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뇌경색후 우울증에서 Homocysteine, Vitamin B12 및 Folate 혈청 농도와 관계
문지수,김광수,유봉구,김종국,김민정 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.1
Background and purpose : Poststroke depression is common and linked to poor prognosis and higher mortality after stroke. Previous studies suggest that high level of serum homocysteine and low levels of vitamin B12 and folate may cause depression. However previous studies has showed large variation concerning the influencing factors of poststroke depression. The purpose of this study was to evaluated the factor that influencing the poststroke depression including serum levels of homocysteine, vitamin B12 and folate. Methods : Beck depression inventory (BDI) was obtained in 62 patients with cerebral infarction, and the patients were divided into non-depression group (BDI ≤ 13) and depression group (BDI ? 14) according to their BDI scores. Then, we compared serum homocysteine, vitamin B12, folate, age, sex, Barthel index, Scandinavian stroke scale, acute aphasia screening protocol, Korean version of mini-mental state examination and ischemic brain lesion between NDG and DG. And also calculate the correlations between serum homocysteine, vitamin B12 and folate with severity of poststroke depression. Results : The NDG were 41 patients (66.1%) and DG were 21 patients (33.9%). Serum homocysteine, vitamine B12 and folate were not different between the groups, and these levels were not correlated with the severity of BDI. The age, sex, BI, SSS, AASP, K-MMSE and location of ischemic stroke were not different between the groups. Conclusion : Frequency of poststroke depression were high in patients with acute ischemic stroke. In contrast with previous studies, poststroke depression was not influenced by the serum levels of homocysteine, vitamin B12 and folate. And poststroke depression was not influenced by age, sex, physical handicap after stroke, aphasia, cognitive function and location of ischemic stroke.
문지수,김민정,김종국,유봉구 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.1
Oculomotor nerve palsy of acute onset with sparing of the pupil in older age is frequently associated with diabetes mellitus. A 73-year-old diabetic woman was admitted because of vertical diplopia and gait disturbance. Neurological examination showed that the left eye had decreased light reflex, dilated pupil, and limited adduction, supraduction and infraduction. Brain MRI and MRA were unremarkable. Two months after onset, movement, pupil size and light reflex of the patient's eyes were normal on examination. It is emphasized that the diabetic ophthalmoplegia can involve the pupil. We report a rare case of diabetic oculomotor nerve palsy with pupil involvement.
H₂O₂에 의한 Tight Junction Protein Occludin의 변화
정봉수 외 중앙대학교 의과대학 의학연구소 2006 中央醫大誌 Vol.31 No.1·2·3
Cerebral microvessel endothelial cells that form blood-brain barrier (BBB) have tight junction for maintaining brain homeostasis. Occludin, one of tight junction proteins, is crucial for BBB function. H₂O₂-induced occludin changes and its effects on bovine brain BBB endothelial cells were examined in this study. The decrease of transelectrical endothelial resistance (TEER) by H₂O₂ was due to occludin redistribution. Occludin disappeared in a dose dependent manner from intercellular junction in immunofluorescent study. But the total amounts of occludin and cell membrane bound occludin did not changed by H₂O₂. These showed that the loss of function of BBB was not due to the decrease of occludin or the internalization of occludin into cytoplasm. Occludin was limited within cell membrane of endothelial cell and H₂O₂ caused the redistribution of occludin within cell membrane. These data strongly suggest that H₂O₂-mediated loss of BBB function involves the loss of tight junction integrity through occludin redistribution.
진행성 폐 종양 환자에서 종양 내 OK-432 주입술의 효과
정수현,김성빈,박진희,탁희상,옥철호,장태원,정만홍,천봉권 고신대학교 의과대학 2009 고신대학교 의과대학 학술지 Vol.24 No.2
Background: Intratumoral injection of OK-432 produced significant antitumor effects. There are reports that OK-432 was injected directly into tumor tissue on gastrointestinal tracts and HCC tissue, producing decrease in serum alpha-fetoprotein level. We adopted this technique for treating locally advanced lung cancer. The object of this study is to evaluate the local therapeutic efficacy, side effects of injection for treating symptomatic mass. Methods: Twenty lung cancer patients (13 males and 7 females) underwent sonography guided OK-432 injection. We analyzed relationships between response of OK-432 and response of skin test, histology and age. Pain that patients feel was evaluated by VAS (Visual Analog scale). Results: A significant decrease of tumor size was observed. The mean pre-injection diameter of the lesions was 54.7±11.3mm, PR rate were 15.0% (3/20) and minimal change (50%<tumor size decreased.) patients were 35.0% (7/20). The VAS score before injecting OK-432 into the lesion was 5±3, this was decreased to 2.5±1.5 (p=0.04). Object response was significantly correlated with skin response, adenocarcinoma, and age. Conclusion: A significant decrease of tumor size and pain was observed. So OK-432 is a valuable treatment option for patients with symptomatic lesion from advanced lung cancer who are not amenable to further therapy.
