Protein profiling predicts the response to anthracycline and taxanes based neo-adjuvant chemotherapy in breast cancer

Shu Wang,Houpu Yang,Jiajia Guo,Miao Liu,Fuzhong Tong,Yingming Cao,Bo Zhou,Peng Liu,Lin Cheng,Fei Xie,Deqi Yang,Jiaqing Zhang 한국바이오칩학회 2011 BioChip Journal Vol.5 No.1

Neo-adjuvant chemotherapy for breast cancer substantially benefits patients who achieve pathological response. However, clinical or pathological response information can only be obtained a period of time after chemotherapy. The identification of novel bio-markers or the application of new technique that can be used to predict treatment response before che-motherapy would allow therapy to be tailored on an individual patient basis. The purpose of this study is to identify the chemo-sensitivity and chemo-resistance related proteins using antibody microarray profiling, and to develop a multi-protein predictive model for breast cancer. Total protein was extracted from core needle biopsy samples obtained from 15 patients before treatment with neo-adjuvant TA(combination of taxanes and anthracycline) chemotherapy. Protein profiling was analyzed by antibody microarray. 10 pati-ents were used as training set to develop the predictive model using the software PAM(prediction analysis of microarray). Another 5 patients were used as a validation set to test the model. In cross-validation, the mole-cular predictive model showed an accuracy of 90%, in independent validation, the model classified the cases with an accuracy of 80%. In conclusion, the proteomic predictive model has the potential to predict pathological response to neo-adjuvant TA chemotherapy.

Wiretapping Strategies for Artificial Noise Assisted Communication in MU-MIMO wiretap channel

( Shu Wang ),( Xinyu Da ),( Zhenyong Chu ) 한국인터넷정보학회 2016 KSII Transactions on Internet and Information Syst Vol.10 No.5

We investigate the opposite of artificial noise (AN)-assisted communication in multiple-input-multiple-output (MIMO) wiretap channels for the multiuser case by taking the side of the eavesdropper. We first define a framework for an AN-assisted multiuser multiple-input-multiple-output (MU-MIMO) system, for which eavesdropping methods are proposed with and without knowledge of legitimate users` channel state information (CSI). The proposed method without CSI is based on a modified joint approximate diagonalization of eigen-matrices algorithm, which eliminates permutation indetermination and phase ambiguity, as well as the minimum description length algorithm, which blindly estimates the number of secret data sources. Simulation results show that both proposed methods can intercept information effectively. In addition, the proposed method without legitimate users` CSI performs well in terms of robustness and computational complexity.

Multi-Phase MPCA Modeling and Application Based on an Improved Phase Separation Method

Shu Wang,Yu-Qing Chang,Zhen Zhao,Fu-Li Wang 제어·로봇·시스템학회 2012 International Journal of Control, Automation, and Vol.10 No.6

Regarding the multi-phase characteristic of batch process, a new phase separation method is developed in this paper. The method realizes a 3-step sub-phase separation of the batch process using the retained principal components number, loading matrixes and principal component matrixes, which can adequately reflect the features variation of the process. In line with the different features and clas-sification step, automatic identification of ‘burrs’ and transition phases has been expounded. The pro-posed method can directly separate the stable phases and transition phases in the batch process, and deduce high-precision transition phase models. Based on the proposed method, the MPCA modeling and online monitoring is applied in the injection molding process. The experimental results have veri-fied the effectiveness of the proposed method.

