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Siahaan Andre Marolop Pangihutan,Susanto Martin,Lumbanraja Sarma Nursani,Ritonga Dwi Herawati 대한소아청소년과학회 2023 Clinical and Experimental Pediatrics (CEP) Vol.66 No.1
Background: Myelomeningocele is a lifelong condition that features several comorbidities, such as hydrocephalus, scoliosis, club foot, and lower limb sensory and motor disabilities. Its management has progressed over time, ranging from supportive care to early postnatal closure to prenatal closure of the defect. Recent research discovered that fetal myelomeningocele closure (fMMC) provided superior neurological outcomes to those of postnatal closure. When performed at 12 months of age, fMMC can avert or delay the need for a ventriculoperitoneal shunt and reversed the hindbrain herniation. Moreover, fMMC reportedly enhanced motor function and mental development at 30 months of age. However, its long-term outcomes remain dubious.Purpose: This systematic review aimed to determine the long-term neurological cognitive, behavioral, functional, and quality of life (QoL) outcomes after fMMC.Methods: The PubMed, Directory of Open Access Journals, EBSCO, and Cochrane databases were extensively searched for articles published in 2007–2022. Meta-analyses, clinical trials, and randomized controlled trials with at least 5 years of follow-up were given priority.Results: A total of 11 studies were included. Most studies revealed enhanced long-term cognitive, behavioral, functional, and QoL outcomes after fMMC.Conclusion: Our results suggest that fMMC substantially enhanced patients’ long-term neurological cognitive, behavioral, functional, and QoL outcomes.
Factors Determining Decision to Rent Low-Cost Flats (RUSUNAWA)
Elisabet SIAHAAN,Khaira Amalia FACHRUDIN,Hilma Tamiami FACHRUDIN,Iskandar MUDA 한국유통과학회 2021 The Journal of Asian Finance, Economics and Busine Vol.8 No.6
The purpose of this study is to analyze and to provide suggestions to the government as developers and managers of RUSUNAWA to make it more effective and efficient in building and managing it. This research was conducted in three locations of rented low-cost flats in North Sumatra, namely RUSUNAWA Kayu Putih, RUSUNAWA Seruwai Belawan, and RUSUNAWA Binjai. The majority of respondents in this study were women who were in the productive age group of 30–40 years, but economic difficulties forced them to live in low-cost flats. This phenomenon shows that in the productive age poverty also occurs. This research applied a quantitative descriptive method by selecting three locations of RUSUNAWA in two cities in the North Sumatra Region and involving 200 tenants as respondents. The data was obtained by observing, interviewing, and distributing research questionnaires, and then were processed by SEM-PLS. The results showed that the factors determining the tenants to rent RUSUNAWA in North Sumatra Province are convenience, attractiveness, sanitation, cleanliness, design, and the location offered. It indicates that a healthy and clean environment, the condition of the building, and the facilities offered become the priorities for the tenants.
Evi Amelia Siahaan,Aviannie Meillisa,우희철,이철우,한정호,전병수 한국식품과학회 2013 Food Science and Biotechnology Vol.22 No.suppl1
Allyl isothiocyanate (AITC), a naturally occurring antimicrobial compound, is an effective inhibitor of various pathogens, but its use in the food industry is limited by its volatility and pungency. The objective of this study was to overcome the volatility of AITC using dried Laminaria japonica and mesoporous silica MCM-41 as its carrier. AITC-loaded L. japonica (raw and deoiled) powder and silica MCM-41 was achieved via vapor adsorption. The study of AITC adsorption and desorption was determined by monitoring sample weight changing with time. AITC presence in L. japonica and MCM-41 samples was confirmed by FTIR spectroscopy. Antimicrobial tests were made against 4 microorganisms: Bacillus cereus, Staphylococcus aureus,Escherichia coli, and Salmonella Typhimurium. Controlled release and antimicrobial activity from MCM-41 was always superior to those from raw and deoiled L. japonica.
