Brain SPECT 영상의 Attenuation Correction 방법들에 대한 비교

조진우,김창호,나수경,이귀원,Jo, Jin U,Kim, Chang Ho,Na, Soo Kyung,Lee, Gui Won 대한핵의학기술학회 2012 핵의학 기술 Vol.16 No.2

이 연구의 목적은 Brain SPECT (Single Photon Emission Computed Tomography)의 Non-attenuation correction (AC-non) 영상에 대한 attenuation correction(AC) 방법 중 Chang's method와 CT based attenuation correction(AC-CT) 사이의 count를 비교하기 위함이다. phantom study는 증류수로 채워진 hoffman 3D phantom에 $^{99m}Tc$ 37Mbq을 투여하였고, patient study는 normal volunteer에 $^{99m}Tc$-HMPAO 750Mbq를 정맥주입하고 Siemens사의 Symbia T6로 Brain SPECT 영상을 획득하였고 뇌 정량 분석을 하였다. 각각의 방법들을 적용한 transverse image는 같은 위치에서 재구성 되었으며 각각 10, 20, 30번째 slice에서 6개의 region of interest(ROI)를 그려 AC-non 과 AC-CT 그리고 Chang's method의 count를 비교하였다. phantom study에서 AC-non, AC-CT, Chang's method의 각각 평균 count는 $4606.8{\pm}511.3$, $16794.6{\pm}2429.4$, $8752.6{\pm}896.5$이었으며 patient study에서 $5460.8{\pm}519.6$, $15320{\pm}1171.6$, $12795{\pm}1422.1$이었다. phantom study에서 AC-CT와 AC-non 사이의 비는 3.70이고 Chang's method와 AC-non 사이의 비는 1.92였으며 patient study에서는 각각 2.85, 2.38이었다. 우리는 이 연구를 통하여 AC-CT가 Chang's method보다 더 높은 AC을 해준다는 걸 알 수 있었다. 그리고 Chang's method는 patient study에서의 AC 값이 phantom study에서의 AC값보다 더 높다는 것을 알 수 있었다. brain SPECT/CT를 시행하는 경우 scatter correction을 같이 시행하고 bone에 의한 감쇠 정보를 반영할 수 있는 AC-CT가 chang's method보다 정확하다 할 수 있겠다. Purpose : The purpose of this study was to compare count between Chang's method and CT-based attenuation correction (AC-CT) among the attenuation correction (AC) methods for non-attenuation correction (AC-non) images of Brain SPECT (Single Photon Emission Computed Tomography). Materials and Methods : We injected $^{99m}Tc$ 37Mbq in a Hoffman 3D phantom filled with distilled water in the phantom study, and injected intravenously $^{99m}Tc$-HMPAO 740Mbq in a normal volunteer in the patient study, and then obtained Brain SPECT images with Symbia T6 of Siemens and conducted quantitative brain analysis. Transverse images to which each method was applied were rebuilt at the same position, and 6 regions of interest (ROI) were drawn on each of Slice No. 10, 20 and 30 and then the counts of AC-non, AC-CT and Chang's method were compared. Results : The mean counts of AC-non, AC-CT and Chang's method were $4606.8{\pm}511.3$, $16794.6{\pm}2429.4$, and $8752.6{\pm}896.5$, respectively, in the phantom study and $5460.8{\pm}519.6$, $15320{\pm}1171.6$ and $12795{\pm}1422.1$, respectively, in the patient study. In the phantom study, the ratio of AC-CT to AC-non was 3.70 and the ratio of Chang's method to AC-non was 1.92, and in the patient study, they were 2.85 and 2.38, respectively. Conclusion : From this study, we found that AC-CT makes higher AC than Chang's method. In addition, when Chang's method was used, AC in the patient study was higher than that in the phantom study. These results need to be considered also in other examinations.

