콘택트렌즈 세척액이 숙주세포와 가시아메바에 미치는 영향

정석률 남서울대학교 2014 남서울대학교 논문집 Vol.S No.-

Acanthamoeba is opportunistic protozoan pathogen causing keratitis and encephalitis in human and experimental animals. Subsequent invasion of the connective tissue and induction of pro-inflammatory responses leads to neuronal damage that can be fatal within days. In this study, lens-clearing solutions were treated to Acanthamoeba castellanii and human brain microvascular endothelial cell (HBMEC) and cytotoxicity was analyzed. When the lens-clearing solutions was treated to the amoeba, the amoeba were changed into round form of no lightness. Cytotoxicity by the lens-clearing solutions of "Eyetec RGP Care (A)" and "Biotrue (B)" were decreased to 14.2% (A) and 30.8% (B), respectively. HBMEC cytotoxicity by the lens solution A and B were similar when compared with a negative control without the lens-clearing solutions. Amoeba when compared lens solution A and B, lens solution B is more effective. Key Words : Lens-Clearing Solution, Acanthamoeba, Eyetec RGP Care, Biotrue, Human brain microvascular endothelial cell

가시아메바 병원성의 이해

정석률 남서울대학교 2010 남서울대학교 논문집 Vol.16 No.1-1

가시아메바 (Acanthamoeba)는 단세포 진핵 원생생물이며 환경에서 자유 생활한다. 인체와 실험동물에서 만성 육아종성 수막뇌염과 아메바성 각막염을 유발하여 사망과 실명을 각각 초래할 수 있다. 특히, 만성 육아종성 수막뇌염은 면역이 저하된 환자나 면역억제제를 투여받고 있는 환자에게서도 발병이 가능하다. 본 연구에서는, 표적세포와 가시아메바의 상호작용 및 병원성을 유발하는 인자를 살펴보았으며 이것으로 가시아메바의 병원성을 이해하고자 하였다. 가시아메바는 주로 비강을 통하여 후신경을 경유하여 뇌-혈관 경계막을 뚫고 뇌에 감염된다. 여러 표적세포 중 소교세포와의 상호작용이 많은 관심이 대상이 되어왔는데, 이는 면역세포이면서 가시아메바를 사멸하기도 하며 가시아메바 또한 소교세포 등을 공격하여 사멸을 유도한다. 이것은 가시아메바의 감염정도와 병원성의 정도에 의존 할 것을 사료된다. 또한, 아메바성 각막염은 콘텍트렌즈를 착용하는 사람에게서 주로 발병되며, 원인은 비위생적인 세척 및 보관에의하여 콘텍트렌즈 보관용기에 가시아메바가 성장하여 눈으로 가서 발병된다. 매우 치명적이며 심할 경우 각막염을 유발하여 실명에까지 이르게 한다. 본 연구에서는, 가시아메바 감염에 의한 수막뇌염과 콘텍트렌즈를 착용하는 사람에게 경고를 해 줄 수 있는 자료로 제공될 것이며 향후, 백신이나 치료제를 개발하기위한 기초연구로써 활용되길 기대하고 있다. 핵심어: 가시아메바, 만성 육아종성 수막뇌염, 아메바성 각막염

<<三國史記>> <新羅本紀> 上代 靺鞨記事의 檢討 : Especially on Ginyun(紀年) of Early Records 初期記錄의 紀年을 중심으로

宣石悅 부산대사학회 1993 역사와 세계 Vol.- No.17

精神科 入院의 季節的 變動

吳碩煥,朴助烈,裵大均,金錫柱,韓東大,張貞富,柳志珍 大韓神經精神醫學會 1964 신경정신의학 Vol.3 No.2

(1) Authors studied seasonal fluctuation of psychiatric admission preliminarily, based on data of admission to Pusan area for a 4 year period of 1960-1963, and obtained following impressions. (2) The rate of admission in Pusan area and its seasonal fluctuation appear quite similar to those reported by investigators for European, American and Japanese cities. Thus the admission increases in spring and reaches the maximum in May and then gradually decreases toward the end of year. (3) The data obtained by statistical analysis of the seasonal fluctuation in Pusan area were compared with those of foreign ones in order to observe how to be related to the latitude of the locality. It is the general tendency that the lower latitude showed increase of admission in earlier months of the year than the higher latitude did. (4) It is a impression that the admission of affective psychoses are more sensitive to the climatic factors than the schizophrenics. (5) It is conjured by the authors that the socio-cultural and economic factors should be considered to give an account of the seasonal fluctuation of psychiatric admission.

