새로운 n형 고분자인 DFPP 기반의 MEH-PPV/DFPP Blend 소자의 광전특성

김수현,문지선,이재우,이석,김선호,변영태,김동영,이창진,김유진,정영철,이긍원,Kim, Su-Hyun,Moon, Ji-Sun,Lee, Jae-Woo,Lee, Seok,Kim, Sun-Ho,Byun, Young-Tae,Kim, Dong-Young,Lee, Chang-Jin,Kim, Eu-Gene,Chung, Young-Chul,Rie, Kung-Won 한국광학회 2006 한국광학회지 Vol.17 No.5

Optical characteristics in polymer films of MEH-PPV/DFPP blends were for the first time investigated. DFPP (N, N'-diperfluorophenyl-3,4,9,10-perylenetetracarboxylic diimide) used here was a novel n-type polymer, which had good stability in air and solubility in common solvents. For a 1:9 DFPP:MEH-PPV blend, highly efficient quenching of photoluminescence (PL) was observed. In addition, the photocurrent responses of these MEH-PPV/DFPP photovoltaic cells were measured. When the light intensity was $50mW/cm^2$, short-circuit photocurrent densities were two times higher than those of single layer MEH-PPV devices. MEH-PPV/DFPP 혼합물의 고분자 박막에서 광학적 특성들이 최초로 조사되었다. 여기서 사용된 BFPP(N, N'-diperfluorophenyl-3,4,9,10-perylenetetracarboxylic diimide)는 새로운 n형 고분자인데 공기 중에서 안정성이 우수하고 일반 용매에서 잘 용해되었다. 1:19 DFPP:MEH-PPV 혼합물의 경우 매우 효율적인 형광소멸이 관측되었다. 더불어 이 MEH-PPV/DFPP 광전 셀의 광전류 응답특성들이 측정되었다. 빛의 세기가 $50mW/cm^2$일 때 단락전류 밀도는 단일 층의 MEH-PPV 소자들보다 2배 이상 되었다.

헤모필루스 인플루엔자 기관염이 확인되면서 진단된 혈관륜 1례

김수현,정윤숙,오성희,김남수,김혁,Kim, Su Hyun,Chung, Yoon Sook,Oh, Sung Hee,Kim, Nam Su,Kim, Hyuck 대한소아청소년과학회 2002 Clinical and Experimental Pediatrics (CEP) Vol.45 No.2

저자들은 출생 후 호흡기 증상이 지속되어 오던 여아가 respiratory syncytial virus와 b형 헤모필루스 인플루엔자균에 의한 하기도 감염에 이환되면서 생후 4개월에 혈관륜으로 진단된 1예를 보고하는 바이다. 환아는 출생 후 협착음과 천명음 등의 잦은 호흡기 증상을 보였고, 3개월에 호흡 곤란을 주소로 입원하였으며 respiratory syncytial virus에 의한 세기관지염으로 치료받고 호전되었다. 퇴원 후 증상이 다시 악화되어 재입원 하였으며 b형 헤모필루스 인플루엔자균에 의한 기관염 및 폐렴이 확인되었고, 치료를 위해 기관내 튜브에 도관 삽입을 시도하였을 때 하부 기도에서 저항감이 감지되어 기도 부위의 해부학적 기형을 의심하게 되었다. 3차원 흉부 단층 촬영에서 이중 대동맥궁으로 인한 혈관륜이 확인되었고, 교정 수술을 시행한 후 좋은 경과를 보이고 있다. Vascular ring, originating from abnormal regression of the aortic arch during fetal life, can cause prolonged and recurrent respiratory symptoms and dysphagia when the diagnosis is delayed. We report a 4 month old girl with vascular ring, who had been treated for persistent respiratory symptoms including stridor, wheezing, and dyspnea soon after birth. Initially her respiratory symptoms were thought to be due to bronchiolitis, for which respiratory syncytial virus was confirmed by immunofluorescent staining. Her clinical course was again complicated with tracheitis and pneumonia due to Haemophilus influenzae type b. The possibility of anatomical anomaly was investigated when it was felt to be difficult to insert a suction catheter deep down through a endotracheal tube which was placed for adequate ventilatory management. A three-dimensional chest CT revealed a vascular ring consisting of a double aortic arch. For 5 months following surgery, her respiratory symptoms have slowly been improving. She developed another episode of pneumonia which was milder than the one which occurred before the surgery.

