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A Simulation of 6R Industrial Articulated Robot Arm Using Backpropagation Neural Network
Supachoke Manigpan,Supaporn Kiattisin,Adisorn Leelasantitham 제어로봇시스템학회 2010 제어로봇시스템학회 국제학술대회 논문집 Vol.2010 No.10
This paper presents a simulation of a 6 degrees-of-freedom (6R) articulated robot arm using backpropagation neural network to solve the problem regarding inverse kinematics for the industrial articulated robot. The Denavit ? Hartenberg model is used to analyze the robot arm movement. Next, the forward kinematics is used to identify the relationships for each joint of the robot arm and to determine various parameters for learning system of random neural network for 5,000 data points. The simulation results show that the robot arm can move to target positions with precision, and the average error for the entire 6 joints is at approximately 4.03 degrees.
β-Adrenergic Receptor and Insulin Resistance in the Heart
( Supachoke Mangmool ),( Tananat Denkaew ),( Warisara Parichatikanond ),( Hitoshi Kurose ) 한국응용약물학회 2017 Biomolecules & Therapeutics(구 응용약물학회지) Vol.25 No.1
Insulin resistance is characterized by the reduced ability of insulin to stimulate tissue uptake and disposal of glucose including cardiac muscle. These conditions accelerate the progression of heart failure and increase cardiovascular morbidity and mortality in patients with cardiovascular diseases. It is noteworthy that some conditions of insulin resistance are characterized by up-reg-ulation of the sympathetic nervous system, resulting in enhanced stimulation of β-adrenergic receptor (βAR). Overstimulation of βARs leads to the development of heart failure and is associated with the pathogenesis of insulin resistance in the heart. However, pathological consequences of the cross-talk between the βAR and the insulin sensitivity and the mechanism by which βAR over-stimulation promotes insulin resistance remain unclear. This review article examines the hypothesis that βARs overstimulation leads to induction of insulin resistance in the heart.
β-Adrenergic Receptor and Insulin Resistance in the Heart
Mangmool, Supachoke,Denkaew, Tananat,Parichatikanond, Warisara,Kurose, Hitoshi The Korean Society of Applied Pharmacology 2017 Biomolecules & Therapeutics(구 응용약물학회지) Vol.25 No.1
Insulin resistance is characterized by the reduced ability of insulin to stimulate tissue uptake and disposal of glucose including cardiac muscle. These conditions accelerate the progression of heart failure and increase cardiovascular morbidity and mortality in patients with cardiovascular diseases. It is noteworthy that some conditions of insulin resistance are characterized by up-regulation of the sympathetic nervous system, resulting in enhanced stimulation of ${\beta}$-adrenergic receptor (${\beta}$AR). Overstimulation of ${\beta}$ARs leads to the development of heart failure and is associated with the pathogenesis of insulin resistance in the heart. However, pathological consequences of the cross-talk between the ${\beta}$AR and the insulin sensitivity and the mechanism by which ${\beta}$AR overstimulation promotes insulin resistance remain unclear. This review article examines the hypothesis that ${\beta}$ARs overstimulation leads to induction of insulin resistance in the heart.
Myofibroblasts and inflammatory cells as players of cardiac fibrosis
Hitoshi Kurose,Supachoke Mangmool 대한약학회 2016 Archives of Pharmacal Research Vol.39 No.8
On myocardial infarction, many cells are injuredor died owing to arterial occlusion. Intracellular moleculesreleased from injured or dead cells initiate inflammatoryresponses that play important roles in cardiac remodelingincluding fibrosis. Fibrosis is an excess accumulation ofextracellular collagen. Currently, drugs used to treat cardiacfibrosis are not commercially available. Myofibroblastsare responsible for the production and secretion ofcollagen. Infiltrating inflammatory cells interact withfibroblasts or other cells and promote myofibroblast formation. Inflammatory cells also modulate the activities ofmyofibroblasts. Regulation of collagen production is criticalfor modulating the progression of fibrosis. Hence, themanipulation of activities of inflammatory cells andmyofibroblasts will provide promising therapeutic targetsfor treatment of cardiac fibrosis.
