장기간 항갑상선제 투여 후 임의 중단 뒤 재복용시 발생한 무과립구증 1 예

김승만;김태영;박수영;배영환;서영경 정은주;김태균;권민정;박정현;이순희 인제대학교 2011 仁濟醫學 Vol.32 No.-

Agranulocytosis, one of the major side effects of antithyroid a gents, probably occurs in less than 0.25% of cases treated with antithyroid agents. It usually occurs within the first several weeks or months after the initiation of therapy, when drug dosage is higher. Most reported cases of agranulocytosis have occurred during the first 3 months of therapy. We describe here a rare case that did not experience the side effect for 6 years of antithyroid agent treatment but presented with agranulocytosis in one month after re-exposure. It suggests that the major side effect such as agranulocytosis can occur in patients who had undergone prior uneventful antithyroid drug therapy.

교원효소로 유발된 랫드 대뇌 출혈병변의 병리학적 관찰

서일복,소경순,김광호,김영석 世明대학교 한의학연구소 1998 韓醫學硏究所 論文集 Vol.1 No.-

This study was carried out to characterized the hemorrhagic lesion sof the collagenase induced hemorrhagic stroke in rats. Fifty three Sprague-Dawley male rats were divided into two group. Group Ⅰ was served as model animals for hemorrhagic stroke, which were infused with 2㎕ saline containing 0.5unit collagenase(type Ⅶ) into the caudaate nuclei. Group Ⅱ was served as control animals, which were infused with 2㎕ saline only into the caudate nuclei. Six heaks of the rats of group Ⅰ were sacrificed at 30 min, 1, 5, 24 hours, 2, 5, 10 days after the infusion , and 3 heads of rats were sacrificed at 15 days after the infusion. Two heads of the rats of group Ⅱ were sacrificed at 30min, 1,5, 24 hours after the infusion. The brains of the rats were removed and examined grossly and histopathologically. Grossly, pin point sized or linear hemorrhage were occurred at 30minutes and the hemorrhagic lesions extended to 5mm in diameter at 24 hours. After then the hemorrhagic lesions faded gradually. Histopathologically, extended hemorrhage with degeneration of brain parenchyma were observed at 5 hours. Large area of malacia were observed at 24 hours. At 5 days, proliferation of astrocytes, proliferation of newly formed capillaries, and infiltration of lipid laden macrophages were seen at the periphery of the area of malacia. At 15 days, most of the area of malacia were replaced by granulation tissue. These observations may be useful parameters for the screening of therapeutic drugs using collagenase induced hemorrhagic stroke animal model.

Helicobacter pylori 양성인 소화성 궤양 및 위염 환자에서 Helicobacter pylori 제균에 대한 판토프라졸 포함 삼제 요법의 임상효과 및 내약성에 대한 연구

서영호,이완식,주영은,김현수,최성규,유종선,김행재,서순팔,김세종 최신의학사 2000 最新醫學 Vol.43 No.11-12

간장 허혈 및 재관류시 vitamin C와 E가 간장기능에 미치는 영향

서민영,김순애,조태순,이선미 성균관대학교 약학연구소 1995 成均藥硏論文集 Vol.7 No.1

Abstract - This study was done to investigate the effect of vitamin C and E on hepatic biliary and microsomal function during ischemia and reperfusion. Rats were treated with vitamin C, E or with vehicle(saline) and then subjected to 60 min no-flow hepatic ischemia in vivo. Control animals were time-matched sham ischemic animals. After 1 or 5 hr of reperfusion, bile was collected, blood was obtained from the abdominal aorta, and liver microsomes were isolated. In vehicle-treated ischemic rats, serum ALT levels peaked at 5 hr and were significantly attenuated by vitamin C, E individually and combination of vitamin C and E treatment. Similarly hepatic wet weight-to-dry weight ratio was increased in the vehicle-treated ischemic group. Vitamin C and E combination minimized the increase in this ratio. Lipid peroxidation was elevated in vehicle-treated ischemic group, but this elevation was also inhibited by vitamin C or E, respectively. Bile flow and cholate output, but not bilirubin output, were markedly decreased by ischemia/reperfusion. Vitamin C treatment restored the secretion. Cytochrome P-450 content was decreased by ischemia/reperfusion and restored by vitamin E treatment to the level of sham operated group. Aminopyrine N-demethylase activity was decreased and aniline p-hydroxylase activity was increased by ischemia/reperfusion. These changes were prevented by vitamin C or E treatment, but not by vitamin C and E combination treatment. Our findings suggest that vitamin C or E individually significantly ameliorates these ischemia/reperfusion-induced hepatic damages and there is no evidence of synergism between vitamin C and E in our system.

