Drosophila melanogaster 韓國 自然集團에 있어서 P-M System에 依據한 Cytotype 分布 硏究

成耆昌,安成晥 성균관대학교 기초과학연구소 1988 論文集 Vol.39 No.1

Hybrid dysgenesis, aberrant phenomena, found in certain interstrain hybrids of Drosophila melanogaster, is caused by the interaction of chromosomal and cytoplasmic factors. 10 natural populations of D. melanogaster from Korea were investigated in order to determine the distribution of P factor and M cytotype, two components of P-M system. The results showed that: 1) The P factor activity for potential GD sterility is absent or present at only very low frequencies in these populations. 2) All locations show rather similar distributions, indicating weak M cytotype. The levels of activity of M cytotype were appeared to be variable among 10 populations. 3) Q cytotype, which cause immune to the P factor, was found at high frequencies in these populations. 4) The results seem to suggest that polymorphism of M and Q cytotype exists in Korean natural population.

정상교합자와 골격성 Ⅲ급 부정교합자의 저작운동형태의 비교

성기혁 慶北大學校 齒科大學 1997 慶北齒大論文集 Vol.14 No.-

정상교합자의 골격성 3급 부정교합자의 저작운동형태를 비교연구하기위해서 30명의 정상교합자와 20명의 골격성 3급 부정교합자를 대상으로 츄잉검을 사용하고 Biopak system을 이용하여 전두면상에서 저작운동을 기록, 분석 하였다. 각 개체마다 대표하는 저작경로를 정하여 저작폭경, 개구거리, 개구각, 페구각, 최대개구속도, 최대폐구속도를 알아보았다. 또 저작 경로의 형태에 따라 특징적인 7가지 패턴으로 분류하여 다음의 결과를 얻었다. 1. 정상교합자군에 비해 골격성 3급 부정교합자군에서는 좀 더 다양하고 수직적인 저작양상을 나타내었다. 2. 저작폭경의 비교에서는 골격성 3급 부정교합자군이 정상교합자군에 비해 더 좁게 나타났다(P<0.01). 3. 개구거리에서는 골격성 3급 부정교합자군이 정상교합자군에 비해 더 작게 나타났으나 통계학적으로 유의성은 없었다(P>0.05). 4. 개구각과 폐구각에서는 골격성 3급 부정교합자군에서 정상교합자군보다 더욱 예각으로 나타났다(P<0.01). 5. 최대개구속도, 최대폐구속도에서는 정상교합자군에 비해 골격성 3급 부정교합자군에서 느리게 나타났으나 통계학적으로 유의성은 없었다(P>.05). 6. 저작운동형태에 따른 분류에서 정상교합자군에서 Type 2가 73.4%로 가장 많은 비율을 차지하였으나, 골격성 3급 부정교합자군에서는 Type 3가 35.0%, Type 2가 30.0%로 가장 많은 비율을 차지하였다. 7. 저작운동형태에 따른 분류에서 골격성 3급 부정교합자군에서는 Type 4(chopping type)가 25.0%로 정상교합자군 3.3%에 비해 많은 비율을 차지하였다.

韓國 Drosophila 屬內 16種에 對한 遺傳的 近緣關係

成耆昌,서민철,金源澤,金溶聲 성균관대학교 기초과학연구소 1987 論文集 Vol.38 No.2

Eleven allozymes from sixteen species of Drosophila were analyzed by using horizontal starch gel electrophoresis in order to estimate genetic relationship among these species. All eleven allozymes were present in all sixteen species examined, and some commom alleles were also detected. The mean genetic identity between inter-and intra-subgenus Drosophila were estimated to be 0.16∼0.20, and 0.24∼0.28, respectively. The results showed that D. nigromaculata, which belongs to subgenus Drosophila, had closer genetic relationship to the species in subgenus Sophophora than to Drosophila. High mean genetic identity was also observed between subgenus Hirtodrosophila and Drosophila, and between subgenus Paradrosophila and Sophophora. Results of Nei's genetic identity test of the present data generally agreed with the previously known Drosophila classification establised based on the cytological and morphological characteristics.

Drosophila melanogaster Meigen 人工集團內의 두 Allozyme 座位에서의 頻度依存選擇에 관한 硏究

성기창,박미란 성균관대학교 기초과학연구소 1988 論文集 Vol.39 No.1

In D. melanogaster, evidence of frequency-dependent selection has been observed at two loci Adh and α-Gpd. From the both loci the gene frequency changes were carried out between inversion free genotypes at two gene frequency levels (F alleles=20%, 80%). Allele frequency changes were recorded for a period of 11 generations. Genes at both Adh and α-Gpd loci second chromosome were scored by agarose electrophoresis. When homozygote (either FF or SS) was persent in low frequency(20%), its fitness was enhanced, but when the frequency is high(80%, its fitness was reduced. This may idea to a stable polymorism because a generation increases as its frequency decreases. The allelic frequency of Adh approached an equilibrium after 11 generations, converging toward the frequency (case A_1=76%, cage A_2=69%). However, the possibility remains that Adh alleles in nature are associated with alleles at closely linked loci. If linkage disequilbrium is present in the experiments because it exists in nature, then observed effects (frequency-dependent selection) would affect the Adh locus in nature as well. The frequency of α-Gpd approached an equilibrium, converging toward the frequency (cage B_1=40%, cage B_2=33%).

