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Johanna Buchert,Annikka Mustranta,Peter Spetz,Rainer Ekman,Kari Luukko 한국펄프·종이공학회 1999 한국펄프종이학회 기타 간행물 Vol.- No.-
During mechanical pulp production and bleaching wood components, such as extractives, carbohydrates and lignin are dissolved and dispersed into the process waters. These components are called dissolved and colloidal substances (DCS). DCS can accumulate during water circulation and can in turn affect paper machine runnability and also the strength and optical properties of the paper. In this work DCS fraction originating from TMP process were treated with enzymes acting on triglycerides, glucomannans, and lignin and the effect of enzymatic treatments on the water composition as well as sheet properties were evaluated. Lipases were found to modify the chemical structure of the extractives resulting in more hydrophilic fibre surface and subsequent improvement in the sheet strength properties. Mannanase treatment, on the other hand, destabilized pitch. As a result, aggregation of pitch to the fibres was observed. which in turn resulted in impaired strength properties. Laccase could effectively polymerize lignans and the reaction products seemed to be sorbed onto the fibres.
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A Novel Recombined Potato virus Y Isolate in China
Han, Shuxin,Gao, Yanling,Fan, Guoquan,Zhang, Wei,Qiu, Cailing,Zhang, Shu,Bai, Yanju,Zhang, Junhua,Spetz, Carl The Korean Society of Plant Pathology 2017 Plant Pathology Journal Vol.33 No.4
This study reports the findings of a distinct Potato virus Y (PVY) isolate found in Northeast China. One hundred and ten samples (leaves and tubers) were collected from potato plants showing mosaic symptoms around the city of Harbin in Heilongjiang province of China. The collected tubers were planted and let to grow in a greenhouse. New potato plants generated from these tubers showed similar symptoms, except for one plant. Subsequent serological analyses revealed PVY as the causing agent of the disease. A novel PVY isolate (referred to as HLJ-C-44 in this study) was isolated from this sample showing unique mild mosaic and crisped leaf margin symptoms. The complete genome of this isolate was analyzed and determined. The results showed that HLJ-C-44 is a typical PVY isolate. Phylogenetic analysis indicated that this isolate belongs to the N-Wi strain group of PVY recombinants ($PVY^{N-Wi}$) and also shared the highest overall sequence identity (nucleotide and amino acid) with other members of this strain group. However, recombination analysis of isolate HLJ-C-44 revealed a recombination pattern that differed from that of other $PVY^{N-Wi}$ isolates. Moreover, biological assays in four different potato cultivars and in Nicotiana tabacum also revealed a different phenotypic response than that of a typical $PVY^{N-Wi}$ isolate. This data, combined, suggest that HLJ-C-44 is a novel PVY recombinant with distinct biological properties.
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S6K1 controls pancreatic 관 cell size independently of intrauterine growth restriction.
Um, Sung Hee,Sticker-Jantscheff, Melanie,Chau, Gia Cac,Vintersten, Kristina,Mueller, Matthias,Gangloff, Yann-Gael,Adams, Ralf H,Spetz, Jean-Francois,Elghazi, Lynda,Pfluger, Paul T,Pende, Mario,Bernal- American Society for Clinical Investigation 2015 The Journal of clinical investigation Vol.125 No.7
<P>Type 2 diabetes mellitus (T2DM) is a worldwide heath problem that is characterized by insulin resistance and the eventual loss of 관 cell function. As recent studies have shown that loss of ribosomal protein (RP) S6 kinase 1 (S6K1) increases systemic insulin sensitivity, S6K1 inhibitors are being pursued as potential agents for improving insulin resistance. Here we found that S6K1 deficiency in mice also leads to decreased 관 cell growth, intrauterine growth restriction (IUGR), and impaired placental development. IUGR is a common complication of human pregnancy that limits the supply of oxygen and nutrients to the developing fetus, leading to diminished embryonic 관 cell growth and the onset of T2DM later in life. However, restoration of placental development and the rescue of IUGR by tetraploid embryo complementation did not restore 관 cell size or insulin levels in S6K1-/- embryos, suggesting that loss of S6K1 leads to an intrinsic 관 cell lesion. Consistent with this hypothesis, reexpression of S6K1 in 관 cells of S6K1-/- mice restored embryonic 관 cell size, insulin levels, glucose tolerance, and RPS6 phosphorylation, without rescuing IUGR. Together, these data suggest that a nutrient-mediated reduction in intrinsic 관 cell S6K1 signaling, rather than IUGR, during fetal development may underlie reduced 관 cell growth and eventual development of T2DM later in life.</P>
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A Novel Recombined Potato virus Y Isolate in China
Shuxin Han,Yanling Gao,Guoquan Fan,Wei Zhang,Cailing Qiu,Shu Zhang,Yanju Bai,Junhua Zhang,Carl Spetz 한국식물병리학회 2017 Plant Pathology Journal Vol.33 No.4
This study reports the findings of a distinct Potato virus Y (PVY) isolate found in Northeast China. One hundred and ten samples (leaves and tubers) were collected from potato plants showing mosaic symptoms around the city of Harbin in Heilongjiang province of China. The collected tubers were planted and let to grow in a greenhouse. New potato plants generated from these tubers showed similar symptoms, except for one plant. Subsequent serological analyses revealed PVY as the causing agent of the disease. A novel PVY isolate (referred to as HLJ-C-44 in this study) was isolated from this sample showing unique mild mosaic and crisped leaf margin symptoms. The complete genome of this isolate was analyzed and determined. The results showed that HLJ-C-44 is a typical PVY isolate. Phylogenetic analysis indicated that this isolate belongs to the N-Wi strain group of PVY recombinants (PVYN-Wi) and also shared the highest overall sequence identity (nucleotide and amino acid) with other members of this strain group. However, recombination analysis of isolate HLJ-C-44 revealed a recombination pattern that differed from that of other PVYN-Wi isolates. Moreover, biological assays in four different potato cultivars and in Nicotiana tabacum also revealed a different phenotypic response than that of a typical PVYN-Wi isolate. This data, combined, suggest that HLJ-C-44 is a novel PVY recombinant with distinct biological properties.
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