유방질환에서 CEA의 분포에 관한 연구

이해혁,양승하,강상균 순천향대학교 1992 논문집 Vol.15 No.2

Carcinoembryonic antigen(CEA), isolated from adenocarcinoma of human digestive system and fetal or gut tissue, is one of tumor associated antigen. In recent years, presence of CEA in various tumors and inflammatory disease has been reported, but studies in mailgnant and bengin cisease of breast, common in female of korea, was rare. Therefore, to understand positive rate of CEA in these disease, the author collected ductal carcinoma 24 cases, fibroadenoma 15 cases, intraductal papilloma 4 cases, and fibrocystic disease 11 cases, and performed immunoenzyme histologic reaction by Avidin-Biotin-complex method using anti-CEA serum, andanalyzed their histologic reaction. 1. In 24 cases of ductal carcinoma, positive reaction of CEA was 16 cases(67%). 2. According to types of ductal carcinoma, positive reaction of infiltrating ductal carcinoma was 9(56%) of 16 cases, intraductal carcinoma all 6 cases, and medullary carcinoma 1(50%) of 2 cases. 3. In benign diseases, positive reaction of fibroadenoma was 2(13%) of 15cases, intraductal papilloma 1(25%) of 4cases, and fibrocystic disease 2(18%) of 11 cases. The above results showed that ductal carcinoma was relatively high positive rate for CEA, especially intraductal carcinoma, and noted that the more differentiation of the carcinoma, the more strong positivity of the CEA. Benign disease showed low positive rate and focal reaction. but evidence of production of CEA was identified in these disease.

소포제를 이용한 초속경 LMC의 특성 개선연구

윤경구,김성환,정원경,권혁찬 강원대학교 부설 석재복합신소재 제품연구센터 2003 석재연 논문집 Vol.8 No.-

본 논문은 콘크리트 배합시 발생하는 과도한 기포 발생 문제점을 해결하기 위하여 최적의 소포제 종류 및 혼입률 범위를 산정하여 초속경 라텍스개질 콘크리트 성능을 개선하는 것이다. 초속경 라텍스개질 콘크리트 실험은 2종류의 소포제 A, C와 혼입률 0, 1, 2, 3%을 주요 변수로 하여 공기량 시험, 압축강도 및 휨강도 시험을 수행하였다. 또한, 내구성 평가를 위하여 염소이온 투과실험도 수행하였다. 초속경 라텍스 개질 콘크리트의 공기량시험 결과 소포제 종류에 상관없이 소포제 혼입률 1%이상 첨가시 공기량은 50%이상 감소하였다. 또한, 소포제 첨가에 의한 기포 발생량 감소에 의해서 압축강도의 증진을 이루었다. 초속경 라텍스개질 콘크리트 실험은 A, C 소포제로 선정하여 실험을 수행하였다. 초속경 라텍스개질 콘크리트의 강도 특성에서는 A 소포제 혼입률 1%에서 압축강도 235kgf/㎠ , 휨강도는 조기 교통개방에 요구되는 휨강도 기준 45kgf/㎠를 초과하는 49kgf/㎠를 나타내었다. The purpose of this study was to remove the excessive air foaming which was produced in mixing the RSLMC(latex-modified concrete with rapid-setting cement) by choosing the best antifoam agent type and the optimized quantity for performance improved RSLMC. The main experimental variables such as antifiamer types(A, C), antifoamer contents(0, 1, 2, 3%), and latex contents(15%). Air content test and compressive, flexural tests were carried out to measure the improved properties of RSLMC. the rapid chloride permeability was carried out to estimate a durability of RSLMC. The results of RSLMC showed that the decrease of 50% air content was obtained by admixturing a antifoam agent by 1%. Two kinds and the optimized quantities of antifoam agent were selected for using in RSLMC. The results of RSLMC were obtained at a latex content of 15% and a antifoam agent quantity of 1% with antifoamer A type. The compressive strength and flexural strength at 3 hours after RSLMC placement were 235kgf/㎠ and 49kgf/㎠, respectively, which exceeded the flexural strength criterion of 45kgf/㎠ in order to open the RSLMC placed to traffic.