Development of a multimedia model (IIAQ-CC) to assess climate change influences on volatile and semi-volatile organic compounds in indoor environments

Chang, Lia,Lee, Yunah,Kim, Chan-Kook,Lee, Dong Soo Elsevier 2018 Building and Environment Vol.143 No.-

<P><B>Abstract</B></P> <P>An indoor air quality model (IIAQ-CC) was developed to assess climate change (CC) influences on indoor level of volatile or semi-volatile organic compounds. With IIAQ-CC, the CC influences is predicted in integrated manners by factors including fate/transport properties of pollutants, building characteristics, occupant behaviors, indoor emission sources, and outdoor air quality. IIAQ-CC was evaluated for the temperature sensitivity of indoor formaldehyde (FA) concentration at outdoor temperature below 20 °C. No significant difference (<I>t</I>-test, <I>p</I> < 0.05) was found between the predicted (3.9 ± 1.0%/<SUP>o</SUP>C) and the measured (5.0%/<SUP>o</SUP>C with a 95% confidence interval (3.7%/<SUP>o</SUP>C to 6.4%/<SUP>o</SUP>C)), demonstrating that IIAQ-CC can successfully predict CC influences driven by temperature change on VOCs of indoor environmental concern. IIAQ-CC predicts that the long-term FA concentration may slowly rise due to increase in the outdoor concentration or may decrease in the presence of strong indoor sources in RCP8.5 conditions of South Korea. In either case, the long-term change does not exceed 12% of the average FA concentration of the base period. Over a shorter period (e.g., a month), the FA level may noticeably rise (by about 4 times) when windows are closed due to exceedingly hot or cold weather. The FA concentration change is primarily governed by duration of windows kept open, which depends on outdoor temperature. That is, temperature manifests its effects on the indoor air quality essentially by change in window opening behavior rather than by changes in kinetics or equilibrium processes such as photo-degradation and sorption/desorption onto/from walls and floor.</P> <P><B>Highlights</B></P> <P> <UL> <LI> IIAQ-CC was developed to assess climate change impacts on indoor pollution level. </LI> <LI> IIAQ-CC predicts well temperature dependence of formaldehyde concentration change. </LI> <LI> Long-term formaldehyde levels digress within 12% of that in base period. </LI> <LI> Monthly mean formaldehyde levels increase up to 4 times under RCP8.5 conditions. </LI> <LI> Window opening behavior in response to temperature governs the indoor air quality. </LI> </UL> </P>

전치개교의 교정치료후 과두위치 변화

신수정,장영일 대한 두개하악장애학회 1993 대한두개하악장애학회지 Vol.5 No.2

ABSTRACTThis study was aimed to evaluate the changes in condylar position when severe anterior open bite pa- tients were treated with MEAW.The subjects consisted of 11 patients(21 TMJs) who visited the departement of orthodontics in SNUH, having severe anterior open bite as a chief complain. They were supposed to wear the up and down elas- tics and MEAW after finishing the leveling. The condylar position was evaluated with individualized cor- rected tomography in centric occlusion taken before and after treatment.The results were as follows; 1. In the change of condylar position after treatment, there were no statistically significant differences in right and left TMJs. 2. In the change of condylar position after treatment, there were no statistically significant differences in each malocclusion groups. 3. There were no statistically significant differences in percent dispacement of condyle between before and after treatment. 4. There were no statistically significant differences in the amount of change in condylar change. This study was aimed to evaluate the changes in condylar position when severe anterior open bite patients were treated with MEAW. The subjects consisted of 11 patients(21 TMJs) who visited the departement of orthodontics in SNUH, having severe anterior open bite as a chief complain. They were supposed to wear the up and down elastics and MEAW after finishing the leveling. The condylar position was evaluated with individualized corrected tomography in centric occlusion taken before and after treatment. The results were as follows ; 1. In the change of condylar position after treatment, there were no statistically significant differences in right and left TMJs. 2. In the change of condylar position after treatment, there were no statistically significant differences in each malocclusion groups. 3. There were no statistically significant differences in percent dispacement of condyle between before and after treatment. 4. There were no statistically significant differences in the amount of change in condylar change.

