골관절염 환자에 대한 Tenxicam(Tilcotil^(�))의 효과에 대한 임상시험 결과

최창욱,나수균,이병일 최신의학사 1990 最新醫學 Vol.33 No.1

Di-(2-ethyl hexyl) phthalate(DEHP)가 rat의 혈액상 및 약물대사효에 미치는 영향

임수한,홍사욱 成均館大學校 科學技術硏究所 1990 論文集 Vol.41 No.1

Di-(2-ethylhexyl) phthalate(DEHP), one of plasticizers in plastic has recently been reported as a potential hepatotoxic agent. Liver enlargement associated with a decrease in the activity of mitochondrial enzyme and modification in biological response of xenobiotics after oral or intraperitoneal administration of DEHP has been observed in rodents. However, their subtle toxic effects have not been fully investiqated and thus more detailed studies are required. In this paper, we examined the toxic effect of DEHP on the liver and kidney function and biochemical parameters in rats. The biochemical parameters such as AST, ALT, ALP, LDH, BUN, albumin and total protein in serum were gradually increased by DEHP treatment. And more increasing tendency was observed by concomitant ethanol treatment. The contents of cytochrome P-450 and activity of NADPH-cytochrome c reductase in hepatic microsomal fraction were increased in initial period and then decreased, but those in renal microsomal fraction were little increased. However, toxic responses of DEHP in hepatic and renal cytochrome P-450 content and the activity of NADPH-cytochrome c reductase were a little suppressed by the administration of ethanol. The activity of Glucose-6-phosphatase in hepatic homogenate was decreased and MDA value in the serum and microsomal fraction of liver and kidney was significantly increased by the administration of DEHP but those of above biochemical function were keeping slowly by ethanol concomitant treatment.

재접합술의 일차 보고

나수균,윤치순,최창욱,김학현 순천향의과대학 1979 Journal of Soonchunhyang Medical Science Vol.2 No.4

It was about 70 years ago that Carrel and Guthrie started experimental limb replantation. Malt succeeded, firstly, replantation of the amputated arm of 12 years old boy in 1962 and Tamai succeeded finger replantation in 1965. Since Jacobson and Suarez described superiority of small vessel repair using microscope, further advances in replantation occurrd with the develop-ment of suture material (18-20μ) and needles (65-120μ); making repair of vessels of 1 mm in diameter. The authors experienced four cases of traumatic amputation during the period from March, 1979 to Sept.. 1979 and the primary result of replantation is reported in this paper. 1. All cases were male and in the age group between 21 to 29. 2. Mode of amputation; two cases were amputated by presser, one case was by iron cutter and one was by paper cutter machine. 3. Tow out of four cases were incomplete amputation and two were complete multiple amputation. One case of multiple amputations was right four digits except thumb at the proximal phalanx level and the other was bilateral wrists. 4. The shortest duration of ischemia was four hours and 45 minutes and the longest was 13 and a half hours. 5. Four out of four replanted digits and two wrists were survived and the remains were failed. The possible cause of failure seems to be too long ischemic time. 6. Further functional results will be reported later.

자운천 유역의 강우특성에 의한 하천 탁도 발생에 관한 연구

김종욱,박수진,최한규 江原大學校 産業技術硏究所 2007 産業技術硏究 Vol.27 No.B

This research investigates the turbidity and flow of river for an year, 2005, in order to examine the relation of the generation of turbidity according to the outflow of min water. For this research, the region of Jawoon river where is the area of high land vegetable growing in the upper Soyang Reservoir is selected to observe actual floating materials that generate negative nutrition and turbidity of the Reservoir water and the changes of water quality by raining of each month, In addition, the researcher has conducted statistical inspection methods, such as correlation analysis and regression analysis on strength of raining force, and rain continuance time among the elements affecting the outflow of floating materials.

