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      • KCI등재

        구개부에 발생한 다형성선종

        정숭룡(Soong Rhyong Jung),김영운(Young Woon Kim),박준아(Jun Ah Park),정종철(Jong Cheol Cheong),오희균(Hee Kyun Oh),이종호(Jong Ho Lee),류선열(Sun Youl Ryu),최흥란(Hong Ran Choi) 대한구강악안면외과학회 1994 대한구강악안면외과학회지 Vol.20 No.4

        Pleomorphic adenoma is a circumscribed tumor characterized microscopically by its pleomorphic or mixed apprearance, and its clearly recognizable epithelial tissue intermingled with areas of mucoid, mixed, or chondroid appearance. Pleomorphic adenoma, the most common tumor of the salivary glands, is now generally accepted as epithelial and benign adenoma, The palate is the most common location for minor salivary gland tumor. The neoplasm has been found in all age groups, the majority being in the fifth decade with an age ranged from 30 to 50. Minor salivary gland lesions appear a decade later, ranging in age from 40 to 60. We experienced three cases of pleomorphic adenoma occuring in the palate. They were treated with complete local exicision and reconstructed with pedicled temporal fascial, flap, pedicled buccal fat pad, and palatal islands flap each.

      • Feasibility of Degenerate Oligonucleotide Primed PCR for Analyzing Allelic Imbalance in Microdissected Paraffin Embedded Tissue

        Jung, Soong-Rhyong,Kim, Sun-Hun,Ryu, Sun-Youl 전남대학교 치과대학 2001 구강과학 Vol.13 No.1

        인간의 유전자에서 degenerate oligonucleotide primed PCR (DOP ­ PCR)에 이용되는 시발체가 반응하는 부위의 분포는 알려져 있지 않고 따라서 DOP ­ PCR을 통해 모든 유전자 부위가 일정하게 증폭되는지 여부는 확실하지 않다. 신선한 인간 DNA를 이용한 genotyping 연구에서 DOP ­ PCR이 유전자의 특정 부위를 선택적으로 결손 또는 증폭시키지 않는 것으로 보고된 바 있으나, 파라핀에 포매되어 부분적으로 손상된 DNA를 이요한 DOP ­ PCR의 유전자의 재혀성에 관한 체계적 연구는 없다. 본 연구는 파라핀 포매된 조직에서 얻은 DNA를 이용하여 DOP ­ PCR 반응산물의 크기는 2 kb에 달하였으나 구명하여 다음과 같은 결과를 얻었다. 신선한 DNA에서 DOP ­ PCR 반응산물의 크기는 2 kb에서 달하였으나 파라핀 포매 조직에서 얻은 DNA에서는 500 bp 이하였다. DOP ­ PCR 증폭하지 않은 정상 DNA와 DOP ­ PCR 증폭을 한 정상 DNA를 이용한 hybridiazation 결과 전체 유전자의 비율은 모든 염색체에서 정상 범위 내에 존재하였다. 또한 DOP ­ PCR 증폭을 한 두 종류의 정상 DNA간의 hybridization 결과에서도 두 유전자의 비율은 정상 범위내에 있었다. 본 연구에 이용된 대부분의 microsatellite CA repeats는 DOP ­ PCR에 의하여 증폭된 DNA로부터 염기서열에 관계없이 증폭되었고, DOP ­ PCR에 의한 DNA의 두 allele의 비는 DOP ­ PCR을 하지 않은 DNA 의 allele 비를 유지하였다. 또한 종양조직의 allelic imbalance는 미세해부후 DOP ­ PCR을 시행한 조직에서 결정할 수 있었다. 이상의 결과는 DOP ­ PCR을 이용하여 allelic imbalnce를 연구할 수 있는 가능성을 제시하며 따라서 파라핀 조직에서 얻은 DNA를 이용한 DOP ­ PCR을 통하여 형태학적 연구 및 역행성 연구가 가능하리라 사료된다.