家兎에서 局所貧血이 筋肉變化에 미치는 影響에 關한 實驗的 硏究

金昌洙,李弘鍵 고려대학교 의과대학 1982 고려대 의대 잡지 Vol.19 No.1

Early detection of muscular changes in ischemia should be the utmost important and urgent problem in management and recovery of the muscles before irreversible picture developes. In the relevant literatures, many authors have studied upon histological changes of muscles. in ischemia employing various staining methods, such as hematoxylin and eosin (H&E), van Gieson etc., and reported that the earliest possible time fot detection of morphological changer in muscles were 3 to 4 hours after ischemia took place. Other methods, such as measurement of pressure in the muscular tissue with wick catheter, never conduction time, electromyography, tissue fluid analysis, enzyme study of serum, lactic acid study, ^(99m)Tc stannous pyrophosphate, electronmicroscopic study did not provide valuable early detection of muscular changes in ischemia. The author has undertaken an experimental study upon morphological changes of the muscles, after ischsmia were produced artificially with ligation of vessels and using tourniquet, and tried to detect early changes in the ischemic muscle by histochemical staining method developed by Lie et al., hematoxylin basic fuchsinpicric acid (HBFP) staining method. Twenty rabbits, weighing 2,000-2,500gm were divided into two groups. In group 1, tourniquet was applied on the proximal thigh, and in group 2, the unilateral common iliac artery and vein were ligated. In each group, muscle biopsies were carried out of the belly of the anterior tibial muscles in 10 minutes, 30 minutes, 1 hour, 2 fours, 3 hours, 6 hours, 24 hours, and 48 hours, respectively, while the applied tourniquet or ligation was released 6hours after application. The biopsied samples were fixed in formalin and stained with H&E and HBFP stain for microscopic evaluation of muscle changes. The results are as follows: 1. In group 1, the earliest evidence of muscular degeneration were detected by HBFP staining-method as early as 30 minutes after application of tourniquet, whereas it was required at least 3 hours to detect such change by H&E staining method. 2. In group 2, the earliest evidence of muscular degeneration were detected by HBFP staining method as early as 10 minutes after ligation of the vessels, whereas it was required atleast 2 hour to detect such change by H&E staining method. 3. In group 2, the minimal elapse of the time to detect muscular necrosis after ligation of the vessel was 2 hours by HBFP staining method whereas it took 24 hours by H&E staining method. 4. The above findings suggest that the HBFP staining is the most practical method to detect not omly early degenerative change of muscle but the evaluation of the extent of the changes due to ischemia.