아동기 가정 내 스트레스가 공동의존성에 미치는 영향 및 공동의존성과 정신병리와의 관련성

곽운환,손지욱,한규희,박철수,김장락,김붕년,김봉조,강여화,하형래 대한생물치료정신의학회 2003 생물치료정신의학 Vol.9 No.1

연구목적: 본 연구는 공동의존성에 영향을 미치는 아동기 가정내 스트레스 요인과 공동의존성과 다른 병리와의 연관성을 규명하고자 하였다. 더불어 특정한 질환에서의 공동의존성의 평가가 가지는 의의를 탐색해 보고자 하였다. 방 법: 연구 대상은 정상 일반인 남성집단 88명과 알코올리즘 남성 집단 76명으로 구성되어 있다. 평가도구는 본 저자가 직접 작성한 '아동기 가정내 스트레스 요인 측정용 설문'과 공동의존 척도(RPS), 간이증상 진단검사(SCL-90-R)를 사용하였다. 통계적 분석은 Mann-Whitmey test, Kruskall- Wallis test, Multiple linear regression analysis, Spearman correlation analysis를 이용하였다. 결 과: 1) 정상 일반인 군과 알코올리즘 군의 공동의존성 평균값은 각각 49.12점(표준편차=15.41)과 88.31점(표준편차=17.48)이었다. 2) 정상 일반인 군에서는 '아동기 부모 사별'(p<0.01) '부모의 알코올리즘'(p<0.01) '부모의 상습적 구타'(p<0.01)의 3가지 요인에서, 알코올리즘 군에서는 '어린시절 부모 사별'(p<0.01) '부모의 알코올리즘'(p<0.01) '부모의 상습적 구타'(p<0.01) '부도의 도박'(p<0.01) '사회 병질자 부모의 존재'(p<0.05)의 5가지 요인에서 스트레스 유무에 따라 공동의존성에 유의한 차이를 보였다. 3) 두 집단 동시에 SCR-90-R의 8개 소척도 중 '대인관계 예민성'이 공동의존성과 가장 높은 연관성(rs>0.06, p<0.01)을 보였다. 이외에도 '우울증' '불안증'등이 두 집단 모두에서 통계적으로 유의한 연관성을 보였다. 결 론: 본 연구는 부모의 알코올리즘뿐만 아니라 여러 가정 내 스트레스 요인이 공동의존성의 발생에 영향을 미칠 수 있음과 공동의존성이 높은 집단이 다른 정신과 질환을 동반할 가능성이 높음을 증명한다고 할 수 있다. Objectives : The aim of this study was to examine the relationships of codependency with family stressors in childhood and psychopathology. Methods : Subjects were a group of 88 normal adult males and a group of 76 alcoholic males. The degree of codependency was assessed with the Korean version of Recovery Potential Survey(RPS). All subjects filled out questionnaires regarding demographic information and family stressors. The psychopathology was measured by self-administred questionnaires using Symptom Check List-90-Revision(SCL-90-R). Results : 1) There were no significant differences in codependency levels by sociodemographic characteristics in two groups, but obvious difference in mean of codependency scores(normal group : 49.12±15.41, alcoholism group : 88.31±17.48). 2) There were significant differences in codependency levels between the presence and absence of parental physical abuse, parental death, and parental alcoholism(p<0.01) in both groups. 3) Among family stressors, parental physical abuse had the largest contribution to codependency level in multiple linear regression. 4) There were significant correlations between the codependency levels and the scores of SCL-90-R's subscales of interpersonal sensitivity, depression, and anxiety in both groups. Conclusion : The codependency levels were related to some family stressors such as parental physical abuse, parental death, and parental alcoholism and the high-level codependency was correlated with higher level of psychopathology in both normal and alcoholism group. These results suggested that various family stressors, as well as parental alcoholism may be predictors of codependency, and codependency also may be a predictor of other psychiatric disorders.

중년 여성의 운동형태별 영양섭취에 관한 연구

최승욱,백영호,김수진,문미자 釜山大學校 附設 體育科學硏究所 2005 體育科學硏究所 論文集 Vol.21 No.1

With middle-aged women living in B metropolitan city as subjects, classified were two groups : the women who take steady exercise for over 6 months and the women who take no exercise, and a comparative analysis was made of the total caloric intake, the ratio of the intake of three major nutrients, the intake of micronutrients, and the amount and ratio of daily dietary intake, according to the type of exercise, with the following results.......

정신분열병 환자에서 얼굴 영상의 작동기억 장애 : 기능자기공명영상연구

이창욱,김태석,주라형,박주미,박여진,김종진,전신수,배치운,김정진,이수정,이철,백인호 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.2

Objectives : Impaired processing of facial information is one of the broad ranges of cognitive deficits seen in patients with Schi-zophrenia. We aimed to elucidate the differences in brain activities involved in the process of facial working memory between schizophrenic patients and healthy comparison subjects. Methods : Twelve patients with schizophrenia were recruited along with twelve demographically matched healthy volunteers as a comparison group. Functional magnetic resonance imaging (fMRI) was used to assess cortical activities during the Perfor-mance of a 2-back working memory paradigm using images of neutral faces as mnemonic content. Rcsults : The patient group performed the tasks with reduced accuracy. Group analysis revealed that the left fusiform gyrus, the right superior frontal gyrus, the bilateral middle frontal gyri/insula, the left middle temporal gyrus, the precuneus, the quadrangular lobules and the vermis of cerebellum showed decreased cortical activities in the patient group. On the other hand, an increased level of activation in the lateral prefrontal cortex and the pahetal lobule was observed from the patient group, all in the right hemisphere. Conulusion : A decreased level of activity in the left fusiform gyrus among the patient group implicates inefficient processing of facial information. An increased level of activation in prefrontal and parietal neural networks from the patient group confirms earlier findings on the impaired working memory of patients with schizophrenia.

