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Zhang, Sheng-Chang,Huang, Peng,Zhao, Yong-Xiang,Liu, Shu-Yan,He, Shu-Jia,Xie, Xiao-Xun,Luo, Gou-Rong,Zhou, Su-Fang Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.4
Senescence marker protein 30 (SMP30), a hepatocellular carcinoma (HCC) associated antigen, was earlier shown by our research group to be highly expressed in HCC paracancerous tissues, but have low levels in HCC tissues. In order to detect anti-SMP30 antibody in serum of HCC patients, we established pET30a-SMP30 and pColdIII-SMP30 expression systems in Escherichia coli. However, the expression product was mainly in the form of inclusion bodies. In this research, we used several combinations of chaperones, four molecular chaperone plasmids with pET30a-SMP30 and five molecular chaperone plasmids with pColdIII-SMP30 to increase the amount of soluble protein. Results showed that co-expression of HIS-SMP30 with pTf16, combined with the addition of osmosis-regulator, and a two-step expression resulted in the highest enhancement of solubility. A total of 175 cases of HCC serum were studied by ELISA to detect anti-SMP30 antibody with recombinant SMP30 protein. Some 22 were positive and x2 two-sided tests all showed P>0.05, although it remained unclear whether there was a relationship between positive cases and clinical diagnostic data.
Zhang, Shao-Kai,Guo, Lan-Wei,Chen, Qiong,Zhang, Meng,Liu, Shu-Zheng,Quan, Pei-Liang,Lu, Jian-Bang,Sun, Xi-Bin Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.23
Background and Aim: No firm evidence of HPV infection in esophageal cancer has been established to date. The aim of this meta-analysis was to investigate the prevalence of HPV 16 in esophageal cancer in China, which had a high burden of the disease. Materials and Methods: Studies on HPV infection and esophageal cancer were identified and a random-effects model was used to pool the summary prevalence and corresponding 95% confidence intervals (CIs). Results: A total of 3,429 esophageal cancer cases were evaluated from 26 eligible studies in this meta-analysis. The summary estimate for HPV16 prevalence was 0.381 (95% CI: 0.283, 0.479). The prevalence varied by geographical areas of the study, publication year, HPV detection method and types of specimen. In sensitivity analysis, HPV 16 prevalence ranged from 0.368 (95% CI: 0.276, 0.460) to 0.397 (95% CI: 0.286, 0.508). Conclusions: The results indicate a relatively high level of HPV 16 prevalence in esophageal cancer among Chinese population, although there was variation between different variables. Further studies are needed to elucidate the role of HPV in esophageal carcinogenesis with careful consideration of study design and laboratory detection method, providing more accurate assessment of the HPV status in esophageal cancer.
Evaluation of an Immune-privileged Scaffold for In vivo Implantation of Tissue-engineered Trachea
Shu Pan,Fei Sun,Hongcan Shi,Fangbiao Zhang,Xingchen Liu,Weidong Zhang 한국생물공학회 2014 Biotechnology and Bioprocess Engineering Vol.19 No.5
Forty tracheas were harvested from donor NewZealand rabbits. Thirty of the tracheas were randomlydivided into four treatment groups corresponding to 4, 5, 6,or 7% NaClO4 and one untreated group (n = 6 each group). Scanning electron microscopy distinctly revealed thecilium of epithelial cells in the fresh trachea. The internalsurface of the trachea was rough in the 4% treatment groupand smooth in the 5% treatment group, whereas the matrixwas fractured in the 6% treatment group and highlyfractured in the 7% treatment group. We observed that thenumber of nuclei in the cells of the 4, 5, 6, and 7%treatment groups decreased compared to the cells of theuntreated group (p < 0.05). Although there was a significantdecrease in maximum tensile strength, tensile strain atfracture and the elastic modulus (p < 0.05) with increasingconcentrations of NaClO4, the content of glycosaminoglycans(GAGs) did not significantly decline (p > 0.05) in the 5%treatment group. In addition, histopathological analysisshowed that the fiber component and basement membraneof the matrix in the 5% treatment group were retained afteroptimal decellularization. Despite the preserved cartilage,in vitro immunohistochemical analysis revealed that thematrix did not show the presence of major histocompatibilitycomplex (MHC) antigens. The remaining ten donor tracheas,which were divided into a positive control group and anoptimal decellularized group, were used for allogeneictransplantation. Blood samples were taken regularly, andhistologic examinations were performed at 30 days postimplantation,which showed no significant immune rejection. In conclusion, we surveyed the structural integrity throughmorphological observation and compared the biomechanicaland immunogenic changes in the tracheal matrix under thedifferent treatments. The optimal decellularized trachealmatrix with preserved cartilage, which was acquired via 5%NaClO4 treatment, exhibited structural integrity, antigen cellremoval and immune privilege and would be suitable for useas a tissue-engineered trachea for in vivo transplantation inrabbit models.