喩昌의 生涯와 醫學思想

金秀烈,尹暢烈 대한한의학원전학회 1990 대한한의학원전학회지 Vol.4 No.-

At early Cheong (淸) dynasty, in medical aspect by dependent on practical studying attitude that must found a theory only by an evidence, there had been a tendancy that hoped direct research of sages' mind-eye by escaping the theory of individual classes since Geum-Won (金-元)dynasty. Yoo Chang(喩昌), born in Man-Ryeok(萬曆) 12th year of Myung(明) dynasty (A.D.1583) and dead in Gang-Hee(康熙) 3rd year of Cheong(淸) dynasty (A.D.1664). The results were as follows after studying his practical idea of medicine. 1. Yoo Chang, by recognizing the 《Sang-Han-Ron》 has lost its true meaning after commented by Wang hee(王熙), Lim Eog(林億), Seong Moo-I(成無己), etc. according to Bang Yoo-Jip's(方有執) Chak-Gan-Jung-Jeong(錯簡重訂) theory, he diversified the protocal of 《Sang-Han-Ron》 397 method and arranged under Six Meridian part.(六經) 2. The theory of Sam-Gang-Jeong-Rip(三網鼎立) can be summerized Gye-Ji(桂枝) syndrome which is the case of WInd(風) has injured Wi(衛) stage, Ma-hwang(麻黃) syndrome which is the case of Cold(寒) ahs injured Yeong(榮) stage, Dae-Cheong-Ryong(大靑龍) syndrome which is the case both of Wind-Cold(風寒) ahs injured Yeong-Wi(榮衛) stage, and there has been Sam-Gang-Jeong-Rip theory by anterior medical practitioners already but the person who formally used its Sam-Gang-Jeong-Rip term is Yoo-Chang. 3. Yoo Chang seized the On Byeng(溫病) by dividing three category and in Byon-Jeung-Si-Chi(辨證施治) he influenced to many aspect of establishment of later Byon-Jeung system On-Byong(溫病의 辨證體系) pertaining to Triple-Warmer by O-Dang(오당) introducing Triple-Warmer Theory.(三焦理論) 4. At Chu-Jo-Ron(秋燥論) of 《Eui-Moon-Beop-Ryol》, while 《Nae-Gyeong》 describing if humidity injury Lung, then occur a disorder in it, Yoo Chang recognized that of autuam when dryness injure Lung there occure a disorder is it so he insisted that at this case, must use Cheong-Joe-Goo-Pye method (淸燥救肺法) with herbs, pertaing to Gam-Yoo-Ja-Yoon(甘柔滋潤性) property and he invented Cheong-Joe-Goo-Pye-Tang.(淸燥救肺湯) 5. You Chang', so called, Dae-Gi(大氣) indicates Yang-Gi(陽氣) of chest, he insisted that man's creation and every physiological activity depends on maintainence of Dae-Gi, and it integrate Yeong-Gi(榮氣), Wea-Gi(衛氣), Jong-Gi(宗氣), Jang-Boo-Ji-Gi(臟腑之氣), Gyeong-Rak-Ji-Gi.(經絡之氣) 6. Yoo Chang's expression about partical function and character of stomach, not only bolster its theory of historical physician's expression, that is stomach is foundatness of postnatal period, but also it has correponding aspect with modern medicine and clinic. 7. Yoo Chang emphasized "if one cure a disease, be must understood the character of disease first and use drugs later"(先議病 後用藥) phrase about of drug usage, and his theory of Geup-Rew-Man-Joo method(急流挽舟) and three therapy of Simple Ascite(單腹脹) are all unique opinion based upon this phrase mentioned above. 8. Yoo Chang's practical idea of medicine greatly influenced to Jang Ro(張??), Hwang Won-A(黃元御), Oh Eui-Rak(吳儀洛) ,Joo Yang-Joon(周??俊), etc. and theory of Sam-Gang-Jeng-Rip(三網鼎立), Thriple Warmer Theory of On Byong (溫疫의 三焦論治), Chu-Jo-Ron(秋燥論), Dae-Gi-Ron(大氣論) etc. became important object to student of Sang-Han(傷寒) and On-Byeng.(溫病) 9. Yoo Chang's Writings has more practical meaning than other physician's, especially, later the idea of Sang-Han(傷寒) and On-Byong(溫病) greatly contributed to development of Sang-Han theory and formation of On-Byong theory.

