increase rapidly with an increment in the thermophoresis parameter, heat source parameter, chemical reaction parameter, and Brownian motion parameter, respectively. This work is relevant to engineering and biotechnological applications, such as in the design of bioconjugates and mass transfer enhancement of microfluidics.