고지방식이로 비만을 유도한 C57BL/6 마우스에서 SM17의 항산화 및 항비만 효과

김수현,김수지,김경조,이아름,노성수,이영철,Kim, Soo Hyun,Kim, Su Ji,Kim, Kyeong Jo,Lee, Ah Reum,Roh, Seong-Soo,Lee, Young Cheol 대한본초학회 2017 大韓本草學會誌 Vol.32 No.5

Objectives : Obesity is caused by the excess accumulation of fat in the body due to energy imbalance, and it causes various diseases. The aim of this study was to investigate an anti-obesity efficacy and an antioxidant activity of water from herbal mixture extract (SM17). Methods : The antioxidant activities were evaluated through radical scavenging assays using 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) radicals. To evaluated anti-obesity effect of SM17, we used a high fat diet fed mouse model. The SM17 (150 mg/kg body weight/day, p.o.) was treated every day for 6 weeks to C57BL/6 mice. Body weight and food intake were measured every day. The changes of reactive oxygen species (ROS), alanine aminotransferanse (ALT), aspartate aminotransferase (AST), triglycerids (TG) and total cholesterol (TC) in serum were analyzed after experiment. Also, expression of lipid metabolism related proteins were investigated by western blot analysis. Results : It was effective in antioxidant measurements, SM17 administration inhibited the biomarkers of lipid metaboism in serum and tissues. The administration of SM17 showed a significant reduction of body and tissue weight. Morever, it decreased ROS, ALT, AST, TG and TC in serum, compared with those of the obese mice. Adipogenesis-related protein expressions increased in obese mice compared to normal mice. However, SM17 group exhibited the down-expression of these proteins. Conclusion : A SM17 aqueous extract has a great effect on the stimulation (AMPK) activation, and may have a benefit to reduce a fatty acid metabolism through inhibition of lipid accumulation.

피로환자에 사암침 치료 효과의 임상연구

김수현,박회진,박현애,장준호,황규선,이소열,Kim, Su-Hyun,Park, Hoi-Jin,Park, Hyeon-Ae,Jang, Jun-Ho,Hwang, Kyu-Sun,Lee, So-Yol 대한침구의학회 2007 대한침구의학회지 Vol.24 No.6

Objectives : This study was performed to evaluate the effect of SAAM acupuncture treatment for patients with fatigue. Methods : The clinical study was carried out with 56 fatigue patients who had visited the Fatigue Clinic in Dong-Seo Oriental Medical Hospital from April 2007 to September 2007. Patients were randomly assigned to two groups : SAAM acupuncture treatment group or control group. The acupuncture points used in the SAAM acupuncture treatment group were $LU_8$, $SP_3$, $HT_8$, $CV_6$, and $BL_{15}$. Acupuncture points used in the control group were non-acupoints near $LU_8$, $SP_3$, $HT_8$, $CV_6$, and $BL_{15}$. The patient's symptoms were assessed at baseline, after 1 week and after 2 weeks of treatment using theMultidimensional Fatigue Scale(MFS). Results : After 2 weeks, MFS score differences between the SAAM acupuncture treatment group and the control group were statistically significant(p<0.05). Conclusions : The results suggest that SAAM acupuncture treatment can be used to improve symptoms in patients with fatigue.

메밀싹 추출물의 항산화 효과 및 유전독성억제 효과

김수현,이의용,함승시,Kim, Su-Hyun,Lee, Eue-Yong,Ham, Seung-Si 한국식품영양과학회 2007 한국식품영양과학회지 Vol.36 No.8

