Antidepressant Effects of Ketamine on Depression-like Behavior in Juvenile Mice after Neonatal Dexamethasone Exposure

Su-Xia Li,갠지하시모토,Ji-chun Zhang,Jin Wu 대한정신약물학회 2014 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.12 No.2

Objective: Pediatric depression is associated with significant functional impairment at school and at work. Recently, we reportedon depression-like behavior in juvenile mice neonatally exposed to dexamethasone (DEX) as a potential animal model for pediatricdepression. The N-methyl-D-aspartate (NMDA) receptor antagonist ketamine has promoted rapid and long-lasting antidepressanteffects in patients with treatment-resistant major depression. This study was conducted to examine whether ketaminehad antidepressant effects in juvenile mice after neonatal DEX exposure. Methods: A single dose (10 mg/kg) of ketamine or vehicle was injected into juvenile mice at days 29-32 after neonatal DEX(or saline) exposure (days 1-3). The sucrose preference test, tail suspension test, and forced swimming test were performed24, 40, and 46 hours, respectively, after injection of ketamine. Results: Ketamine (10 mg/kg) significantly improved depression-like behavior in DEX-treated juvenile mice. Conclusion: This finding suggests that ketamine confers antidepressant effects in an animal model of pediatric depression

Berberine suppresses in vitro migration of human aortic smooth muscle cells through the inhibitions of MMP-2/9, u-PA, AP-1, and NF-κB

( Su Jian Liu ),( Cai Xia Yin ),( Ming Chao Ding ),( Shao You Xia ),( Qin Min Shen ),( Ji Dong Wu ) 생화학분자생물학회(구 한국생화학분자생물학회) 2014 BMB Reports Vol.47 No.7

Berberine, a type of isoquinoline alkaloid isolated from Chinese medicinal herbs, has been reported to have various pharmacological activities. Studies have demonstrated that berberine has beneficial effects on vascular remodeling and alleviates restenosis after vascular injury. However, its mechanism of action on vascular smooth muscle cell migration is not fully understood. We therefore investigated the effect of berberine on human aortic smooth muscle cell (HASMC) migration. Boyden chamber assay was performed to show that berberine inhibited HASMC migration dose- dependently. Real-time PCR and Western blotting analyses showed that levels of matrix metalloproteinase (MMP)-2, MMP-9, and urokinase-type plasminogen activator (u-PA) were reduced by berberine at both the mRNA and protein levels. Western blotting assay further confirmed that activities of c-Fos, c-Jun, and NF-κB were significantly attenuated. These results suggest that berberine effectively inhibited HASMC migration, possibly by down-regulating MMP-2, MMP-9, and u-PA; and interrupting AP-1 and NF-κB mediated signaling pathways. [BMB Reports 2014; 47(7): 388-392]

한·중 연어 대조를 위한 연어 개념 구축과 범주 한정

소효하 ( Su¸ Xiao-xia ),최순희 ( Cui¸ Shun-ji ) 한민족어문학회 2021 韓民族語文學 Vol.- No.93

본 연구는 한국어 '연어'(collocation)와 중국어 '搭配'를 논의함으로써 한·중 연어 대조를 위한 연어 개념을 구축하는 데 목적을 둔다. 최근 한·중 연어 대조 연구가 활발해진 것에 비하면 한국어 연어에 상응하는 중국어 개념에 대한 이론적 논의가 많이 부족하다. 영어 'collocation'에 대하여 일반적으로 한국어에서는 연어라고, 중국어에서는 '搭配'라고 한다. 본고는 한국어 연어와 중국어 搭配에 관한 논의를 살펴봄으로써 두 가지 개념은 일치하지 않는다고 지적하였다. 그리고 搭配의 유형을 분석한 결과 特定搭配/有限组合/受限搭配/限制性搭配 등을 한국어 연어에 상응하는 개념으로 볼 수 있으며, 이 중 본고에서 주장하는 연어 판별 기준을 고려해 '特定搭配'가 가장 적합하다고 보았다. 또한 일차적으로 '의미 해석의 투명성'을, 이차적으로 '어휘 선택 제약'을 연어와 特定搭配를 판별하는 기준으로 제시하고 그들의 범주를 규정하였다. The purpose of this study was to establish the concept of collocation for the Korean-Chinese collocation contrast by discussing Korean "collocation" and Chinese "搭配". Compared to recent active studies on Korean-Chinese collocation, there is a lack of theoretical discussion on Chinese concepts corresponding to Korean collocation. This paper points out that these two concepts do not match, looking at discussions on Korean collocation and Chinese 搭配. After analyzing the type of 搭配, "特定搭配/有限组合/受限搭配/限制性搭配" can be considered as a corresponding concept to Korean collocation, among which "特定搭配" is the most appropriate one considering the collocation discrimination criteria proposed in this paper. In addition, in terms of the criteria for collocation or 特定搭配, this study proposed "meaning interpretation of transparency" as the primary criterion and "lexical selection restrictions" as the secondary standard. This study also specified their category.

