구강점막 부착용 케토프로펜 고분자 필름의 제조 및 평가

박진석,이상은,강봉석,이경록,이은주,박정숙 충남대학교 약학대학 의약품개발연구소 2014 藥學論文集 Vol.29 No.-

Abstract – The objective of this study was to prepare ketoprofen-loaded buccal adhesive patch. The adhesive patch was formulated by casting method using aqueous soluble polymer povidone K17 (PVP 17PF) as film-forming agent and hydroxypropylmethylcellulose (HPMC) as adhesive agent. To compare the effect of HPMC type, different molecular weight of K4M and K15M HPMC was used. The physicochemical properties of patches such as appearance, thickness, in vitro release, and adhesiveness were investigated. The concentration of ketoprofen was determined spectrophotometrically at a wavelength of 233 nm. The appearance of prepared patches was semi-transparent, light-yellow or almost colorless, and odorless. Thickness of each patches (n=6) was 0.895 ± 0.033 mm for K4M patch and 0.727 ± 0.036 mm for K15M patch. In vitro release test, both K4M and K15M patches showed over 20% release within 30 min. At 120 min, K4M and K15M patches demonstrated 95% and 67.5% release of ketoprofen, respectively, and up to 240 min, both patches released drug completely. Maximum adhesive force of K4M and K15M patches was 6.571 ± 2.703 gf and 2.735 ± 1.151 gf, respectively. Moreover, it took 28.29 ± 0.38 sec and 28.30 ± 0.34 sec for K4M and K15M patch to peel off them after adhesion, showing no significant difference. In conclusion, thickness, in vitro release, and maximum adhesive force could be modulated by alteration of polymer types.

캐나다 건강관리 체계 : 노인간호 및 장기요양시설을 중심으로

김인숙,김옥란,정경옥 김천과학대학 2001 김천과학대학 논문집 Vol.27 No.-

간호행정학회지 게재논문의 학문적 가치와 성과

서문경애,고명숙 대한간호행정학회 2007 간호행정학회지 Vol.13 No.4

Purpose: This study was performed to identify current characteristics(Academic Value and Outcome) of the Journal of Korean Academy of Nursing Administration. Method: This 57 papers analyzed the Journal of Korean Academy of Nursing Administration(2006) and comparisons were made with similar studies in Health and Social Science(2006). Results: The analysis of the contents for the papers were suggested according to research purposes: research compatibility, research creativity, research excellence. Conclusion: It is suggested that in depth research be made on nursing management based on evidence practice, nursing informatics, legal and ethical issues, It is developmental direction for academic value and outcome of the Journal of Korean Academy of Nursing Administration.

지시사의 의미기능에 관한 연구

김경숙 청주대학교 학술연구소 2003 淸大學術論集 Vol.1 No.-

Notre e´tude a pour but de montrer les diffe´rences re´fe´rentielles de ce et celles de le qui proviennent de leur opposition de proprie´te´s se´mantiques : inde´xicalite´/de´finitude Le proble`me se pose de faire la distinction entre le sens(de´finition dans le syste`me de la langue) et emploi, ou effet de sens(interpre´tation dans le discours donne´). S'il est plus difficile a` re´soudre pour le de´monstratif pour que les autres de´terminants; c'est parce que 1'instruction se´mantique donne´e par le de´monstratif est pre´cise´ment de mettre le re´fe´rent du GN introduit en relation avec le couple je/tu constitutif du discours. La de´finition nouvelle sur la deixis et 1'anaphore fonde´e sur le concept de repe´rage nous permet d'analyser les e´le´ments en question conime suit ; - ce de´ictique marque une ope´ration de repe´rage par rapport au sujet e´nonciateur. Il repre´sente une identification avec le sujet e´nonciateur: - ce anaphorique marque uniquement une ope´ration de repe´rage par rapport a` une proprie´te´ spatiale: II repre´sente une relation de rupture entre le terme de´signe´ et le sujet e´nonciateur:

「양부 고민 해결담」에 나타난 '속 이야기'에 의한 문제 해결적 말하기 방식

최경숙 한국문학교육학회 1999 문학교육학 Vol.3 No.-

If education intends to bring up adaptable people, it should focus on developing the ability of solving problems. The curriculum of the department of Korean education shows the importance of problem-solving ability in teaching mother tongue. This thesis will inquire into the problem-solving way of speaking in the Story of Solving Stepfather's Problem* by analyzing speaker's 'story in story.' The procedures are as follows: To begin with, grasp the essence of the problem. Then explain the characteristics of the performance-arena in 'story in story.' After that look into the function of 'story in story' in the context of solving problems. In that story, the stepfather has a problem with his son's natural father. The natural father asserts that the son is his. He insists on the ideology that the paternal line takes precedence of maternal line. Because the stepfather regards the ideology as right, he is torn between keeping his son and sending him back to the natural father. To solve his stepfather's problem, the sun emphasizes the importance of 'love and devotion' instead of 'the paternal line' in the relationship of father to son. But it is difficult to convince people of the new ideology in direct way. So the performance-arena-the banquet and the encounter-is created. There are many people in the banquet and court. The king stands for the official event, and the natural father is the person concerned. So the result holds in all cases. By the way, 'the story of seeds and fields' asks for the listener's decision. That story features the trivial matters and common things in life the importance of love and devotion. By performing this story, the speaker let the listener make his own decision, and that the speaker finds some common ground as a basis for his opinion. Therefore, performing the story which is similar to one's own problem can be regarded as a way of persuading the other party.