대학 교양으로서 일반생물학 수업에서 ‘기후 변화’ 교육

박돈하(Don Ha Park),장수철(Soo Chul Chang) 목원대학교 교양교육혁신연구센터 2024 지식과 교양 Vol.- No.14

기후변화는 인류 모두가 풀어야 할 급하고도 중요한 과제이다. 그래서 대학 교육, 특히 교양교육에서 기후변화 교육을 수행해야 함은 이론의 여지 없이 너무도 당연하다. 본 연구는 생물학에서 가능한 ‘기후변화’ 교육을 모색하였다. 이를 위해 교양교육 과정의 일반생물학 교과 내용을 분석하였고 수도권과 지방의 국공립과 사립 대학이 개설한 교양생물학 교과 주제를 조사, 분석하였다. 분석 결과, 지구 기후 이해를 위한 원리와 개념을 제공하는 생태학 교육은 매우 중요하므로 교양 교과로서 일반생물학 수업은 원칙적으로 반드시 교과 과정에 생태학 단원을 포함하여야 한다는 결론에 이르렀다. 그런데 대학들의 교과 주제를 분석한 결과, 대부분 대학은 일반생물학 교과목에 이 단원을 포함하지 않았다. 이에 대한 대책으로, 생태학 단원 전체를 한 학기 또는 두 학기 교과 과정에 포함하지 못하더라도 기후변화에 관련된 5~6 주제를 다른 단원에 연결하여 수업을 진행할 수 있을 것이다. 또는 몇몇 대학처럼 생태학 교과목을 따로 개설할 필요가 있다. 또는 기후변화를 포함하는 다른 과학 교과목을 개설할 수도 있다. 다만, 이 경우 학생들의 교과목 수강 지도가 필요한데, 수강 지도를 담당하는 교원을 위한 기후변화 교육이 필요한 점은 과제로 남게 된다. 더불어 생물학뿐만이 아닌 자연과학과 인문사회과학을 포함한 여러 교양교육 교과들이 이러한 시도를 함으로써 기후변화라는 과제를 푸는 데에 도움을 제공하여야 한다. 더불어 교양기초교육원에서 제정한 ‘교양기초교육의 목적’에 기후변화에 관한 내용을 추가할 것을 제안한다. Climate change is an urgent and important problem that all humanity must solve. Therefore, it is indisputable that climate change education should be provided in universities, especially as part of liberal education. This study explored possible climate change education in biology. For this purpose, we analyzed the contents of the general biology curriculum in the general education curriculum and investigated and analyzed the topics of the general biology curriculum offered by public and private universities in the metropolitan area and local regions. As a result we came to the conclusion that general biology classes as a liberal arts subject must, in principle, include an ecology unit in the curriculum. However, most universities in Korea do not include this unit in their general biology curriculum. As a countermeasure, even if the entire ecology unit cannot be included in the curriculum for one or two semesters, the class can connect five to six topics related to climate change to other units. Otherwise, like some universities, there is a need to open a separate ecology course. Alternatively, other science courses that include climate change could be offered. In this case, though, guidance is needed for students to take the courses, and the need for climate change education for teachers in charge of course guidance remains an issue. In addition, various other liberal arts education subjects, including not only biology but also natural sciences, humanities, and social sciences, should also make such attempts to help solve the problem of climate change. Moreover, we propose adding content on climate change to the ‘Purpose of Liberal Education’ statement established by the Korea National Institute for General Education.

펠던크라이스 기법, 탄성밴드 운동 및 복합운동 적용이 현대무용전공자의 체간근력에 미치는 영향

김채수(Kim Chae-Soo),권혜영(Kwon Hye-Young),이원재(Lee Won-Jae),조창모(Jo Chang-Mo),김진환(Kim Jin-Hwan),주성범(Ju Sung-Bum),이미경(Lee Mi-Kyoung) 한국체육과학회 2011 한국체육과학회지 Vol.20 No.1