호산구성 간농양 54예의 임상상

강혜련,권혁수,송우정,이상민,김태범,박혜경,장윤석,김윤근,조상헌,민경업,김유영 대한알레르기학회 2004 천식 및 알레르기 Vol.24 No.2

알코올 금단 섬망 발생의 예측

이충헌,이은,박성혁,정승용,박상진,석정호,남궁기 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.5

Objectives : Alcohol withdrawal delirium is a serious clinical condition with high mortality rate if not treated. This study was to examine whether readily available clinical variables can predict the development of alcohol withdrawal delirium. Methods : The authors performed a retrospective study by reviewing charts of 566 patients who had been admitted for alcohol dependence. The cases were divided into two groups: delirium group (n=40) and control group (n=40). We compared baseline characteristics and serum analysis data at admission between two groups. We used logistic regression to predict risk factors for alcohol withdrawal delirium among potential risk factors. Results : The delirium group had significantly lower hemoglobin, hematocht, platelet counts, and potassium level than countrol group, Presence of previous withdrawal delirium history, AST, GGTP, and bilimbin level of delirium group were significantly higher than those of control group. Among potential risk factors, past history of withdrawal delirium, decreased hemoglobin, elevated bilirubin level, and number of previous detoxification were predictable factors of the development of alcohol withdrawal delirium by 72.5%. Conclusion : Our results suggest that the infomation obtained at admission can be useful to predict the development of al-cobol withdrawal delirium. Also, it makes the individualization of detoxification strategies possible.

한국어판 정신분열병 삶의 질 척도의 개발과 PANSS와의 관련성

김진훈,임선진,민성길,김승업,손소정,Diane J Wild,박성혁,이황빈 大韓神經精神醫學會 2006 신경정신의학 Vol.45 No.5

Objectives : The present study was performed to verify the validity and value of 4th revision of Schizophrenia Quality of Life Scale (SQLS-R4) as an assessment tool in a Korean-language version (SQLS-R4K). Methods : The subjects for present study were 174 patients with a diagnosis of schizophrenia as defined by DSM-IV. The SQLS-R4K was administered together with self-report Korean version of World Health Organization Quality of Life-Brief Scale(WHOQOL-BREF) to assess validity. A subset of respondents also completed the SQLS-R4K for a second time to assess test-retest reliability. To evaluate the relationship SQLS-R4K and clinical characteristics, psychotic symptoms and general functioning were evaluated using the Positive and Negative Syndrome Scale (PANSS) and the Global Assessment of Functioning Scale (GAF) score respectively. Results : All the scales of SQLS-R4K showed good internal consistency reliability. The correlations of items with their scale total revealed that all items were significantly correlated with their own scale score. In test-retest reliability, paired t-tests indicated that responses did not alter significantly between the two assessment. There was moderate correlation between WHOQOL-BREF sub-scores and SQLS-R4K score total. Also relevant correlations between PANSS, current GAF and SQLS-R4K were proved. Conclusion : From the results of the testing the reliability and validity of the SQLS-R4K, it is concluded that the SQLS-R4K is a simple and reliable scale for measuring quality of life in schizophrenic patients.

플라즈마 소결 PZT 세라믹스의 유전특성

이형직,송두규,권혁병,정해경,윤상옥,이형복,이홍림 국립7개대학공동논문집간행위원회 2003 공업기술연구 Vol.3 No.-

소결첨가제나 바인더를 넣지않고 만든 무첨가 PZT 분말 성형체를 플라즈마 소결-로 열처리 후의 미세조직의 변화, PbO의 거동 그리고 이에 따른 유전특성을 로소결한 경우와 비교하여 다음과 같은 결과를 얻었다. 플라즈마 소결-로 열처리로 만든 PZT 시편이 로 소결 시편과 비교하여 입성장이 크게 일어나지 않은 미세조직을 나타내었으며, 또한 균일한 Pb, Zr, Ti 성분분포를 보였다. 유전특성에 있어서는 1kHz에서 20%정도의 유전율의 향상을 얻을 수 있었으며 유전소실 또한 40%정도 낮출 수 있었다. 상기의 결과는 DC 플라즈마 소결법의 특징인 소결초기의 급속가열 효과와 PbO의 증발 억제 효과에 의한 것으로 고려된다. PZT powder compacts without additives and binder were processed by plasma sintering-furnace annealing. Microstructures, PbO behaviour and dielectric properties were investigated, and compared to the specimen obtained by furnace sintering. The specimen prepared by plasma sintering-furnace annealing showed more not only fine microstructures but also homogeneous pb, Zr, Ti composition distribution, and revealed 20% higher dielectric constant as well as 40% lower dielectric loss (measured at 1kHz). Above results might be considered to be caused by rapid heating effects, high temperature sintering effects and preventing effects of PbO evaporation characterized by dc plasma sintering.

