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- 저자 : Srikanth (검색결과 84 건)
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Role of hyperforin in diabetes and its associated hyperlipidemia in rats
Srikanth Ineedi,Anshul Shakya,Gireesh Kumar Singh,Vikas Kumar 셀메드 세포교정의약학회 2012 TANG Vol.2 No.3
The aim of the present study was to evaluate the possible roles of hyperforin against hyperglycemia, hyperlipidemia and oxidative stress in streptozotocin-induced diabetic rats. Diabetes was induced by a single intraperitoneal injection of streptozotocin (65 mg/kg). Biochemical parameters were measured following hyperforin treatment (10 mg/kg, i.p.) for 7 days. Hyperforin treatment significantly reversed the elevations in plasma glucose, triglycerides, total cholesterol and LDL-cholesterol. Hyperforin also reversed the declines in plasma HDL-cholesterol and liver glycogen, but did not reverse the change in plasma insulin levels when compared to the diabetic control rats. Hyperforin treatment also reversed the oxidative stress induced by streptozotocin. Moreover, the effect of the hyperforin on peripheral glucose utilization in normal rats was evaluated by an oral glucose tolerance test (OGTT). Hyperforin treatment significantly increased (p < 0.05) the glucose tolerance compared to the vehicle in OGTT. The antihyperglycemic, antihyperlipidemic and antioxidant activities of hyperforin (10 mg/kg, i.p.) were comparable qualitatively to glibenclamide (1 mg/kg, p.o.). In conclusion, we report for the first time through an in vivo study that hyperforin is potentially valuable for the treatment of diabetes and its associated hyperlipidemia and oxidative stress by enhancing the glucose utilization by peripheral tissues such as muscle and adipose tissues.
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Plasmatocyte‐spreading peptide influences hemocyte behavior via eicosanoids
Srikanth, Koigoora,Park, Junga,Stanley, David W.,Kim, Yonggyun Wiley Subscription Services, Inc., A Wiley Company 2011 Archives of Insect Biochemistry and Physiology Vol.78 No.3
<P><B>Abstract</B></P><P>Hemocyte‐spreading behavior is required for expressing a cellular immune response, nodulation, which clears the vast majority of invading microbes from circulation. The nodulation response is completed by a layer of plasmatocytes, which spread over the nodule and initiate a malanization process leading to darkened nodules. Plasmatocyte‐spreading peptide (PSP), the first reported insect cytokine, is responsible for mediating the spreading and attachment of some subclasses of plasmatocytes to nodules. Prostaglandins (PGs), one group of eicosanoids formed from arachidonic acid (AA), also mediate plasmatocyte spreading (PS), although the potential interactions between the PSP and PG signal transduction pathways have not been investigated. We tested our hypothesis that PSP acts via biosynthesis of eicosanoids, specifically PGs, in the beet armyworm, <I>Spodoptera exigua</I>. In this study, we report that (1) PSP and PGE<SUB>2</SUB> independently stimulated Ca<SUP>++</SUP>‐dependent PS, (2) inhibitors of PG biosynthesis reversibly blocked PS, (3) dsRNA silencing the gene encoding proPSP blocked PS, which was rescued by PSP and by AA, (4) PSP‐stimulated PS was reversibly impaired by inhibitors of PG biosynthesis, and (5) the inhibitor‐impaired spreading was rescued by AA. Taken together, these points strongly support our model showing that PSP acts via a plasmatocyte‐surface receptor, which stimulates biosynthesis of the PGs responsible for mediating plasmatocytes spreading. © 2011 Wiley Periodicals, Inc.</P>
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Laparoscopic ‘D2 first’ approach for obscure gallbladders
Srikanth Gadiyaram,Murugappan Nachiappan 한국간담췌외과학회 2021 Annals of hepato-biliary-pancreatic surgery Vol.25 No.4
Laparoscopic cholecystectomy has a reported incidence of 4%–15% of conversion to an open procedure and one of the main reasons behind the conversion is a gallbladder (GB) wrapped with dense adhesions. It is prudent to convert the procedure to an open operation in patients with particularly dense adhesions when the GB is not visible, preventing safe dissection which carries a potential risk of duodenal or colonic injury. The technique described, namely laparoscopic ‘D2 first’ approach, enables the completion of laparoscopic procedure in patients with ‘obscure’ GBs.
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Srikanth Gadiyaram,Murugappan Nachiappan 한국간담췌외과학회 2021 Annals of hepato-biliary-pancreatic surgery Vol.25 No.3
A secure pancreatic-enteric anastomosis is widely accepted as the ‘Achilles heel’ in reconstruction following a pancreaticoduodenectomy. Most morbidity following the procedure is related to the failure of this anastomosis, resulting in intra-abdominal collections, secondary haemorrhage, delayed gastric emptying, need for radiological interventions and re-operation for some patients. Of several techniques available, the ‘duct-to-mucosa’ technique is widely employed for pancreaticojejunal anastomosis. Among several refinements to facilitate this anastomosis, viz; mobilization of pancreatic stump, magnification with loupes and modifications made on the jejunal side to enable a tension free anastomosis, none seems to address the pancreatic duct in particular. The operative technique of anterior pancreatic duct split described by us enables a wider, well visualized pancreatic duct for a secure duct to mucosa pancreaticojejunal anastomosis.
