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Sohn, Seil,Chung, Chun Kee,Park, Sung-Hye,Kim, Eun-Sang,Kim, Ki-Jeong,Kim, Chi Heon M. Nijhoff ; Kluwer Academic Publishers 2013 Journal of neuro-oncology Vol.114 No.3
<P>The fate of residual spinal schwannomas needs to be estimated in order to plan further management after subtotal removal. Our aim was to evaluate the growth rate of residual spinal schwannomas and compare results in regrowth and no regrowth groups by using data collected from the Korea Spinal Oncology Research Group database. From January 1989 to August 2011, 27 patients with residual spinal schwannomas were selected. Patients with at least two follow-up magnetic resonance image (MRI) studies after subtotal resection were included. The mean period of MRI follow-up was 62.4 months. A tumor size increase of over 2 mm in the maximal diameter was considered indicative of regrowth. Age, sex, size at initial diagnosis, postoperative tumor size, and Ki-67 labeling index were compared between regrowth and no regrowth groups. Eight residual schwannomas regrew (29.6 %), and 19 (70.4 %) did not regrow. Average growth rate of the regrowing tumors was 1.0 4.4 mm/year. The mean percentage increase in tumor size during follow-up was 10.0 28.8 %. The Ki-67 labeling indices were significantly different between regrowth and no regrowth groups (P = 0.014). Two patients underwent a revision operation for significant tumor regrowth. Nineteen cases (70.4 %) among 27 residual spinal schwannomas did not regrow significantly, but further surgical treatments were necessary in 2 patients due to significant regrowth. The Ki-67 labeling index was higher in the regrowth group. Earlier follow-up MRI is recommended for patients whose tumors have higher Ki-67.</P>
Choi, Euno,Kim, Seonk-Ik,Won, Jae-Kyung,Chung, Chun Kee,Kim, Seung Ki,Choi, Seung-Hong,Choi, Seongmin,Han, Bome,Ahn, Bokyung,Im, Sun-Wha,Park, Sung-Hye Elsevier 2019 Human pathology Vol.86 No.-
<P><B>Summary</B></P> <P>Multinodular and vacuolating neuronal tumor (MVNT) of the cerebrum is a recently recognized rare neuronal tumor, and its pathogenesis is unclear. We analyzed 7 cases of histologically typical MVNT: 6 were adults (mean age, 43.0 years [range, 23-56 years]) and 1 was a child (age, 10 years). The most common symptoms were seizures (n = 4) and headache (n = 2). The tumors were supratentorial (temporal, 5; frontal lobes, 2) in origin as reported. Vacuolated tumor cells were robustly positive for α-INA and Olig2 and at least partly positive for synaptophysin and MAP2, but negative for Neu-N, nestin and CD34. GFAP and vimentin were expressed in reactive astrocytes but not in tumor cells. Negative results were obtained for p53, IDH-1, BRAF<SUP>V600E</SUP>, H3 K27M, EGFR, Lin28A, and L1CAM. ATRX, BRG1, INI-1, and TMHH were retained. The Ki-67 labeling index was very low (<1%), and pHH3 revealed no mitotic figure. Ultrastructural features of tumor cells were comparable with those of immature neuronal cells, with several intracytoplasmic myelin-like autophagosomes and pericellular vacuolization. No <I>IDH1</I>/<I>IDH2</I> and <I>BRAF</I> <SUP> <I>V600E</I> </SUP> mutations were found upon direct sequencing. Whole-exome sequencing revealed <I>FGFR2</I>-<I>ZMYND11</I> gene fusion in 1 case. After gross total resection, all patients were alive without seizures. There was no tumor recurrence during an average period of 68 months (range, 23-101 months). The analysis of 7 typical cases of MVNT suggested that these lesions may be clonal tumors because <I>FGFR2</I>-<I>ZMYND11</I> fusion was found (1 case).</P> <P><B>Highlights</B></P> <P> <UL> <LI> “MVNT” of the cerebrum is a recently recognized rare epileptogenic neuronal tumor. </LI> <LI> Whole-exome sequencing revealed <I>FGFR2</I>-<I>ZMYND11</I> gene fusion in one of our MVNT cases. </LI> <LI> The tumor cell is robustly positive for α-INA and Olig2, but negative for Neu-N. </LI> <LI> Ultrastructurally, tumor cells have autophagolysosomes with pericellular vacuolization. </LI> <LI> There was no tumor recurrence during an average period of 68 months. </LI> </UL> </P>
Efficacy of Serum PIVKA-2 in the Diagnosis and Follow-up after Treatment of Hepatocellular Carcinoma
( Sang-hee Lee ),( Gum-gyoung Gu ),( Tae-jin Han ),( Byung-yoon Paik ),( Sail Chun ),( Won-ki Min ) 대한임상검사과학회 2011 대한임상검사과학회지(KJCLS) Vol.43 No.4
It is a very important diagnosis and evalution of Hepatocellular carcinoma (HCC) in Korea where hepatitis B-virus is endemic. Protein induced by vitamin K absence or antagonist II (PIVKA-II) appears to be a useful tumor marker. This study was purposed to investigate usefulness of PIVKA-II in the diagnosis and fallow-up after treatment of HCC. A total of 418 patients were included in 187 patients (44.7%) of HCC, 83 patients (19.9%) of liver cirrhosis, 74 patients (17.7%) of chronic hepatitis and 74 patients (17.7%) of other liver diseases with serum PIVKA-II levels by Hicatch PIVKA-II kit. PIVKA-II level were analysed for difference of groups and the comparison of treatment responses. The sensitivity and specificity of PIVKA-II in the diagnosis of HCC were 80.2%, 87.0% at the cut-off value of 40 mAU/mL. There were statistically significant difference between the HCC and other groups (p <0.001), before and after PIVKA-II levels after treatment in HCC (p <0.001). PIVKA-II can be used as a useful tumor marker for patients with HCC, especially early diagnosis in high risk groups, treatment response assesment and monitoring of recurrence.
