Low Frequency Dielectric Anomaly of Tris-Sarcosine Calcium Manganese Chloride ( ( CH3NHCH2COOH ) 3 Ca1-x MnxCl3 ) Mixed Crystals

Ho Sueb Lee 기초과학연구소 1996 기초과학논문집 Vol.8 No.-

Low Frequency Dielectric Anomaly of Tris-Sarcosine Calcium Manganese Chloride (((CH₃NHCH₂COOH)₃??) Mixed Crystals.

Lee, Ho Sueb 昌原大學校 基礎科學硏究所 1996 基礎科學硏究所論文集 Vol.8 No.-

(CH₃NHCH₂COOH)₃??혼정(x=0, 0.05 및 0.1)의 저주파수 유전특성을 조사하였다. 순수한 (CH₃NHCH₂COOH)₃CaCl₂의 유전상수와 손실은 Tc근방에서 예리한 peak를 보인 반면 Mn을x=0.05 및 0.1 치환시킨 혼정에서는 그 anomaly가 broader하였다. 특히 Mn이 10mol% 첨가한 시료에서는 임계영역안에서 극소점이 나타났으며 이는 (CH₃NHCH₂COOH)₃CaCl₂의 상전이 기구가 임계영역내에서는 질서무질서형 거동하는 것을 뒷받침 하였다.

와전류(eddy-current)방법에 의한 비접촉 전기비저항 측정기술 개발

박진습(Jin Sueb Park),유권상(Kwon Sang Ryu),류제천(Je Cheon Ryu),유광민(Kwang Min Yu) 대한전기학회 1999 대한전기학회 학술대회 논문집 Vol.1999 No.11

Gd₂(MoO₄)₃단결성의 자발복굴절현상

이호섭,김상수 國立昌原大學校 基礎科學硏究所 1992 基礎科學硏究所論文集 Vol.3 No.-

Spontaneous Birefringence and Electro-Optical properties of Gd₂(MoO₄)₃single crystals were studied. Electro-Optic coefficient and its temperature dependence and Spontaneous Birefringence near the Curie temperature and measured by using the Babinet-Soleil compensator with A/D converter. The value of ??? is 4×??? m/V at room temperature and decreased to zero at phase transition one. The values of temperature and electric field dependence near the phase transition point are presented as hysterosis phenomena.

Gd₂(MoO₄)₃단결정의 적외선 반사스펙트럼

이호섭 國立昌原大學校 基礎科學硏究所 1992 基礎科學硏究所論文集 Vol.3 No.-

Infrared reflection spectra of Gd₂(MoO₄)₃single crystals are measured in the range 600-??????. The spectra are analysed with dielectric dispersion analysis and Kramers-Kronig relation. Optical phonon modes TO and LO phonon modes of B₁and B₂show very strong oscillator strengths and small damping constants, whreras A₁polar mode have shows large damping constant. The frequency inversion between TO and LO phonons are observed near the TO phonon with large oscillator strength.

企業의 表見責任

安東燮 단국대학교 경영대학원 1982 經院論叢(壇國大學校) Vol.2 No.-

Dielectric Response and Ferroelectric Polarization of Piezoelectric Enhanced (Na 0.535K0.475)(Nb0.55Ta0.45)O3 Ceramics at the Orthorhombic-Tetragonal Polymorphic Phase Transition

Jin Soo Kim,Ho Sueb Lee 한국물리학회 2020 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.76 No.9

The piezoelectric-enhanced (Na0.535K0.475)(Nb0.55Ta0.45)O3 (NKNT) ceramics with Na/K excess and Ta substitution were prepared near the polymorphic phase composition with an orthorhombic-tetragonal structure. The dielectric, piezoelectric, and ferroelectric properties of the lead-free NKNT ceramics are discussed. The temperature dependences of the specific dielectric and ferroelectric properties were investigated in detail. Broadened dielectric anomalies and saturated ferroelectric P-E hysteresis loops were observed over the phase transitional temperature range of the orthorhombic-tetragonal phase (TO-T). Additionally, the particular behaviors of the dielectric and the ferroelectric polarizations at the polymorphic phase boundary (PPB) are also discussed.

Obovatol extracted from Magnolia Obovata inhibits inflammation mediator generation and prostate carcinoma PC-3, LNCap cell growth through induction of apoptotic cell death via inactivation of NF-κB

