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Su, Long,Li, Xian,Gao, Su-Jun,Yu, Ping,Liu, Xiao-Liang,Tan, Ye-Hui,Liu, Ying-Min Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.2
Objectives: The present study aimed to examine the cytogenetic and genetic mutation features of acute myeloid leukemia (AML) in elderly Chinese patients. Methods: A retrospective analysis of cytogenetics and genetic mutations was performed in 113 cases (age range 50-82 years) with de novo AML. Results: The most frequent cytogenetic abnormality was t (15;17) (q22;q21), detected in 10.0% (n = 9) of successfully analyzed cases, followed by t (8;21) (q22;q22) in 8.89% (n = 8), and complex karyotypes in 5.56% (n = 5). Those with complex karyotypes included 4 cases (4.44%) of monosomal karyotypes. The frequencies of NPM1, FLT3-ITD, c-kit, and CEBPA mutations were 27.4% (31/113), 14.5% (16/110), 5.88% (6/102), and 23.3% (7/30), respectively. The complete remission rates of patients in low, intermediate, and high risk groups were 37.5%, 48.6%, and 33.3%, respectively (${\chi}^2$ = 0.704, P = 0.703) based on risk stratification. Conclusion: Cytogenetics and genetic mutations alone may not be sufficient to evaluate the prognoses of elderly AML patients. The search for a novel model that would enable a more comprehensive evaluation of this population is therefore imperative.
Su, Long,Gao, Su-Jun,Tan, Ye-Hui,Han, Wei,Li, Wei Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.9
Objectives: To explore the relationships between age, cytogenetic subgroups, molecular markers, and cells with leukemic aberrant immunophenotype in patients with acute myeloid leukemia (AML). Methods: In this study, we evaluated the correlations between age, cytogenetic subgroups (normal, balanced and unbalance karyotype), molecular mutations (NPM1, FLT3-ITD, and CEBPA mutations) and marrow leukemia cells (LC) identified by flow cytometry in 256 patients with de novo AML. Results: From age group 10-19 years to age group ${\geq}60$ years, the percentage of LC decreased from $67.0{\pm}18.4%$ to $49.0{\pm}25.1%$ (F=2.353, P=0.041). LC percentage was higher in patients with balanced karyotypes ($65.7{\pm}22.4%$), than those with unbalanced karyotypes ($46.0{\pm}26.6%$) (u=3.444, P=0.001) or a normal karyotype ($49.9{\pm}22.1%$) (u=5.093, P<0.001). Patients with FLT3-ITD ($64.3{\pm}19.5%$) had higher LC percentages compared with those without ($54.2{\pm}24.3%$) (u=2.794, P=0.007). Conclusions: Associations between age, cytogenetics, molecular markers, and marrow leukemia cells may offer beneficial information to understand the biology and pathogenesis of AML.
Wear Behavior of Functionalized Multi-walled Carbon Nanotube Reinforced Epoxy Matrix Composites
Sulong, Abu Bakar,Park, Joohyuk,Lee, Naesung,Goak, Jeungchoon Sage Publications 2006 Journal of composite materials Vol.40 No.21
<P>This article studies the tribological behavior of functionalized multi-walled carbon nanotubes (MWNTs) reinforced epoxy matrix composites. MWNTs reinforced epoxy composites are fabricated by an injection molding process. The effects on the tribological properties of different loading concentrations and different functional groups of MWNTs are investigated by using a linear reciprocal wear tester. As increasing the concentration of MWNTs reduces wear loss, better tribological property was attained on functionalized MWNTs than as-produced MWNTs. The changes in worn surface morphology are observed in order to investigate the wear behavior. The MWNTs in the epoxy matrix near the surface are exposed and became a lubricating working film on the worn surface. The dispersion and interfacial bonding of MWNTs in the epoxy matrix are investigated from the fracture surface. The existence of MWNT at the wear surface is verified by a Raman spectrometer.</P>
Modelling of beam-to-column connections at elevated temperature using the component method
N.H. Ramli Sulong,A.Y. Elghazouli,B.A. Izzuddin,N. Ajit 국제구조공학회 2010 Steel and Composite Structures, An International J Vol.10 No.1
In this paper, a nonlinear model is developed using the component method in order to represent the response of steel connections under various loading conditions and temperature variations. The model is capable of depicting the behaviour of a number of typical connection types including endplate forms (extended and flush) and angle configurations (double web, top and seat, and combined top-seat-web) in both steel and composite framed structures. The implementation is undertaken within the finite element program ADAPTIC, which accounts for material and geometric nonlinearities. Verification of the proposed connection model is carried out by comparing analytical simulations with available results of isolated joint tests for the ambient case, and isolated joint as well as sub-frame tests for elevated temperature conditions. The findings illustrate the reliability and efficiency of the proposed model in capturing the stiffness and strength properties of connections, hence highlighting the adequacy of the component approach in simulating the overall joint behaviour at elevated temperature.
