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RISS 인기검색어
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- 저자 : Sirota, (검색결과 3 건)
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Transcranial electric stimulation entrains cortical neuronal populations in rats.
Ozen, Simal,Sirota, Anton,Belluscio, Mariano A,Anastassiou, Costas A,Stark, Eran,Koch, Christof,Buzsá,ki, Gyö,rgy The Society 2010 The Journal of neuroscience Vol.30 No.34
<P>Low intensity electric fields have been suggested to affect the ongoing neuronal activity in vitro and in human studies. However, the physiological mechanism of how weak electrical fields affect and interact with intact brain activity is not well understood. We performed in vivo extracellular and intracellular recordings from the neocortex and hippocampus of anesthetized rats and extracellular recordings in behaving rats. Electric fields were generated by sinusoid patterns at slow frequency (0.8, 1.25 or 1.7 Hz) via electrodes placed on the surface of the skull or the dura. Transcranial electric stimulation (TES) reliably entrained neurons in widespread cortical areas, including the hippocampus. The percentage of TES phase-locked neurons increased with stimulus intensity and depended on the behavioral state of the animal. TES-induced voltage gradient, as low as 1 mV/mm at the recording sites, was sufficient to phase-bias neuronal spiking. Intracellular recordings showed that both spiking and subthreshold activity were under the combined influence of TES forced fields and network activity. We suggest that TES in chronic preparations may be used for experimental and therapeutic control of brain activity.</P>
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Dendrite-like Process Formation and Cytoskeletal Remodeling Regulated by δ-Catenin expression
Kim, Kwonseop,Sirota, Anna,Chen, Yan-hua,Jones, Shiloh B.,Dudek, Ronald,Lanford, George W.,Thakore, Chittam,Lu, Qun 전남대학교 약품개발연구소 2002 약품개발연구지 Vol.11 No.-
Actin- and microtubule-mediated changes in cell shape are essential for many cellular activities. However, the molecular mechanisms underlying the interplay between the two are complex and remain obscure. Here we show that the expression of δ-catenin (or NPRAP/Neurojungin), a member of p120^ctm subfamily of armadillo proteins can induce the branching of dendrite-like processes in 3T3 cells and enhance dendritic morphogenesis in primary hippocampal neurons. This induction of branching phenotype involves initially the disruption of filamentous actin, and requires the growth of microtubules. The carboxyl-terminal truncation mutant of δ-catenin can cluster and redistribute the full-length protein, and dominantly inhibit its branching effect. δ-Catenin forms protein complexes and can bind directly to actin in vitro. The carboxyl-terminal truncation of δ-catenin does not interfere with its actin-binding capability; therefore the actin interaction alone is not sufficient for the induction of dendrite-like processes. When δ-catenin-transformed cells establish elaborate dendrite-like branches, the main cellular processes become stabilized and resist the disruption od both actin filaments and microscopy and time-lapse recording analyses. We suggest that δ-catenin can effect a biphasic cytoskeletal remodeling event which differentially regulates actin and microtubules and promotes cellular morphogenesis.
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Surfaces and slabs of fractional topological insulator heterostructures
Sahoo, Sharmistha,Sirota, Alexander,Cho, Gil Young,Teo, Jeffrey C. Y. American Physical Society 2017 Physical Review B Vol.96 No.16
<P>Fractional topological insulators (FTIs) are electronic topological phases in (3 + 1) dimensions enriched by time reversal (TR) and charge U(1) conservation symmetries. We focus on the simplest series of fermionic FTIs, whose bulk quasiparticles consist of deconfined partons that carry fractional electric charges in integral units of e* = e/(2n + 1) and couple to a discrete Z(2n+1) gauge theory. We propose massive symmetry preserving or breaking FTI surface states. Combining the long-ranged entangled bulk with these topological surface states, we deduce the novel topological order of quasi-(2 + 1)-dimensional FTI slabs as well as their corresponding edge conformal field theories.</P>
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