Creativity, Communication and Collaboration: The Identification of Pedagogic Progression in Sustained Shared Thinking

Iram Siraj-Blatchford 환태평양유아교육연구학회 2007 Asia-Pacific journal of research in early childhoo Vol.1 No.2

The central purpose of this paper has been to provide a conceptual model that is capable of supporting the development of appropriate early childhood practices for the 21st Century. A strong consensus has emerged regarding the importance of devel- oping Communication, Collaboration and Creativity during the early years. The paper argues that these three principles are related to each other very closely at the level of theory and in some of the very best early childhood education practice. It is argued that, at the level of practice; creativity, communication, and collaboration are all combined in ‘sustained shared thinking’, which has been identified as a particularly effective pedagogic strategy in the qualitative case studies conducted to support the longitudinal study Effective Provision of Pre-School Education in England (Siraj- Blatchford and Sylva, 2004). These ‘three Cs’ (Communication, Collaboration and Creativity) are also explicitly prioritised in each of the five international models of early childhood education (ECE) identified in the 2004 Starting Strong: Curricula and Pedagogies in Early Childhood Education and Care Report (OECD, 2004). But it is extremely important to recognise that the pedagogic form that ‘Sustained Shared Thinking’ takes with children under age two is quite different from that most appro- priate for three to five year olds when, in their socio-dramatic play, young children are quite naturally separating objects and actions from their meanings in the real world and giving them new meanings. By around age five, children’s powers of ex- pression and abstraction may also be enhanced when they are encouraged to commu- nicate these creative representations in the play room (van Oers, 1999). The paper concludes by identifying some key principles to be applied in developing effective ‘Pedagogic Progression’ in nurseries and kindergartens that often cater for a broad age range of young children. These were illustrated at the PECERA

The Investment Protection Chapter of the EU-Singapore Free Trade Agreement: A Model for the Post-Brexit UK IIAs

Siraj Shaik Aziz (사) 이준국제법연구원 2017 Journal of East Asia and International Law Vol.10 No.1

The impending British exit (Brexit) from the European Union has placed the UK’s investment policy at a crossroads. A post-Brexit UK will now have to reorganise its investment relationships with its economic partners through bespoke UK IIAs. This exercise will have to accommodate the shifting zeitgeist concerning the balance of investors’ rights and the right to regulate IIAs that is expected. This paper examines the continued relevance of the recently minted Investment Protection Chapter in the EU-Singapore Free Trade Agreement, acknowledged by Britain’s power brokers, as a persuasive model for the UK to emulate for this purpose. This is notwithstanding the uncertainties that now surround the implementation and efficacy of the Agreement in light of Brexit and a pending decision from the Court of Justice of the European Union. Such emulation would ultimately make for a better Investor-State Dispute Settlement System in the UK IIAs by providing a much needed update to its old investment treaty architecture.

Structural investigation of ginsenoside Rf with PPARγ major transcriptional factor of adipogenesis and its impact on adipocyte

Siraj, Fayeza Md,Natarajan, Sathishkumar,Huq, Md Amdadul,Kim, Yeon Ju,Yang, Deok Chun The Korean Society of Ginseng 2015 Journal of Ginseng Research Vol.39 No.2

Background: Adipocytes, which are the main cellular component of adipose tissue, are the building blocks of obesity. The nuclear hormone receptor $PPAR{\gamma}$ is a major regulator of adipocyte differentiation and development. Obesity, which is one of the most dangerous yet silent diseases of all time, is fast becoming a critical area of research focus. Methods: In this study, we initially aimed to investigate whether the ginsenoside Rf, a compound that is only present in Panax ginseng Meyer, interacts with $PPAR{\gamma}$ by molecular docking simulations. After we performed the docking simulation the result has been analyzed with several different software programs, including Discovery Studio, Pymol, Chimera, Ligplus, and Pose View. All of the programs identified the same mechanism of interaction between $PPAR{\gamma}$ and Rf, at the same active site. To determine the drug-like and biological activities of Rf, we calculate its absorption, distribution, metabolism, excretion, and toxic (ADMET) and prediction of activity spectra for substances (PASS) properties. Considering the results obtained from the computational investigations, the focus was on the in vitro experiments. Results: Because the docking simulations predicted the formation of structural bonds between Rf and $PPAR{\gamma}$, we also investigated whether any evidence for these bonds could be observed at the cellular level. These experiments revealed that Rf treatment of 3T3-L1 adipocytes downregulated the expression levels of $PPAR{\gamma}$ and perilipin, and also decreased the amount of lipid accumulated at different doses. Conclusion: The ginsenoside Rf appears to be promising compound that could prove useful in antiobesity treatments.

COLLOCATION METHOD USING QUARTIC B-SPLINE FOR NUMERICAL SOLUTION OF THE MODIFIED EQUAL WIDTH WAVE EQUATION

Siraj-ul-Islam,Fazal-i-Haq,Ikram A. Tirmizi 한국전산응용수학회 2010 Journal of applied mathematics & informatics Vol.28 No.3

A Numerical scheme based on collocationmethod using quartic B-spline functions is designed for the numerical solution of one-dimensional modified equal width wave (MEW) wave equation. Using Von-Neumann approach the scheme is shown to be unconditionally stable. Performance of the method is validated through test problems including single wave,interaction of two waves and use of Maxwellian initial condition. Using error norms L2 and L1 and conservative properties of mass, momentum and energy, accuracy and efficiency of the suggested method is established through comparison with the existing numerical techniques.