병원근무자에 대한 특수건강진단 적용 가능성에 관한 연구
이수일,조병만,조봉수,김영욱,고광욱,문남출,김주원 大韓産業醫學會 1996 대한직업환경의학회지 Vol.8 No.2
병원근무자들에 대한 특수건강진단 적용 여부를 판단하기 위한 기초자료를 제공하기 위해 1995년 3월 10일부터 4주간에 걸쳐 부산시내에 위치하는 2개 종합병원 근무자 830명을 대상으로 설문조사를 시행해 얻은 결과를 요약하면 다음과 같다. 1. 조사된 43개 항목 중 10% 이상의 대상자가 유해요인에 폭로되고 있다고 응답한 항목은 소음, 분진 등 16개 항목이었다. 이 중 분진, 소음 및 스트레스는 연구대상자의 50%이상에서 폭로되고 있다고 응답했으며 그 외 알콜류 소독제(41.3%), 방사선(34.6%), 일반약제(33.3%)의 순으로 폭로되고 있었고 VDT의 경우 25.2%, aldehyde류는 18.7%에서 폭로되고 있는 것으로 나타났다. 2. 대상자의 63.1%에서 병원근무 환경 중에 유해인자가 존재한다고 응답했고 병원의 환경측정이 필요하다고 대답한 사람은 80%에 달했다. 35.7%가 유해인자에 대한 교육을 받은 적이 없다고 응답했다. 전체 응답자의 35.7%가 유해인자에 폭로시 보호 장비를 착용하지 않는다고 응답했고 주기적인(격년) 건강진단은 48.6%에서 받는 것으로 조사되었다. 근무부서의 환기상태는 7.2%만이 좋은 편이라고 응답했다. 이상에서 살펴본 바와 같이 병원근무자들이 여러 가지 유해환경에 노출되고 있고 또, 이로 인해 발생할 수 있는 건강장해에 대한 예방대책이 소홀한 것으로 나타나 병원의 작업환경측정의 시행이 필요하고 이 결과를 바탕으로 병원근무자들에 대한 특수건강진단 적용여부를 결정해야 할 것이다. This study was performed to decide the possibility of special health examination to the hospital employees. We carried out questionnaire survey for 830 subjects at 2 general hospitals located in Pusan city. The summary of this study are as follows. 1. Above 10% of total hospital employees were replied that they exposed to 16 hazard items, such as dust, noise, stress and etc. Among them, over 50% of hospital employees exposed to dust(69.8%), noise(52.3%), stress(60.1%). And hospital employees exposed to alcoholic disinfectant(41.3%), radiation(34.6%), drug(33.3%), VDT(25.2%), and aldehyde(18.7%) also. 2. 63% of the hospital employees replied that there were hazardous factors in hospital environments, and 80% insisted the necessity for hospital environment measuring. 35.7% of respondents replied that they had never taken the education about hazardous factors. 35.7% of the total respondents answered that they didn't use protective equipment when exposed to hazardous factors. And 48.6% answered they took periodic health examination. Only 7.2% replied that ventilation condition of office room was proper. As shown in above results, hospital employees are exposed to various hazards, and turn out neglecting to health problems caused these hazardous factors. So at first, it is necessary to measuring hospital working environment, and then will be decided the possibility of special health examination to the hospital employees.