Zhang, Hao,Huang, Meng-Shu,Zhang, Yi-Meng,Yoshihara, Tsutomu The Institute of Electronics and Information Engin 2014 Journal of semiconductor technology and science Vol.14 No.1
A nano-power CMOS voltage reference is proposed in this paper. Through a combination of switched-capacitor technology with the body effect in MOSFETs, the output voltage is defined as the difference between two gate-source voltages using only a single PMOS transistor operated in the subthreshold region, which has low sensitivity to the temperature and supply voltage. A low output, which breaks the threshold restriction, is produced without any subdivision of the components, and flexible trimming capability can be achieved with a composite transistor, such that the chip area is saved. The chip is implemented in $0.18{\mu}m$ standard CMOS technology. Measurements show that the output voltage is approximately 123.3 mV, the temperature coefficient is $17.6ppm/^{\circ}C$, and the line sensitivity is 0.15 %/V. When the supply voltage is 1 V, the supply current is less than 90 nA at room temperature. The area occupation is approximately $0.03mm^2$.
Cascade Selective Window for Fast and Accurate Object Detection
Shu Zhang,Yong Cai,Mei Xie 대한전기학회 2015 Journal of Electrical Engineering & Technology Vol.10 No.3
Several works help make sliding window object detection fast, nevertheless, computational demands remain prohibitive for numerous applications. This paper proposes a fast object detection method based on three strategies: cascade classifier, selective window search and fast feature extraction. Experimental results show that the proposed method outperforms the compared methods and achieves both high detection precision and low computation cost. Our approach runs at 17ms per frame on 640× 480 images while attaining state-of-the-art accuracy.
Cascade Selective Window for Fast and Accurate Object Detection
Zhang, Shu,Cai, Yong,Xie, Mei The Korean Institute of Electrical Engineers 2015 Journal of Electrical Engineering & Technology Vol.10 No.3
Several works help make sliding window object detection fast, nevertheless, computational demands remain prohibitive for numerous applications. This paper proposes a fast object detection method based on three strategies: cascade classifier, selective window search and fast feature extraction. Experimental results show that the proposed method outperforms the compared methods and achieves both high detection precision and low computation cost. Our approach runs at 17ms per frame on 640×480 images while attaining state-of-the-art accuracy.
Zhang, Zhen Xiu,Zhang, Shu Ling,Kim, Jin Kuk De Gruyter 2008 E-Polymers Vol.8 No.1
<P><B>Abstract</B></P><P>Polymer blends of WRT (waste rubber tire) powder/LLDPE (linear low density polyethylene) have been attempted to prepare thermoplastic elastomers (TPEs). The effects of maleic anhydride-grafted styrene-ethylene-butylene-styrene (SEBS-g-MA) and dicumyl peroxide (DCP) on mechanical, morphological and thermal properties of the blends were evaluated using universal testing machine (UTM), scanning electron microscopy (SEM), differential scanning calorimetry (DSC) and thermogravimetric analyses (TGA). It was found that combination of SEBS-g-MA and DCP could better enhance the mechanical properties of WRT powder/LLDPE blends compared to SEBS-g-MA or DCP alone. Better compatibility between WRT powder and LLDPE was responsible for the enhancement of mechanical properties, as supported by SEM. The incorporation of SEBS-g-MA and DCP with WRT powder/LLDPE blends reduced the crystallizable perfectness of the blends, but slightly increased the thermal stability of the blends, as shown from DSC and TGA results</P>
Zhang, Shu Ling,Zhang, Zhen Xiu,Xin, Zhen Xiang,Pal, Kaushik,Kim, Jin Kuk Elsevier 2010 MATERIALS AND DESIGN Vol.31 No.4
<P><B>Abstract</B></P><P>Polypropylene (PP)/waste ground rubber tire powder (WGRT) composites were studied with respect to the effect of bitumen and maleic anhydride-grafted styrene–ethylene–butylene–styrene (SEBS-g-MA) content by using the design of experiments (DOE) approach, whereby the effect of the four polymers content on the final mechanical properties were predicted. Uniform design method was especially adopted for its advantages. Optimization was done using hybrid artificial neural network–genetic algorithm (ANN–GA) technique. The results indicated that the composites showed fairly good ductibility provided that it had a relatively higher concentration of bitumen and SEBS-g-MA under the studied condition. A quantitative relationship was presented between the material concentration and the mechanical properties as a set of contour plots, which were confirmed experimentally by testing the optimum ratio.</P>