진행성 비소세포폐암의 이차항암화학요법으로서 Docetaxel 단독요법의 성적

강현모,이정은,장필순,이연선,권선중,안진영,정성수,김주옥,김선영 충남대학교 암공동연구소 2006 암공동연구소 업적집 Vol.5 No.

Background : The survival benefit associated with first-line chemotherapy in lung cancer has led to the need for second -line chemotherapy, for which Docetaxel (Taxotere^(?)) has proven efficacy in both settings. This study evaluated the safety and efficacy of docetaxel in patients with non-small cell lung cancer who had failed first-line platinum-based chemotherapy. Methods : Thirty one patients with non-small-cell lung cancer, who had failed first line platinum-based chemotherapy, between March 1999 and August 2003, were enrolled in this study. Patients received intravenous docetaxel, either 75 mg/㎡ or 100 mg/㎡, with routine premedication every three weeks. Results : Fourteen patients (45.2%) had a partial response. The median survival and progression- free survival times were 12.5 months (95% CI 7.3-17.6) and 3.0 months (95% CI 1.6-4.5), respectively. This study showed 2 factors gave different survival benefits; the age (< 60 years: 20.1 months vs. > 60 years: 6.6 months, p=0.0105) and the histological type (adenocarcinoma: 25.6 months vs. others: 7.9 months, p=0.0055). The predominant toxicity was neutropenia, which occurred as WHO grade 3 or 4 in 38.7 % of patients. One treatment related death was also reported. Non-hematological toxicity was minor and easily controlled. There were no significant statistical differences in the survival benefit and toxicity between the two doses. Conclusion : Docetaxel, as second-line monotherapy, was well tolerated and effective in patients with non-small-cell lung cancer who failed first line platinum -based chemotherapy. (Tuberc Respir DiS 2005: 58: 465-472) 연구배경 : 일차항암화학요법 후에 생존의 이득을 얻었음에도 불구하고 비소세포폐암 환자들의 대다수가 결국은 재발하거나 진행성 병변을 보인다. 이에 저자들은 기존의 여러 연구에서 보고 된 구제요법으로서 docetaxel의 항암효과와 비교적 적은 독성의 결과를 바탕으로,platinum을 근거로 한 항암화학요법을 시행 밖았으나 개발되거나 진행된 비소세포폐암 환자들을 대상으로 docetaxel 단독요법의 치료효과와 부작용에 대하여 알아보고자 하였다. 방법 : 조직학적으로 비소세포폐암으로 진단을 받고 platinum을 근거로 한 항암화학요법을 받았으나 재발 또는 진행성 병변을 보인 31명의 환자들을 대상으로 docetaxel 75 mg/m² 또는 100 mg/m²을 3주마다 정주하였다. 임상기록을 통한 후향적인 방법으로 분석하였다. 결과 : 1) 재발 또는 진행성 병변을 보인 31명중 남녀 비는 24:7이고 중앙연령은 60세였다. 2) 반응평가로 완전 관해는 없었고 부분관해는 14명(45.2%), 불변이 10명(32.3%), 진행이 7명(22.6%)으로 전체적인 반응율은 45.2%이었다. 3)중앙생존기간은 12.5개월(95% 신뢰구간: 7.3개월 17.6개월) 이었고, 1년 생존율은 52%였다. 무진행생존기간의 중앙값은 3.0개월(95%신뢰구간: 1.6개월 -4.5개월)이며, 반응군에서의 중앙반응지속피간은 3.7개월(95% 신뢰구간: 3.0개월 - 4.4개월)이었다. 4) 60세 미만인 경우(20.1 months vs 6.6 months. p=0,0105), 조직학적 아형이 선암일 경우(25.6 months vs 7.9 months, 0=0.0055) 통계적으로 유의한 생존기간의 증가가 있었다. 5) 부작용으로 3도 이상의 백혈구 감소증은 12명(38.7%),호중구 감소증에 동반된 발열은 6명(19.3%),감염이 동반된 호중구 감소증은 4명(12.9%)에서 발생했다. 치료와 관련되어 1명이 사망하였다. 6) Docetaxel 용량에 따른 생존기간의 차이나 독성의 차이는 없었다. 결론 : Platinum을 근거로 하는 항암화학요법으로 치료받은 후 재발 또는 진행성 병변을 보이는 비소세포폐암환자들에게 docetaxel을 투여하는 것은 비교적 안전하고 효과적인 항암치료법으로 사료된다.