정서 사진에 대한 정서 반응성 : 평가 공간에서의 분포

이은,강지인,박성혁,전종희,최재혁,김재진,안석균 大韓神經精神醫學會 2006 신경정신의학 Vol.45 No.1

Objectives : To investigate the nature of emotional responsiveness in norma) adults, we exam the emotional responses to emotional pictures in an evaluative space defined by arousal and valence. Methods : Subjects were instructed to rate the arousal and valence that they experienced from the presentation of one of two sets of 60 emotional pictures. These two picture sets were comprised of 107 pictures : 101 selected from Intetnational Affective Pictures System and six pictures from our own collection. According to "evaluative space model", the authors set an evaluative space defined by the arousal scores as independent variable and the valence scores as dependent variable. In this evaluative space, one-hundred-and-seven pairs of coordinates representing respective emotional pictures were plotted. With regression analyses, the steepness of the regression lines on the plots with positive emotional responsiveness (n=51) and those with negative emotional responsiveness (n=56) were compared. Results : In the evaluative space, the regression line of negative emotional responsiveness was significantly different from that of positive responsiveness. The slope of negative responsiviveness was significantly steeper than that of positive responsiveness. At a low arousal level, the absolute valence of a positive stimuli was larger than that of a negative picture. Conclusion : This finding indicates that the function of the negative affective responsiveness might be different from that of the positive responsitiveness. IAPS also seems applicable to Korean subjects.

한국인 강박장애와 Val-158-Met Catechol-O-Methyltransferase 유전자 다형성 간의 상관성 연구

천근아,김세주,김찬형,구민성,남윤영,박성혁,이홍식 大韓神經精神醫學會 2006 신경정신의학 Vol.45 No.5

목적 COMT(Catechol-O-Methyltransferase) 효소는 도파민성과 노어아드레날린성 체계의 조절에서 매우 중요한 작용을 하며 염색제 22q11에 위치해 있다. 일부의 강박장애 환자들은 도파민 차단제에 좋은 치료 반응을 보이며 이런 현상은 COMT가 강박장애의 병인론에 역할을 하고 있을 가능성을 말해준다. Val-158-Met COMT 유전자의 다형성은 효소의 감소를 유도하는 L(저활성) 대림형질, 활성의 증가를 유발하는 H(고활성) 대립형질로 알려져 있으며 L 대립형질 또는 LL 유전형이 강박장애와 연관이 있다는 보고가 있으나, 아직까지 강박장애와 COMT 다형성 사이의 연관성에 대한 연구결과들은 일관되지 않다. 따라서 본 연구에서는 한국인 강박장애 환자들을 대상으로 Val-158-Met COMT 유전자의 다형성과의 연관성을 알아보고자 하였다. 방법 2002년 3월부터 2004년도 2월까지 약 24개월동안 서울지역 일 대학병원과 경기지역 일 대학병원 강박장애 클리닉을 방문하여 강박장애로 진단받은 124명의 환자들을 연구대상으로 하였고 정상 대조군으로는 나이와 성별을 고려하여 자원자 170명이 선별되어 포함되었다. 강박장애군과 정상 대조군의 혈액으로부터 유전자 추출 후 COMT 유전자 형벌 (genotyping)을 시행하였다. 다형성을 H/H 와 H/L, L/L 유전형으로 나눈 뒤 강박장애와 정상대조군 사이의 유전자 빈도를 카이 검정법으로 비교하여 연관성을 관찰하었다. 또한 강박장애 환자들에게 시행한 YBOCS로부터 측정한 강박장애 심각도 및 Hamilton Depression Raing Scale (HDRS) 총점과 COMT 유전자 다형성 사이의 연관성을 비교하였다. 결과 본 연구 결과 한국인 강박장애와 COMT 다형성 간에는 유의한 상관성이 관찰되지 않았다. YBOCS 심각도와 COMT 유전자형과의 유의한 연관성이 관찰되지 않았다. 그러나, 강박장애 환자군들의 COMT 유전자형 세 군 사이의 우울증상 점수에서는 유의한 차이가 관찰되었다. 결론 한국인에서 강박장애와 COMT 유전자 다형성 사이에는 연관성이 없었다. 그러나, COMT의 H 대립형질과 강박장애 군에서 공존하는 우울증상 척도가 유의한 연관성을 보인 현상은 COMT 유전자의 다형성이 강박장애의 공존 우울증상에 영향을 미칠 수 있는 가능성을 시사한다고 생각된다. Objectives : The definite cause of obsessive-compulsive disorder (OCD) is still unknown. Evidences from familial, twin and segregation studies support the role of a genetic factor. There are also growing evidence indicating that OCD has specific neurochemical and neuroanatomical basis. Derived from the effectiveness of treatment with dopamine receptor blocker in certain part of OCD patients (eg. SSRI treatment-resistant OCD), several candidate genes related to dopamine dysregulation have been hypothesized to play an important role in the development of OCD. One of them is the Catechol-O-Methyltransferase (COMT) gene. The aim of this study was to investigate the association between COMT and OCD in Korean population. Methods : 124 OCD patients and 170 normal controls participated in this study. Genomic DNA was extracted from their blood. The genotypes and allele frequencies of the COMT polymorphism between OCD group and control group were compared. We investigated the association between severity of OCD assessed by Yale-Brown obsessive compulsive symptom scale (YBOCS) and Hamilton depression rating scale (HDRS) scores and COMT polymorphism. Results : In this case-control study, we could not find any association between COMT gene polymorphism and development of OCD. In OCD group, patients with H/H genotype had significantly higher scores for the HDRS than those with H/L or L/L genotype. Conclusion : In this study, there was no difference in genotype distributions of COMT between OCD and control groups. However, H/H genotype of COMT gene polymorphism might be related to depressive symptoms in OCD patients.