비타민 E와 알츠하이머병

서애리,이현숙,김영순 高麗大學校 倂設 保健大學 保健科學硏究所 2000 保健科學論集 Vol.26 No.1

Cognitive decline is perceived to be a characteristic of the aging process, and is profoundly manifested in age-related neurodegenerative disorders such as Aizheimer's Disease(AD). The pathologic mechanisms underlying neurodegeneration are complex and not completely understood, but a contributing factor is believed to be oxidative stress. The brain has a high metabolic requirement for oxygen and a high concentration of polyunsaturated fatty acids, and therefore is prone to lipid peroxidation. Lipid peroxidation leads to the production of free radicals that may attack and irreversibly damage neural tissue, thus contributing directly or synergistically to neurodegenerative process. Accumulating evidence from preclinical and clinical studies supports the hypothesis that oxidative stress may be associated with the onset and progression of AD. Antioxident therapies are being promoted in the lay press to enhance mental functions and delay cognitive losses with aging. This paper summarizes the oxidative stress hypothesis of AD and reviews the strengths and limitations of published antioxidant studies in AD in relation to the role of such therapies in practice.

주사전자현미경을 이용한 온실가루이(Trialeurodes vaporarium) 성충 부속지의 외부 미세구조 관찰

서미자,김기덕,김남성,박수진,채순용,윤영남 충남대학교 농업과학연구소 1999 농업과학연구 Vol.26 No.2

온실가루이의 외부형태적 특징을 주사전자현미경 사진을 통해 관찰하였다. 우선 이들은 포탄모양의 알을 산란하는데 짧은 갈고리모양의 구조에 의해 잎 뒷면에 붙어있는 것이 확인되었다. 촉각의 길이는 0.3㎜로 전체가 6마디로 구성되어 있고, 첫마디는 굵고 짧으며 둘째 마디부터 가늘고 긴 채찍모양을 하고 있다. 끝마디인 6번째 마디의 끝에는 길이가 10㎛정도의 가늘고 비교적 긴 감각기를 가지고 있어 기주를 탐색하는 과정에서 식물체의 표면을 탐지하는데 사용하는 것으로 사료되며, 바로 밑부분에는 길이가 7-8㎛정도의 비교적 굵은 감각기 2개가 존재하고 있는 것으로 확인되었다. 이 감각기는 반대편에는 존재하고 있지 않은 비대칭 분포를 보이고 있으며, 또한 두개의 모양이 서로 상이함으로 볼 수 있다. 이들의 기능은 주로 기주식물을 탐색하거나 후각기능의 화학적 감각기의 역할을 하는 것으로 추정할 수 있다. 섭식행동이 이루어지는 온실가루이 구기는 전형적인 piercing-sucking type으로, 구침이 길게 잘 발달되어 있다. 구기의 끝부분은 10여개의 미세감각기가 분포고 있어 식물체 표면을 탐색하고 맛을 보는 미각기능을 하고 있으리라 추측할수 있다. 구침은 종종 구기에서 분리되기도 하지만, 구침을 잡아주는 지지대가 기부쪽에 자리하고 있음을 알 수 있다. 구침은 두 개의 반원형이 붙어 있는 형상을 하고 있으며, 다른 흡즙형 구침과는 달리 톱날모양의 구조를 볼 수 없었다. 한편 온실가루이의 다리 끝에 붙어 있는 발톱은 식물체에 고정시키기 위한 구조로 보이는 두 개의 갈고리 형태의 발톱과 그 사이에 중앙지지대 형태의 구조인 paranychium을 포함하여 3갈래의 구조를 하고 있다. External morphology characteristics of the greenhouse whitefly, Trialeurodes vaporarium were investigated by scanning electron microscopy. The antennae of the greenhouse whitefly was 6 segments, rod-shape, and 0.3mm length. On the 6th segment, there were many sensilla for searching host-plant as olfactory receptor. The mouthpart of the greenhouse whitefly was a piercing-sucing type, then its stylet was well developed for piercing plant leaf tissue. Claw of the foreleg was a 3-war hook shape including paranychium for attaching plant surface to pierce and lay egg.