진행성 비소세포폐암의 이차항암화학요법으로서 Docetaxel 단독요법의 성적

강현모,이정은,장필순,이연선,권선중,안진영,정성수,김주옥,김선영 충남대학교 암연구소 2006 암연구소 업적집 Vol.5 No.-

Background : The survival benefit associated with first-line chemotherapy in lung cancer has led to the need for second -line chemotherapy, for which Docetaxel (Taxotere^(?)) has proven efficacy in both settings. This study evaluated the safety and efficacy of docetaxel in patients with non-small cell lung cancer who had failed first-line platinum-based chemotherapy. Methods : Thirty one patients with non-small-cell lung cancer, who had failed first line platinum-based chemotherapy, between March 1999 and August 2003, were enrolled in this study. Patients received intravenous docetaxel, either 75 mg/㎡ or 100 mg/㎡, with routine premedication every three weeks. Results : Fourteen patients (45.2%) had a partial response. The median survival and progression- free survival times were 12.5 months (95% CI 7.3-17.6) and 3.0 months (95% CI 1.6-4.5), respectively. This study showed 2 factors gave different survival benefits; the age (< 60 years: 20.1 months vs. > 60 years: 6.6 months, p=0.0105) and the histological type (adenocarcinoma: 25.6 months vs. others: 7.9 months, p=0.0055). The predominant toxicity was neutropenia, which occurred as WHO grade 3 or 4 in 38.7 % of patients. One treatment related death was also reported. Non-hematological toxicity was minor and easily controlled. There were no significant statistical differences in the survival benefit and toxicity between the two doses. Conclusion : Docetaxel, as second-line monotherapy, was well tolerated and effective in patients with non-small-cell lung cancer who failed first line platinum -based chemotherapy. (Tuberc Respir DiS 2005: 58: 465-472)

한국 전통장류가 한우 반힘줄모양근(M. Semitendinosus)으로 제조한 건염햄의 육질 특성에 미치는 영향

성필남,조수현,강근호,김동훈,박범영,강선문,박경미,Seong, Pil-Nam,Cho, Soo-Hyun,Kang, Geun-Ho,Kim, Dong-Hoon,Park, Beom-Young,Kang, Sun-Moon,Park, Kyoung-Mi 한국축산식품학회 2013 한국축산식품학회지 Vol.33 No.6

This study was conducted to develop a processing method for dry-curing beef ham with Korean traditional sauces and to investigate the quality properties of the dry-cured beef hams. Semitendinosus muscle from Hanwoo was spread with sundried salt (C), sun-dried salt mixed with red pepper paste (T1), and sun-dried salt mixed with soybean paste (T2), and inserted into washed Hanwoo large intestine. It was then dried and fermented for 75 d. Moisture contents of the hams were 46-48%, without any significant differences. T1 showed the lowest pH among the three dry-cured hams, while water holding capacity (WHC) of T2 was found the lowest (p<0.05). In mechanical color determination, C showed higher CIE $a^*$ and CIE $b^*$ than T1 and T2 (p<0.05), however CIE $L^*$ did not show any significant difference. In texture, T1 demonstrated significantly lower springiness than C (p<0.05). The sensory properties of all dry-cured hams did not show any significant difference, but T1 indicated a higher taste, saltiness and overall acceptability than others, whereas C gathered the highest score in color and flavor. In conclusion, the dry-curing by combination of sun-dried salt mixed with red pepper sauce (T1) showed higher quality properties of the Hanwoo dry-cured ham. 우리나라 전통장류를 건염햄 제조에 접목한 건염햄의 제품을 개발하기 위해 염지과정에서 첨가한 고추장과 된장이 건염햄 품질에 미치는 영향을 조사하고자 실시하였다. 천일염(C), 천일염+고추장(T1), 천일염+된장(T2)을 한우의 반힘줄모양근(m.emitendinosus)의 표면에 골고루 발라주고 세척한 한우 대장에 충진한 후 75일 동안 건조 및 발효시켰다. 한우 반힘줄모양근 건염햄 품질을 조사한 결과, 건염햄 수분함량은 46.45-48.04% 수준으로 유의적인 차이는 없었다. T1은 모든 처리구 중에서 pH가 가장 낮았고 T2는 WHC가 가장 낮았다(p<0.05). 기계적 육색 측정에서 C가 $a^*$와 $b^*$가 전통장류 처리(T1, T2)보다 높았으나(p<0.05), $L^*$은 유의적인 차이가 없었다. 조직감에서 T1은 C보다 탄력성이 유의적으로 낮았다(p<0.05). 관능평가 결과 모든 처리구에서 유의적인 차이가 없었고 C는 제품색과 향미가 높은 점수를 받은데 반해, T1은 높은 맛, 짠맛, 그리고 전체적 기호도가 다른 처리구에 비해 높았다.

