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Chondroid metaplasia of paraspinal connective tissue in the degenerative spine
Sjoerd Stevens,Sjoerd Stevens,Anouk Agten,Erika Wisanto,Melissa Lo Monaco,Jonas Verbrugghe,Annick Timmermans,Ivo Lambrichts,Frank Vandenabeele 대한해부학회 2019 Anatomy & Cell Biology Vol.52 No.2
A 51-year-old male was routinely biopsied during a paraspinal muscle study. The biopsy sample was taken from the right erector spinae muscle at the fourth lumbar vertebra. The patient had no history of (diagnosed) major back trauma. The obtained sample was histologically analyzed (hematoxylin and eosin, safranin O), and complementary magnetic resonance imaging was performed. The biopsied sample contained chondroid tissue. Based on its location, the biopsy sample was appointed as chondroid metaplasia. Although chondroid metaplasia is not uncommon in humans, this is the first report of chondroid metaplasia within the paraspinal connective tissue. We propose a novel mechanism to explain the paraspinal chrondrogenic changes, related to spinal degeneration.
The lumbar multifidus is characterised by larger type I muscle fibres compared to the erector spinae
Anouk Agten,Sjoerd Stevens,Jonas Verbrugghe,Bert O,Eijnde,Annick Timmermans,Frank Vandenabeele 대한해부학회 2020 Anatomy & Cell Biology Vol.53 No.2
The metabolic capacity of a muscle is one of the determinants of muscle function. Muscle fiber type characteristics give an indication about this metabolic capacity. Therefore it might be expected that the lumbar multifidus (MF) as a local stabilizer contains higher proportions of slow type I fibers, compared to the erector spinae (ES) as a global mobilizer. The aim of this study is to determine the muscle fiber characteristics of the ES and MF to provide insight into their structural and metabolic characteristics, and thereby the functional capacity of both muscles. Muscle fiber type characteristics in the ES and MF were investigated with an immunofluorescence staining of the myosin heavy chain isoforms. In both the ES and MF, type I muscle fibers are predominantly present. The cross-sectional area (CSA) of type I muscle fibers is significantly larger in the lumbar MF compared to the ES. However, the mean muscle fiber type percentage for type I was not significantly different, which resulted in an insignificant difference in relative cross-sectional area (RCSA) for type I. No significant differences were found for all other muscle fiber types. This may indicate that the MF displays muscle fiber type characteristics that tend to be more appropriate to maintain stability of the spine. However, because we could not demonstrate significant differences in RCSA between ES and MF, we cannot firmly state that there are functional differences between the ES an MF based only on structural characteristics.
Wulphert Venderink,Sjoerd FM Jenniskens,JP Michiel Sedelaar,Tsutomu Tamada,Jurgen J Fütterer 대한영상의학회 2018 Korean Journal of Radiology Vol.19 No.4
Objective: This study’s purposes were to determine the yield of repeat direct in-bore magnetic resonance-guided prostate biopsy (MRGB) (MRGB-2) after the first one was found to be negative (MRGB-1), to correlate with clinical parameters, and to present the subgroup analyses of patients with positive repeat biopsies, despite having a negative initial biopsies. Materials and Methods: We retrospectively included patients with MRGB-2 after a negative MRGB-1 both between January 2006 and August 2016. This study included 62 patients (median age, 63 years; interquartile range [IQR], 58−66 years) with 75 sampled lesions during MRGB-2 left for analysis, and 63 lesions were resampled and 12 new lesions were sampled. Included patients had a prostate specific antigen (PSA) at MRGB-1 of 13 ng/mL (IQR, 5.8−20.0) and a PSA at MRGB-2 of 15 ng/mL (IQR, 9.0−22.5). All anonymized magnetic resonance imaging (MRI) data were retrospectively reassessed according to Prostate Imaging-Reporting and Data System version 2 by two radiologists. Images of MRGB were compared to determine whether the same prostate lesion was biopsied during MRGB-1 and MRGB-2. Descriptive statistics were utilized to determine the yield of clinically significant prostate cancer (csPCa) at MRGB-2. Gleason score of ≥ 3 + 4 was considered csPCa. Results: In 16/75 (21%) lesions csPCa was detected during MRGB-2. Of 63 resampled lesions, 13 (21%) harbored csPCa at MRGB-2. In two patients, csPCa was detected on repeat biopsy, while the volume of the lesion decreased between MRGB-1 and MRGB-2. Conclusion: Patients could benefit from repeat biopsy after negative initial MRGB, especially in the case of increasing PSA values and persisting PCa suspicion in MRI. Further research is needed to establish predictors for positive repeat targeted biopsies.
