Differential settlement and soil dynamic stress of a culvert-embankment transition zone due to an adjacent shield tunnel construction

Yao Shan,Shunhua Zhou,Yao Shu 대한토목학회 2018 KSCE Journal of Civil Engineering Vol.22 No.7

The effects of shield tunnel construction on the differential settlement and the distribution of soil dynamic stress of an adjacentculvert-embankment transition zone are investigated. A construction project of shield tunnels in Hangzhou (China) beneath anexisting railroad culvert-embankment transition zone is employed as a case study. Firstly, the shield tunneling activities in the vicinityof a culvert-embankment transition zone are simulated by a three-dimensional (3D) Finite Element Analysis (FEA) method. Thedifferential settlement of the transition zone is calculated to evaluate the influence of the shield tunneling on the safety of the passingtrain. Secondly, a plane strain model is employed to investigate the discipline of the soil dynamic stress in transition zones, which isinduced by the passing train and the shield tunnel beneath the railroad. Results indicate that the reinforcement treatment of thefoundation is required since the embankment differential settlement is significantly affected by the shield tunneling. Finally, arecommended treatment is introduced according to the property of the surrounding soil. Numerical simulation reveals that thistreatment is appropriate for reducing the differential settlement and soil dynamic stress of the transition zone.

한중 인터넷 통신 별명의 비교 분석

서형요(Shu Xin Yao),이정복(Lee Jeong Bok) 한국사회언어학회 2015 사회언어학 Vol.23 No.3

Internet nickname is a kind of temporary names that netizen want to use them to show the identity and differentiation from other netizen in the internet communication. The purpose of this paper is to compare and analyze the internet nicknames which are created and used distinctively in SNS of Korea and China. The main emphasis of this study is on the structures, the types of meanings, and making motivations of internet nicknames. The data are collected from the Twitter used by Korean netizen, and the Weibo used by Chinese netizen. The structural aspects of internet nicknames are divided into single structure and composite structure. The meaning types of internet nicknames are divided into ‘self-information’, ‘idol information’, ‘pursuit information’ and ‘the others’. The motivations of creating internet nicknames by netizen are divided into ‘linguistic efficiency motivation’, ‘creative expression motivation’, ‘play motivation’, ‘strengthen relation motivation’, and ‘psychological liberation motivation’. As a result of research, we could clarify the sameness and the difference of the linguistic culture on cyberspace between Korea and China by analyzing the internet nicknames.

Conversation, Context and Practice: Study on Classified Conversations of Master Zhu from the View of Philosophical Practice

Fang Shu-yao,Zhang Jin-bo 강원대학교 인문과학연구소 2020 Journal of Humanities Therapy Vol.11 No.1

From the perspective of philosophical practice, Classified Conversations of Master Zhu is composed of three basic elements: the thread of discourse, context and practice. Thread of discourse means gathering both sides into the same dialogue context, which provides a relatively “fair” communication status and also the theme and direction for the entire practice as well. In terms of context, the differences between two parties in a conversation will temporarily dissolve. Both parties can fully express their own opinions so as to achieve the goal during the conversation, which has provided reassurance and a road to the success of the whole philosophical practice. Practice, embodying in the whole discourse, makes conversation not merely a rational sermon or the cause of one of the interlocutors, but also a performance of a clear practical character and realistic solicitudes, as well as a fully reflection of the theory values and practical significance of Chinese traditional philosophy.

RON and MET Co-overexpression Are Significant Pathological Characteristics of Poor Survival and Therapeutic Targets of Tyrosine Kinase Inhibitors in Triple-Negative Breast Cancer

Tian-Hao Weng,Min-Ya Yao,Xiang-Ming Xu,Chen-Yu Hu,Shu-Hao Yao,Yi-Zhi Liu,Zhi-Gang Wu,Tao-Ming Tang,Pei-Fen Fu,Ming-Hai Wang,Hang-Ping Yao 대한암학회 2020 Cancer Research and Treatment Vol.52 No.3