Canonical Transient Receptor Potential Channels and Vascular Smooth Muscle Cell Plasticity
Motohiro Nishida,Tomohiro Tanaka,Supachoke Mangmool,Kazuhiro Nishiyama,Akiyuki Nishimura 한국지질동맥경화학회 2020 지질·동맥경화학회지 Vol.9 No.1
Vascular smooth muscle cells (VSMCs) play a pivotal role in the stability and tonic regulation of vascular homeostasis. VSMCs can switch back and forth between highly proliferative (synthetic) and fully differentiated (contractile) phenotypes in response to changes in the vessel environment. Abnormal phenotypic switching of VSMCs is a distinctive characteristic of vascular disorders, including atherosclerosis, pulmonary hypertension, stroke, and peripheral artery disease; however, how the control of VSMC phenotypic switching is dysregulated under pathological conditions remains obscure. Canonical transient receptor potential (TRPC) channels have attracted attention as a key regulator of pathological phenotype switching in VSMCs. Several TRPC subfamily member proteins—especially TRPC1 and TRPC6—are upregulated in pathological VSMCs, and pharmacological inhibition of TRPC channel activity has been reported to improve hypertensive vascular remodeling in rodents. This review summarizes the current understanding of the role of TRPC channels in cardiovascular plasticity, including our recent finding that TRPC6 participates in aberrant VSMC phenotype switching under ischemic conditions, and discusses the therapeutic potential of TRPC channels.
Antipsychotic Prescribing Pattern for Geriatric Patients with Delirium in Thailand
Pornjira Pariwatcharakul,Witchuda Chantarat,Supachoke Singhakant,Lalida Jantarak,Tidarat Suriyachaiwattana,Chanin Sakulisariyaporn,Nantawat Sitdhiraksa,Sunanta Chantakarn,Panom Ketumarn,Sornsiri Yanta 대한정신약물학회 2010 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.8 No.3
Objective: To describe the antipsychotic prescribing pattern for the treatment of delirium among hospitalized elderly patients when compared to those younger adults referred to a psychiatric consultation-liaison service in Thailand Methods: All psychiatric consultations performed upon hospitalized patients at a university hospital in Bangkok, Thailand, during a one-year period were reviewed. We collected the data from consultation request forms and medical records. Results: Among all 840 patients referred for psychiatric consultation, 656 of them had complete medical records available. The consultant psychiatrists diagnosed 172 (26.2%) of them with delirium. After excluding 16 patients with substance-withdrawal delirium,data on antipsychotics prescription of 156 (23.8%) patients were analyzed. The mean age was 61.3±17.6 years old (22-95);91 (61.9%) were 60 years old or more, and 103 (70.1%) were male. Antipsychotics were prescribed for 85.3% of all patients. Atypical antipsychotics were more commonly prescribed for the elderly (60 years or older) than for the young (51.6% vs 35.4%,p=0.038). Risperidone was the most frequently prescribed antipsychotic for elderly patients accounting for 44% of prescriptions. We found negative correlation between age of the patients and the dose of haloperidol; r=0.233, p=0.043. Conclusion: To our knowledge, this is the first study on current antipsychotics prescribing practice for the hospitalized elderly with delirium in a consultation-liaison service in Asia. Although the current evidence show no superiority for atypical antipsychotics over haloperidol, as well as limited evidence of their efficacy and safety in managing delirium, most doctors had the tendency to prescribe atypical antipsychotics for the hospitalized elderly patients with delirium. Further study is required to determine the optimal pharmacological therapies for delirium in the elderly.
A Novel Nucleic Lateral Flow Assay for Screening phaR-Containing Bacillus spp.
( Nay Yee Wint ),( Khine Kyi Han ),( Wariya Yamprayoonswat ),( Pattarawan Ruangsuj ),( Supachoke Mangmool ),( Chamras Promptmas ),( Montri Yasawong ) 한국미생물생명공학회(구 한국산업미생물학회) 2021 Journal of microbiology and biotechnology Vol.31 No.1
Polyhydroxyalkanoate (PHA) synthase is a key enzyme for PHA production in microorganisms. The class IV PHA synthase is composed of two subunits: PhaC and PhaR. The PhaR subunit, which encodes the phaR gene, is only present in class IV PHA synthases. Therefore, the phaR gene is used as a biomarker for bacteria that contain a class IV PHA synthase, such as some Bacillus spp. The phaR gene was developed to screen phaR-containing Bacillus spp. The phaR screening method involved two steps: phaR gene amplification by PCR and phaR amplicon detection using a DNA lateral flow assay. The screening method has a high specificity for phaR-containing Bacillus spp. The lowest amount of genomic DNA of B. thuringiensis ATCC 10792 that the phaR screening method could detect was 10 pg. This novel screening method improves the specificity and sensitivity of phaR gene screening and reduces the time and cost of the screening process, which could enhance the opportunity to discover good candidate PHA producers. Nevertheless, the screening method can certainly be used as a tool to screen phaR-containing Bacillus spp. from environmental samples.