Prognostic Value of Combined Biomarkers in Patients With Heart Failure: The Heartmarker Score
van der Stam Jonna A.,Bouwmeester Sjoerd,van Loon Saskia L. M.,van Riel Natal A. W.,Dekker Lukas R.,Boer Arjen-Kars,Houthuizen Patrick,Scharnhorst Volkher 대한진단검사의학회 2023 Annals of Laboratory Medicine Vol.43 No.3
Background: Heart failure (HF) biomarkers have prognostic value. The aim of this study was to combine HF biomarkers into an objective classification system for risk stratification of patients with HF. Methods: HF biomarkers were analyzed in a population of HF outpatients and expressed relative to their cut-off values (N-terminal pro-B-type natriuretic peptide [NT-proBNP] >1,000 pg/mL, soluble suppression of tumorigenesis-2 [ST2] >35 ng/mL, growth differentiation factor-15 [GDF-15] >2,000 pg/mL, and fibroblast growth factor-23 [FGF-23] >95.4 pg/mL). Biomarkers that remained significant in multivariable analysis were combined to devise the Heartmarker score. The performance of the Heartmarker score was compared to the widely used New York Heart Association (NYHA) classification based on symptoms during ordinary activity. Results: HF biomarkers of 245 patients were analyzed, 45 (18%) of whom experienced the composite endpoint of HF hospitalization, appropriate implantable cardioverter-defibrillator shock, or death. HF biomarkers were elevated more often in patients that reached the composite endpoint than in patients that did not reach the endpoint. NT-proBNP, ST2, and GDF-15 were independent predictors of the composite endpoint and were thus combined as the Heartmarker score. The event-free survival and distance covered in 6 minutes of walking decreased with an increasing Heartmarker score. Compared with the NYHA classification, the Heartmarker score was better at discriminating between different risk classes and had a comparable relationship to functional capacity. Conclusions: The Heartmarker score is a reproducible and intuitive model for risk stratification of outpatients with HF, using routine biomarker measurements.
A Novel DPP Based Polymer HTL for PbS CQD-SCs
천형진,김홍일,백세웅,류승언,이승진,최민재,최경원,Margherita Biondi,Sjoerd Hoogland,F. Pelayo Garcia de Arquer,권순기,박태호,Edward H. Sargent,김윤희 한국고분자학회 2021 한국고분자학회 학술대회 연구논문 초록집 Vol.46 No.1
DPP-based polymers are widely used in organic photovoltaics (OPV) and organic field-effect transistors (OFET) as the p-type materials. DPP with bithiophene (π-bridge) has already been proven to have excellent charge transport properties owing to an attractive S···O electrostatic interaction that induces π–π stacking. Therefore, we were performed Stille coupling reaction to combine these D–A building blocks to form the desired HTL. PD2FCT-29DPP (D1–A1–D1–A2) is a D–A alternating copolymer from the DPP (A2) and CPDT (D1) with fluorinated BT (A1). PD2FCT-29DPP-based devices achieve an FF of 70.0% and a PCE of 14.0%.
Perovskite energy funnels for efficient light-emitting diodes
Yuan, Mingjian,Quan, Li Na,Comin, Riccardo,Walters, Grant,Sabatini, Randy,Voznyy, Oleksandr,Hoogland, Sjoerd,Zhao, Yongbiao,Beauregard, Eric M.,Kanjanaboos, Pongsakorn,Lu, Zhenghong,Kim, Dong Ha,Sarge Nature Publishing Group 2016 Nature nanotechnology Vol.11 No.10
<P>Organometal halide perovskites exhibit large bulk crystal domain sizes, rare traps, excellent mobilities and carriers that are free at room temperature-properties that support their excellent performance in charge-separating devices. In devices that rely on the forward injection of electrons and holes, such as light-emitting diodes (LEDs), excellent mobilities contribute to the efficient capture of non-equilibrium charge carriers by rare non-radiative centres. Moreover, the lack of bound excitons weakens the competition of desired radiative (over undesired non-radiative) recombination. Here we report a perovskite mixed material comprising a series of differently quantum-size-tuned grains that funnels photoexcitations to the lowest-bandgap light-emitter in the mixture. The materials function as charge carrier concentrators, ensuring that radiative recombination successfully outcompetes trapping and hence non-radiative recombination. We use the new material to build devices that exhibit an external quantum efficiency (EQE) of 8.8% and a radiance of 80 W sr(-1) m(-2). These represent the brightest and most efficient solution-processed near-infrared LEDs to date.</P>
High Efficiency Colloidal Quantum Dot Photovoltaics via Robust Self-Assembled Monolayers
김기환,F. Pelayo Garcia de Arquer,윤영진,Xinzheng Lan,Mengxia Liu,Oleksandr Voznyy,Zhenyu Yang,Fengjia Fan,Alexander H. Ip,Pongsakorn Kanjanaboos,Sjoerd Hoogland,김진영,Edward H. Sargent 한국고분자학회 2016 한국고분자학회 학술대회 연구논문 초록집 Vol.41 No.1