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Rare and Fatal Gastrointestinal Mucormycosis (Zygomycosis) in a COVID-19 Patient: A Case Report
Epifanio Silvino do Monte Junior,Marcos Eduardo Lera dos Santos,Igor Braga Ribeiro,Gustavo de Oliveira Luz,Elisa Ryoka Baba,Bruno Salomão Hirsch,Mateus Pereira Funari,Eduardo Guimarães Hourneaux De Mo 대한소화기내시경학회 2020 Clinical Endoscopy Vol.53 No.6
The novel coronavirus disease (COVID-19) quickly spread to all continents. However, data regarding all the signs and symptomsof COVID-19 are insufficient. Patients with COVID-19 might present higher susceptibility to fungal coinfections. Mucormycosis isa rare and often life-threatening fungal disease characterized by vascular invasion by hyphae, resulting in thrombosis and necrosis. This is the first case report of mucormycosis in a COVID-19 patient. An 86-year-old male patient was admitted to the emergencyroom with acute diarrhea, cough, dyspnea, and fever from 5 days prior. Blood tests revealed a hemoglobin level of 14.3 mg/dL. Fivedays following the admission, the patient presented with melena and a hemoglobin level of 5.6 mg/dL. A transfusion of three unitsof red blood cells was required. Esophagogastroduodenoscopy revealed two giant gastric ulcers with necrotic debris and a deephemorrhagic base without active bleeding. Furthermore, biopsies confirmed mucormycosis. Despite intensive care, the patient died36 hours after the esophagogastroduodenoscopy.
Everaldo Silvino dos Santos,Carlos Eduardo de Araújo Padilha,Nathália Kelly de Araújo,Domingos Fabiano de Santana Souza,Jackson Araújo de Oliveira,Gorete Ribeiro de Macedo 한국화학공학회 2016 Korean Journal of Chemical Engineering Vol.33 No.9
A phenomenological model was used to describe sequentially the three steps (flowthrough, washing and elution) of expanded bed adsorption chromatography for recovery of chitosanases from Bacillus cereus. Additionally, a hybrid strategy for model parameter estimation was carried out using particle swarm optimization and Gauss-Newton algorithms. The model was validated with independent experimental data and the statistical criteria (χ 2 and mean squared error tests) showed that the hybrid strategy was more promising than just the heuristic method. With the calibrated model, surface response methodology was applied to obtain the optimal operational conditions, and experiments were performed to confirm these results. Overall, a value of 41.08% for yield was obtained using 700mM NaCl during elution. In summary, all approach employed in this work was relevant for maximizing the yield of the chromatographic process.
Sergio Carvalho de Santana,Everaldo Silvino dos Santos,Raimundo Cosme da Silva Filho,Jorge dos Santos Cavalcanti,Jackson Araujo de Oliveira,Gorete Ribeiro de Macedo,Francine Ferreira Padilha 한국화학공학회 2014 Korean Journal of Chemical Engineering Vol.31 No.4
A mathematical model was developed to predict breakthrough curves during purification of the two chitosanasesfrom Metarhizium anisopliae by expanded bed adsorption, taking into account the axial dispersion of liquid andusing Streamline DEAE and SP XL adsorbents, anion and cation exchange resins, respectively. All the experimentswere performed without clarification (with cells) aiming at the reduction of unit operations in future projects of separationprocesses, thereby reducing capital and operating costs. Chitosanases are enzymes that hydrolyze the carbohydratechitosan, resulting in oligosaccharides that have many remarkable biological activities, such as anti-cancer, anti-HIVand antioxidant activities. The two adsorbents had similar performance in relation to hydrodynamics and mass transfer. The results of the parametric sensitivity analysis agree with the literature, and the model was validated with an averagehigh degree of fit (94.68%) between simulated and experimental data obtained in this work.