Reduction of Electromagnetic Vibration and Noise in Permanent Magnet Motor for EVs by Optimizing Design of Rotor Based on GPR‑PSO Model

Shu Wang,Hongfeng Li 대한전기학회 2020 Journal of Electrical Engineering & Technology Vol.15 No.3

Radial electromagnetic force of motor causes electromagnetic vibration and noise. Reasonable improvement of the rotor structure can efectively reduce the radial electromagnetic force and weaken the electromagnetic vibration and noise. Based on a permanent magnet synchronous motor for EVs, this paper proposes an improved rotor structure with auxiliary fux barriers to reduce the radial electromagnetic force, thereby weakening the electromagnetic vibration and noise. The sample data sets of the relationship among the parameters of the improved rotor structure, the radial electromagnetic force and the output torque of the motor are established by the orthogonal method. Gaussian process regression models are used to ft the data sample sets. Then the regression functions are used as ftness function and constraint function for particle swarm optimization. Thus the optimal rotor structure parameters are gotten. The radial electromagnetic forces of motor before and after improvement are simulated. Then the vibration and noise characteristics are analyzed and compared. The results show that the improved structure can reduce the vibration and noise efectively on the premise of ensuring the electromagnetic performance. The modal analysis and strength check are carried out to ensure the rationality of the improvement. The validity of the simulation results is verifed by experiments.

Seoul National University AGN Monitoring Project (SAMP): Investigating the High-Luminosity End of the H Radius-Luminosity Relation

Shu Wang,Jong-Hak Woo,SAMP Collaboration 한국천문학회 2022 天文學會報 Vol.47 No.2

Analysis of Stress-strain Characteristics of Geogrid Reinforced Crushed Gravel

Ruiqing Lang,Aiwu Yang,Shuwang Yan 대한토목학회 2019 KSCE JOURNAL OF CIVIL ENGINEERING Vol.23 No.2

To study the stress-strain characteristics of reinforced cushion with multi-layer geogrids, a new calculation method was proposed. Based on hyperbolic model, the reinforced cushion was regard as a nonlinear elastomer. The effect of reinforcing geogrids was considered as an equivalent additional pressure and included into the gravel skeleton. Considering the friction effect between geogrids and crushed gravel, the calculation method of stress-strain relationship and shear strength of the reinforced crushed gravel was deduced through definite integral. The proposed method was verified by triaxial tests and the calculated results were in good agreement with the measured data. Furthermore, the key parameters influencing the shear strength, such as the total number of geogrids, the geogrids spacing and the corresponding position, were quantified through sensitivity analysis. The effects of the key parameters on the stress-strain relationship of reinforced cushion were determined. It is shown that the ability of reinforced body to resist bulging deformation is great improved by geogrids. The key parameters are the confining pressure and the total number of geogrids. With the increase of the total number and the confining pressure, the shear strength of the reinforced body increases; but the shear strength is less affected by its location. The research results can provide reference for practical projects.

Load distribution analysis and eccentricity characteristics for marble screw-loading device of dry disc brakes

Yanzhong Wang,Kai Yang,Shuwang Jia,Wei Yang 대한기계학회 2021 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.35 No.1

Stress distribution and stability under extreme conditions of screw-loading device are investigated in the present study. The finite element model of core component is established to obtain the loading process. Influence of screw position on magnitude, distribution, and types of component structure is also investigated. Eccentricity phenomenon of screw-loading device is analyzed, and loading performance under noncoincident central line of moving and rotating disc is obtained. Results showed that transmission force formation of screw groove structure is similar to concentrated force. The transmission force is remarkably different from other positions when marble is on top or bottom of the screw groove. An optimization design based on these results is proposed in this study.

Analytical solutions for geosynthetic tube resting on rigid foundation

Guo, Wei,Chu, Jian,Yan, Shuwang,Nie, Wen Techno-Press 2014 Geomechanics & engineering Vol.6 No.1

Geosynthetic tubes inflated with water, clay slurry or sand have been widely used for large dike construction in land reclamation projects. In this paper, analytical solutions for geosynthetic tube resting on rigid foundation is presented by adopting an approach similar to that presented by Leshchinsky et al. (1996). The proposed method allows a quick preliminary design to be made for using a closed-form solution. To simplify the analysis, relationships between geometrical parameters and pumping pressure are established using numerical method. The analytical solutions were compared with several existing solutions and good agreements were achieved.