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Shumin Wang,Mei Ping,Bin Song,Yarong Guo,Yuanfei Li,Junmei Jia 연세대학교의과대학 2020 Yonsei medical journal Vol.61 No.9
Purpose: Gastric cancer (GC) is a malignant tumor with a high mortality rate. Drug resistance is a major obstacle to GC therapy. This study aimed to investigate the role and mechanism of exosomal circPRRX1 in doxorubicin resistance in GC. Materials and Methods: HGC-27 and AGS cells were exposed to different doses of doxorubicin to construct doxorubicin-resistantcell lines. Levels of circPRRX1, miR-3064-5p, and nonreceptor tyrosine phosphatase 14 (PTPN14) were detected by quantitativereal-time PCR or Western blot assay. Then, 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide, transwell,and Western blot assays were used to explore the function of circPRRX1 in GC cells. Interactions among circPRRX1, miR-3064-5p,and PTPN14 were confirmed by dual-luciferase reporter assay. The in vivo function of circPRRX1 was analyzed in a xenograft tumormodel. Results: CircPRRX1 was highly expressed in doxorubicin-resistant GC cell lines. Knockdown of circPRRX1 reversed doxorubicinresistance in doxorubicin-resistant GC cells. Additionally, extracellular circPRRX1 was carried by exosomes to spread doxorubicinresistance. CircPRRX1 silencing reduced doxorubicin resistance by targeting miR-3064-5p or regulating PTPN14. In GC patients,high levels of circPRRX1 in serum exosomes were associated with poor responses to doxorubicin treatment. Moreover, depletionof circPRRX1 reduced doxorubicin resistance in vivo. Conclusion: CircPRRX1 strengthened doxorubicin resistance by modulating miR-3064-5p/PTPN14 signaling and might be atherapeutic target for GC patients.
The Analysis and Application of Competition and Cooperation between the Bus Lines
Shumin Feng,Xianglong Sun,Dixin Wang 대한토목학회 2016 KSCE JOURNAL OF CIVIL ENGINEERING Vol.20 No.4
It is very valuable for planning bus routes and improving transport efficiency to quantify the cooperation and competition between lines. Cooperation modes and competition modes between two lines are defined respectively based on the location of bus stops. Cooperative coefficient and competitive coefficient are proposed to calculate different modes quantitatively in term of the number of overlapped stops and overlapped service area. These coefficients can be used to convert multi-relation transit network into weighted single network to analyze the close degree between lines. Taking Qiqihar City transit network as an example, cooperative coefficient and competitive coefficient between two lines are calculated. The bus network is converted into weighted single network, and the single network is then clustered with social network analysis method. The cluster result indicates that the network can be divided into three groups whose bus lines have different cooperation and competition strength, so distinguish management modes for different group are quite necessary.
Antibacterial and Hydrophilic Modification of PET Fabrics by Electron Beam Irradiation Process
Shumin Zhang,Fang Ding,Yingfeng Wang,Xuehong Ren,Tung-Shi Huang 한국섬유공학회 2020 Fibers and polymers Vol.21 No.5
Electron beam (EB) irradiation has been utilized to modify materials for various applications due to its remarkableadvantages. As an efficient and environmental-friendly way for antibacterial and hydrophilic purposes, EB irradiation wasapplied to modify polyethylene terephthalate (PET) fabrics by grafting with a N-halamine precursor monomer 3-allyl-5,5-dimethylhydantoin (ADMH) and acrylic acid (AA) in this study. The grafted PET fabrics were loaded with silver ions tofurther enhance the antimicrobial efficacy. The hydrophilicity of the modified PET fabrics was evaluated by testing the watercontact angles with different contact times. The breaking strength and thermal stability of the modified swatches werestudied. The UVA light stability results showed the chlorine loading of the modified PET fabrics decreased with the extensionof UVA exposure time, and most chlorine loading could be recovered by re-chlorination. The antibacterial test showed thatthe modified PET swatches can inactivate all inoculated S. aureus and E. coli with short contact times.
Shumin Zhang,Fang Ding,Zhiguang Li,Xuehong Ren,Tung-Shi Huang 한국섬유공학회 2020 Fibers and polymers Vol.21 No.10
The numerous functional groups and dendritic structure of hyperbranched polymers render them for a wide rangeof applications. In this study, hyperbranched polymer Boltorn H20, containing abundant hydroxyl groups, was modified toprepare quaternary ammonium functionalized hyperbranched polymers, QAS-HPs. The synthesized QAS-HPs were coatedon polyethylene terephthalate (PET) fabrics by electron beam radiation. The PET fabrics were endowed antimicrobial andhydrophilic properties after modification. The water contact angles of the modified PET fabrics were tested, and the resultsshowed significant improvement in hydrophilicity. The results of antibacterial efficacy tests showed that the modified PETfabrics could inactivate 100 % of Staphylococcus aureus (S.aureus) and 90.8 % of Escherichia coli O157:H7 (E. coliO157:H7) with 30 min of contact time.
Decision diagram based methods and reliability analysis for k-out-of-n: G systems
Shumin Li,Shudong Sun,Shubin Si,Shuai Zhang,Hongyan Dui 대한기계학회 2014 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.28 No.10
Binary k-out-of-n systems are commonly used reliability models in engineering practice. Many authors have extended the concept ofk-out-of-n system to multi-state k-out-of-n systems. This paper proposes a binary decision diagram (BDD) based approach for binary kout-of-n: G system and a multi-state multi-valued decision diagram (MMDD) based approach for multi-state k-out-of-n: G system. BDDand MMDD have been extensively used for representing and manipulating logic functions in many areas, including reliability modelingand analysis. In this paper, patterns of BDD/MMDD for binary/multi-state k-out-of-n: G system are summarized and proved, a two-stepalgorithmic process is proposed for modeling the BDD/MMDD and three case studies are implemented to demonstrate the presentedmethods. Complexity analysis shows that the presented method is more computationally efficient than the traditional algorithms for kout-of- n: G system.