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      • Solar urticaria in Korean patients

        ( Sung Min Kim ),( Young Ah Cho ),( Ji Su Lee ),( Ji Youn Hong ),( Jin Hee Kim ),( Joo Ran Hong ),( Hye In Cheon ),( Yang Won Lee ),( Yong Beom Choe ),( Kyu Joong Ahn ) 대한피부과학회 2020 대한피부과학회 학술발표대회집 Vol.72 No.1

        Background: Solar urticaria (SU) is an uncommon type of photodermatoses characterized by erythematous wheal with pruritus after sunlight exposure, which shows a female predominance. Only a few studies to analyze the clinical features of SU were reported in Asia. Objectives: We aimed to analyze the clinical and photobiological characteristics of SU in Korea. Methods: We retrospectively investigated the medical records of patients with SU who visited the department of dermatology, Konkuk university medical center from January 2005 to January 2020. Results: Of a total of 44 patients, 36 (81.8%) were male and 8 (18.2%) were female. The mean age at onset was 17.6 years (range, 5-47) and the mean threshold time was 19.7 minutes. Among 32 patients who underwent phototesting, the action spectrum most commonly implicated was ultraviolet (UV) A only in 12 (37.5%), and then visible light (415nm) only was responsible for SU in 8 (25.0%). Three patients (9.4%) were induced by both UVA and visible light (415nm). Even 4 patients (12.5%) were triggered by only natural sunlight. Serum immunoglobulin E levels were measured in 33 patients, and 17 (51.5%) showed values higher than normal. The treatment most widely used were oral antihistamine (43.2%), followed by phototherapy (13.6%). Conclusion: SU is a rare photodermatosis in Korea, which shows a male preponderance. In this study, UVA and visible light (415nm) were predominant action spectrum of SU.

      • KCI등재

        β-1,3/6-linked glucan 첨가사료가 넙치의 비특이적 면역반응에 미치는 영향

        원경미,김수미,박수일 한국어병학회 2004 한국어병학회지 Vol.17 No.1

        glucan 첨가 사료 투여가 넙치에 미치는 영향을 조사하기 위하여 넙치에 glucan 0%, 0.01%, 0.1%, 0.5% 첨가 사료를 연속 투여구와 격주 투여구로 나누어 공급하면서, 성장, 혈액 성분, 비특이적 면역능을 분석하였으며, 나아가 어병 세균인 Edwardsiella tarda균의 공격 실험에 대한 방어능을 조사하였다. gulcan 첨가 사료 투여는 넙치의 성장에 긍정적인 효과를 보였는데, 특히 0.05% 연속 투여구와 0.1% 격주 투여구에서 대조구보다 유의하게 높은 성장을 나타내었다. glucan 첨가사료의 투여가 넙치의 비특이적 면역 반응에 미치는 영향을 조사하기 위해 혈청 lysozyme과 전신 식세포의 확성 산소를 측정한 결과, 거의 모든 실험구에서 실험 기간 내내 대조구보다 높은 활성을 보였다. glucan 첨가 사료의 투여가 넙치의 생리에 영향을 미치는 지를 조사하기 위하여, total protein, glucose, GOT, GPT, Ht를 측정한 결과, 3주째 GPT 수치가 다소 높은 것을 제외하고는 그다지 큰 변화를 보이지 않았다. 마지막으로 Edwardsiella tarda (4×10^(6) cells/fish) 균을 공격 실험한 결과, 0.01% 연속 투여구를 제외한 모든 실험구에서 높은 방어력을 보였다. The effects of dietary β-1,3/1,6-linked glucan administration on nonspecific immune responses, hematology and disease resistance against Edwardsiella tarda in olive flounder, Paralichthys olivaceus were evaluated. Fish were fed the experimental diets supplemented with 0 %, 0.01 %, 0.05 %, 0.1 %, and 0.5 % of β-glucan to a commercial diet for 7 weeks. The test was performed in two ways such as fed on each β-glucan concentrations daily and every other week alternately. The body weight gain from the fish fed on daily the 0.05 % supplemented diet and fed on alternately the 0.1 % supplemented diet of β-glucan were significantly higher than the control. Both lysozyme activity and intracellular superoxide anion production of kidney phagocytes were higher in the all experimental groups than in the control. But there was no large difference in hematology among each group. The relative percent survival rate (RPS) after an artificial challenge with 4×10^(6) cells of E. tarda per fish was higher than the control, except for that fed on daily the 0.01 % supplemented diet.

      • 세선화된 결과와 종횡비를 이용한 한글과 영어의 구별

        元南植,全日秀,李修美 慶一大學校 1997 論文集 Vol.14 No.2

        This paper proposes a distinction algorithm of Korean and English characters which can be applied to multi-font from the results of thinning and aspect ratio. The proposed algorithm distinguishes Korean and English characters as the number of connected components. If it can not distinguish those characters with the number of connected components, it distinguishes them as the vowel included in Korean characters and aspect ration of the character image. In experimental results, the distinction rate is about 99.82% for the 2.350 characters of three widely used fonts.