KimGoon-Joong,Song Ho-sueb 대한침구의학회 2007 대한침구의학회지 Vol.26 No.2

Objectives : To evaluate effect of obovatol extracted from Magnolia Obovata inhibits inflammation mediator generation and prostate carcinoma PC-3, LNCap cell growth through induction of apoptotic cell death via inactivation of NF-κB.Methods : We conducted an in vitro analysis to evaluate RAW264.7 cell and the prostate cell response to obovatol in order to determine the ability and related mechanism of this therapeutic agent from natural herb to inhibit inflammation and to suppress prostate cell growth by affecting inflammation-related gene expression, cell proliferation and apoptosis via inactivation of NF-κB and other cell survival signals.Results : We found that obovatol inhibited a pronounced down- regulation of nuclear localized protein levels of nuclear factor-κB family members. Down regulated NF-κB signals by obovatol is consistent with inflammation and cell growth inhibition. These data suggest that NF-κB signal may be significant contributor in obovatol-induced anti-inflammatory effect and human prostate cancer cell PC-3, LNCap cell death. 연구목적 : 厚朴(Magnolia Obovata)에서 추출한 낮은 농도의 Obovatol 약침액의 RAW264.7 세포에서 LPS로 유발된 염증, TNF-α로 유발된 human Prostate carcinoma PC-3 및 LNCap 세포의 세포증식에 대한 영향과 그 기전을 살펴보고자 하였다. 실험방법 : RAW264.7 세포에서 LPS로 염증을 유발하고 낮은 농도의 Obovatol 약침액을 처리한 후 cell viability, NO 생성량, iNOS와 COX-2의 발현, NF-κB활성, 전사능력을 관찰하기 위해 MTT assay, NO determination assay, western blot analysis, EMSA, luciferase activity assay를 시행하였고, LNCap, PC-3 세포에 TNF-α로 증식을 유도하고 낮은 농도의 Obovatol 약침액을 처리한 후 cell growth, apoptosis 및 apoptosis와 연관된 NF-κB의 활성 변화를 관찰하기 위해 WST-1, Cell morphogy test, DAPI staining and TUNEL assay, EMSA, luciferase activity assay를 시행하였다. 결 과: 1. RAW264.7 세포에서 낮은 농도의 Obovatol 약침액 처리는 NF-κB의 활성 및 전사능력을 낮추고 iNOS와 COX-2의 발현과 NO 생성을 감소시켜 LPS로 유발된 염증을 억제하였다. 2. LNCap, PC-3 세포에서 낮은 농도의 Obovatol 약침액 처리는 NF-κB의 활성을 낮추어 세포자멸사을 촉진함으로써 TNF-α로 유발된 암세포의 성장을 억제하였다. 결 론 : 이상의 결과는 낮은 농도의 Obovatol 약침액이 항염 및 인간 전립선암세포주인 PC-3, LNCap에 대한 증식억제 효과가 있음을 입증한 것이며, 향후 이를 바탕으로 한 생체 연구에서의 긍정적인 결과는 Obovatol 약침액이 만성염증성 질환 및 전립선암의 예방과 치료에 대한 효과적인 치료제 개발에 초석이 될 것으로 기대된다.

Effects of Scutellaria baicalensis Extract on Gout-Induced Rats

Eunchang Lee,Ho-Sueb Song 대한침구의학회 2023 대한침구의학회지 Vol.40 No.2

Background: This study aimed to investigate hyperuricemia, renal inflammation, and xanthine oxidase (XO) activity improvement in a rat model treated with Scutellaria baicalensis extract (SBE). Methods: The rats were divided into 4 groups (n = 5 each), including sham, potassium oxonate (PO) injected hyperuricemia (control group), PO + 10 mg/kg allopurinol administrated (allopurinol group), and a PO + 50 mg/kg SBE administrated (SBE group), to investigate the effectiveness and molecular mechanisms of SBE. The effects of SBE on PO-induced hyperuricemia rats, renal inflammation, and XO activity were measured. Body weight and organ index of the kidney and liver were measured in PO-induced hyperuricemia rats, and serum uric acid level was extracted from whole blood and was measured. Renal inflammation was observed under a microscope after sections. XO activity was measured by liver tissue and serum XO levels. Results: Organ indexes of the kidney and liver in rats were significantly decreased in the allopurinol group than in the control group and with no significant difference in the SBE group. A PO injection for 5 days significantly increased serum uric acid levels in the control group compared to the sham group. Meanwhile, the SBE and allopurinol groups have significantly decreased serum uric acid levels compared to the control group. The SBE group revealed effectively improved renal histopathological changes compared to the control group. The XO inhibitor, allopurinol, significantly decreased XO activity. Additionally, SBE significantly lowered XO activity in rats. Conclusion: SBE can be used as an effective treatment for gout in the future.

Scutellaria baicalensis Extract Alleviates Pain and Inflammation in Animal Models

Haeni Seo,Ho-Sueb Song 대한침구의학회 2023 대한침구의학회지 Vol.40 No.1

Background: This study aimed to examine the effect of Scutellaria baicalensis extract (SBE) on ameliorating pain response and inflammation in an animal model. Methods: The effects of SBE on joint inflammation-induced rats and pain writhing response were measured. In rats with monosodium iodoacetate (MIA)-induced knee osteoarthritis (OA), the weight-bearing distribution of the hind legs was measured, the actual joint condition was visually confirmed, and serum cytokines were extracted from whole blood and measured. In addition, the acetic acid-induced pain was measured by the number of abdominal wall contractions and writhing responses. Results: 1. The weight-bearing distribution of the hind limbs of the SBE group was remarkably improved compared with that of the control group 7 days after MIA treatment, and the SBE 300 group was improved similarly to that of the indomethacin group. 2. Cartilage erosion was significantly recovered in the SBE and indomethacin groups, and the degree of healing of cartilage erosion by SBE was similar to that by indomethacin. 3. The serum levels of cytokines interleukin-1β, tumor necrosis factor-α, and interleukin-6 were significantly decreased in the SBE group compared with that in the control group, and the SBE 300 group had reduced levels of cytokines similar to the indomethacin group. 4. As regards acetic acid-induced writhing response, the number of writhes was significantly reduced in the SBE and ibuprofen groups, and the SBE 600 group had fewer writhes than the ibuprofen group. Conclusion: SBE significantly improves knee OA and pain and is expected to show similar therapeutic effects to indomethacin and ibuprofen.