메밀싹을 건조 후 세절하여 70% 에탄올을 가하여 추출한 추출물과 용매의 극성에 따라 분별분리를 행하여 핵산, 클로로포름, 에틸아세테이트, 부탄올 및 물 분획물로 조제하여 여섯 가지의 추출물 및 분획물을 얻었다. 이들 시료들에 대하여 항산화활성을 측정한 결과 에틸아세테이트 분획물에서 $RC_{50}$ 값이 26.1 ${\mu}g/mL$의 강한 항산화활성을 나타내었다. 염색체 유발 물질인 MNNG(N-methyl-N'-nitro-N-nitro-soguanidine)를 마우스에 50, 100, 150 그리고 200 mg/kg으로 투여한 경우의 소핵생성은 각각 3.7${\pm}$0.7, 4.3${\pm}$0.6, 12.8${\pm}$0.8 그리고 15.6${\pm}$1.1로써 농도증가에 비례적으로 증가하였으며 대조군에서는 1.4${\pm}$0.5의 소핵생성을 나타내었다. MNNG를 150 mg/kg과 메밀싹 추출물을 각각 10, 20, 40 그리고 80 mg/kg으로 동시에 투여한 경우 각각 23.4, 40.6, 56.3 그리고 73.4%의 소핵생성 억제효과를 나타내었다 . 메밀싹 용매 분획물 실험에서는 핵산, 클로로포름, 에틸 아세테이트, 부탄올 그리고 물 분획물이 시료농도 80 mg/kg의 투여군에서 양성대조군에 비해 각각 64.1, 67.9, 75.8, 74.2 및 63.3%의 소핵생성 억제율을 나타내었다. 따라서 메밀싹은 건강식품으로서의 개발가능성을 가진 매우 유용한 원료임을 알 수 있었고, 추후 이러한 생리활성을 나타내는 부분만을 분리, 정제하여 추가적인 검색 및 활용방안에 대하여 충분한 연구가 이루어져야 한다고 사료된다. This study was carried out to determine the antioxidative and antigenotoxic effects of buckwheat (Fagopyrum esculentum Moench) sprout using 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical donating method and micronucleus test. Buckwheat sprout were extracted with 70% ethanol and then further fractionated to n-hexane, chloroform, ethyl acetate (EtOAc), butanol and water. Among the five fractions, the EtOAc fraction showed the highest electron donating activity ($RC_{50}$ 26.1 ${\mu}g/mL$). The effects of buckwheat sprout extracts on the frequencies of micronucleated polychromatic erythrocytes (MNPCEs) induced by MNNG (N-methyl-N'-nitro-N-nitrosoguanidine) were investigated in the bone marrow. 10, 20, 40 and 80 mg/kg of each extract were administered to animals immediately after injection of MNNG and the exposure time was 36 hrs. Inhibition effects of buckwheat sprout ethanol extract were 23.4%, 40.6%, 56.3% and 73.4%, respectively. When the fraction of hexane, chloroform, ethyl acetate, butanol and water from 70% ethanol extract were treated with concentration of 80 mg/kg, the suppression rates of the MNPCE were 64.1, 67.9, 75.8, 74.2 and 63.3%, respectively.

녹용대보탕을 투여한 ITP 의증 환자 증례보고

김수현,서인교,정혜인,김준형,전상우,안수빈,강세영,Kim, Soo-hyun,Seo, In-kyo,Jeong, Hye-in,Kim, Jun-hyung,Jeon, Sang-woo,Ahn, Su-bin,Kang, Sei-young 대한한방내과학회 2021 大韓韓方內科學會誌 Vol.42 No.5

Objectives: This study demonstrated the positive effect of herbal medication on a suspected idiopathic thrombocytopenic purpura (ITP) patient-a 57-year-old male with suspected ITP and a decreased platelet count. Methods: The patient was treated with an herbal medicine named Nokyongdaebo-tang, and its effect was measured with periodic platelet blood tests. Results: Before taking the herbal medicine, the patient's blood platelet count was 98 K/μl, but following treatment, the blood platelet count increased to 201 K/μl and maintained a continuously elevated level. Conclusion: The results indicated that herbal medication may improve the blood platelet count of suspected ITP patients.

좌절된 소속감의 개념분석

김수현,Kim, Su-Hyun 한국융합학회 2021 한국융합학회논문지 Vol.12 No.4

The purpose of this study is conceptual analysis study on the thwarted belongingness, and was based on the conceptual analysis method of Walker & Avant to make clear concept. Thwarted belongingness can be defined by the following attributes: distorted beliefs, insufficient need to belong, a sense of alienation, and insufficient interaction and affection needs. The prerequisites for thwarted belongingness were social isolation, experiences of exclusion or conflict in interpersonal relationships, perfectionist tendencies, and sensitivity to rejection. The consequences occurring as a result of thwarted belongingness were suicidal ideation, decreased happiness and life satisfaction, negative emotions such as anxiety about rejection, depression, shame, loneliness, stress or anger, aggression, hostility and self-criticism, despair, suppression of emotional expression, lethargy, self-exclusion from relationships, and identity confusion. This study is valuable to identify the extent of preventable nursing interventions related to individual mental health and suicidal ideation related to interpersonal relationships, and suggests future tool development and field studies of thwarted belongingness. 본 연구는 좌절된 소속감에 대한 개념분석 연구로 개념의 속성을 확인하고 명확히 정의하기 위해 Walker & Avant의 개념분석 방법을 근거로 하였다. 좌절된 소속감의 속성은 왜곡된 신념, 소속욕구 불충족, 소외감, 상호교류와 애정욕구의 불충족으로 도출되었다. 선행요인은 사회적 고립, 대인관계에서 배제 또는 갈등 경험, 완벽주의적 성향, 거부민감성이며, 결과는 자살생각, 행복 및 삶의 만족 감소와 거부에 대한 불안, 우울, 수치심, 외로움, 스트레스 또는 분노, 공격성, 적대감 같은 부정적 정서 및 자기비난, 절망감, 자포자기, 정서표현 억제, 무기력, 관계에서 스스로 배제, 정체성 혼란이다. 본 연구는 대인관계와 관련된 개인의 정신적 건강 및 자살생각과 관련된 예방 가능한 간호중재의 범위를 파악할 수 있었다는 것에 의의가 있고, 향후 좌절된 소속감을 측정할 수 있는 도구개발 및 현장연구를 통해 본 연구의 속성을 검증해 볼 수 있는 후속 연구를 제언한다.