Adaptive RLS Filtering for the Reduction of Blind Spot in a Cable Fault Locator
Chun Ku Lee,Ki Seok Kwak,Tae Sung Yoon,Jin Bae Park 제어로봇시스템학회 2010 제어로봇시스템학회 국제학술대회 논문집 Vol.2010 No.10
A cable fault locator based on a reflectometry is used to test the integrity of a cable. It is well known that all the reflectometries have an inherited drawback known as a blind spot that indicates the minimum length of the cable that can be measured. This paper proposes a method based on an adaptive recursive least squares filtering and a normalized cross correlation to reduce the blind spot. The experimental results show that the proposed method can estimate a fault location on the cable with high spatial resolution.
A Study on the General Characteristics and Instrumental Analysis of Natural Omija Extract
( Ki Chun Sung ),( Ki Jun Kim ),( Yong Ryul Kim ),( Sang Sung Nam ) 한국유화학회 2013 한국응용과학기술학회지 Vol.30 No.2
Omija component was known to possess natural odor, taste, color, and various general characteristics. Omija extraction was extracted using ethanol as a solvent. Omija extract showed a red-purple color of some viscous liquid state. Some conclusions from natural Omija extract were obtained as follow. The result of antimicrobial experiment to add Omija extract, the number of microbial population showed negative reaction from 3 days after it cultivated. This phenomenon could confirm that Omija component affected to antimicrobial effect. The result of dyeing experiment to add Omija extract, fiber dyeing effect showed with some ivory color after dyed to cotton and silk. Also, this phenomenon could confirm that Omija component affected to natural dyeing effect from observated dye state with biological microscope(BM). The result of instrumental analysis, inorganic components of K(109.60ppm), Na(3.500ppm), Ca(1.205ppm), Mg(0.900ppm), Li(0.350ppm), Si(0.380ppm), Cu(0.250ppm), Fe(0.125ppm), Zn(0.090ppm), etcs from Omija were ascertained with ICP/OES, and organic components of benzene(10.808), borny lacetate(11.289), phenol(14.183), β-terpinene(15.840), α-terpinolene(17.616) etcs from Omija were ascertained with GC/MSD.
Characteristics of Electric Generation for High Concentration Solar PV System
( Ki Ho Kim ),( Sang Chun Lee ) 경남대학교 신소재연구소 2013 신소재연구 Vol.25 No.-
Among new types of renewable energy, photovoltaic power generation is being developed by many researchers as an energy source without any kind of pollution. In this research, Ⅲ-Ⅴ Multi-junction Chips whose generating efficiency is high are used and by adding the optical/photovoltaic system- dual axis- tracking HCPV(High Concentration Photovoltaic) system- to the established generating system in the experiment by increasing energy integration by focusing sunlight into one point, Comparing the difference in generation capacity in accordance with the mirror`s area and the difference in the generation rate in accordance with the size of the solar cell. The result shows that generated energy is proportional to the area of the 1st parabolic reflector. Then we got our conclusion, 1. When the reflection area is proportionally increased, generation electricity is increased. 2. Test for accordance with the sizes of the solar cells (0.16 ㎠(4mm*4mm), 0.3 ㎠(5.5mm*5.5mm), 1.0㎠ (10mm*10mm)), there was not a dramatic increase as had we expected. This test is carried out using the same 1st parabolic reflector.