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Ivana Matić,Zeljko Zizak,Mladen Simonovic,Branislav Simonovic,Dejan God-evac,Katarina Savikin,Zorica Juranic 한국식품영양과학회 2010 Journal of medicinal food Vol.13 No.4
Red and white wine polyphenols have been reported to provide substantial health benefits. In this study, the cytotoxic activity of red and white wine polyphenolic extracts and of resveratrol was evaluated against different cancer cell lines—human cervix adenocarcinoma HeLa, human breast adenocarcinoma MDA-MB-361, and human breast carcinoma MDA-MB-453—and normal human peripheral blood mononuclear cells (PBMCs). Qualitative and quantitative compositions of wine polyphenolic extracts obtained by fractional vacuum distillation of corresponding wines were determined using spectrophotometric methods and high-performance liquid chromatography with diode array detection and liquid chromatography with electrospray ionization-time of flight mass spectrometry analysis. It was demonstrated that wine polyphenolic extracts and resveratrol exerted higher cytotoxic activity against HeLa and MDA-MB-453cells in comparison to MDA-MB-361cells and unstimulated and stimulated PBMCs. Furthermore, white wine polyphenolic extract exhibited a significantly higher antiproliferative action on cancer cell lines than red wine extract. The presence of condensed or fragmented nuclei in HeLa cells, pretreated with extract of white wine and stained with a mixture of acridine orange and ethidium bromide, pointed to the morphological signs of apoptosis. In addition, HeLa cells in late stages of apoptosis or secondary necrosis were also observed. Results from our study suggest that polyphenolic extracts from red and white wine may have anticarcinogenic potential.
Systematic Approach for Variable Selection in the Weather Generator Model
Hyung-Il Eum,Slobodan P,Simonovic 한국방재학회 2016 Journal of Disaster Management Vol.1 No.3
This study provides an analytical procedure for selecting variables for the Weather Generator (WG) model to be used in the assessment of climatic change impacts at a local scale. The approach integrates the K-NN technique with the Principle Component Analysis (PCA), termed of WG-PCA. The Upper Thames River Basin in South-Western Ontario, Canada is selected as a case study. The outcome of the WG model includes 38 years of synthetically generated data. In the study we tested three models: (a) the WG-1Var employing only one variable (precipitation); (b) WG-3Var employing three variables (precipitation, maximum temperature, and minimum temperature); and (c) WG-PCA. The simulation results indicate that WG models employing three variables (WG-3Var and WG-PCA) produce the meteorological variables with better temporal and spatial correlation compared to the WG-1Var. More notable result is that the WG-PCA employing only the first principle component provides the comparable results to those of WG-3Var and much better results than WG-1Var.
Parameters of Calcium Metabolism Fluctuated during Initiation or Changing of Antipsychotic Drugs
Dragan R. Milovanovic,Marijana Stanojevic Pirkovic,Snezana Zivancevic Simonovic,Milovan Matovic,Slavica Djukic Dejanovic,Slobodan M. Jankovic,Dragan Ravanic,Milan Petronijevic,Dragana Ignjatovic Risti 대한신경정신의학회 2016 PSYCHIATRY INVESTIGATION Vol.13 No.1
ObjectiveaaSerum parameters of calcium homeostasis were measured based on previously published evidence linking osteoporotic fractures and/or bone/mineral loss with antipsychotics. MethodsaaProspective, four-week, time-series trial was conducted and study population consisted of patients of both genders, aged 35-85 years, admitted within the routine practice, with acute psychotic symptoms, to whom an antipsychotic drug was either introduced or substituted. Serial measurements of serum calcium, phosphorous, magnesium, 25(OH)D, parathyroid hormone, calcitonin, osteocalcin and C-telopeptide were made from patient venous blood samples. ResultsaaCalcium serum concentrations significantly decreased from baseline to the fourth week (2.42±0.12 vs. 2.33±0.16 mmol/L, p=0.022, n=25). The mean of all calcemia changes from the baseline was -2.6±5.7% (-24.1 to 7.7) with more decreases than increases (78 vs. 49, p=0.010) and more patents having negative sum of calcemia changes from baseline (n=28) than positive ones (n=10) (p=0.004). There were simultaneous falls of calcium and magnesium from baseline (63/15 vs. 23/26, p<0.001; OR=4.75, 95% CI 2.14–10.51), phosphorous (45/33 vs. 9/40, p<0.001; 6.06, 2.59–14.20) and 25(OH)D concentrations (57/21 vs. 13/35, p<0.001; 7.31, 3.25–16.42), respectively. Calcemia positively correlated with magnesemia, phosphatemia and 25(OH)D values. Parathyroid hormone and C-telopeptide showed only subtle oscillations of their absolute concentrations or changes from baseline; calcitonin and osteocalcin did not change. Adjustment of final calcemia trend (depletion/accumulation) for relevant risk factors, generally, did not change the results. ConclusionaaIn patients with psychotic disorders and several risks for bone metabolism disturbances antipsychotic treatment was associated with the decrease of calcemia and changes in levels of the associated ions.