의사를 위한 호스피스 교육 프로그램의 개발 - 2004 호스피스.완화의료 시범사업을 중심으로 -

김수현,신상원,정미경,이순남,이소우,이경식,최윤선,Kim, Su-Hyun,Shin, Sang-Won,Chong, Mi-Kyong,Lee, Soon-Nam,Lee, So-Woo,Lee, Kyung-Shik,Choi, Youn-Seon 한국호스피스완화의료학회 2006 한국호스피스.완화의료학회지 Vol.9 No.2

목적: 2004년 호스피스 완화의료 시범사업을 실시하면서 의사를 대상으로 한 사업을 위하여 호스피스 완화의료에 관한 교육 프로그램을 개발하고 이를 기초로 교육을 실시하고 성과를 분석하였다. 방법: 교육 분과위원회에서 3차례의 회의를 통해 교육 요구도(총 79문항) 설문지를 개발한 후 125개 전국 호스피스 관련 기관에 종사하는 의사를 대상으로 우편을 이용하여 설문지를 발송하였다. 교육 중요도는 호스피스 전문가 27명에게 이메일을 통하여 조사하였다. 결과: 교육 요구도 및 중요도 조사 결과, 다양한 문헌 검토 및 외국의 호스피스 완화의료 관련 교육과정을 기초로 호스피스 완화의료 교육 프로그램이 개발되었으며 교육 시간은 총 36시간(이론 21, 실습 15시간)이었다. 이를 토대로 1일 교육 코스를 전국에서 4회에 걸쳐 시행하였으며 47명의 의사가 참여하였다. 교육 이수 후 참가자들은 교육 과정이 향후 업무에 도움이 된 정도는 항목마다 $3.0{\sim}3.6$점, 교과 강사의 적절성은 $3.1{\sim}3.3$점으로 평가하였다(1: 전혀 아니다 ${\sim}4$: 매우 그렇다). 전반적인 만족도는 100점 중 80점이었다. 결론: 개발된 교육 프로그램은 전체적으로는 운영되지 않았으며 일부만 시험교육으로 운영하였다. 대상자들은 대체로 만족하였으나 강의보다는 사례, 토론 중심의 교육 및 주제별 심화교육을 원하였다. 향후 지속적인 요구도 조사와 프로그램 개발 및 시행이 필요하다. Purpose: The purpose of this study was to develop education program for physicians who work at hospice palliative care settings in Korea, to practice abridged education program extracted from the full contents of the proposed education, and to improve the quality of hospice palliative care service. Methods: To develop the education program, questionnaire for hospice education need assessment (total 79 items) was distributed to 125 organizations practicing hospice service via mail and the data was collected from 1 Sep. to 10 Oct. 2004. Another questionnaire for hospice education importance assessment was asked to the palliative specialists from Sep. 23 to 17 Oct. 2004. Based on the analysis of the questionnaires, and reviewing various references and actual hospice palliative education programs of other countries, the education programs were developed. Results: Ore-day-Hospice education 2004 was conducted based on the suggested education program, and it was practiced four times on a national basis (2 times in Seoul, and once in Busan and Gwangju, respectively). 47 physicians attended the education program. The education program lasted about 7 hours, comprising 5 hours of common lectures for all attendants regardless of their professions and 2 hours of specific seminar for physicians only. Attendants positively responded to the contents of the education program. But they pointed out that the program should be offered on weekday and it should be more in-depth and more discussion based lesson. Conclusion: The suggested education program was not fully conducted yet. After practicing the abridged education program, more in-depth and discussion oriented rather than lecture-based education were suggested. It may be argued that the proposed education, which requires much longer period education, should also reflect the evaluation of the 1-day education program to successfully implement the proposed education program.

