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Kyoung-Mee Kim,박철근,손진희,Jin Sook Jeong,조미연,So-Young Jin,Jong Sang Choi,Dae Young Kang,Gastrointestinal Stromal Tumor Committee,The Korean Gastrointestinal Pathology Study Group,Dong Wook Kang,Woo Sung 대한의학회 2005 Journal of Korean medical science Vol.20 No.6
Koreans who were diagnosed between 2001 and 2002 were analyzed to evaluate their occurrence and their clinical, pathologic and immunohistochemical findings. The most frequent location of tumor was in the stomach (63%), followed by the small intestine (30%), the colorectum (5%), and the esophagus (2%). c-kit expres-sion was found in 93.6% of the cases, while CD34, SMA and S-100 protein was positive in 80.1%, 28.2%, and 20.2%, respectively. c-kit positivity was high in the stomach (94.2%) and small intestine (94.6%), while it was relatively low in the col-orectum (85.0%), and esophagus (81.2%). The positivity for CD34 was correlated with the higher risk of GISTs (p=0.04). Follow up of the patients showed that 58 primary GISTs patients died and 20 of these patients were recurrent or metastatic at the time of diagnosis. The pathologic diagnosis to predict the risk of aggressive behavior of GISTs was correlated with the numbers of tumor, clinical stage, epithe-lioid histologic type, cellularity, cellular atypia, necrosis, and mucosal invasion (p= 0.00). GISTs with a poor prognosis were closely related to the clinical stage at pre-sentation, the locations of the tumor, and the ages of the patients.Seven hundred forty seven cases of gastrointestinal stromal tumors (GISTs) in