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Metal stain on monolithic zirconia restoration: A case report
Min-Sang Cha,Sang-Woon Lee,Yoon-Hyuk Huh2,Lee-Ra Cho2,Chan-Jin Park 대한치과보철학회 2017 The Journal of Advanced Prosthodontics Vol.9 No.2
In restorative treatment using fixed dental prostheses, dentists should select appropriate restoration material among various types of dental materials. The strength, marginal fit, esthetics, wear resistance, biocompatibility, and cost are important factors in the choice of restoration materials. The present case showed a surface stain on a monolithic zirconia restoration that was due to wear between the monolithic zirconia restoration and the base metal alloy restoration. This phenomenon was confirmed by surface roughness measurement and electron probe micro-analysis.
Deposition of SiCxNy Thin Film as a Membrane Application
Huh,Sung-Min(Sung-Min Huh),Park,Chang-Mo(Chang-Mo Park),Jinho Ahn(Jinho Ahn) 한국마이크로전자및패키징학회 2001 마이크로전자 및 패키징학회지 Vol.8 No.1
SiCxNy film is deposited by electron cyclotron resonance plasma chemical vapor deposition system using SiH_4(5% in Ar), CH₄ and N₂. Ternary phase SiCxNy thin film deposited at the microwave power of 600 W and substrate temperature of 700 contains considerable amount of strong C-N bonds. Change in CH₄flow rate can effectively control the residual film stress, and typical surface roughness of 34.6 (rms) was obtained. Extremely high hardness (3952 Hv) and optical transmittance (95% at 633 nm) was achieved, which is suitable for a LIGA mask membrane application.
Microfluidic generation of Prussian blue-laden magnetic micro-adsorbents for cesium removal
Kang, Sung-Min,Rethinasabapathy, Muruganantham,Hwang, Seung Kuy,Lee, Go-Woon,Jang, Sung-Chan,Kwak, Cheol Hwan,Choe, Sang-Rak,Huh, Yun Suk Elsevier 2018 CHEMICAL ENGINEERING JOURNAL -LAUSANNE- Vol.341 No.-
<P><B>Abstract</B></P> <P>Here, we designed and synthesized a recoverable multifunctional adsorbent using a microfluidic reaction system and evaluated the removal performance of the smart adsorbent toward radioactive cesium as a model sample. Prussian blue-laden magnetic micro-adsorbents (PB-MNPs-MAs) with uniform morphology and monodispersity were generated via two-step sequential procedures using a glass capillary microfluidic system, followed by chemical co-precipitation with a high production rate. The cesium removal efficacy of the PB-MNPs-MAs was analyzed based on Langmuir and Freundlich isotherms by controlling adsorption parameters such as adsorbent size, initial cesium concentration, and contact time. The adsorption isotherm of the PB-MNPs-MAs was better fitted to the Langmuir model with a maximum cesium adsorption capacity of 58.73 mg g<SUP>−1</SUP>, which was 40% higher than that of macro-adsorbents in a dynamic magnetic field. This result can be attributed to their large specific area, which increased the kinetic rate of cesium adsorption and achieved saturation within 20 min. Additionally, the PB-MNPs-MAs were recovered from wastewater within 5 s under a static magnetic field, indicating their great potential for magnetic actuation. We believe that our PB-MNPs-MAs can encapsulate nano-functional adsorbents and prevent actuation, making them promising for environmental remediation and especially for removal of radionuclides.</P> <P><B>Highlights</B></P> <P> <UL> <LI> PB-MNPs-MAs were generated in microfluidic device using chemical co-precipitation. </LI> <LI> The prepared PB-MNPs-MAs are monodispersed with uniform morphology. </LI> <LI> PB-MNPs-MAs exhibited high Cs adsorption capacity (58.73 mg g<SUP>−1</SUP>). </LI> <LI> 100% recovery of PB-MNPs-MAs is possible under static magnetic field after Cs adsorption. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Huh, Seong,Suh, Min-Jung,Vien, Vo,Kim, Youngmee,Hwang, Seong-Ju,Kim, Sung-Jin WILEY-VCH Verlag 2009 Small Vol.5 No.10