Evolvulus alsinoides: A potential antihypertensive herb

Siraj, Mantasha Binth,Khan, Asim Ali,Jahangir, Umar,Hashimi, Ayshah,Ahmad, Yasmeen Cellmed Orthocellular Medicine and Pharmaceutical 2019 셀메드 (CellMed) Vol.9 No.4

In spite of the fact that a variety of unfailing guidelines are existing for the management of hypertension, the problem of inadequate managing of this condition still continues. Several classes of existing antihypertensive drugs are associated with various side-effects. Since ancient times before the advent of anti-hypertensive drugs, this disease has been treated by the prominent classical scholars. Various herbal drugs are being used since ages for the treatment of hypertension and some of them are validated too. Evolvulus alsinoides is also one such herb used in classical literature since ages for various disorders like insanity, anxiety, nervous debility, epilepsy, melancholy, palpitation and many others. This review is to highlight the antihypertensive potential of Evolvulus alsinoides.

Ginsenoside F2 possesses anti-obesity activity via binding with PPARγ and inhibiting adipocyte differentiation in the 3T3-L1 cell line

Siraj, Fayeza Md.,SathishKumar, Natarajan,Kim, Yeon Ju,Kim, Se Young,Yang, Deok Chun Informa UK Ltd. 2015 Journal of enzyme inhibition and medicinal chemist Vol.30 No.1

<P><I>Panax ginseng</I> Meyer has been shown to be effective in mitigating various diseases. Protopanaxadiols (PPD) and protopanaxatriols (PPT), which are the main constituents of ginseng, have been shown to impact obesity. Therefore, we selected several important ginsenosides to perform our docking study and determine if they had binding affinity with the peroxisome proliferator activated receptor gamma (PPARγ), which is a major transcription factor in adipocytes. Among them, only a few ginsenosides demonstrated binding affinity with PPARγ. Other than ginsenoside F2 rest of them were previously reported by the researchers in experimental study in case of obesity cell line 3T3-L1 adipocyte. In few recent studies, it was reported that F2 has protective effects on malignant brain tumors as well as anti-cancer activity in breast cancer. Therefore, we felt it was important to focus on F2 when considering obesity. Our study focused on this ginsenoside and analyzed its impact on 3T3-L1 adipocytes. Following the molecular interaction studies, further experimental studies were carried out and demonstrated that ginsenoside F2 when treated with different doses reduces the level of lipid accumulated by the 3T3-L1 cell line during adipogenesis. Reverse transcriptase polymerase chain reaction (RT-PCR) and quantitative real-time PCR results showed reduction in PPARγ and perilipin gene expression levels compared to that of differentiated adipocytes without any treatment. So considering the binding with a major adipocyte transcription factor and the performed experiments, we suggest that ginsenoside F2 may reduce obesity via the inhibition of adipogenesis in the 3T3-L1 cell line.</P>

Temperature dependency rare earth free Fe5SiC permanent magnet

Haq Siraj,Jisang Hong 한국자기학회 2023 한국자기학회 학술연구발표회 논문개요집 Vol.33 No.1

Prediction of Lysine 2-Hydroxysisobutyrylation sites by using a deep learning approach

Arslan Siraj,Jung Mu Kim,Minho Song,Kil To Chong 대한전기학회 2021 대한전기학회 워크샵 Vol.2021 No.4

Protein hydroxysisobutyrylation is an important post-translational modification process that performs a critical role in a wide range of biological processes as regulating protein function, regulating gene transcriptional activity, tricarboxylic acid cycle, role in glycolysis/gluconeogenesis, and especially enriched in mitochondrial proteins within energy metabolic networks. Owing to the significant role of protein hydroxysisobutyrylation, these sites can be identified by enzymatic approaches, mass spectrometry analysis, and combinations of multidimensional liquid chromatography and tandem mass spectrometry. However, these large-scale experimental screening techniques are time-consuming, expensive, and laborious. To overcome the drawbacks of experimental methods, machine learning and deep learning-based predictors were considered for prediction in a timely and cost-effective manner. In this study, we proposed a novel approach for predicting plant hydroxysisobutyrylation sites using a deep learning model by utilizing different types of techniques. The proposed method uses the actual protein sequence will take inputs to the model and provides more robust predictions.

Highly Efficient Oxygen Reduction Reaction Activity of Graphitic Tube Encapsulating Nitrided Co<i>_x</i> Fe<i>_y</i> Alloy

Sultan, Siraj,Tiwari, Jitendra N.,Jang, Jue-Hyuk,Harzandi, Ahmad M.,Salehnia, Foad,Yoo, Sung Jong,Kim, Kwang S. Wiley (John WileySons) 2018 ADVANCED ENERGY MATERIALS Vol.8 No.25

Atomistic Simulation of Temperature Dependent Magnetic Properties of Hole Doped 2H-VSe2 Bilayer

Haq Siraj,Jisang Hong 한국자기학회 2023 Journal of Magnetics Vol.28 No.1

Density functional theory calculations provide very accurate physical quantities at zero Kelvin. Nonetheless, it is necessary to understand how the physical quantities are changed at finite temperatures for real device application purposes. Here, we investigate the finite temperature dependent magnetic properties of hole doped 2H-VSe2 bilayer structure using atomistic simulation. We find that the Curie temperature of 600 K at the hole concentration of 2.27×1020 cm-3, and this is enhanced to 620 K at the hole concentration of 3.01×1020 cm-3. We fit the temperature dependent magnetization curve (M(T)) using both Curie-Bloch and Kuz’min equations. We also calculate temperature dependent magnetic anisotropy energy. We find that the magnetic anisotropy energy is almost linearly decreased with increasing temperature. Besides, we obtain that the normalized temperature dependent anisotropy constant [K(T)/K(0)] shows the relation to the temperature dependent magnetization curve of [M(T)/M(0)] 2.9, and this is well converged with the exponent of 2.9 in the Callen-Callen theory.