Advanced Fast 3-D Electromagnetic Solver for Microwave Tomography Imaging
Simonov, Nikolai,Bo-Ra Kim,Kwang-Jae Lee,Soon-Ik Jeon,Seong-Ho Son IEEE 2017 IEEE transactions on medical imaging Vol.36 No.10
<P>This paper describes a fast-forward electromagnetic solver (FFS) for the image reconstruction algorithm of our microwave tomography system. Our apparatus is a preclinical prototype of a biomedical imaging system, designed for the purpose of early breast cancer detection. It operates in the 3-6-GHz frequency band using a circular array of probe antennas immersed in a matching liquid; it produces image reconstructions of the permittivity and conductivity profiles of the breast under examination. Our reconstruction algorithm solves the electromagnetic (EM) inverse problem and takes into account the real EM properties of the probe antenna array as well as the influence of the patient's body and that of the upper metal screen sheet. This FFS algorithm is much faster than conventional EM simulation solvers. In comparison, in the same PC, the CST solver takes similar to 45 min, while the FFS takes similar to 1 s of effective simulation time for the same EM model of a numerical breast phantom.</P>
3D Microwave Breast Imaging Based on Multistatic Radar Concept System
Nikolai Simonov,Soon-Ik Jeon,Seong-Ho Son,Jong-Moon Lee,Hyuk-Je Kim 한국전자파학회JEES 2012 Journal of Electromagnetic Engineering and Science Vol.12 No.1
Microwave imaging (MI) is one of the most promising and attractive new techniques for earlier breast cancer detection. Microwave tomography (MT) realizes configuration of a multistatic multiple-input multiple-output system and reconstructs dielectric properties of the breast by solving a nonlinear inversion scattering problem. In this paper, we describe ETRI 3D MT system with 3D MI reconstruction program and demonstrate its robustness through some examples of the image reconstruction.
Ion implantation of Rare-Earth elements in a structure of optical materials
Radjabov T.D.,Simonov A.A. 대한전자공학회 2008 ICEIC:International Conference on Electronics, Inf Vol.1 No.1
Developed a modern technology of rareearths metal ions implantation in optical fibers by means of vacuum ion bombardment. High temperature annealing enhanced the ions penetration depth. Fabricated fibers were used in EDFA.
Preclinical Prototype Development of a Microwave Tomography System for Breast Cancer Detection
Seong-Ho Son,Nikolai Simonov,Hyuk-Je Kim,Jong-Moon Lee,Soon-Ik Jeon 한국전자통신연구원 2010 ETRI Journal Vol.32 No.6
As a supplement to X-ray mammography, microwave imaging is a new and promising technique for breast cancer detection. Through solving the nonlinear inverse scattering problem, microwave tomography (MT) creates images from measured signals using antennas. In this paper, we describe a developed MT system and an iterative Gauss-Newton algorithm. At each iteration, this algorithm determines the updated values by solving the set of normal equations using Tikhonov regularization. Some examples of successful image reconstruction are presented.
Investigation of Phase Singularity Problem in Microwave Breast Tomography
Soon-Ik Jeon,Kwang-Jae Lee,Nikolai Simonov,Seong-Ho Son 한국전자파학회JEES 2014 Journal of Electromagnetic Engineering and Science Vol.14 No.4
This paper investigates the phase singularity problem in microwave image reconstruction utilizing unwrapped phase data. The measured phases of the electric fields in most microwave measurement systems are wrapped. Thus, a certain phase unwrapping process is necessary for reconstruction of the image of a high contrast object. This unwrapping, however, is difficult in the presence of scattering nulls on/near the unwrapping path. At the null point, the phase value will be rendered, resulting in a poor image reconstruction. In this paper, we investigate the phase singularity arising from electromagnetic scattering nulls in microwave breast tomographic imaging. We then propose a transformation technique for the measured electric fields that avoids phase singularity.