<B>Graphic Abstract</B> <P>The octahedral [Re<SUB>6</SUB>Se<SUB>8</SUB>(CN)<SUB>6</SUB>]<SUP>4−</SUP> ions with various bridging metal ions form well-defined cubic and hexagonal mesostructures (see image) in the presence of liquid-crystal template in formamide. The interaction between the positively charged micellar head groups of the template and the [Re<SUB>6</SUB>Se<SUB>8</SUB>(CN)<SUB>6</SUB>]<SUP>4−</SUP> ions is a pure noncovalent electrostatic interaction. These materials are coordination polymers with exceptionally large 1D or 3D potential pores because of the dimension of mesoscale liquid-crystal template. <img src='wiley_img/16136810-2009-5-10-SMLL200801677-content.gif' alt='wiley_img/16136810-2009-5-10-SMLL200801677-content'> </P>
Huh, Keun,Lee, Sang-Il,Park, Jong-Min,Kim, Seok-Hwan The Pharmaceutical Society of Korea 1986 Archives of Pharmacal Research Vol.9 No.4
Glutathione s-transferase in thought to play a key role in initiating the detoxication of potential alkylating agents, including pharmacologically active compounds. It is widely accepted that garlic contained allin which is converted to allicin by allinase. Allicin is easily degraded to diallyl disulfide and other components. This report attempted to observe the effect of diallyl disulfide on some biological activities. It was observed that the activity of serum transaminase was not changed by the treatment of diallyl disulfide. The liver cytosolic glutathione s-transferase was significantly increased. where as the microsomal glutathione s-transferase was not increased.
Min-Jung Kim,Won-Tak Cho,Su-Hyun Hwang,Ji-Hyeon Bae,Eun-Bin Bae,June-Sung Shim,Jong-Eun Kim,Chang-Mo Jeong,Jung-Bo Huh 대한치과보철학회 2023 The Journal of Advanced Prosthodontics Vol.15 No.4
PURPOSE. This prospective clinical study was conducted to evaluate the clinical usefulness of the freely detachable zirconia ball- and spring-retained implant prosthesis (BSRP) through a comparative analysis of screw- and cement-retained implant prosthesis (SCRP). MATERIALS AND METHODS. A multi-center, randomized, prospective clinical study evaluating the clinical usefulness of the detachable zirconia ball- and spring-retained implant prostheses was conducted. Sixty-four implant prostheses in 64 patients were examined. Periodic observational studies were conducted at 0, 3, 6, and 12 months after delivery of the implant prosthesis. Factors such as implant success rate, marginal bone resorption, periodontal pocket depth, plaque and bleeding index, and prosthetic complications were evaluated, respectively. RESULTS. During the 1-year observation period, all implants survived without functional problems and clinical mobility, showing a 100% implant success rate. Marginal bone resorption was significantly higher in the SCRP group than in the BSRP group only at the time of implant prosthesis delivery (P = .043). In all observation periods, periodontal pocket depth was slightly higher in the BSRP group than in the SCRP group, but there was no significant difference (P > .05). The modified plaque index (mPI) scores of both groups were moderate. Higher ratio of a score 2 in modified sulcus bleeding index (mBI) was observed in the BSRP group in the 6- and 12-months observation. CONCLUSION. Within the limitations of this study, the newly developed zirconia ball- and spring-retained implant prosthesis could be considered as an applicable and predictable treatment method along with the existing screw- and cement-retained prosthesis.