Cordblood-Based High-Throughput Screening for Deafness Gene of 646 Newborns in Jinan Area of China

Shou-Xia Li,Ding-Li Chen,Su-Bin Zhao,Li-Li Guo,Hai-Qin Feng,Xiao-Fang Zhang,Li-Li Ping,Zhi-Ming Yang,Cai-Xia Sun,Gen-Dong Yao 대한이비인후과학회 2015 Clinical and Experimental Otorhinolaryngology Vol.8 No.3

Objectives. Infants with slight/mild or late-onset hearing impairment might be missed in universal newborn hearing screening (UNHS). We identified the mutation hot spot of common deaf gene in the newborns in Jinan area population by screening the mutation spot with neonate cord blood, in order to make clear whether the neonate cord blood for screening is feasible. Methods. Six hundred and forty-six newborns were subjected to both UNHS and genetic screening for deafness by using neonate cord blood. The newborn genetic screening targeted four deafness-associated genes, which were commonly found in the Chinese population including gap junction beta-2 protein (GJB2), gap junction beta-3 protein (GJB3), solute carrier family 26 member 4 (SLC26A4), and mtDNA 12S rRNA. The most common 20 spot mutations in 4 deaf genes were detected by MassARRAY iPLEX platform and mitochondrial 12S rRNA A1555G and C1494T mutations were sequenced using Sanger sequencing. Results. Among the 646 newborns, 635 cases passed the UNHS and the other 11 cases (1.7%) did not. Of the 11 failures, two cases were found to carry homozygous GJB2 p.R143W pathogenic mutation, one case was found to have heterozygous GJB2 235delC mutation, and another one case carried heterozygous GJB3 p.R180X pathogenic mutation. Six hundred and thirty-five babies passed the newborn hearing screening, in which 25 babies were identified to carry pathogenic mutations, including 12 heterozygotes (1.9%) for GJB2 235delC, eight heterozygotes (1.3%) for SLC26A4 IVS7-2A>G, one heterozygote (0.2%) for p.R409H, two homozygotes (0.3%) for m.1494C>T, and two homozygotes (0.3%) for m.1555A>G. Conclusion. Newborn genetic screening through the umbilical cord blood for common deafness-associated mutations may identify carriers sensitive to aminoglycoside antibiotic, and can effectively prevent or delay hearing loss occurs.

Kano 모델 및 PCSI 지수를 활용한 O2O 서비스 품질에 대한 탐색적 연구:

Hai Xia Su,김진민(Jin Min Kim),김영대(Young Dae Kim),최성용(Sung Yong Choi) 중앙대학교 한국전자무역연구소 2017 전자무역연구 Vol.15 No.2