참개구리 배아를 이용한 최기형성 및 Cd2+독성평가 연구

고선근,윤필상 호남대학교산업기술연구소 2011 산업기술연구논문집 Vol.17 No.2

최근 화학물질 및 환경오염물질의 독성 시험법으로 Frog Embryo Teratogenesis Assay-Xenopus(FETAX) 방법이 독성평가에 활용되어지고 있다. 본 연구에서는 FETAX방법에 따라 한국산개구리 중 참개구리(Rana nigromaculata)의 배아를 이용하여 Cd2+의 기형성을 조사하였으며 치사율과 기형률은 Probit 분석법으로 조사하였다. Cd2+에 따른 teratogenic concentration(EC50)은 0.18ppm을 나타내었으며 embryolethal concentrations (LC50)은 0.31ppm을 나타내었다. Teratogenic index(TI=LC50/EC50)는 1.74를 나타내었다. Cd2+은 참개구리(R. nigromaculata)배아에 최기형성을 나타내었으며 이들의 농도에 의존하여 수포형성, 꼬리, 척추기형 등이 증가하였다. 이상의 결과들은 Cd2+이 낮은 농도에서 배아의 발달을 억제하며, 따라서 참개구리 배아의 기형성 시험방법은 화학물질 및 환경오염물질의 독성검정에 효과적으로 활용할 수 있을 것으로 판단된다. 주요어: Cd2+, 독성, 참개구리 The Frog Embryo Teratogenesis Assay-Xenopus(FETAX) protocol was recently adopted as a valuable tool for evaluating of chemical toxicity and the effect of environmental contaminants in frogs. In this study, the teratogenecity of Cd2+ was determined in Black spotted pond frog, Rana nigromaculata using the FETAX protocol. The mortality rate and the percentage of malformed larvae were investigated by probit analysis. The teratogenic concentrations(EC50) of Cd2+ was 0.18ppm. The embryolethal concentrations(LC50) of Cd2+ was 0.31ppm. The teratogenic index (TI=LC50/EC50) was 1.74 for Cd2+. The study results reveal that Cd2+ suppress the development of embryos at relatively low concentrations, and therefore the Rana nigromaculata embryo teratogenesis assay system was proven to be a useful tool to evaluate the toxicity of the environmental pollutants. Key words: Cd2+, Toxicity, Rana Nigromaculata

헌번재판소 재판관에 대한 탄핵심판제도

음선필 순천향대학교 교수학습개발센터 2005 순천향 사회과학연구 Vol.11 No.2

In case Justices of the Constitutional Court(hereafter "justices") have violated the Constitution or the oter Acts in the performance of the official duties, the National Assembly may pass motions for their impeachment(Constitution, Art 65). The impeachment against Justices ins adjudicated by no other than the Constitutional with other countries. Also it has several weak points including the infraction of its political neutrality. So fundamental changes of the impeachment against Justices should be made. In the lege ferenda, the grounds of the impeachment against Justices are to be specified more, firstly. Secondly, the impeachment against Justices by the National Assembly is to be abolished and the dismissal procedure of the Justices within the Court itself it to be introduced instead, which protects the Court from political pressure. Thirdly, the procedure of dismissal of the Justices is to be made reasonably with considerations of political neutrality and constitutional functions of the Court.

에어로빅댄스의 안전성과 유효성에 관한 연구

이보선,윤필규,이필영 龍仁大學校 1998 용인대학교 논문집 Vol.15 No.-

In order to study a program for exercise prescription that can satisfy both safety and effectiveness on the basis of exercise strength according to heart rate during aerobic dance a study was made with thirty members of mothers' aerobic classroom as an object for twelve weeks(conducted five times a week) at S sports center and following conclusions have been obtained. Firstly, as a result of having aerobic exercises for twelve weeks and measuring heart rates the values of heart rate after twelve weeks by each stage of exercise fell significantly compared with the time when they started the exercise. Secondly, the matters for investigation prior to exercise such as physical strength test on the basis of heart rate before starting exercise or the past history of a case were not being kept properly. Thirdly, when performing the exercise they were all doing exercise with the same strength at the same time without entirely considering age or weather-or physique condition. Fourthly, as standards of heart rate for each stage of warming-up exercise, main exercise and adjustment exercise were not established there was no adequate program of exercise prescription.