Huh, Jeong-Eun,Lee, Eun-Ok,Kim, Min-Seok,Kang, Kyung-Sun,Kim, Cheol-Ho,Cha, Bae-Cheon,Surh, Young-Joon,Kim, Sung-Hoon Oxford University Press 2005 Carcinogenesis Vol.26 No.8
<P>Recent studies have revealed that 1,2,3,4,6-penta-<I>O</I>-galloyl-beta-<SMALL>D</SMALL>-glucose (PGG) has anti-tumorigenic activity <I>in vitro</I>. In the present work, we evaluated the <I>in vitro</I> and <I>in vivo</I> antiangiogenic and antitumor activities of PGG and examined its molecular mechanisms. PGG significantly inhibited the proliferation and tube formation in basic fibroblast growth factor (bFGF)-treated human umbilical vein endothelial cells (HUVECs) at non-cytotoxic concentrations. PGG effectively disrupted the bFGF-induced neo-vascularization in chick chorioallantoic membrane (CAM) and in Matrigel plugs in the mice. When mice were intraperitoneally injected, PGG also significantly inhibited tumor angiogenesis induced by Lewis lung carcinoma (LLC) and the growth of LLC by 57 and 91% of control tumor weight at 4 and 20 mg/kg, respectively. Immunohistochemical analysis revealed decreased microvessel density, decreased expression of cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF), reduced tumor cell proliferation and increased tumor cell apoptosis. Similarly, PGG significantly attenuated the expression of COX-2 and VEGF and reduced the secretion of VEGF and prostaglandin E<SUB>2</SUB> in bFGF-treated HUVECs. Furthermore, the COX-2 inhibitor NS398 significantly inhibited tube formation and neo-vascularization in CAM, supporting the role of COX-2 in PGG inhibition of angiogenesis. PGG diminished the phosphorylation of extracellular signal regulated kinase 1/2, Jun NH<SUB>2</SUB>-terminal kinase and activated phospho-p38 mitogen-activated protein kinase (MAPK) in a dose-dependent manner in bFGF-treated HUVECs. In addition, p38 inhibitor SB203580 abolished the downregulation of COX-2, VEGF and the antiproliferative activity by PGG. Taken together, our data demonstrate that PGG exerts antitumor activity primarily via inhibition of angiogenesis through COX-2 and MAPK- dependent pathways.</P>
Huh Yeon-Ju,Cho Sung-Yup,Cho Min-Sun,Lee Kyoung-Eun,Lee Joo-Ho 한국유전학회 2022 Genes & Genomics Vol.44 No.11
Background: Investigation of responsiveness-associated genes using longitudinal mutation analyses after standard treatments in recurrent gastric cancer (GC) is limited. Objective: To evaluate the somatic mutations associated with resistance to combined treatment involving fluorouracil (FU) or platinum (PL) in advanced GC. Methods: Samples from patients with advanced GC treated with FU or PL alone, or surgery plus FU/PL, were studied. GC patients who relapsed after standard chemotherapy (FU/PL) and with presence of tumor samples from initial diagnosis and recurrence were included. Targeted sequencing analysis of 143 cancer-related genes was performed using an Oncomine Comprehensive Cancer Panel. Results: Matched samples of primary and recurrent lesions were analyzed in sixteen patients with GC. When genes with recurrent mutations in two or more patients were used as specific findings, a total of 26 genes were found. TP53 was the most predominantly increased allele frequency (AF) in recurrent GCs after standard treatment. The mutational AF of ERBB2, PTEN, and BRCA2 also commonly increased, suggesting the role of these mutations in treatment resistance, whereas the mutational AF of VLH, NF1, and STK11 frequently decreased in recurrent tumors, suggesting the role of these mutations in increasing sensitivity to treatment. TCGA gastric cancer data (n = 436) were analyzed, and mutation sites detected in 16 GC patients in this study were in agreement with TCGA cohort with some exceptions. Overall survival according to gene expression associated with chemotherapy responsiveness exhibited compatible patterns with gain or loss-of-function mutations of each gene. Conclusions: Mutations in TP53, ERBB2, PTEN, BRCA2, VHL, NF1, and STK11 are candidate somatic alterations related to chemoresistance in GC.