Purpose Triple-negative breast cancer (TNBC) is highly malignant and has poor prognosis and a high mortality rate. The lack of effective therapy has spurred our investigation of new targets for treating this malignant cancer. Here, we identified RON (macrophage-stimulating 1 receptor) and MET (MET proto-oncogene, receptor tyrosine kinase) as a prognostic biomarker and therapeutic targets for potential TNBC treatment. Materials and Methods We analyzed RON and MET expression in 187 primary TNBC clinical samples with immunohistochemistry. We validated the targeted therapeutic effects of RON and MET in TNBC using three tyrosine kinase inhibitors (TKIs): BMS-777607, INCB28060, and tivantinib. The preclinical therapeutic efficacy of the TKIs was mainly estimated using a TNBC xenograft model. Results Patients with TNBC had widespread, abnormal expression of RON and MET. There was RON overexpression, MET overexpression, and RON and MET co-overexpression in 63 (33.7%), 63 (33.7%), and 43 cases (23.0%), respectively, which had poor prognosis and short survival. In vivo, the TKI targeting RON ant MET inhibited the activation of the downstream signaling molecules, inhibited TNBC cell migration and proliferation, and increased TNBC cell apoptosis; in the xenograft model, they significantly inhibited tumor growth and shrank tumor volumes. The TKI targeting RON and Met, such as BMS-777607 and tivantinib, yielded stronger anti-tumor effects than INCB28060. Conclusion RON and MET co-overexpression can be significant pathological characteristics in TNBC for poor prognosis. TKIs targeting RON and MET have stronger drug development potential for treating TNBC.

SOME DESIGN CONSIDERATIONS IN NETWORK DATABASE DESIGN

Yao Wan Sheng,Xu Shu Hua,Wang Xiao Li,Zhao Man Hua 대한전자공학회 1992 대한전자공학회 Conference Vol.1992 No.2

Effects of lycopene on number and function of human peripheral blood endothelial progenitor cells cultivated with high glucose

Yao-Chi Zeng,Gui-Ping Mu,Shu-Fen Huang,Xue-Hui Zeng,Hong Cheng,Zhong-Xin Li 한국영양학회 2014 Nutrition Research and Practice Vol.8 No.4

BACKGROUND/OBJECTIVES: The objectives of this study were to investigate the effects of lycopene on the migration, adhesion, tube formation capacity, and p38 mitogen-activated protein kinase (p38 MAPK) activity of endothelial progenitor cells (EPCs) cultivated with high glucose (HG) and as well as explore the mechanism behind the protective effects of lycopene on peripheral blood EPCs. MATERIALS/METHODS: Mononuclear cells were isolated from human peripheral blood by Ficoll density gradient centrifugation. EPCs were identified after induction of cellular differentiation. Third generation EPCs were incubated with HG (33 mmol/L) or 10, 30, and 50 μg/mL of lycopene plus HG. MTT assay and flow cytometry were performed to assess proliferation and apoptosis of EPCs. EPC migration was assessed by MTT assay with a modified boyden chamber. Adhesion assay was performed by replating EPCs on fibronectin-coated dishes, after which adherent cells were counted. In vitro vasculogenesis activity was assayed by Madrigal network formation assay. Western blotting was performed to analyze protein expression of both phosphorylated and non-phosphorylated p38 MAPK. RESULTS: The proliferation, migration, adhesion, and in vitro vasculogenesis capacity of EPCs treated with 10, 30, and 50 μg/mL of lycopene plus HG were all significantly higher comapred to the HG group (P < 0.05). Rates of apoptosis were also significantly lower than that of the HG group. Moreover, lycopene blocked phosphorylation of p38 MAPK in EPCs (P < 0.05). To confirm the causal relationship between MAPK inhibition and the protective effects of lycopene against HG-induced cellular injury, we treated cells with SB203580, a phosphorylation inhibitor. The inhibitor significantly inhibited HG-induced EPC injury. CONCLUSIONS: Lycopene promotes proliferation, migration, adhesion, and in vitro vasculogenesis capacity as well as reduces apoptosis of EPCs. Further, the underlying molecular mechanism of the protective effects of lycopene against HG-induced EPC injury may involve the p38 MAPK signal transduction pathway. Specifically, lycopene was shown to inhibit HG-induced EPC injury by inhibiting p38 MAPKs.