연구목적: 본 연구는 중국 소비자들을 대상으로 O2O 서비스에서 Kano 모형을 이용해 서비스 품질을 분류하고, 고객만족계수와 불만족계수를 각각 산출하였다. 이후 순차적으로 잠재적 고객만족개선지수(PCSI Index)를 산출하였다. 그 결과 O2O 서비스 제공 시 우선적으로 고려하여 관리 및 개선해야 할 서비스 품질속성을 판단하고, 최종적으로 중국 소비자들의 고객만족을 높일 수 있는 우선적인 개선사항들을 제시하고자 한다. 논문구성/논리: 본 논문은 전체 5절로 구성되어 있다. 1절에서는 연구의 배경 및 방향에 대하여 제시한다. 이 후 2절에서는 관련 문헌에 대하여 검토한다. 3절에서는 연구모형과 연구방법을 제시하고, 4절에서는 연구방법을 통해 도출된 결과를 분석하였다. 최종적으로 5절에서는 결론을 도출하고, 연구의 시사점 및 한계점을 설명한다. 결과: 첫째로 중국 소비자들을 대상으로 하는 기업에서는 본 연구에서 확인된 당연적 품질요소나 일원적 품질요소 이외에도 이러한 매력적 품질요소에 투자를 하고 꾸준한 관리를 해야 한다. 둘째로 PCSI 지수 값이 높을수록 고객의 만족도를 증가시킬 수 있는 요인들이다. 따라서 지수 값이 높게 나온 요인들을 중점적으로 개선한다면 고객들의 만족도가 크게 증가할 것이다. 마지막으로 PCSI지수의 상위에 위치한 항목들은 개선이 가장 시급하고 고객만족이 가장 크게 증가될 수 있다. 따라서 이와 같은 항목에 투자하여 소비자들을 끌 수 있도록 해야 할 것이다. 독창성/가치: 본 연구는 중국 소비자들을 대상으로 O2O 서비스 품질을 Kano 모형에 따라 매력적 품질, 일원적 품질, 당연적 품질, 무관심 품질, 역 품질로 분류하였다. 이 후 고객만족계수를 이용하여 품질 요인들 중 고객의 만족도의 상승가능여부 또는 하락가능여부를 파악하고 잠재적 고객만족 개선지수(PCSI index)를 산출하였다. 이로써 고객만족을 높이기 위해 우선적으로 개선되어야 하는 품질 요인들이 결정되었다. 따라서 본 연구에서는 Kano 모형과 PCSI 지수를 기반으로 O2O 서비스 품질에 관한 고객만족을 높일 수 있는 우선적인 개선사항들이 효과적으로 제시되었다. Purpose: In our study, we classify the quality factors involved in the online to offline (O2O) service to Chinese consumers by using the Kano model and calculate the customer satisfaction and dissatisfaction coefficients. Next, we calculate the PCSI (Potential Customer Satisfaction Improvement) index. As a result, we determine the service quality attributes in O2O service that should be managed and improved first, and finally present some preemptive improvements that will enhance customer satisfaction among Chinese customers. Composition/Logic: This paper has five sections. In section 1, we present the objectives and overview of the study. We review related literature in section 2. We describe our research model and methodology in section 3 and analyze the results in section 4. In section 5, we draw conclusions from the study, and explain both the implications and limitations of the study. Findings: First, in the companies targeting Chinese consumers, the attractive quality factors, which are identified in this study, should be invested in and maintained at a constant level, along with the must-be and one-dimensional quality factors. Second, the higher the value of PCSI index, the more likely is the increase in the satisfaction of the customer. Thus, customer satisfaction will increase significantly if we focus on the factors that have high PCSI index values. Third, the top ranked items in the PCSI index are the quality factors that not only need the most urgent improvement but can also increase customer satisfaction the most. Therefore, consumers should be attracted by investing in these items. Originality/Value: This study categorizes O2O service quality into attractive quality, one-dimensional quality, must-be quality, indifferent quality and reverse quality by applying the Kano model to Chinese consumers. We then use the customer satisfaction coefficient to determine whether the customer s satisfaction level could increase or decrease and calculate the Potential Customer Satisfaction Improvement index (PCSI index). This has led to the identification of quality factors that should be improved first to improve customer satisfaction. Therefore, in this study, based on the Kano model and the PCSI index, the priority improvements that can improve customer satisfaction on O2O service quality are presented effectively.

중국인 유학생을 위한 코로나-19 관련 어휘 선정 및 교육 방안

수시아(SU, XIA) 국어교육학회 2023 국어교육연구 Vol.- No.81

Isorhamnetin Protects Human Keratinocytes against Ultraviolet B-Induced Cell Damage

( Xia Han ),( Mei Jing Piao ),( Ki Cheon Kim ),( Susara Ruwan Kumara Madduma Hewage ),( Eun Sook Yoo ),( Young Sang Koh ),( Hee Kyoung Kang ),( Jennifer H Shin ),( Yeun Soo Park ),( Suk Jae Yoo ),( Su 한국응용약물학회 2015 Biomolecules & Therapeutics(구 응용약물학회지) Vol.23 No.4

Isorhamnetin (3-methylquercetin) is a flavonoid derived from the fruits of certain medicinal plants. This study investigated the photoprotective properties of isorhamnetin against cell damage and apoptosis resulting from excessive ultraviolet (UV) B exposure in human HaCaT keratinocytes. Isorhamnetin eliminated UVB-induced intracellular reactive oxygen species (ROS) and attenuated the oxidative modification of DNA, lipids, and proteins in response to UVB radiation. Moreover, isorhamnetin repressed UVB-facilitated programmed cell death in the keratinocytes, as evidenced by a reduction in apoptotic body formation, and nuclear fragmentation. Additionally, isorhamnetin suppressed the ability of UVB light to trigger mitochondrial dysfunction. Taken together, these results indicate that isorhamnetin has the potential to protect human keratinocytes against UVB-induced cell damage and death.

