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Key settings for successful Open Innovation Arena
Ashwin Sivam,Teresa Dieguez,Luís Pinto Ferreira,F.J.G. Silva 한국CDE학회 2019 Journal of computational design and engineering Vol.6 No.4
The purpose of this paper is to examine settings for the Open Innovation Arena. In greater depth, this paper aims to analyse and reveal which factors influence the formation of an appropriate arena for doing open innovation and furthermore to prescribe how a firm can create an effective arena to gain access to external knowledge. This paper presents a review on open innovation literature with the purpose of examining the current understanding of factors influencing a firm’s capacity to embrace and practice open innovation as well as understanding what is critical when fitting outside systems. It presents the results of a survey conducted among 25 researchers from INESC TEC, the Portuguese Institute for Systems and Computer Engineering, Technology, and Science. The study concludes that conditions, namely culture, leadership and strategy, are the main drivers to an open innovation arena, highlighting culture as the most important one.
Yu-Huan Gu,Gowsala Sivam 한국식품영양과학회 2006 Journal of medicinal food Vol.9 No.2
Twenty species of edible mushrooms and three purified mushroom polysaccharides were screened for their an-titumor potential on human androgen-independent cancer PC-3 cells. A water-soluble extract (POE) prepared from the freshoyster mushroom Pleurotus ostreatusproduced the most significant cytotoxicity on PC-3 cells among the mushroom speciestested. At the same time, POE induced a rapid apoptosis on PC-3 cells detected with annexin V-fluorescein isothiocyanateflow cytometry when the cells were exposed to POE (150 .g/mL) for 2 hours. Induced apoptosis was also confirmed by DNAfragment terminal deoxynucleotidyl transferase-mediated X-dUTP nick end labeling staining while POE (200 .g/mL) wasadded to PC-3 cells for 6 hours. Both cytotoxicity and induced apoptosis mediated by POE in PC-3 cells are dose-dependent.Interestingly, PC-3 cells appeared to be more sensitive to POE in anchorage-independent growth condition. Tumor colony-forming efficiency was dramatically reduced to 4.5% or 0.5% in POE (60 or 120 .g/mL)-supplemented soft agar mediumcompared with that of POE-free medium (defined as 100%). Temperature in POE processing plays a decisive role for the cy-totoxic activity. Bioactivity of POE was eliminated by exposure to high temperature (80°C) for 2 hours; however, it remained