Characteristics of the Abdominal and Neck Flexor Muscles of Children with Cerebral Palsy

( Sung-jin Choi ),( Dae-hyouk Bang ),( Hyun-jung So ),( Won-seob Shin ) 대한물리치료학회 2014 대한물리치료학회지 Vol.26 No.6

Purpose: The purpose of this study was to compare the activities of the abdominal and neck flexor muscles of children with and without cerebral palsy (CP) while lifting the head in a supine position. Methods: The subjects were eight children with CP and eight children without the disease. The activities of the external abdominal oblique (EO), internal abdominal oblique (IO), rectus abdominis (RA), sternocleidomastoid (SCM), and RA/SCM muscles were collected by surface electromyography (EMG) when the children lifted their heads. A Mann-Whitney U test was used to compare the activity of each muscle during the head-lifting exercise. Statistical significance was accepted at p<0.05. Results: The activities of the EO, IO, and RA, and RA/SCM muscles differed significantly between the children with and without CP, but there was no significant between-group difference in the activity of the SCM muscle. Conclusion: These findings suggest that the abdominal muscles are not employed as much in the activities of children with CP compared to those without the disease. Additionally, those with CP were more dependent on the neck flexor muscle during the head-lifting exercise in a supine position.

The Results of B-scan Ultrasonography in Different Positions after Vitrectomy and Gas Tamponade

( Sang Hyouk Park ),( Sung Jin Lee ) 대한안과학회 2007 Korean Journal of Ophthalmology Vol.21 No.2

Purpose: To determine the proper time frame in which to assess retinal attachment status and to evaluate the superior retinal attachment status by performing B-scan ultrasonography in different positions on patients who have undergone pars plana vitrectomy and gas tamoponade. Methods: In this prospective study, 23 patients (23 eyes) who had undergone pars plana vitrectomy and gas tamponade were investigated between June 2005 and February 2006. SF6 (18%) was injected into the vitreous cavity of 15 eyes, and C3F8 (14%) was injected into the vitreous cavity of 8 eyes. At postoperative day 1, day 3, week 1, week 2, and week 4, B-scan ultrasonography was performed in the supine, sitting, prone, right decubitus, and left decubitus positions. Results: The proper time to evaluate the retinal attachment status was three days post-operatively in 10 eyes (66.7%) with SF6 (18%) injections and two weeks post-operatively in six eyes (75%) that had C3F8 (14%) injections. The superior retinal attachment status can be evaluated from the summation of B-scan ultrasonography results performed in the right decubitus and left ducubitus positions. Conclusions: The proper time to evaluate the retinal attachment status was related to the degree of the gas absorption when performing B-scan ultrasonography after pars plana vitrectomy and gas tamponade. To evaluate the entire retina, it is useful to perform B-scan ultrasonograhy in the prone, right decubitus and left decubitus positions. Korean Journal of Ophthalmology 21(2):100-105, 2007