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New tricyclic systems as photosensitizers towards triple negative breast cancer cells
Marilia Barreca,Angela Maria Ingarra,Maria Valeria Raimondi,Virginia Spanò,Antonio Palumbo Piccionello,Michele De Franco,Luca Menilli,Valentina Gandin,Giorgia Miolo,Paola Barraja,Alessandra Montalbano 대한약학회 2022 Archives of Pharmacal Research Vol.45 No.11
Nineteen pyrrolo[1,2- h ][1,7]naphthyridinonesand pyrido[2,3- c ]pyrrolo[1,2- a ]azepinones were synthesizedas new tricyclic systems in which the pyridine ringis annelated to the 6,7-dihydroindolizin-8(5 H )-one and5,6,7,8-tetrahydro-9 H -pyrrole[1,2- a ]azepine-9-one moietiesto obtain potential photosensitizing agents. They were testedfor their photoantiproliferative activity on a triple-negativebreast cancer cell line, MDA-MB-231, in the dark and underUVA light (2.0 J/cm 2 ). We demonstrated that their toxicity,only when exposed to light, was primarily due to the generationof reactive oxygen species while their photodegradationproducts were not responsible for their activity. The mostactive compounds exhibited photocytotoxicity with IC 50 valuesat low micromolar level inducing a decrease in the intracellularcontent of thiol, thus triggering cancer cell deaththrough apoptosis. All the pyridone derivatives revealed tobe pure photosensitizers with preferential photocytotoxicactivity towards cancerous over healthy cells. Altogether,the results obtained confi rm pyrrolo[1,2- h ][1,7]naphthyridinonesand pyrido[2,3- c ]pyrrolo[1,2- a ]azepinones as promisingphotosensitisers against triple-negative breast cancer.
John Span 합동신학대학원대학교 출판부 2021 Hapshin Theological Review Vol.9 No.-
In describing the times that led up to Herman Bavinck delivering his rectorial address in 1904, entitled Christelijke wereldbeschouwing, the historian T. C. W. Blanning suggested, “the ground [was] moving beneath their feet.” Slightly more than a century later, Voddie Baucham in his book, Fault Lines: The Social Justice Movement and Evangelicalism’s Looming Catastrophe suggests that seismic shifts-caused by moving ground, no less-in society’s thinking around the religion of Anti-Racism is showing up as cracks in the foundation of the church. This article will examine how each author examines the worldviews of their day, and why a Biblical-Christian “world-and-life view”-as Bavinck termed it-is the only possible response.
Tampering with the Gospel by Listening to the Whispers of the Spirit of the Age
John Span 합동신학대학원대학교 출판부 2014 Hapshin Theological Review Vol.3 No.-
The Gospel is tampered with when seductive voices of the spirit of the age (Zeitgeist) tickle the itching, uncritical and responsive ears of too many in church missions’ leadership. The most deafening whisper today is the voice of accommodation at all costs. Using the convention of accounting I offer ten sample additions or subtractions to demonstrate how tampering with the Gospel can result in a bottom line of bankruptcy as far as missions is concerned. The question posed to the reader is “Where is the concern for the five Solas of the Reformation, which surely are compromised by such accommodation?”
John Calvin"s views of "the Turks" and of Finding Truth in Non-Biblical Sacred Texts
Rev. John Span 합동신학대학원대학교 출판부 2015 Hapshin Theological Review Vol.4 No.-
Is there truth in non-Biblical sacred texts? After some brief definitions and a brief survey of Christian attitudes throughout history to Islam and the Qur"an, this paper will examine Calvin"s writings for his theology of religions, and largely limit our examination to his view of "the Turks" [=Ottoman Muslims]. We will find that even though John Calvin has been accused of having an "unthematic" theology of religions, the primary sources demonstrate a consistent approach to the "religious other" that is revealed in his sermons, commentaries, letters, polemical writings and his Institutes. It will be seen that Christ as "the Truth" is a completely different genus and species than the "truthlets" which some modern writers are so fond of. Calvin thus can help the contemporary reader to analyse the sacred texts of any religion.