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Duplication or deletion of chromosome 17p11.2-p12 in CMT1 and HNPP peripheral neuropathy patients
Kim, Hyo-Sun,Jang, Young-Eun,Chung, Ki-Wha 公州大學校 基礎科學硏究所 2003 自然科學硏究 Vol.10 No.-
CMT와 HNPP 말초신경증은 가장 흔하게 발병하는 운동 및 감각 말초신경계의 선천성 질환이다. CMT1과 HNPP의 유전적 원인으로는 염색체 17p11.2-p12의 1.5 Mb 지역의 중복과 결실이 각각 50%이상과 70% 이상을 차지하는 것으로 알려졌다. 본 연구에서 한국인 CMT1 및 HNPP 환자를 대상으로 중복 및 결실을 조사하였는데, 31 CMT1 가족 중 13 가족에서 중복을 보였으며 (42%), 24 HNPP 가족 중 19 가족에서 결실을 보였다 (79%). 17p11.2-p12 중복을 보이는 CMT1A 환자가 HNPP 결실환자보다 발병 연령, 발병 기간, 근육 이양성 및 족 기형성에서 훨씬 심한 증상을 보였다. Charcot-Marie-Tooth disease (CMT) and hereditary neuropathy with liability to pressure palsies (HNPP) are most common inherited motor and sensory peripheral neuropathies. The majority of CMT1 patients have a 1.5 Mb duplication in chromosome 17p11.2 while most HNPP patients have a deletion of the same region. In the analysis of Korean CMT1 and HNPP patients, each HNPP deletion and CMT1A duplication was observed from 79% (19 families) among 24 HNPP families and 42% (13 families) among 31 CMT1 families. CMT1A duplication patients showed more severe clinical symptoms than HNPP deletion patients, when we examined oneset age, disease duration, muscular atrophy, foot deformity and scoliosis.
Korean English Teacher's Disempowerment in English-only Classes
Sung-Sam Hwang,Hyo-Sun Seo,Tae-Young Kim 한국사회언어학회 2010 사회언어학 Vol.18 No.1
Hwang, Sung-Sam, SeD, Hyo-Sun, Kim, Tae-Young. 2010. Korean English Teacher's Disempowerment in English-only Classes: A Case Study Focusing on Korea-specific Cultural Aspects. The Sociolinguistic journal of Korea 18(1). In this case study, we have focused on the disempowerment of a Korean English teacher (KET) in English-only classrooms. Six English as a foreign language (EFL) classrooms in a Korean high school were observed and analyzed by using interpretive discourse analysis. Out of the six classes, three representative classrooms were both video- and audio-taped. The results show that the English-only classes could weaken the KETs' power via three mechanisms: (a) calling the KETs' last name for choral greetings at the beginning of the class, (b) students' group solidarity and peer pressure between classmates, and (c) the students' excessively collaborative approach to peer assistance. It is argued that the exclusive English-only instruction disempowers the KETs' status and dismantles their vocational identity. In order to remedy the current situation, within a scaffolding supported by the eclectic use of first language where necessary for effective class management, KETs are empowered and overcome constraints imposed by the limited L2 oral competence of some non-native English teachers.
알코올의 섭취가 흰쥐의 혈액과 간의 지질대사에 미치는 영향
이명숙,김영연,김효숙,김매하,전진순,서진숙,송선미,양영재,윤원손,이미라,이효영,정승현 誠信女子大學校 生活文化硏究所 2004 生活文化硏究 Vol.18 No.-
To investigate the effects of ethanol on the lipid metabolism in blood and liver, twenty one male Sprague Dawley rats had orally taken the 25% alcohol and 50% alcohol by 5g per Kg of weight during 3 weeks after the adjusting period. For the energy balance, 85% sucrose and 45% sucrose was added in control group and 25% alcohol group each. The weight was reduced by alcohol treatment according to the levels, otherwise the weight of liver and heart was little increased in alcohol groups rather than in control without significance. Moreover, RBC, WBC, hemoglobin and hematocrit were increased by alcohol treatment according to the levels without significance. Otherwise, adjusted bilirubin levels by 100g of weight was significantly increased by alcohol treatment dose dependently. Alcohol induced RBC degradation and increased circulated bilirubin because of liver damage. For blood lipid profiles, blood cholesterol was increased in 50% of alcohol group compared to that of 25% and control groups, otherwise, blood triglycerides (TG) was increased by 30% in 25% alcohol groups rather than in control but not significantly different. The hepatic lipid composition, cholesterol levels in alcohol treatment groups was lower than those in control. The hepatic TG was not influenced by alcohol treatment. The two reasons of decreasing hepatic lipids were suggested by 85% sucrose of control for energy balance more synthesized cholesterol and TG than those in 25 or 50% alcohol groups, and by cholesterol and TG could not be synthesized because of liver damage from alcohol.