조선대학병원에서 경험한 삼일열 말라리아의 임상적 고찰

서영선,김양수,김태균,박유환,홍순표,정춘해 조선대학교 부설 의학연구소 1999 The Medical Journal of Chosun University Vol.24 No.1

In the five years since 1993 Malaria has made a ceaseless attack on the native Koreans as an indigenously formed disease in addition to the imported one. This study was aimed at clinical symptoms and signs of Malaria which had occurred indigenously in Cheon-Nam. 18 cases were reviewed retrospectively in this study which was composed of 17 men and 1 woman. They were admitted to Chosun Hospital because of the indigenous Malaria in 1998. Fever and chill , the most frequent symptoms in early stages made a 100% occurrence followed by general myalgia(89%) and headache(83%). Physical examination of those admitted showed the splenomegaly most frequently in 61% of the patients. It took four to ten days to visit the hospital since the symptoms first occurred in the patients. Gametocytes among the Malarial life cycle were observed most commonly (91.3%) in the occurrence of the disease and the prestages of the life cycle as well. The hematologic abnormalities observed was Anemia(89%), Thrombocytopenia(61%), and Neutropenia(50%) in the order named. On the third hospital day since giving the standard Malarial drugs parasitemia decreased remarkably (1540/㎕ : Mean parasitic concentration) and 28th day of treatment no parasitemia were found. In conclusion the patients suffering from malaria in Cheon-Nam had been in an armistice area and the symptoms were so relatively mild that the responses to treatment were good and relapses occurred. But, it requires further epidemiologic survey and more concern about the indigenous Malaria.

여대생의 피부유형에 따른 식생활습관 및 식품기호도

서동희,박금순,신영자 한국식생활문화학회 2005 韓國食生活文化學會誌 Vol.20 No.1

This study seeks to classify the skin types and determined the relation between the dietary habit and preference of foods targeting college women in Daegu and Gyeong-Buk Province. Skin types of the subjects were 31% of combination skin, 25% of dry skin and 22% of normal ? oily skin. College women mostly had two meals a day, and those who had less frequent meals developed more combination skin. Many of them did not exercise, and women with normal skin who did not exercise showed the lowest at 13.9%, supporting the significance (p〈.05). It was exposed that don't have breakfast and have irregular meal and don't have easy meal in all skin types. Instant foods was exposed that ingested the most in dry skin and the least in oily skin, supporting the significance(p〈.05) and fruit or vegetable ingested much in dry skin. It was exposed that considered atmosphere at meal and meal helps in health in all skin types, normal skin type considered balanced diets the most and supporting the significance(p〈.01) Food preference in all skin types showed the strongest in drinks and showed strong in greenish yellow vegetables, fruits, confectioneries, drinks, milk and dairy goods. On the other hand. it showed low in nuts and salted fishes. In sum, regular and balanced meals give the skin a healthy status. and intake of protein, vitamins and minerals has impact on the skin status. Thus. sufficient quality nutrition is crucial in staying a healthy skin.