Abnormality Pattern of F-18 FDG PET Whole Body with Functional MRI Brain in Post-Acute COVID-19
Kiatkittikul Peerapon,Promteangtrong Chetsadaporn,Kunawudhi Anchisa,Dheeratama Siripongsatian,Taweegrit Siripongboonsitti,Piyanuj Ruckpanich,Supachoke Thongdonpua,Attapon Jantarato,Chaiyawat Piboonvor 대한핵의학회 2022 핵의학 분자영상 Vol.56 No.1
Purpose The study aimed to investigate imaging abnormalities associated with post-acute COVID-19 using F-18 FDG PET/ CT and PET/ rsfMRI brain. Methods We retrospectively recruited 13 patients with post-acute COVID-19. The post-acute COVID-19 symptoms and neuropsychiatric tests were performed before F-18 FDG PET/CT whole body with PET/rsfMRI brain. Qualitative and semiquantitative analyses were also conducted in both whole body and brain images. Results Among the 13 patients, 8 (61.5%) had myositis, followed by 8 (61.5%) with vasculitis (mainly in the thoracic aorta), and 7 (53.8%) with lung abnormalities.. Interestingly, one patient with a very high serum RBD IgG antibody demonstrated diffuse myositis throughout the body which potentially associated with immune-mediated myositis. One patient experienced psoriasis exacerbation with autoimmune-mediated after COVID-19. Most patients had multiple areas of abnormal brain connectivity involving the frontal and parieto-temporo-occipital lobes, as well as the thalamus. Conclusion The whole body F-18 FDG PET can be a potential tool to assess inflammatory process and support the hyperinflammatory etiology, mainly for lesions in skeletal muscle, vascular wall, and lung, as well as, multiple brain abnormalities in post-acute COVID-19. Nonetheless, further studies are recommended to confirm the results.
Piti Rattanaprichavej,Artit Laoruengthana,Supachok Rasamimogkol,Panapol Varakornpipat,Kongpob Reosanguanwong,,Krit Pongpirul 대한정형외과학회 2019 Clinics in Orthopedic Surgery Vol.11 No.4
Background: Various pre- and perioperative risk factors have been reported in association with blood loss in knee arthroplasty. However, the effect of the uncovered cancellous surface on blood loss in simultaneous bilateral total knee arthroplasty (SBTKA) by different prosthetic designs is not well elucidated. Therefore, this study aimed to compare the blood loss and transfusion rate between different knee prostheses in SBTKA and to identify risk factors that influence blood loss and transfusion after SBTKA. Methods: Demographic and perioperative data of patients who underwent SBTKA using either a closed-box or an open-box femoral component of posterior-stabilized fixed-bearing (PS FB) knee system were retrospectively reviewed. The calculated blood loss (CBL) and blood transfusion rate were compared by using Student t-test and confirmed with multivariate regression analysis. Results: There was no significant difference in preoperative parameters between 54 closed-box and 56 open-box PS FB TKAs. The CBL of the closed-box TKA group was 135.23 mL less (95% confidence interval [CI], –215.30 to –55.16; p = 0.001) than that of the open-box TKA group. However, the blood transfusion rates of the closed- and open-box TKA groups were not significantly different (24.1% and 38.5%, p = 0.11). For each additional minute of total operative time, 3.75 mL (95% CI, 1.75 to 5.76; p < 0.001) of blood loss was anticipated. For each additional mg/dL of preoperative hemoglobin, 71% (p < 0.001) reduction of blood transfusion probability was predicted. Conclusions: The use of closed- and open-box knee prostheses resulted in a significant difference in blood loss in SBTKA. Prolonged operative time also significantly increased CBL. Therefore, strategies to control the bleeding surface and shorten operative duration may be considered if blood loss is of special concern. The preoperative hemoglobin was the only factor that affects the probability of blood transfusion in SBTKA.