[논문]반응성 골재의 입자 크기와 입도가 모르타르의 알칼리-실리카 반응 팽창에 미치는 영향
전쌍순,이효민,진치섭 釜山大學校生産技術硏究所 2003 生産技術硏究所論文集 Vol.62 No.-
골재의 알칼리-실리카 반응성을 판정하는 방법으로 모르타르 바 법 (Mortar-Bar method) 이 일반적으로 사용되고 있다. 본 연구에서는 알칼리 골재 반응성을 판정하는 모르타르 바 법 중에서 촉진시험법인 ASTM C 1260 시험방법을 이용하여 반응성 골재를 판별하고l 판별된 반응성 골재의 입자 크기와 입도가 모르타르의 알칼리-실리카 반응 팽창에 미치는 영향에 관하여 검토하였다. 그 결과I 반응성 골재의 입자 크기 및 입도에 상관없이 반응성 골재의 총표면적이 커질수록 팽창률도 증대하여,알칼리-실리카 반웅에 의한 팽창과 반웅성 골재의 총표면적과의 사이에는 상관관계가 있는 것을 확인할 수 있었다.
[논문]재생골재의 광물학적 및 화학적 특성과 동결융해 저항성
전쌍순,이효민,진치섭 釜山大學校生産技術硏究所 2003 生産技術硏究所論文集 Vol.62 No.-
급속한 산업화와 인구증가 및 대량소비에 따른 페기물에 의하여 초래되는 지구 환경오염을 위한 사회시스템의 구축이 필요함을 암시한다고 볼 수 있다. 본 연구에서는 지금까지 주로 저급재료로 사용되던 재생골재의 구성광물,화학조성 및 물리화학적 특성과 알칼리-골재 반응성 여부를 조사하고, 재생굵은골재의 대체율에 따른 콘크리트 강도와 동결융해 저항성을 검토하여 재생골재의 재활용을 위한 기초자료를 제시하고자 한다. 본 연구에 사용된 재생골재는 천연골재에 비교하여 공학적 기초 물성치에서 현저히 큰 차이는 나타내지 않았으며, 이를 사용한 재생콘크리트의 공학적 특성도 보통 콘크리트의 기준에 근접하는 것으로 나타났다.
고등학생의 자기표현과 자아존중감 향상을 위한 독서요법효과분석
선효원,심혜숙 부산대학교 과학교육연구소 2006 교사교육연구 Vol.45 No.-
The purpose of this study is determine effects of the reading therapy program on the self-expression and self-esteem of boy students of academic high schools. For the purpose, this researcher surveyed 2nd-grade boy students of academic high schools located in Busan. All of the surveyed students, 170 in number, were asked to receive self-expression and self-esteem tests before the program is applied. Out of them, 30 who were low in both self-expression and self-esteem were selected. Then out of the thirty, 20 who wanted to participate in the program wore finally selected. Those 20 participants were divided into experimental and control groups, each consisting of 10 members. The reading therapy program used here was first developed by Watson(1994), and adapted by this researcher appropriately. The program was applied on the basis of 2 hours(120 min.) a session. Group activities under the program were made over 10 sessions totally, with 2 session a week based. The control group was not treated in any way over the same sessions. In the study, the following research questions were given. 1. Will the reading therapy program increase self-expression? 2. Will the reading therapy program improve self-esteem? Scales by Rakos & Schroeder were used as a device for measuring the subjects' self-expression. And Coopersmith's scale(1969) was applied to the measurement of the subjects' self-esteem. For data collected here, means of scores obtained from self-expression and self-esteem tests before the application of the program, similarities between the experimental and control groups, means of scores from such tests after the program and differences between the two groups were all processed through t-test. Results of the study can be summarized as follows. 1. The self-expression of the experimental group which participated in the reading therapy program was significantly higher than that of the control group, at the significance level of P < .05. 2. The self-esteem of the experimental group significantly improved more than that of the other group, at the significance level of P < .05. In conclusion, the reading therapy program improved self-expression and self-esteem significantly. This study was carried out on 2nd-grade boy students of academic high schools, so its results are difficult to be generalized. In future, therefore, it is needed to examine effects of the program on the self-expression and self-esteem o high schools for male, female and the both sexes and compare results of the examination.