울산지역 유아의 영양 상태에 관한 연구 : Ⅰ. 식습관과 식행동

홍순명,서영은,김현주 울산대학교 2001 생활과학논문집 Vol.3 No.1

본 연구는 울산에 거주하는 학령 전 어린이 142명을 대상으로 식습관과 식행동에 관하여 조사하였다. 조사대상 어린이는 남아 72명, 여아 70명으로 연령분포는 2세에서 7세 이었으며 규칙적인 식사시간을 지키는 남아가 48.6%이고, 여아는 42.9%였다. 조사대상자의 식습관에 있어서는 남아가 '좋은 편(13.9%)', '보통(58.3%)', '나쁜 편(27.8%)'으로 나타났고, 여아의 경우는 '좋은 편(11.4%)', '보통(62.9%)', '나쁜 편(25.7%)'으로 나타났다. 식습관 점수는 '보통'으로 평가되었고 남녀간의 유의적인 차이는 없었다. 조사대상자들의 긍정적인식행동 점수는 남아의 경우, '좋은 편(15.3%)', '보통(76.4%)', '나쁜 편(8.3%)' 이고, 여아는 '좋은 편(15.7%)', '보통(74.3%)', '나쁜 편(10.0%)'로 나타났다. 조사대상자들의 부정적인 식행동 점수는 남아의 경우, '나쁜 식행동이 적은 편(23.6%)', '보통(76.4%)', '나쁜 식행동이 많은 편(0.0%)'이고, 여아는 '나쁜 식행동이 적은 편(21.4%)', '보통(75.7%)', '나쁜 식행동이 많은 편(2.9%)'으로 나타났다. 조사대상자들의 식행동 총점은 '보통'으로 평가되었고, 남녀간의 유의적인(p<0.001) 차이를 나타내었다. 긍정적인 식행동과 식습관 간에는 유의적인 (p<0.05, p<0.001) 양의 상잔성이 있었고, 부정적인 식행동과 식습관 간에는 유의적인 ((p<0.05, p<0.001) 응의 상관성이 있었다 본 연구의 결과는 학령전 어린이에게 적용할 메뉴를 계획하는 프로그램과 영양교육의 자료로 이용될 수 있을 것이다. The nutritional status of 142 preschool children in Ulsan area was surveyed. A survey was conducted on parents using lluestionnaires including general characteristics, subjective symptoms, flood habit and eating behavior The children involved in this study were 72 boys and 70 girls, aged 2 to 7 years old. 48.6% in boys and 42.9% in girls were on'regular'meal times, The food habit score of the subjects was divided into Poor(27.8%), fair(58.3%) and good(13.9%) in boys, poor(25.7%), fair(62.9%) and good(11.4%) in girls. The positive eating behavior score of the subjects was divided into poor(8.3%), fair(76.4%) and good(15.3%) in boys, poor(10.0%), fair(74.3%) and good(15.7%) in girls. The negative eating behavior score of the subjects was divided into poor(0.0%), fair(76.4%) and good(23.6%) in boys, poor(2.9%), fair(75.7%) and good(21.4%) in girls. The relation of the flood habit and positive eating behavior is significantly(p<0.05, p<0.001) positive correlation and the relation of the food habit and negative eating behavior is significantly(p<0.05, p<0.001) negative correlation. The results of this study indicate that nutrition education and menu planning program should be applied to preschool children.

주사전자현미경을 이용한 무당벌레에 기생하는 무당벌레기생파리(Degeeria separata)의 외부형태적 특징

윤영남,김남성,김기덕,박수진,서미자,채순용 충남대학교 농업과학연구소 2000 농업과학연구 Vol.27 No.1

External morphological characteristics of male and female of Degeeria separata, which was endoparasited in adult of the Asian ladybird, were studied by using the scanning electron microscopy(SEM). The antenna of Degeeria separata was consisted of three segment and arista. Anstae were about 750㎛ length and 30㎛ in diameter. The surface of antennae was covered with many sensilla. They were long or short, slender or thick, and straight or curved. Each three morphological types of sensilla were observed on the second and third segment of antennae. The mouthpart was sponging type. It was consisted with clypeus, labellum, labium, labrum, and maxillary palp. The labellum is 400㎛ width and double folded vertically. The leg consist of tarsus, tarsus claw, pulvilli, and empodium.