충적과정중 미국인삼 종자의 생리 및 생화학적 지표에 관한 동태학적 연구 ( Ⅱ ) ( Dynamic Studies on Physiology and Biochemistry in American Ginseng Seed During Stratification - Part Ⅱ. Contents of Soluble Carbohydrate , Crude Fat , Fatty Acid and Soluble Protein - )

Yao Ge Huang,Xiang Gao Li,Shu Yu Cui,Wen Bo Yu,Ya Lan Kuang,Jie Kun Yan,Ji Xiang Yang,Ren Song Liu,김학성 고려인삼학회 1997 Journal of Ginseng Research Vol.21 No.1

Robust Control for Bidirectional Stabilization System With Time Delay Estimation

Shu-sen Yuan,Wen-xiang Deng,Jian-yong Yao,Guo-lai Yang 제어·로봇·시스템학회 2024 International Journal of Control, Automation, and Vol.22 No.4

In this paper, to address the problem of high precision tracking control for bidirectional stabilization system of marching all-electric tank, a continuous nonsingular terminal sliding mode (CNTSM) control method combined with time delay estimation (TDE) technique is presented. First, the nonlinear mathematical model of the bidirectional stabilization system with consideration of actuator dynamics is established. Second, the TDE method is invoked to estimate the unknown system dynamics and provide fascinating model-free structures. Then, a CNTSM surface and a fast TSM reaching law are constructed to guarantee finite-time convergence. The proposed controller no longer requires system dynamics benefiting from TDE, while ensuring high accuracy, fast convergence and good robustness against lumped uncertainty due to the CNTSM manifold and the fast TSM reaching law. The stability and finite-time convergence of the closed-loop system are analyzed applying Lyapunov theory. Extensive comparative results verify the superiority with the proposed controller.

Eukaryotic Translation Initiation Factor 3a (eIF3a) Promotes Cell Proliferation and Motility in Pancreatic Cancer

Shu-qian Wang,Yu Liu,Min-ya Yao,Jing Jin 대한의학회 2016 Journal of Korean medical science Vol.31 No.10

Identifying a target molecule that is crucially involved in pancreatic tumor growth and metastasis is necessary in developing an effective treatment. The study aimed to investigate the role of the eukaryotic translation initiation factor 3a (eIF3a) in the cell proliferation and motility in pancreatic cancer. Our data showed that the expression of eIF3a was upregulated in pancreatic ductal adenocarcinoma as compared with its expression in normal pancreatic tissues. Knockdown of eIF3a by a specific shRNA caused significant decreases in cell proliferation and clonogenic abilities in pancreatic cancer SW1990 and Capan-1 cells. Consistently, the pancreatic cancer cell growth rates were also impaired in xenotransplanted mice. Moreover, wound-healing assay showed that depletion of eIF3a significantly slowed down the wound recovery processes in SW1990 and Capan-1 cells. Transwell migration and invasion assays further showed that cell migration and invasion abilities were significantly inhibited by knockdown of eIF3a in SW1990 and Capan-1 cells. Statistical analysis of eIF3a expression in 140 cases of pancreatic ductal adenocarcinoma samples revealed that eIF3a expression was significantly associated with tumor metastasis and TNM staging. These analyses suggest that eIF3a contributes to cell proliferation and motility in pancreatic ductal adenocarcinoma.

Inhibition Effects of Pulp on Seed Germination of American Ginseng

Yao Ge Huang(황요각),Xiang Gao Li(이향고),Shu Yu Cui(최수옥),Ji Xiang Yang(양계상),Ren Song Liu(류인송),Hack Seang Kim(김학성) 한국약용작물학회 1997 한국약용작물학회지 Vol.5 No.2

The germination inhibitory effects of American ginseng (Panax quinquefolium Linne) pulp were discussed. The germination inhibitory effects of pulp juice were decreased in a concentration de-pendent manner. When the pulp juice was diluted 0 (original juice), 1, 2, 5, 10, 20, 50 and 100 times, the radicle lengths of the assay plant, Chinese cabbage (Brassica chinensis Linne), showed 0, 0.32, 0.72, 3.13, 4.83, 16.07, 16.73 and 23.50 mm, respectively (CK=25.98 mm) The pulp evidently inhibited the embryo growth in natural fruit. The longer was the duration that the pulp stayed around the seed, the longer was the time course needed for embryo getting free from the inhibitory effects of pulp. When the depulping was performed on the day 0, 15, 30 and 60 after harvest, the time courses needed for embryo extricating the residual inhibitory effects from pulp were 30, 75, 135 and 135 days, respectively. Moreov-er, if the pulp stayed around the seed with time, that would make the seed rotten ratio increase. When the pulp stayed around the seed for 0, 15, 30, 60 and 270 days, the seed rotten ratios were 5.47, 5.71, 19.05, 27.14 and 33.33%, respectively. Therefore, we concluded that the pulp could be included in the inhibitory components which made American ginseng seed get into dormancy.