한국 민주주의의 발전과 선거제도

음선필 순천향대학교 교수학습개발센터 2004 순천향 사회과학연구 Vol.10 No.2

Since 1987 Korea experienced a remarkable democratic development, which was influenced by the world-wide "democracy's third wave". The 1987 Constitiution provided the new form and contents of Korean democracy including the electoral system of the president. An electoral system si composed of many ingredients, which have several political effects on voter's selection and politician's behaviour. So it can be also used as a channel for democratization of political powers. In Korea, anyway, the electoral systems of the president and the National Assembly have made a great influence on the system of political parties, the relations between political powers and changes of regime turn-over etc. However, they are also criticized as an institutional device bringing about the severe divided-government which is an obstacle to economic development and social stability. So it is worthy of a careful consideraton to rearrange the structure of political powers such as the vice presidents, the electoral systems of the president and the National Assembly etc.

온라인 전자 지도안 시스템의 구축 및 활용에 관한 연구

천종필,백장미,한선관,이철환 한국컴퓨터교육학회 2003 컴퓨터교육학회 논문지 Vol.6 No.1

본 연구자들은 ICT 활용 교육을 위한 초등교육 지도안을 온라인상에서 작성하고 활용할 수 있는 Web기반 전자지도안 시스템을 개발하였다. 개발된 온라인 전자지도안 시스템 은 ICT 교수-학습 과정안 자료를 데이터베이스화하여 체계적으로 관리할 수 있도록 하였으며, 교수-학습 과정안의 공유, 활용, 저장성의 극대화를 도모하여 학교 정보화에 이바지할 수 있다. 이렇게 개발된 시스템이 현장에서 활용되면서 나타난 교육적 효과 및 문제점을 분석하여 해결 방안을 제시하는 것은 시스템의 개발 못지않게 중요하다고 할 수 있다. 따라서 본 연구에서는 첫째, 본 시스템 개발을 위한 ICT 활용 교수·학습 과정안 형태의 구안과정과 둘째, 본 시스템의 설계와 구현 방법의 개요, 그리고 셋째, 초등학교 현장에서 적용하면서 나타난 시스템의 효과와 문제점 분석 및 개선방안을 제시하였다 또 연구를 통하여 초등교육에서 사용하게 될 전자 교육 시스템의 개발 과정 및 활용 상의 고려사항과 문제점의 해결 방안에 대한 교육적 근거를 제공하였다. The researchers developed On-line Lesson Planner System so that teachers can make a lesson plan using ICT(Information & Communication Technology) on line. Developed On-line Lesson Planner System can make ICT using lesson plans store in the database, manage them systematically and help maximize share, use and storage of the lesson plans. It can contribute to the school informatization. It is important to suggest solution through analyzing the educational effects and problems appeared during applying to this developed system in real fields. Thus, this study suggests first, procedure of designing the lesson plan using ICT for the development of this system, second, the summary of designing and embodying methods, and third, the improvement and analysis of the effects and problems revealed in elementary school fields. This study provided educational grounds of the solution to the problems and consideration of this On-line Lesson Planner system.

스퍼터로 제작된 WO ₃박막의 CMP 광역평탄화 특성

이우선,최창주,고필주,최권우 조선대학교 에너지.자원신기술연구소 2004 에너지·자원신기술연구소 논문지 Vol.26 No.1

Chemical mechanical polishing (CMP) process has been widely used to planarize dielectric layers, which can be applied to the integrated circuits for sub-micron technology. Despite the increased use of CMP process, it is difficult to accomplish the global planarization of in the defect-free inter-level dielectrics (ILD). we investigated the performance of WO_(3) CMP used silica slurry, ceria slurry, tungsten slurry. In this paper, the effects of addition oxidizer on the WO_(3) CMP characteristics were investigated to obtain the higher removal rate and lower non-uniformity.

수소화 비정질 실리콘 박막 트랜지스터 특성의 2차원 수치해석

최종선,이필주 弘益大學校 科學技術硏究所 1995 科學技術硏究論文集 Vol.6 No.-

A non-uniform finite-difference Thin Film Transistor Simulation Program (TFTSP) has been developed with very flexible and accurate physical model for hydrogenated amorphous silicon. In order to insure its usefulness and versatility as an analytic and design tool the code has been employed to compute the static terminal characteristics of a-Si:H TFTs under a wide range of bias conditions to allow the comparision of the model with experiment. On the basis of the usefulness of this computer model. TFTSP has been employed to analyze the source/drain contact behavior and/or other geometric factors of a-Si:H TFTs. The effects of the channel and overlap length on TFT performances have been analyzed to suggest the principles for the optimum transistor design.