      • SCIESCOPUSKCI등재

        Analysis of Judicial Precedents Cases Regarding Skin Cancer from 1997 to 2017 in Republic of Korea

        ( Su Hwan Shin ),( Won Lee ),( So Yoon Kim ),( Gwanghyun Jo ),( Je-ho Mun ),( Soo Ick Cho ) 대한피부과학회 2019 Annals of Dermatology Vol.31 No.3

        Background: Both medical disputes and the incidence of skin cancer are increasing in Korea. Objective: The aim of this study was to figure out the medical litigation related to skin cancer and propose a method to prevent the medical disputes. Methods: Skin cancer-related judgments were searched by The Supreme Court of Korea’s Written Judgment Management System based on the keywords for skin cancer. The search system included sentenced cases at the Lower Courts, the Appellate Courts, and the Supreme Court from 1997 to 2017. Results: Seven cases were selected as the litigation cases related to skin cancer. Four cases (57.1%) presented malignant melanoma, while the rest presented squamous cell carcinoma, metastatic skin cancer, and peripheral T cell lymphoma (1 case in each). Four cases resulted in death from cancer metastasis, and 3 cases presented as sequelae. The legal issues related to the medical disputes could be categorized as follows: misdiagnosis, delayed diagnosis, performance error, and lack of informed consent. Delayed diagnosis and lack of informed consent were the most common issues (n=4) in the precedents. Five cases (71.4%) were sentenced the awarded amounts to the plaintiff, including 2 cases of settlement decision. The average awarded amount was 42,553,644±27,567,455 Korean won. Conclusion: Physicians should pay attention to the cases of the skin cancer to prevent medical malpractice and disputes. The practices pertaining to proper diagnosis, treatment plans, and obtaining an informed consent should be followed during the course of treating skin cancer. (Ann Dermatol 31(3) 300∼306, 2019)

      • 진행성 폐 종양 환자에서 종양 내 OK-432 주입술의 효과

        정수현,김성빈,박진희,탁희상,옥철호,장태원,정만홍,천봉권 고신대학교 의과대학 2009 고신대학교 의과대학 학술지 Vol.24 No.2

        Background: Intratumoral injection of OK-432 produced significant antitumor effects. There are reports that OK-432 was injected directly into tumor tissue on gastrointestinal tracts and HCC tissue, producing decrease in serum alpha-fetoprotein level. We adopted this technique for treating locally advanced lung cancer. The object of this study is to evaluate the local therapeutic efficacy, side effects of injection for treating symptomatic mass. Methods: Twenty lung cancer patients (13 males and 7 females) underwent sonography guided OK-432 injection. We analyzed relationships between response of OK-432 and response of skin test, histology and age. Pain that patients feel was evaluated by VAS (Visual Analog scale). Results: A significant decrease of tumor size was observed. The mean pre-injection diameter of the lesions was 54.7±11.3mm, PR rate were 15.0% (3/20) and minimal change (50%<tumor size decreased.) patients were 35.0% (7/20). The VAS score before injecting OK-432 into the lesion was 5±3, this was decreased to 2.5±1.5 (p=0.04). Object response was significantly correlated with skin response, adenocarcinoma, and age. Conclusion: A significant decrease of tumor size and pain was observed. So OK-432 is a valuable treatment option for patients with symptomatic lesion from advanced lung cancer who are not amenable to further therapy.

      • 소산장 흡수를 이용한 다채널 광섬유 미각센서

        김수진,이수미,강신원 경북대학교 센서기술연구소 1998 센서技術學術大會論文集 Vol.9 No.1

        The application of fiber-optic for chemical and biochemical sensing is a field of increasing interest and importance. This work represents new design for taste sensor based on the fiber-optic evanescent field absorption. A 10cm length of plastic-clad-silica(PCS) fiber having a 400μm-diameter was used for fabrication of sensor. The cladding of the fiber were removed from 3cm of the middle portion and coated with a six kinds of dye/silicon on the surface of uncladed fiber core. Sensor output signal represented the several hexagonal response pattern from the different output signals of the six-channel optical fiber sensor by changing each taste solution's concentration. Optical fiber taste sensor based on the evanescent field absorption provides a quantitative, objective measure of taste solutions with improved sensitivity and lower detection limits better than conventional electrode type taste sensor. This device will be useful in diverse ranges from food industry to environmental and biomedical monitoring.

      • 속도 Observer를 이용한 유도전동기 센서리스 벡터제어

        이수원,전칠환,이성룡 국립7개대학공동논문집간행위원회 2002 공업기술연구 Vol.2 No.-

        The stability for a speed sensorless vector control of an induction machine has been studied. These studies show that the sensorless control is apt to be more unstable than the control with sensor on the variation for stator resistance, rotor resistance and system parameters of the machine. First, this paper investigates the start-up and transient characteristics when the inertia, J, changes and the rotor resistance, R_r, changes respectively for a step change of a speed reference, ω_r. Then, the new speed estimation algorithms with no effects on the parameters variation of the machine and the system is proposed. The proposed method is to implement the observer using voltage, current and constant of the machine. The results are verified by simulation.

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