宣孝任,姜泰範,李奭鎬 상명대학교 논문집 1993 상명대학교논문집 Vol.31 No.-
The polymeric sols were prepared by hydrolysis and polymerization of titanium tetraisopropoxide in diethanolamine. TiO_2 coating films prepared by dip coating of alumina substrate with polymeric sols were heated at various temperature for 7 hours in NH_3 gas. TiN thin films obtained from TiO_2 were investigated by XRD. TiO_2 coating film on alumina substrate was converted into the TiN thin film by nitridation under the flow of NH_3 gas at 1100℃ for 7 hours.
Cr-Mo강 시효재의 취화손상 평가를 위한 전기화학적 분극시험에 관한 연구
유효선 韓國非破壞檢査學會 1999 한국비파괴검사학회지 Vol.19 No.6
에너지 변환설비와 관련된 기계구조물의 내열재료는 350℃∼550℃의 온도범위에서 장시간 사용되는데 이때 조직의 결정입계에는 불순물 원소(P, Sn, Sb 등)의 편석과 탄화물의 석출 등으로 인하여 재료의 취화 현상이 발생되고, 그로 인해 입계강도의 저하가 초래된다. 따라서 노후화된 고온설비의 안전성 및 효율적인 운전조건을 확보하고, 취성파괴 방지를 위해서는 취화손상의 정량적 평가는 매우 중요하다. 그러나 가동중인 고온설비에서 파괴시험을 위한 대량의 시험편채취가 거의 불가능한 경우가 대부분이므로 비파괴적인 시험방법이 요구된다. 본 연구에서는 인공시효열처리된 2.25Cr-1Mo강의 비파괴적인 취화손상도 평가를 위해 적정 부식환경하에서 전기화학적 분극시험 방법에 의한 최적의 평가인자를 조사하였다. 또한 전기화학 시험결과들은 준비파괴시험인 SP시험에 의한 취화도 평가결과와 비교되었다. It has been well recognized that a long term service at elevated temperature of 350℃∼550℃ induces embrittlement damage due to carbide precipitation and/or P, Sb and Sn segregation at grain boundaries and thereby deteriorates the grain boundary strength of heat resisting components in the energy-related plants. Therefore, it is very important to assess quantitatively the extent of embrittlement damage of heat resisting components to secure the reliable and efficient service condition and to prevent brittle failure in service. However, because fracture tests are limited in size and number of specimen obtained from the structural components, nondestructive test method is required. In this study, the optimum electrochemical parameters are investigated and discussed to evaluate nondestructive embrittlement damage for aged 2.25Cr-1Mo steels by means of electrochemical polarization test method(ECPTM) in proper corrosive environment. In addition, the electrochemical test results are compared with embrittlement degree evaluated by semi-nondestructive SP test.
현대 패션에 나타낸 보보스 스타일 : 2001년부터 2003년까지의 컬렉션을 중심으로
박효은,유영선,이신희 한국의류산업학회 2004 한국의류산업학회지 Vol.6 No.5
The purpose of this study is to know outer and inner characteristics of Bobos style regarded the latest fashion and to estimate the characteristics of fashion trend in 21st century and direction of fashion in the future. In terms of contentions of this studs we firstly studied concept, background, general characteristics which had been introduced in Sociology And then, we studied the effect which the style of Bobos had been given by investigating the concept and style of Hippies and Yuppies. Also, we analysed trend of Bobos represented in modern fashion and tried to examine outer and inner features of Bobos through the result of analysis. Bobos can defined as `Bourgeois Bohemian' who have both mundane desire about success and are high-educated elite class in information-oriented society. The fashion styles which had affected Bobos were psychedelic, naturalism, unisex, ethnic, layered, grunge of Hippies in 1960s and traditional, power-look, contemporary-look, sports wear, casual wear of Yuppies in 1980s. As a result of examining features of Bobos style, we can know that outer feature of Bobos style showed a reasonable harmony regardless of formalities and inner features showed a tendency to seek comforts. Also, Bobos style showed various and free styles, textile materials and colors and complex features to transcend the time and region, and culture.