      • 발치와에 이식된 탈회동결건조골과 흡수성 수산화인회석이 신생골 형성에 미치는 영향

        정숭룡,류선열 전남대학교 치과대학 1994 전남치대논문집 Vol.6 No.1

        The present study was aimed to evaluate the effect of demineralized freeze-dried bone (DFDB) and resorbable hydroxyapatite (RHA) on bone formation in the extracted socket. The lower left and right 2nd and 3rd premolar were extracted in adult dogs. The one group was grafted with DFDB into the extracted socket, and the other group grafted with RHA. The extracted socket was sutured without any graft materials as control. The animals were killed on the 1st, 2nd, 4th, and 8th weeks after the graft for macroscopic and microscopic examination. Results obtained were as follows: 1. Macroscopically, nor infection of the graft site and dislodgement of the grafted material were noted in any animals used. 2. Young trabeculae of osteoid were formed in the socket wall in control group at 2 weeks after the graft. Osteoid tissue was formed in DFDB group at 1 week after graft, and a fine osteoid tissue was grown through the RHA particles in RHA group at 2 weeks after graft. 3. The grafted groups showed more rapid bone formation than the control. Between the grafted groups, DFDB group showed more rapid formation than RHA group, DFDB group showed osteoinductive bone formation and RHA group showed osteoconductive bone formation. These results suggest that DFDB and RHA are useful to preserve the alveolar bone and to improve new bone formation by immediate grafting into the extraction sokets.

      • KCI등재

        안면부에 발생한 괴사성 근막염

        김영운(Young Woon Kim),정숭룡(Soong Rhyong Jung),박준아(Jun A Park),정종철(Jong Cheul Jung),오희균(Hee Kyun Oh),이종호(Jong Ho Lee),류선열(Sung Youl Ryu) 대한구강악안면외과학회 1994 대한구강악안면외과학회지 Vol.20 No.4

        Necrotizing fasciitis is a rapidly progressing necrotizing process which affects subcutaneous tissue and fascia and is accompanied by severe systemic toxicity. Although necrotizing fasciitis can affect any part of the body including the back and neck, it is rather a rare entity in the head and neck. The rate of spread is remarkably rapid, with the tendency towards systemic toxicity related to delayed initiation of treatment. The infection process may be caused by any type of trauma. The infectious process usually begins 2 to 4 days after the initial insult. The skin becomes smooth, tense, and shiny: no sharp demarcation is seen between normal and affected skin. As the disease progresses, the pathognomonic sign of necrotizing fasciitis appears: a dusky discoloration of the skin as small purplish patches with ill-defined borders. An early exploration and drainage of all the involved fascial planes is important. We have had much difficulty in differentiating necrotizing fasciitis from other infections diseases. When infection is present in the oral & maxillofacial area, we thin abscess and cellulitis first of all. With failure of the lesion to respond to conventional treatment, we have to rule out the necrotizing fasciitis due to its alarming toxicity. Successful treatment of necrotizing fasciitis is bases on the early recognition of the infection process, aggressive surgical intervention systemic medical and supportive therapy, and intensive antibiotic therapy, with emphasis placed on early surgical care. The early exploration and drainage of al the involved fascial planes is critical. We experienced two cases of necrotizing fasciitis of the face. With early recognition of the infection process, aggressive fasciotomy and various medically supported therapy, we resolved the edema and exudate with offering the best chance for core. The patient was treated successfully.

      • KCI등재

        조직확장술을 이용한 두경부 연조직 재건

        정종철,박준아,김영운,정숭룡,이종호,류선열,Jeong, Jong-Cheol,Park, Jun-Aa,Kim, Young-Woon,Jung, Soong-Rhyong,Lee, Jong-Ho,Ryu, Sun-Youl 대한악안면성형재건외과학회 1994 Maxillofacial Plastic Reconstructive Surgery Vol.16 No.3

        Tissue expansion has now been widely used in various soft tissue defects and deformities. It is to reconstruct the lesion site by providing donor tissue of the same color, texture, and similar thickness and sensation with minimal scar formation and minor donor site morbidity. It is achieved through using a temporary expander capable of accumulating normal saline. Internal pressure from expander exerts its force on the flap, which gradually expands to provide additional tissue for reconstruction. We have applied tissue expander in three patients. The first case was soft tissue loss on the left forehead. The second case was multiple scar formation on the left mandibular angle and upper cervical area. The third case was scar contraction on the right cheek. All cases have been successfully reconstructed without complications. 저자들은 1예의 전두부 연조직 결손과 2예의 경부와 안면에 형성된 다발성의 반혼구축 환자에서 조직확장술올 이용하여 양호한 두경부의 연조직 재건을 얻을 수 있었다. 다양한 연조직의 결손이나 변형에서 적절한 증례를 선택하여 올바르게 적용할 경우 조직 확장술은 유용한 재건방법이 될 수 있을 것으로 생각된다.

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