( Posma Budianto Siahaan ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Dengue haemorhagic fever (DHF) and malaria are two of tropical infectious disease that endemic in Indonesia and may relaps. Artemeter-lumefantrine often used to malaria case without add on primaquine treatment to prevent malaria relaps (especially plasmodium vivax that often hiding at visceral tissue). Methods: This multiple case reports observed at Myria Hospital, Palembang, South Sumatera, Indonesia. The limitation of case from 1 Juni 2013 to 31 Mei 2014.We observed the patients that diagnosed with DHF (WHO criteria) combined with malaria (malaria rapid test) that gave artemether-lumefantrine treatment with/without add on primaquine. Patients may discharge from the hospital if the malaria rapid test negatif and the trombosit arise 2 days consecutive, more than 50.000/mm3. Patient re-admitted to the hospital with same case was re-observed,another patients were followed up once after discharged and we suggested to follow up again if they have fever. Results: Fourteen patients was reported, 12 with malaria tertiana and 2 with malaria tropicana. Two patients with malaria tertiana had add on primaquine treatment for 14 days, another patients had not. One of 10 (10%) patients with malaria tertiana without add on primaquine treatment re-admitted to the hospital with the same case 5 mounths later. Conclusions: We suggest to use add on primaquine treatment to DHF combine with malaria to prevent its relaps, especially in malaria tertiana case.
A Critical Analysis of Intracranial Hemorrhage as a Fatal Complication of Dengue Fever
Andre Marolop Pangihutan Siahaan,Steven Tandean,Bahagia Willibrordus Maria Nainggolan,Junita Tarigan,Johan Samuel Sitanggang 대한신경외과학회 2023 Journal of Korean neurosurgical society Vol.66 No.5
Dengue fever is the most rapidly spreading mosquito-borne virus in the world, infecting about 100 million individuals. A rare but possibly dangerous consequence of dengue illness is intracranial hemorrhage (ICH). Currently, the pathogenesis of ICH is unknown. A number of studies have found a variety of risk factors for ICH in dengue. In addition, studies have reported the use of emergency surgery while monitoring thrombocytopenia in the therapy of dengue ICH. This review enumerates the potential predictors of ICH in dengue, discusses the use of brain imaging, and mentions the possibility of emergency surgery.
COVID-19-Associated Encephalopathy: Systematic Review of Case Reports
Yusak Mangara Tua Siahaan,Vivien Puspitasari,Aristo Pangestu 대한신경과학회 2022 Journal of Clinical Neurology Vol.18 No.2
Background and Purpose Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) primarily attacks the respiratory system, but there are also several reports of the involvement of the central nervous system, with one of the manifestations being encephalopathy. The relatively new emergence of COVID-19 means that few studies have investigated the clinical profile of encephalopathy associated with this disease. This study aimed to determine the clinical profile, laboratory, and imaging results of encephalopathy associated with COVID-19. Methods Three databases, namely PubMed/MEDLINE, Embase, and Scopus, were systematically searched for case reports and case series related to COVID-19-associated encephalopathy published from January 1, 2019 to July 20, 2020. Results This review included 24 studies involving 33 cases. The most-reported neurological symptoms were disorientation/confusion (72.72%), decreased consciousness (54.54%), and seizures (27.27%). Laboratory examinations revealed increases in the C-reactive protein level (48.48%), the lactate dehydrogenase level (30.30%), and lymphopenia (27.27%). Brain imaging did not produce any pathological findings in 51.51% of the cases. Electroencephalography showed generalized slowing in 45.45% of the cases. Elevated protein (42.42%) and lymphocytosis (24.24%) were found in the cerebrospinal fluid. Fifteen patients were reportedly discharged from the hospital in a stable condition, while four cases of mortality were recorded. Conclusions The clinical, laboratory, and imaging findings in this review support the hypothesis that cerebral damage in COVID-19-associated encephalopathy is caused by cytokine-immunemediated inflammation rather than by direct invasion.