This study is carried out to examine the effect of applying Feldenkrais method, elastic band training and combined training on trunk muscle. The subjects of this study were 32 modern dance majors and they were divided into four groups which consists of 8 peoples each, Feldenkrais method group(modern dance + Feldenkrais method), elastic band training group(modern dance + elastic band training), combined training group(modern dance + Feldenkrais method + elastic band training), and control group(modern dance). Measurement variables which are trunk muscle were measured before training, and after 4 and 8 weeks training and the results are as follow: In the left muscle strength change at Centaur 0°, Feldenkrais method group, elastic band training group and combined training group showed significant increase after 8 weeks training compared to before training. In the right muscle strength change, Feldenkrais method group and combined training group had significant increase after 8 weeks training. In the left muscle strength change at Centaur 45°, Feldenkrais method group and combined training group showed significant increase after 8 weeks training compared to before training and after 4 weeks training. Also elastic band training group showed significant increase after 8 weeks training compared to before training. In the right muscle strength change, Feldenkrais method group and elastic band training group significantly increased after 8 weeks training compared to before training. In the left muscle strength change at Centaur 90°, Feldenkrais method group and combined training group showed significant increase after 4 and 8 weeks training compared to before training. In the right muscle strength change, Feldenkrais method group showed significant increase after 4 and 8 weeks training compared to before training, and elastic band training group significantly increased after 8weeks training compared to before training. In the left muscle strength change at Centaur 135°, there was no significant changes. In the right muscle strength change, elastic band training group and combined training group showed significant increase after 8 weeks training compared to before training. In the left muscle strength change at Centaur 180°, combined training group showed significant increase after 4 and 8 weeks training compared to before training. In the right muscle strength change, combined training group showed significant increase after 4 and 8 weeks training compared to before training. From above results, applying 8 weeks regular program of Feldenkrais method, elastic band training and combined training to modern dance majors showed positive changes on improvement of trunk muscle strength and physical strength. Also this study implemented to verify the effects of trunk muscle strength and body balance through supplementary training program, and showed the effects in the training group and control group after 8 weeks trunk muscle strengthening program. Feldenkrais method, elastic band training and combined training are very effective to improve trunk muscle strength of modern dance majors so that continuous implementation and application of these effective training program shall be provided for strengthening trunk muscle.

Long second toe: its nail and skin changes

( Geun-hwi Park ),( Woo-il Kim ),( Min-young Yang ),( Won-ku Lee ),( Tae-wook Kim ),( Sung-min Park ),( Hyun-joo Lee ),( Gun-wook Kim ),( Hoon-soo Kim ),( Hyun-chang Ko ),( Byung-soo Kim ),( Moon-bum 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.2

Background: Nail can be affected by trauma, infection, and systematic disorders. In particular, the toe nails are exposed to the repeated and cumulative minor traumas, which usually result in thickened, splitted, and discolorated nails. Considering these, it can be inferred that the long second toe can be related to various nail and skin changes by repeated minor traumas such as friction in shoes, but the study or report on this topic hasn’t been done yet. Objectives: The purpose of this study was to introduce various nail and skin changes on long second toe. Methods: We analyzed the kinds of nail/skin changes of 50 patients with long second toe, enrolled at Pusan National University Hospitals (Busan and Yangsan) from 2013 to 2018. Results: There was no significant difference in the incidence of left and right toe and toenail, and 7 (14%) patients presented bilateral distribution. The most common nail change on long second toe was melanonychia (23, 46%), followed by subungual hematoma (15, 30%), onycholysis (2, 4%), subungual hyperkeratosis (2, 4%), onychomadesis (1, 2%), and retronychia (1, 2%). The most common skin change was corn (9, 18%), followed by paronychia (2, 4%). Twenty (20/50, 40%) patients also had other toe or toenail changes. Among them, the most common site was big toe/nail (13, 62%), and the most common change was subungual hematoma (8, 42%). Conclusion: Through this study, the dermatologists can recognize and diagnose the nail and skin changes of long second toe.