Salvage Therapy of Gemcitabine Plus Endostar Significantly Improves Progression-free Survival (PFS) with Platinum-resistant Recurrent Epithelial Ovarian Cancer

Su, An,Zhang, Jing,Pan, Zhan-He,Zhou, Qi-Ming,Lv, Xia Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.3

Anti-angiogenic agents have played crucial roles in the treatment of ovarian cancer in recent years, but potential benefits of endostatin have been largely unexplored. The present retrospective study evaluated its efficacy and toxicity with two cohorts of patients with platinum-resistant recurrent ovarian cancer. One cohort received gemcitabine plus endostar (rh-endostatin), and the second cohort received gemcitabine regimen alone, with totals of 31 and 27 patients, respectively. The main endpoints were disease control rate (DCR), PFS, overall survival (OS) and safety. There were statistically significant differences in DCR (70.9% vs. 40.7%; P = 0.02) and PFS (6.3 months vs. 3.2 months, P = 0.001) between the two cohorts. Though the endostar cohort also improved median OS by 2.1 months, there was no statistically significant difference compared with gemcitabine alone cohort in this case (12.5 months vs. 10.4 months, P = 0.201). Treatment was well tolerated for most patients, and toxicity of endostar was negligible. Gemcitabine plus endostar significantly improved the prognosis in patients with platinum-resistant recurrent ovarian cancer, especially in those with malignant effusion. The endostar-containing regimen is recommended in this setting.

Effects of PTTG Down-regulation on Proliferation and Metastasis of the SCL-1 Cutaneous Squamous Cell Carcinoma Cell Line

Xia, Yong-Hua,Li, Min,Fu, Dan-Dan,Xu, Su-Ling,Li, Zhan-Guo,Liu, Dong,Tian, Zhong-Wei Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.11

Aims: To study effects of down-regulation of pituitary tumor-transforming gene (PTTG) on proliferation and metastasis ability of the SCL-1 cutaneous squamous cell carcinoma (CSCC) cell line and explore related mechanisms. Methods: SCL-1 cells were divided into 3 groups (untreated, siRNA control and PTTG siRNA). Cell proliferation assays were performed using a CCK-8 kit and proliferation and metastasis ability were analyzed using Boyden chambers. In addition, expression of MMP-2 and MMP-9 was detected by r-time qPCR and Western blotting. Results: Down-regulation of PTTG could markedly inhibit cell proliferation in SCL-1 cells, compared to untreated and control siRNA groups (P < 0.05). Real-time qPCR demonstrated that expression levels of PTTG, MMP-2 and MMP-9 in the PTTG siRNA group were 0.8%, 23.2% and 21.3% of untreated levels. Western blotting revealed that expression of PTTG, MMP-2 and MMP-9 proteins in the PTTG siRNA group was obviously down-regulated. The numbers of migrating cells ($51.38{\pm}4.71$) in the PTTG siRNA group was obviously lower than that in untreated group ($131.33{\pm}6.12$) and the control siRNA group ($127.72{\pm}5.20$) (P < 0.05), suggesting that decrease of proliferation and metastasis ability mediated by PTTG knock-down may be closely correlated with down-regulation of MMP-2 and MMP-9 expression. Conclusion: Inhibition of PTTG expression may be a new target for therapy of CSCC.

Construction of Genetic Microsatellite Maps for Some Chromosomes in Chinese Swine Reference Population

Su, Yuhong,Xiong, Yuanzhu,Zhang, Qin,Liu, Weimin,Jiang, Siwen,Yu, Li,Xia, Xuanyan,Zeng, Rong,Deng, Changyan Asian Australasian Association of Animal Productio 2002 Animal Bioscience Vol.15 No.10

In aiming to identify the genes or genetic regions responsible for quantitative traits, a swine reference population had been constructed using three Large White boars and seven Meishan dams as parents. Five $F_1$ males and 23 $F_1$ females were intercrossed to generate 147 $F_2$ offspring. Thirty-one microsatellite markers covering Sus scrofa chromosomes (SSC) 2, 4, 6 and 7 were genotyped for all members. Construction of genetic microsatellite maps was performed using the CRIMAP software package. The lengths of these chromosomes were longer than MARC maps. They were 158.6cM, 180.3cM, 197.3cM and 171.4cM, respectively. A two modified orders of markers were observed for SSC6 and SSC7. The female map on SSC6 was shorter than male map, and the contrary was on SSC 2, 4 and 7.