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젖소 Ornithine Decarboxylase mRNA의 염기서열
Sung, Chang Keun,Sparks, Robert 충남대학교 농업과학연구소 1993 농업과학연구 Vol.20 No.2
Ornithine Decarboxylase는 동물세포에 있어서 polyamines을 생합성하는 반응의 율속 단계에 있는 효소이다. 세포의 성장기간 동안에 이 효소는 mRNA하 단백질 수준에서 급격한 변화를 일으키며 조절된다. 이와 같은 polyamines농도의 급변화를 분자수준에서 탐구하기 위하여 ODC 특이 cDNA colne이 cDNA libray에서 분리되었다. cDNA의 clone이 이루어진 부분은 open reading frame과 3'-noncording region, 그리고 poly A의 tail이 있는 부분으로서 각각 456, 348, 14개의 nucleotides로서 구성되어 있었다. 인간, mouse, rat, hamster로부터 같은 지역내 추론된C-말단으로부터의 아미노산의 비교는 단백질 상동성에 88%이상을 보였다. 이와같은 아미노산 염기순서에 있어서의 잘 보존된 특징은 ODC가 세포성정과 분화에 있어서 중요한 역할이 있음을 잘 나타내고 있다.
Sulfoxaflor, a Novel Sulfoximine Insecticide
Yi, Jeehwan,J. Babcock,M. Loso,G. Watson,T. Sparks,J. Thomas 한국응용곤충학회 2012 한국응용곤충학회 학술대회논문집 Vol.2012 No.05
Sulfoxaflor, a novel sulfoximine insecticide, discovered by and proprietary to Dow AgroSciences is being developed globally. Sulfoxaflor will be used in all major crop groups, including fruits, vegetables, rice, cereals, soybean, and many other crops. Sulfoxaflor provides excellent efficacy at low use rates through contact and ingestion against important and difficult-to-control sap-feeding insect pests, including certain species of aphids, scales, plant bugs, whiteflies, planthoppers and other sap feeders. Sulfoxaflor’s mode of action is via agonism of the insect nicotinic acetylcholine receptor (nAchR), which is the same target site of neo-nicotinoid insecticides. However, relative to most neonicotinoids, sulfoxaflor is a high efficacy agonist of the nAchR with relatively low affinity for the imidacloprid binding site. Furthermore, sulfoxaflor is less susceptible to metabolism by monooxygenase enzymes and displays a broad lack of metabolism-based cross-resistance with neonicotinoids. This difference as well as its novel chemical structure led to sulfoxaflor being designated as the sole member of Group 4, Subgroup C of the IRAC Mode of Action Classification Scheme. Because of broad lack of crossresistance, sulfoxaflor will be a useful rotational partner with other insecticide chemistries, enhancing Insect Resistance Management strategies. In Korea, sulfoxaflor is being developed for use in fruit and leafy and fruiting vegetable by several companies. Results from several laboratory and field trials revealed that sulfoxaflor at use rate of 35 ppm (7% product, X2,000 dilution rate) provided excellent performance against economically important aphids in several crops compared with current sap-feeding pest control agents. Sulfoxaflor was registered in October 2011 as brandname TRANSFORM® (Sulfoxaflor 7% SC which is produced by Dongbu Hannong) will be launched for apple, pear and red-pepper in 2012.