골다공증으로 인한 대퇴 근위부 안정 골절 환자의 골밀도치와 수술후 고정 소실과의 관계에 대한 고찰

나수균,최필근,서유성,신병준,최창욱 대한골대사학회 1995 대한골대사학회지 Vol.2 No.2

MMPI를 이용한 악교정 수술환자의 인성에 관한 연구

박우경,박재억,박수병 대한치과교정학회 1998 대한치과교정학회지 Vol.28 No.5

이 연구에서는 악교정 수술환자의 술전, 술후 인서의 특성 및 술후 변화를 알아보기 위해 실시되었으며 객관적인 인성검사의 한가지인 MMPI를 이용하였다. 악교정 수술환자들의 수술동기와 술후 만족도는 질문지를 통하여 조사하였다. 연구대상은 술전교정 중인 환자 50명과 악교정 수술을 받은 환자 22명으로 이루어졌다. 이 연구에서 얻은 결과는 다음과 같다. 1. 술전 환자군에서 K 척도를 제외한 모든 T-scores는 정상적인 범주에 놓여 있었다. K 척도값은 57.7이었으며 이것은 이 환자들이 다소 스트레스를 많이 받고 있음을 보여주었다. 2. 술후 환자군은 모든 척도에서 정상범주에 놓여 있었다. 3. 술전, 술후 환자군을 비교했을 때, 단지, T-score만이 수술 후에 통계학적으로 유의성있는 증가를 보였다.(P<0.05) 4. 남성환자는 술전 K 척도를 제외한 모든 척도에서 정상적이었으며, 술후에 K, Hs 척도에서 통계학적으로 유의성있는 증가를 보였다.(P<0.05) 5. 여성환자는 모든 T-score기 정상적인 범주에 놓여 있었다. 6. 수술동기는 크게 심미적, 기능적, 악관절문제, 정신사회학적 동기로 나눌 수 있었으며, 각각 28.2, 32.1, 9.0, 30.7%였다. 7. 수술 후 수술 동기에 대한 만족도는 매우 만족하는 환자가 전체의 14.3%, 만족하는 환자가 71.4%, 그저그렇다고 답한 환자가 9.5%였으며, 매우 불만족스러움을 답한 환자가 4.8%였다. This study was designed to evaluated the personality characteristics of orthognathic surgery patients preoperatively and postoperatively through the MMPI. Comparison was made between the personality characteristics of preoperative and postoperative groups. Motivation for undergoing orthognatic surgery and postoperative satisfaction were examined trough the questionnaire. Subjects used in this study consisted 50 patients under presurgical orthodontic treatment and 22 patients who had received orthognathic surgery. From this study, the results were followings. 1. In preoperative patients group, all T-scores were within the normal range except for K-scale. The T-score of K-scale is 57.7, this showed that these patients underwent some of less stress. 2. In postoperative patients group, all T-scores were within the normal range. 3. Only in K-scale, there was statistically significant increase after surgery(P<0.05). 4. In male patients group, all T-scores were within the normal range except for that of preoperative K-scale. Postoperatively, there were statistically significant increase in K and Hs scales(P<0.05). 5. In female patients group, all T-scores were within the normal range. 6. Motivation for undergoing orthognathic surgery could be divided into 4 categories.:esthetic goal(28.2%), functional goal(32.1%), TMJ problem(9.0%), and psychosocial reason(30.7%). 7. The degree of postoperative satisfaction was quite high(85.7%). 14.3% of all patients were very satisfied, 71.4% were satisfied, 9.5% were neither satisfied or dissatisfied, and 4.8% were very dissatisfied.

대퇴골두 골괴사를 동반한 슬관절 골괴사 : 증례 보고

송준민,이병일,나수균,신영수,최창욱,박종석,권희 순천향의학연구소 1996 Journal of Soonchunhyang Medical Science Vol.2 No.1

본 순천향대학교 의과대학 정형외과학 교실에서는 2명의 환자에서 발견된 대퇴골두 골괴사와 함께 발생한 양측 슬관절 골괴사를 경험하였기에 보고하는 바이다. 대퇴골두 골괴사가 있는 환자에서 슬관절 동통을 호소하는 경우 연관통 등으로 여겨 간과하기 쉬우며, 대개 고관절의 통증으로 체중부하 보행이 어려운 경우가 많아 통증이 약하게 나타나기도 하기 때문에 관심을 가지고 슬관절 골괴사를 동반하는지 여부를 판단하여야 할 것이다. Osteonecrosis of the knee associated with osteonecrosis of the femoral head was very rare and reported cases were quite rare. We have experienced two cases of osteonecrosis of both knees associated with osteonecrosis of the femoral head. One is a 44-year-old man who had avascular necrosis of the righ femoral head and osteonecrosis of both knees, femoral condyle and metaphysis of proximal tibia. Another case is a 39-year-old man who had osteonecrosis of both femoral head and osteonecrosis of the both knees, medial condyles of both tibias. They were treated with total hip replacement arthroplasty for avascular necrosis of the femoral head and conservatively for osteonecrosis of the knee. If a person complains of pain in hip and knee simultaneously, we should pay attention and rule out osteonecrosis of the knee.