4세기 加耶와 新羅의 관계 : 廣開土王 南征의 배경과 관련하여

선석열 동의대학교 인문과학연구소 2000 인간과 문화 연구 Vol.5 No.-

日本의 團體協約의 實態

조석률 건국대학교 1992 대학원 학술논문집 Vol.35 No.-

In Japan, since the collective agreement had shown their instances with emerging the union movement from Meiji era, though those had scarcely existed, those had soaked into the lowest stratum of lavor movements like as underground water and had a great influence upon those of post-world war 2. But before the war, because that the whole field of labor movements including collective bargainings and strikes ha been brought severe tressure and control upon, and that most enterprises centering on macro-enterprises of heavy industry had made efforts to establish the in-plant labor relation like as the family relation which was supported by seniority-based wage and career employment, and so on, actually the growth and development of the trade union could not help but hindered, therefore, under such circumstances, it is though that there was no practicability of the spread and settlement of the collective agreement. Such collective agreements of Japan made a new start with the labor-reform by GHQ and the end of World War 2 as truning-point. While other countries, premising a historical fact that the union had established and maintained the specific social power as the responsible position in charge of the collective autonomy and the collective order, approved the right to organization legally and determined the type of legislations to those, but Japan only received the external assistance such as the formulation of the collective order and the collective autonomy based on the legal approval of the right to organization as a result of the liberation policy on the union by GHQ's labor-reforms. Therefore, studying on the developmental process of the collective agreement of Japan referring to the developmental process of Japanese capitalism, the changing process of the whole political factors represented by GHQ and the developmental process of the labor movement coping with this situation, the collective agreement what is called right declaration type agreement came out, that should declare the right of worker rather than stipulate labor conditions by reason of the specific situation following the war defeat and the state without establishing the constitutional law and the labor law at the period just after the war regarded as the first step period of those developmental process. But according that labor laws were enacted and reformed under the influence of GHQ and labor movements were influenced by GHQ, the American type agreement based on the mutual understanding and the equal and bilateral relation between employers and workers, came to be introduced to Japan through the translation of American agreements. Hawever, Japan should have been formulated the Japanese style agreement in the developmental process because the organization system of the union and the collective bargaining system as well as the recognition on the history of labor relations formulation and the collective agreement is different from those of America. It is said that to understand the status and the developmental process of the collective agreement in Japan has great significance because such a understanding should be premised in unfolding the labor law theory of those.

치매노인의 인지능력에 미치는 꽃장식의 효과와 꽃의 선호도 조사

윤숙영,김홍열,--,우태양 한국화훼연구회 2002 화훼연구 Vol.10 No.1

본 연구는 대구광역시에 위치한 <햇빛치매어르신주간보호센터>에 있는 치매노인을 대상으로 꽃장식이 치매노인의 인지기능에 미치는 영향을 알아보고 꽃장식에서 꽃의 색과 크기의 선호도를 조사하기 위해서 치매노인 6명을 대상으로 2002년 2월 14일부터 2002년 5월 9일까지 주 1회씩 총 12회 원예치료 프로그램을 실시하였다. 대상자는 모두 여성이었다. 평가결과는 다음과 같다. MMSE-K 평가결과 대상자 A는 원예치료 실시 전 13점에서 실시 후 18점으로, 대상자 D는 원예치료 실시 전 5점에서 13점으로 유의하게 향상되는 것을 볼 수 있었다. 대상자 B는 7점에서 8점으로, 대상자 E는 3점에서 7점으로 향상되었으나 유의차가 없었다. 대상자 C는 원예치료 실시 전 15점에서 실시 후에는 14점으로 오히려 낮아졌으나 유의차는 없었다. 대상자 F는 인지능력이 없는 대상자로서 실시 전후 큰 변화가 없었다. 꽃의 선호도 조사결과 색은 적색과 황색 그리고 분홍색 순으로 선호하였고 크기는 중간형보다는 크거나 작지만 풍성한 꽃을 선호하였다. 이상의 결과로부터 꽃장식은 치매노인의 인지기능 향상에 효과적이었다. 재료는 매회 달랐지만 작품을 구사하여 다듬고, 자르고, 꽂고 하는 반복적인 활동을 통해 흥미를 유발하여 적극적으로 자신감을 갖게 되었으며, 또한 결과물을 가족들과 함께 공유하게 함으로써 가족관계도 개선되었다. Abstract. This study set out to research preference of flowers, to analyze the impacts of floral decoration on the improvement of recognition ability in the demented old adults in order to develop an more effective horticultural therapy program for the demented old adults. The subjects were made out of the demented old adults who were taken care of at <HABIT Demented Old Adults Day Care Center> located in Icheon-dong, Nam-gu, Daegu Metropolitan City. Total six subjects were included in experiment. They were all female, and their average age was 76. The experiment was conducted once a week from February 14 to May 9, 2002, total in 12 times. The experiment was only focused on floral decorations. The color and size of flowers were considered to decide the subjects preference. The subjects preferred red and yellow flowers. They also liked big flowers or small but opulent ones. As for floral decoration, the material flowers were different each session. But the subjects were aroused into interest via repetitive activities such as designing their works and arranging, cutting, and putting in flowers. Their active and confident attitudes became evident, and their relationships with their family grew better as they shared their works with them.