표면 개질화된 탄소나노튜드 강화 고분자 복합재료의 마로 특성
아부바카 술롱(Abu Bakar Sulong),박주혁(Joohyuk Park) 한국트라이볼로지학회 2005 한국윤활학회지(윤활학회지) Vol.21 No.6
Various carbon nanotubes (CNTs) are added into the epoxy matrix as reinforcements to investigate the effect on the wear behavior. Effects to the tribological properties of different loading concentrations and types of surface modification are investigated by using a linear reciprocal wear tester. As increasing the concentration of CNTs shows the reduction of the wear loss. Moreover, surface modified CNTs give better tribological property than as produced CNTs. It is due that the functional groups on the surface of CNTs increase the interfacial bonding between CNTs and epoxy matrix through chemical bonding. Changes in worn surface morphology are observed by optical microscope and SEM to investigate the wear behavior. CNTs in the epoxy matrix near the surface are exposed and it becomes the lubricating working film on the worn surface. It reduces the friction and results in the lower surface roughness morphology in the epoxy matrix as increasing the contents of the CNTs.
Bolted connections to tubular columns at ambient and elevated temperatures - A review
N.H. Ramli Sulong,S.H. Leong,Mohammed Jameel 국제구조공학회 2016 Steel and Composite Structures, An International J Vol.21 No.2
Tubular column members have been widely adopted in current construction due to its numerous advantages. However, the closed-section profile characteristics of tubular columns severely limit the connection possibilities. Welding type is acceptable but discouraged because of on-site issues. Blind-bolted connection is preferable because of its simplicity, economic benefit, and easy assembly. This paper presents a state-of-the-art review on bolted connections to tubular columns for bare steel tubes, including square and circular sections. Available studies on bolted connections at ambient and elevated temperatures are reviewed, but emphasis is given on the latter. Various methods of determining the connection performance through experimental, analytical, component based, and finite element approaches are examined. Future research areas are also identified.
Zohair Al-Ameen,Ghazali Sulong 보안공학연구지원센터 2016 International Journal of Grid and Distributed Comp Vol.9 No.10
Computed Tomography (CT) has remained an important component of medical imaging since its inception. In general, it is preferred to keep the radiation dose as low as possible during the CT examinations to prevent patients as well as operators from the dangerous side effects of these radiations, which in an extreme case may lead to cancer. However, reducing the radiation dose leads to undesirable degradations which not only reduce the visual quality of CT images, but also make such images difficult to interpret in clinical routines. The most common degradations in low-dose CT images include blur, noise and low-contrast. Over the recent years, considerable research has been made to process these degradations. However, they still remain open for research due to the wide variety of challenges they offer. In this article, the causing factors of such degradations are addressed adequately. Furthermore, the challenges that face the processing of these degradations are mentioned in detail. Finally, this article is intended for researchers who are approaching this topic to understand the aforesaid issues extensively.