단어생성시 기능적 자기공명영상을 통한 운동 언어중추의 국소화

정상욱,김주용,송인찬,이경민,이상건,장기현 대한신경과학회 1998 대한신경과학회지 Vol.16 No.5

光州ㆍ大田地域 서비스산업의 構造分析

奇聖來,金陣洙 大田工業大學 1992 한밭대학교 논문집 Vol.9 No.2

In the future of the industrial society, the demand of soft section trends increasingly than that of hard section, owing to the diversification of national life and change of the international situation, The propotion of the service industries to the GDP is rated 6% at the present 1991 in Korea. In the point of views, this study analyzed comparatively structure of the service industries which the economic environment is smilar in Kwangju and Taejon. The main contents of this study are as follows : In chapter Ⅱ, it is presumed population of the future by time-series of Kwangju-Taejon. It is analyzed the change of structure, wage and employment in the service industries at two rigions. In chapter Ⅲ, it is analyzed the structure of the service industries by using LQ (locational quotient)and shift -share analysis. According to LQ analysis, Kwangju was very specialized a land carrige and Taejon a communications service. According to shift-share analysis, the state of the industrial structure was relatively good for industrial mix effect, but the external competitive power appeared very weak in Kwangju. The service industries in Taejon will be highly-specialized because the effect of the net employment change and regional share effect was increased. On the other hand, the section of the financial business was relatively weak. As a results, the provincial government should establish the policy, improve the system for rearing of the service industries.

기저세포암, 피부전이암과 유사한 조직소견을 보인 안검 외 피지선암 1예

김상태,노효진,서기석 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.1

Backgroud : Extraocular sebaceous carcinoma is a malignant tumor derived from the adnexal epithelium of sebaceous glands. A poorly differentiated sebaceous carcinoma shows variable histopathologic findings and mimics other primary tumor and cutaneous metastases mostly composed of clear cells. Case : Our patient consultation was requested for a 53 year?old female with solitary mild painful tumor on the scalp. The first histopathlogic impression of this case was basal cell carcinoma on the other hospital. After reevaluation, our diagnosis is not basal cell carcinoma but extraocular sebaceous carcinoma. Conclusion : A thorough exact recognition of characteristic histopathologic features of extraocular sebaceous carcinoma is necessary for making diagnosis, treatment plan and determining the prognosis.

Drosophila quinaria Species Group의 遺傳的 近緣關係

成耆昌,金正洙,金大鎰,金彧,金溶聲 성균관대학교 기초과학연구소 1985 論文集 Vol.36 No.2

The genetic relatedness among the Korean Drosophila quinaria species group, including D. nigromaculata, D. unispina, D. brachynephrose, and D. angularis, has been examined by using horizontal starch gel electrophoresis. The results showed that none of the ten isozyme patterns examined for these four species was identical. The average genetic similarity among the four species was found to be 0.440. The similarity among three species. D. unispina, D. brachynephrose, and D. angularis was 0.466. The relatedness was found to be closest between D. nigromaculata and D. unispina, showing 0.640. D. nigromaculata and D. angularis showed relatedness of 0.258. The results suggested that these four species appear to be genetically related at the level of sibling species. The percent polymorphism in D. brachynephrose was found to be 76.9%, showing significant genetic variations.

한국 노랑 초파리 (Drosophila melanogaster) 자연 집단의 ADH & α-GPDH 동위효소 빈도의 분포 상태와 연속변이 (Cline)에 관한 연구