천연골재 및 재생골재콘크리트의 Na₂SO₄침식에 의한 화학저항성에 관한 실험적 연구

김규용,이정율,박유신,강석표,김무한 忠南大學校 産業技術硏究所 1998 산업기술연구논문집 Vol.13 No.1

Now a day, the more Proportion of concrete used in practice is exposed to serious chemical attack Chemical reactions that involve formation of expansive products in hardened concrete can lead to certain harmful effects. In this study, it is to compare and investigate the chemical resistance of natural and recycled aggregate concrete by attacked Na₂SO₄according to W/C ratio. The result of this study is that the chemical resistance of recycled aggregate concrete is lower than natural aggregate concrete. But it is developed the chemical resistance by decreasing the W/C ratio.

신속한 간흡충증 진단과 혈청 및 혈구 변화양상 분석

박지현,최혜정,정석률 남서울대학교 2010 남서울대학교 논문집 Vol.16 No.2

Diagnosis of Clonorchis sinensis requires specific proteins as antigens and it has been developed by using a rapid detection kit which identify circulating antibodies. In this study during Namseoul University Health/Medicine Care Service conducted in October 2010, with the residents in Wondeok-eup Samcheok Kangwon-do, the rapid diagnosis of C. sinensis infections was performed and patients' blood sera were analyzed. From 12 patients' sera of total 83, antibodies to C. sinensis were detected. According to the patients' sera analysis, about 73% of Total bilirubin, 40% of Cholesterol and 40% of Creatinine were abnormally exhibited. In the C. sinensis-positive sera detected by a rapid diagnostic kit, about 92% of Total bilirubin, 33% of Cholesterol and 50% of Creatinine were abnormally exhibited. According to analysis of blood cells, there was no abnormal result except for Hematocrit. In particular, high Eosinophil which means high incidence of C. sinensis infection was not observed. Taken together, it implied that the positive diagnosis of clonorchiasis would be previous infections of C. sinensis and its patients recovered from clonorchiasis have still antibodies in their sera. In addition, it also suggested that C. sinensis-positivity by the rapid diagnostic kit be not consistent with the present infections of C. sinensis. Key Words : Clonorchis sinensis, Rapid diagnostic kit, Serum, Blood cell, Antibody

유기용제 취급근로자들의 요중대사물질과 말초임파구 자매염색분체교환 발현빈도에 관한 조사연구

김돈균,황인경,류철인,이수일,정갑열,이용환,이충렬,현원일,김석봉,전용덕 大韓産業醫學會 1990 대한직업환경의학회지 Vol.2 No.1

저자들은 유기용제 취급여성근로자 90명을 대상으로 1988년 7월부터 1989년 8월까지 말초혈액임파구에서의 자매염색분체교환의 발현빈도를 조사하고 이들의 업종, 근속연수, 요중마뇨산 농도등이 자매염색분체교환의 발현빈도에 미치는 영향을 조사하였으며 그 결과를 요약하면 다음과 같다. 1. 유기용제 취급근로자들의 말초혈액임파구에서의 자매염색분체교환의 발현빈도는 대조군에 비하여 유의하게 증가되었다. 2. 말초혈액임파구에서의 자매염색분체교환의 발현빈도가 가장 높은 업종은 프라스틱제품 제조업이었다. 3. 근속연수가 말초혈액임파구에서의 자매염색분체교환의 발현빈도에 미치는 영향은 현저하지 않았다. 4. 요중마뇨산농도와 말초혈액임파구에서의 자매염색분체교환의 발현빈도간에는 유의한 상관관계가 있었다. In order to know the possibility of utilizing the sister chromatid exchanges as an index which could evaluate the effect of organic solvents on the health in industrial workers, the authors studied the effects of the inductivity of sister chromatid exchanges in peripheral lymphocytes from 90 female workers expoxed to organic solvents and 20 non-exposed female workers. The results obtained were as follows : 1. The frequency of sister chromatid exchanges in peripheral lymphocytes from 90 female workers exposed to organic solvents was significantly increased in comparison with 20 control subject. 2. The frequency of sister chromatid exchanges was significantly increased in the workers who were employed in the manufacture of plastic materials than the other manufactures. 3. There were no significant differences in the frequency of sister chromatid exchanges by carriers of the exposed workers.