간호행정학회지 게재논문 주요어 분석(2002년~2006년)

서문경애,고명숙,김인아 대한간호행정학회 2007 간호행정학회지 Vol.13 No.1

Purpose: This study was to understand the major subjects of the recent nursing research in Nursing administration from keywords. Method: Keywords of journals were extracted and the frequency of the appearance of each key words was sorted by a descending order. Results: A total of 327 key words were used. The most frequently used key words were 'Job satisfaction', 'Organizational commitment', 'Leadership'. Out of them, organizational culture, nursing performance, nursing classification, patient satisfaction, and ethics appeared most frequently in descending order. Conclusion: From the above it can be noted that many nursing administration concepts were handled in the papers. But there were not enough papers on the characteristics of the Nursing administration. It is suggested that in depth research be made on 'Nursing error', 'Nursing informatics', 'Web based learning'.

일 대학 보건복지 특성화 교육과정의 평가와 향후 방향에 관한 연구

고명숙,서문경애 대한간호행정학회 2007 간호행정학회지 Vol.13 No.2

Purpose: The purpose of this study was to evaluate the care manager curriculum for elderly's health & welfare and exam it's perspectives. Method: A descriptive survey was used. four hundred eight students of S university and seventy seven professionals were participated for this study. The curriculums evaluated for the elderly's health and welfare was care managers. eight times Brainstormings were done with five faculty members of S university to exam the current curriculums and to guide new perspectives. Result: Brainstorming results are as follow: the best curriculum contents is NEWSTART, we need new role for elderly's health & welfare. Conclusion: Even though, care manager have been working for the elderly, their role focuses not the direct care but the management. Therefore we need new role to do direct care to the elderly.

플라즈마용사 TiO₂코팅 강재의 음향방출 특성

김귀식,박경석,홍용의 제주대학교 산업기술연구소 1999 尖端技術硏究所論文集 Vol.10 No.2

In this paper, adhesiveness of plasma thermal sprayed coating steels is investigated through AE(acoustic emission) in loading a tensile. AE parameters used are event, count, energy and peak amplitude. The powders used for the coating are nickel aluminum composite powder Ni-4.5wt.%Al (BOND ) and titanium dioxide powder TiO2 (TOP). Test specimens are BOND, TOP and BT(BOND + TOP) that are sprayed on carbon steel(S45C) by plasma thermal spray. In the tensile testing, the process and occurrence of the exfoliation of the sprayed coating layer can be estimated by AE. Characteristics of AE parameters, such as event, count, amplitude and energy, on the layer exfoliation have all the similar aspects. The exfoliation of BOND specimen occurs from 16% tensile strain to fracture point, TOP specimen does from 1% to 5%, and BT specimen does from 6% to 11%.

트리암시놀론 아세토니드를 함유한 구강점막 부착성 패치의 제조 및 평가

엥흐자야,여동기,박진석,이은주,이경록,박정숙 충남대학교 약학대학 의약품개발연구소 2013 藥學論文集 Vol.28 No.-

The objective of this study was to prepare triamcinolone acetonide-loaded buccal adhesive patch. The adhesive patch was formulated by casting method using aqueous soluble polymer povidone K17 (PVP 17PF) as a film-forming agent and hydroxypropylmethylcellulose (HPMC) as an adhesive agent. To compare the effect of HPMC type, different molecular weight of K4M and K15M HPMC was used. The physicochemical properties of patches such as appearance, thickness, in vitro release, and adhesiveness were investigated. The concentration of triamcinolone acetonide was determined spectrophotometrically at a wavelength of 240 nm. The appearance of prepared patches was semi-transparent, light-yellow or almost colorless, and odorless. Thickness of each patches (n=6) was 0.942 ± 0.026 mm for K4M patch and 0.703 ± 0.036 mm for K15M patch, respectively. In vitro release test, both K4M and K15M patches showed over 20% release within 30 min. At 120 min, K4M and K15M patches demonstrated 80% and 76% release of triamcinolone acetonide, respectively, and up to 240 min, both patches released drug completely. Maximum adhesive force of K4M and K15M patches was 4.66 ± 0.76 gf and 2.69 ± 0.90 gf, respectively. Moreover, it took 28.73 ± 0.44 sec and 28.68 ± 0.61 sec for K4M and K15M patch to peel off them after adhesion, showing no significant difference. In conclusion, thickness, in vitro release, and maximum adhesive force could be modulated by alteration of polymer types.

음향방출 신호처리에 의한 플라즈마용사코팅 피막부식재의 파손해석

김귀식,박경석,홍용의,현창해 濟州大學校 産業技術硏究所 2001 산업기술연구소논문집 Vol.12 No.1

This paper was to investigate of a adhesiveness of the plasma sprayed coating materials did a salt spray by acoustic emission method in tensile loading. The powders used for the coating were nickel aluminum composite powder Ni-4.5wt.%Al and titanium dioxide powder T_(i)O_(2). These powders were coated on a carbon steel S45C by plasma spray method. The salt solution was a 5% NaCl and the salt spray times were 2. 5 and 10 hours respectively. The salt solution penetrated into the surface of the substrate through pore of the coating layer built in the process of plasma spay. Corrosion productions formed on the surface of substrate. The adhesiveness between the substrate and the coating layer is weaken by corrosion and the exfoliation initiated chiefly at the corrosion surface of the substrate. The AE events and energy of the corroded coating specimens decreased as the salt spray times increased. The AE amplitudes increased at strain range of 6%-11%.