최봉철,정구회,임봉수 大田大學校 産業技術硏究所 2003 산업기술연구소 論文集 Vol.14 No.1
This study was performed to evauate for the noodles wastewater with high viscosity and low nutrient (Nitrogen, and Phosphorus). To add nutrient to grow activated sludge highly, about. 2 kg/day fertilizer that contains nitrogen was fed to the influent. Both the status of the aeration tank and the treatment performance were observed. Before feeding nutrient, the MLSS concentration in aeration tank was about 1,400 ㎎/L, and Spharotilous, Thiothrix. Prordon etc. were detected, while the BOD, COD and SS removal efficiency were so low as 78%, 77% and 56%, respectively. After feeding nutrient the MLSS concentration in aeration tank was increased to about 2,700 ㎎/L, and Epistylis. Monostyla, Voticella etc. were observed to be prolific. Meanwhile average 98% of BOD, 94% of COD, 71% of SS were removed, the microorganism can be activated to improve the noodles wastewater treatment performance. It is recommend to set up thickener and dewatering facilities to treat wasted activated sludge.
秋落畓에 있어서 消石灰와 生藁施用이 土壤 pH, 水稻의 養分吸收 및 收量에 미치는 影響
安壽奉 충남대학교 농업과학연구소 1976 農業技術硏究報告 Vol.3 No.2
This study was conducted to determine the effect of slaked lime and straw used on the soil pH in the flooded condition and yield of rice grown in AKIOCHI paddy field and their residual effects on the rice plants. The results obtained were summarized as follow: when lime and straw were applied, there was on the average 41% of yield increase over plots treated with three elements of chemical fertilizers. When lime plus straw were used, the growth rate at later stage of rice plant was prominent. Damage due to helminthosporium and blast were found less, the rate of lower-leaf death was low, and grain number per head, filled grain ratio, and weight of rice grain were higher than control. When lime plus straw were used, higher amount of silicate, calcium, nitrogen and potassium was found in the plants at heading stage. The residual effects of lime plus straw were 20% in the first year, about 10% in the second year and 5% in the third year, respectively. Soil pH was affected by both straw and slaked lime, and it was fixed about 8 days after applying in the flooded condition. The following formulae was suggested from the results in the flooded conditions. pH=5.5293+8.6007X_1+2.7836X_2-6.7422X_1^2-1.8522X_2^2-7.000X_1X_2 (X_1=slaked line,, X_2=straw)
벼種子 傳染性 病原菌의 發生에 미치는 培養 方法 및 光源의 影響
白壽鳳 建國大學校附設 農業資源開發硏究所 1980 論文集 Vol.5 No.-
벼品種 豊玉에 寄生하는 중요한 種子傳染性 病原菌의 發生에 미치는 培養方法 및 光源의 영향을 調査한 結果를 보면 다음과 같다. 1) Blotter method에서는 8種의 種子傳染性 病原菌이 檢出되었으나 Agar plate method에서는 4種의 種子傳染性 病原菌만 檢出되었다. 2) 계속 暗黑處理에서는 5種의 種子傳染性 病原菌이 檢出되었으나 近紫外線과 暗黑 12時間 交互照射 및 晝光色光線과 暗黑 12時間 交互照射處理에서는 각각 8種의 種子傳染性 病原菌이 檢出되었다. 3) 도열병균(Pyricularia oryzae)은 Agar plate method 와 暗黑處理에서는 檢出되지 않았으며 近紫外線과 暗黑 12時間 交互照射處理가 晝光色光線과 暗黑 12時間 交互照射處理에 비하여 效果가 있었다. 4) 이삭마름병균(Trichoconis padwickii)도 暗黑에서는 檢出되지 않았으며 近紫外線과 暗黑 12時間 交互照射處理가 晝光色 光線과 暗黑 12時間 交互照射處理에 비하여 현저히 效果가 있었다. The effect of incubation method and light on the development of an important seed-borne fungi which are parasiting on Pung-ok, a variety of rice, was investigated. Two incubation methods, Blotter method and Agar plate method were used. Three light conditions, cycles of 12 hour light/12 hour darkness with near ultraviolet light, the same cycles with artificial daylight, and continuous darkness were given. The results were as follows: 1. Eight different species of seed-borne fungi were detected when incubated by Blotter method, while only four species were detected by Agar plate method. 2. Either when incubated under the cycles of 12 hour light/12 hour darkness with near ultraviolet or artificial daylight eight species of the fungi were detected, but in darkness only five species were found. 3. Pyricularia oryzae was not detected by Agar plate method and in continuous darkness. It was found when incubated under light and darkness. The near ultraviolet was more effective than the artificial day light. 4. Trichoconis padwickii was detected by Agar plate method. Otherwise, the fungi showed the same results as Pyricularia oryzae.