신경추적자를 이용한 신맥과 조해에서 투사되는 신경원의 표지부위에 대한 연구

김수현,이창현,육상원,이광규,이태영,이상룡,Kim, Su-Hyun,Lee, Chang-Hyun,Yuk, Sang-Won,Lee, Kwang-Gyu,Lee, Tae-Young,Lee, Sang-Ryoung 대한침구의학회 2001 대한침구의학회지 Vol.18 No.2

The purpose of this morphological studies was to investigate the central neural pathway projecting to the acupoints $B_{62}$ and $K_6$ using the neuroanatomical method following injection of transsynaptic neurotropic virus, pseudorabies virus(PRV-Ba and PRV-Ga) into the $B_{62}$ and $K_6$. After survival times of 96 hours following injection into the twenty rats with PRV-Ba(Bartha strain) and PRV-Ga(Bartha strain, ${\beta}$-galacidodase insertion). They were perfused, and their spinal cord and brain were frozen sectioned($30{\mu}m$). These sections were stained by X-gal histochemical and PRV immunohistochemical staining method, and observed with light microscope. The results were as follows : 1. In spinal cord, overlaped PRV-Ba and PRV-Ga labeled neurons projecting to the $B_{62}$ and $K_6$ were founded in thoracic, lumbar and sacral spinal segments. In thoracic spinal segments, Densely labeled areas were founded in lamina IV, V, VII(intermediolateral nucleus) and X areas. In lumbar segemnts, labeled areas were founded in lamina II, IV, V and X areas. In sacral spinal segments, labeled areas were founded in lamina IV, V and VI areas. 2. In brain, overlaped PRV-Ba and PRV-Ga labeled neurons projecting to the $B_{62}$ and $K_6$ were founded in the $A_1$ noradrenalin cells/$C_1$ adrenalin cells/caudoventrolateral reticular nucleus, rostroventrolateral reticular nuclens, nucleus tractus solitarius, area postrema, raphe obscurus nucleus, raphe paltidus nucleus, raphe magnus nucleus, lateral paragigantoceltular nucleus, lateral rcticular nucleus, gigantocellular nucleus, locus coeruleus, subcoeruleus nucleus, motor trigeminal nucleus, Kolliker-Fuse nucleus, $A_5$ cell group, central gray matter, oculomotor nerve, paraventricular hypothalamic nucleus, median eminence, amygdaloid nucleus, frontal cortex, forelimb area, hindlimb area, 1, 2 areas of parietal cortex and granular and agranular cortex. This results were suggest that overlaped PRV-Ba and PRV-Ga labeled areas projecting to the $B_{62}$ and $K_6$ may be related to the emotional relay pathway in the central autonomic center.

SSGDBR 레이저 다이오드의 파장변환 특성 해석

김수현,정영철,Kim, Su-Hyun,Chung, Young-Chul 대한전자공학회 1999 電子工學會論文誌, D Vol.d36 No.2

다양한 파장변화 기술중에서 레이져 다이오드의 발전상태에서 교차이득변도(Cross-Gain Modulation)을 이용한 파장변환은 고속의 신호를 매우 간단하고 효율적으로 처리할 수 있다. 본 논문에서는 SSGDBR (Superstructure Grating Distributed Bragg Reflector) 레이저 다이오드의 파장변환기로서 특성을 분석하고 광통신 네트웍 모델링을 위한 CAD 도구로서 개선된 시영역 대신호 동적모델(Time-Domain Large-Signal Dynamic Model)의 유용성을 제시하였다. 이 모델을 l용하여 이런 구조의 파장변환 소자는 10Gbps이상 고속데이터를 처리할 수 있고 광대역 파장변환이 가능하다는 것을 확인하였다. 입력 광신호의 세기와 주입되는 전류가 파장변환된 신호의 소광비 등에 미치는 영향 및 Eye Diagram 등을 살펴 보았으며, 기존에 발표된 실험결과들과 매우 유사한 경향을 보임을 관측하였다. Among various wavelength conversion technologies, that using the cross-gain modulation in laser diode makes it possible to deal with the high speed signal quite simply and efficiently. In this paper, presented was the applicability of an improved time-domain large-signal dynamic model as a CAD tool to analyzed the characteristics of SSGDBR(Superstructure Grating Distributed Bragg Reflector) laser diodes used for wavelength converters. Using this model, it was shown that this kind of wavelength converter can provide the widely tunable wavelength conversion of the high speed data above 10 Gbps. We also investigated the effect of input optical power and the bias current on the characteristics of the device such as extinction ration and eye diagram. The modeling results show very similar trend to the experimental reports.