成耆昌,姜德泳 성균관대학교 기초과학연구소 1990 論文集 Vol.41 No.1

본 실험은 한국지역을 위도와 경도별로 각각 35˚∼39˚, 126∼130˚의 범위내에서 1˚씩 구획을 정하여 14개 지역으로부터 채집된 노랑 초파리 (D. melanogaster)의 ADH & α-GPDH allozyme의 전체적인 분포상태 및 그 유전자 빈도가 위도와 경도에 따라 연속변이 (Cline)를 형성하고 있는지를 살펴보고, 그러한 관계에 기후요소가 어떻게 관련되어 있는가를 조사하여 Selectionist & Neutra1ist의 Allozyme polymorphism의 진화적 의미에 대한 해석에 좀 더 유의한 자료로 활용될 수 있기를 바라는 뜻에서 진행된 바, 그 결과를 요약하여 정리하면 다음과 같이 표현될 수 있다. 1. 한국지역의 ADH & α-GPDH 동위효소 빈도의 분포는 대체적으로 다음과 같이 표시할수 있다. ADH 동위효소의 빈도와 순위는 FF(48.76%)>FS(38.10%)>SS(13.13%)로 나타나며, α-GPDH 동위효소의 빈도와 순위는 FS(43.30%)>FF(34.66%)>SS(22.04%)로 나타나고 있다. 2. 한국지역의 Adh & α-Gpdh 대립유전자 빈도 분포는 대체적으로 다음과 같이 표시할수 있다: Adh 대립유전자 빈도는 Adh^F(67.81%), Adh^s(32.19%)로 나타나며, α-Gpdh 대립유전자 빈도는 α-Gpdh^F(56.31%), α-Gpdh^s(43.69%)로 나타나고 있다. 3. 한극지역의 Adh & α-Gpdh 대립유전자 빈도는 위도와 경도의 변화에 따라 유의적인상관 관계를 나타내는 경향이 있음을 알 수 있다: Adh^F 유전자 빈도와 위도 사이이 유의적인 양의 상관관계(r=0.557, p<0.05)를 나타내는 바, 이는 위도가 증가할수록 Adh^F 빈도가 증가함을 나타내는 것으로 해석된다. α-Gpdh^F 유전자 빈도와 경도 사이의 유의적인 양의 상관관계 (r=0.516, p<0.1)를 나타내는 바, 이는 경도가 증가할수록 α-Gpdh^F 빈도가 증가함을 나타내는 것으로 해석된다. 그러나 Adh^F 유전자 빈도와 경도 사이, α-Gdph^F 유전자 빈도와 위도 사이에는 유의적인 상관관계가 형성되어 있다고 해석하기에는 미흡한 점이 있다. 4. Adh & α-Gpdh 대립유전자 빈도의 위도와 경도의 변화에 따른 연속변이에 영향을 줄수 있는 기후 요소를 분석한 결과 최대 강우량(Rmax)이 Adh^F 유전자 빈도와 음의 상관 관계 (r=-0.501, p<0.1)를 나타내고 있는 변수로 분석되고, 평균 강우량(Rmean)이 α-Gdph^F유전자 빈도와 음의 상관 관계 (r=-0.461, p<0.1)를 나타내고 있는 변수로 분석된 바, 온도 변수보다는 강우량 변수가 위도에 따른 Adh 대립유전자 빈도의 연속변이와 경도에 따른α-Gpdh 대립유전자 빈도의 연속변이에 좀 더 밀접한 관계를 지니면서, 영향을 주는 요인으로 추정된다. The samples of D. melanogaster were captured from 14 localities in the range of 35°∼39°(latitude) and 126°∼130°(longitude). The Adh & α-Gpdh variants were analysed by agarose gel electrophoresis. Adh and α-Gpdh were considered to have two common electraphoretically distinguishable alleles: Adh^F & Adh^S, α-Gpdh^F & α-Gpdh^s. This experiment was conducted to investigate the geographic clines and climatic associations of the Adh and α-Gpdh gene frequencies in Korean natural populations of D. melanogaster. The results of experiment can be summerized like the following: 1. The distribution and rank of ADH and α-GPDH allozyme frequencies showed the ADH-FF(48.76%)> -FS(38.10%)> -SS(13.13%) and FS(43.30%)> -FF(34.66%)> -SS(22.04%), respectively. 2. The Adh allelic gene frequencies showed the Adh^F(67.81%) and Adh^s(32.19 %): The lowest frequency of Adh^F gene was 62.00% (Kimhae-Gun), the highest frequency of Adh^F gene was 73.10% (Sokcho-Shi). 3. The α-Gpdh allelic gene frequencies showed the α-Gpdh^F(56.31%) and α-Gpdh^s(43.69%): The lowest frequency of α-Gpdh^F gene was 45.61%(Sosan-Gun), the highest frequency of α-Gpdh^F gene was 64.46% (Tonghae-Shi). 4. There were a geographic clines in Adh frequency with latitude and α-Gpdh frequency with longitude: Adh^F gene frequency increased markedly and significantly with latitute while α-Gpdh^F gene frequency increased much less dramatically but also significantly with longitude. 5. The most highly correlated variable with the latitudinal cline of Adh gene frequency was the Rmax: It correlated negatively and significantly with the Adh^F frequency(r=-0.501, P<0.1). 6. The most highly correlated variable with the longitudinal cline α-Gpdh gene frequency was the Rmean: It correlated negatively and significantly with α-Gpdh^F frequency (r=-0.461, <0.1). Therefore, the dines in Adh and α-Gpdh gene frequencies in the Republic of Korea explained largely by more variation in rainfalls than variation in temperatures. The effect of rainfall on Adh & α-Gpdh phenotypes is likely to be indirect.

초파리(Drosophila melanogaster)의 實驗集團에 있어서 連關不平衡

成耆昌 成均館大學校 1982 論文集 Vol.31 No.-

In order to clarify the linkage disquilibrium, six experimental populations were surveyed at two mutant loci (cinnabar and brown) on the second chromosome of Drosophila melanogaster. The experimantal results indicated: (1) the linkage disequilibrium would be due to an epistatic relationship between the cinnabar and the brown mutants. (2) the rate of decay of linkage disequilibrium was similar to the expected value during first three generations and become lower than the expected value after the fourth generation. (3) there was no significant difference in linkage disequilibrium between populations which consist of different genetic background. and (4) the frequency changes of brown gene was significant between population which consisted of linked gene and single gene.