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Real Earnings Management and Persistence of Firm Value: Evidence from India
Srikanth POTHARLA,Kaushik BHATTACHARJEE,Durga Prasad SAMONTARAY 한국유통과학회 2021 The Journal of Asian Finance, Economics and Busine Vol.8 No.12
The present study aims to examine the impact of real earnings management on the future value of the firm and its persistence. The study also tests suspect firm effects on the relationship between real earnings management and the future value of the firm. The sample of the present study consists of all listed non-financial firms from the year 2011 to 2018. Real earnings management has been measured in three alternative ways viz., abnormal operating cash flows, abnormal discretionary spending, and abnormal production cost. Tobin’s Q is used as a measure of firm value. The interaction term of real earnings management and Tobin’s Q is used to test firm value persistence. The results of the analysis disclose that out of three measures of real earnings management, abnormal reduction in discretionary spending only has a significant negative impact on the persistence of firm value. Moreover, the suspect firm analysis reveals that when the underlying motive of real earnings management is to meet zero earnings, both abnormal increases in operating cash flows and abnormal reduction in discretionary spending have a significant negative impact on firm value persistence.
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Srikanth Parikibandla,Sreenivas Alluri 한국전자통신연구원 2021 ETRI Journal Vol.43 No.6
Lightweight ciphers are increasingly employed in cryptography because of the high demand for secure data transmission in wireless sensor network, embedded devices, and Internet of Things. The PRESENT algorithm as an ultra‐lightweight block cipher provides better solution for secure hardware cryptography with low power consumption and minimum resource. This study generates the key using key rotation and substitution method, which contains key rotation, key switching, and binary‐coded decimal‐based key generation used in image encryption. The key rotation and substitution‐based PRESENT architecture is proposed to increase security level for data stream and randomness in cipher through providing high resistance to attacks. Lookup table is used to design the key scheduling module, thus reducing the area of architecture. Field‐programmable gate array (FPGA) performances are evaluated for the proposed and conventional methods. In Virtex 6 device, the proposed key rotation and substitution PRESENT architecture occupied 72 lookup tables, 65 flip flops, and 35 slices which are comparably less to the existing architecture.
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Srikanth Naga Divi,Mark M. Mikhael 대한척추외과학회 2017 Asian Spine Journal Vol.11 No.3
Study Design: Retrospective case series. Purpose: To report our early experience using allogenic mesenchymal cellular bone matrix (CBM) products in cervical spine fusion. Overview of Literature: Multi-level cervical fusions have historically yielded lower fusion rates than single level fusions, especially in patients with high risk medical comorbidities. At this time, significant literature in cervical fusion outcomes with this cellular allograft technology is lacking. Methods: Twenty-one patients underwent either multilevel (3 or 4 level) anterior cervical discectomy and fusion, anterior cervical corpectomy and fusion, or posterior cervical fusion. ViviGen (DePuy Synthes Spine, Raynham, MA, USA), an allogenic bone matrix product, was used in addition to standard instrumentation. Radiographic evaluation was performed at 2 weeks, 12 weeks, 24 weeks and 1 year postoperative. Visual analog scale (VAS) and neck disability index (NDI) scores along with return to work and leisure activity were recorded. Results: At 6 months postoperative, all patients had radiographic evidence of bone fusion regardless of age or medical comorbidities. All patients reported subjective improvement with a mean decrease in VAS from 8.3 to 1.5 and a mean decrease in NDI from 40.3% to 6.0% at 1 year. All patients also returned to work and/or regular leisure activity within 3 months. Conclusions: Twenty-one patients undergoing high-risk anterior and posterior cervical spine fusion, with the use of a commercially available mesenchymal CBM product, went on to radiographic fusion and all had improvement in subjective outcomes. While further effort and research is needed to validate its widespread use, this study shows favorable use of CBM in cervical fusion for high-risk cases.
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Srikanth, K.,Kwon, A.,Lee, E.,Chung, H. Springer Science + Business Media 2017 Cell Stress Chaperones Vol.22 No.1
<P>This study aimed to investigate the genes and pathways that respond to heat stress in Holstein bull calves exposed to severe ranges of temperature and humidity. A total of ten animals from 4 to 6 months of age were subjected to heat stress at 37 A degrees C and 90 % humidity for 12 h. Skin and rectal temperatures were measured before and after heat stress; while no correlation was found between them before heat stress, a moderate correlation was detected after heat stress, confirming rectal temperature to be a better barometer for monitoring heat stress. RNAseq analysis identified 8567 genes to be differentially regulated, out of which 465 genes were significantly upregulated (ae<yen>2-fold, P < 0.05) and 49 genes were significantly downregulated (ae<currency>2-fold, P < 0.05) in response to heat stress. Significant terms and pathways enriched in response to heat stress included chaperones, cochaperones, cellular response to heat stress, phosphorylation, kinase activation, immune response, apoptosis, Toll-like receptor signaling pathway, Pi3K/AKT activation, protein processing in endoplasmic reticulum, interferon signaling, pathways in cancer, estrogen signaling pathway, and MAPK signaling pathway. The differentially expressed genes were validated by quantitative real-time PCR analysis, which confirmed the tendency of the expression. The genes and pathways identified in this analysis extend our understanding of transcriptional response to heat stress and their likely functioning in adapting the animal to hyperthermic stress. The identified genes could be used as candidate genes for association studies to select and breed animals with improved heat tolerance.</P>
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