Effect of Total Hip Arthroplasty on Ipsilateral Lower Limb Alignment and Knee Joint Space Width: Minimum 5-Year Follow-up

Choi Yun Seong,Park Jung-Wee,Kim Tae Woo,Kang Kee Soo,Lee Young-Kyun,Koo Kyung-Hoi,Chang Chong Bum 대한의학회 2023 Journal of Korean medical science Vol.38 No.20

Background: This study aimed to 1) assess the effect of total hip arthroplasty (THA) on coronal limb alignment, namely, the hip–knee–ankle angle (HKA), 2) identify factors that determine changes in the HKA, and 3) determine whether alignment changes influence the knee joint space width. Methods: We retrospectively evaluated 266 limbs of patients who underwent THA. Three types of prostheses with neck shaft angles (NSAs) of 132°, 135°, and 138° were used. Several radiographic parameters were measured in the preoperative and final radiographs (at least 5 years after THA). A paired t-test was used to confirm the effect of THA on HKA change. Multiple regression analysis was performed to identify radiographic parameters related to HKA changes following THA and changes in knee joint space width. Subgroup analyses were performed to reveal the effect of NSA change on the HKA change, and the proportion of total knee arthroplasty usage and changes in radiographic parameters between maintained joint space and narrowed joint space groups were compared. Results: The preoperative mean HKA was 1.4° varus and increased to 2.7° varus after THA. This change was related to changes in the NSA, lateral distal femoral angle, and femoral bowing angle. In particular, in the group with a decrease in NSA of > 5°, the preoperative mean HKA was largely changed from 1.4° varus to 4.6° varus after THA. The prostheses with NSA of 132° and 135° also led to greater varus HKA changes than those with an NSA of 138°. Narrowing of the medial knee joint space was related to changes in the varus direction of the HKA, decrease in NSA, increase in femoral offset. Conclusion: A large reduction in NSA can lead to considerable varus limb alignment after THA, which can have adverse effects on the medial compartment of the ipsilateral knee.

환경, 전략 및 조직특성의 변화와 벤처기업의 성과변화 : A Longitudinal Analysis

장수덕,송영화 한국중소기업학회 2003 中小企業硏究 Vol.25 No.1

본 연구의 목적은 IMF 경제위기를 전투한 벤체기업의 환경, 전략 및 조직특성의 변화와 성과변화간의 관계를 규명하는 것이다. 이를 위채 연구자들은 기존 연구를 토대로 연구모형과 가설을 개발했다. 그리고 가검증을 위해 IMF를 전후한 두 기간(1994년-7995년과 1997년-1999년)에 걸쳐 74개 벤처기업을 대상으로 종단적 자료를 수집했다. 수집된 자료를 토대로 연구자들은 벤처기업의 환경, 전략 및 조직특성의 변화와 성과변화 유형간의 관계를 다중 로지스틱 회귀분석을 통해 분석했다. 그 벨과 연구자들은 다음과 같은 연구결과를 얻을 수 있었다. 첫째, 벤처기업의 성과변화에는 원가 및 기술에 있어서 유리하게 전개된 환경적 변화가 중요한 영향을 미쳤다. 둘째, 벤처기업의 성과변화에는 원가우위, 마케팅차별화, 그리고 외부자원활용 전략의 변화가 중요한 영향을 미쳤다. 셋째, 벤처기업의 성과변화에는 조직특성에 있어서 계층화의 변화가 중요한 영향을 미쳤다. 이러한 연구결과를 토대로 연구자들은 본 연구가 가지는 몇 가지 이론적 및 실무적 시사점 도출할 수 있었다. This research purports to examine the relationship between changes in performance and changes concerning environmental, strategic and organizational aspects through a longitudinal study of Korean high-tech ventures before and after the IMF bailout programs. We developed a research model as well as a set of hypotheses by examining the previous studies. Longitudinal data were collected from 74 venture firms in two periods (1994-1996 and 1997-1999) to test the hypotheses. On the basis of collected data, we analysed how environmental, strategic and organizational factors are related to performance changes of ventures. The findings of this study are summarized as follows: 1) Performance changes of ventures were significantly related to favorable cost and technology transfer after the IMF-bailout program. 2) Performance changes of ventures were significantly related to strategies such as cost leadership, marketing differentiation, and external resource utilizing strategy. 3) Although the model 111 was low, it was shown that performance changes of ventures were related to organizational structure such as classification.