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Shu Rui,Bai Jiaming,Guo Feiqiang,Mao Songbo,Qiao Qixia,Dong Kaiming,Qian Lin,Bai Yonghui 한국화학공학회 2023 Korean Journal of Chemical Engineering Vol.40 No.7
Carbon/P-zeolite composites (CPZCs) were synthesized by high-temperature activation followed by hydrothermal crystallization using waste coal gasification fine slag as the raw material and NaOH as the activator. Methylene blue was selected as a dye pollutant for the adsorption experiment to investigate the adsorption property of the carbon/P-zeolite composites. It was found that the structure of CPZCs mainly depended on the mass ratio of NaOH to the coal gasification slag. At a proper NaOH to the coal gasification fine slag mass ratio of 1.0, the as-synthesized CPZC-1.0 exhibited a typical Na-P zeolite structure with a relatively high specific surface area of 200 m2/g and pore volume of 0.21 cm3/g. CPZC-1.0 showed excellent performance on methylene blue adsorption, with the adsorption capacity reaching 130 mg/g with removal efficiency of 81.6% at 303 K for the 100 mg/L initial methylene blue solution. The calculation results of adsorption thermodynamics indicated that the adsorption process to methylene blue by CPZCs was a spontaneous and entropy-driven endothermic process. Based on the above research, it is speculated that the adsorption mechanism of CPZCs to methylene blue might be due to the van der Waals force, intermolecular hydrogen bond and electrostatic attraction between Na-P zeolite and methylene blue.
Shu Hu,Xiaoyi Zhao,Guping Mao,Ziji Zhang,Xingzhao Wen,Chengyun Zhang,Weiming Liao,Zhiqi Zhang 생화학분자생물학회 2019 Experimental and molecular medicine Vol.51 No.-
MicroRNAs (miRNAs, miR) play a key role in the pathogenesis of osteoarthritis (OA). Few studies have examined theregulatory role of P21-activated kinases (PAKs), a family of serine/threonine kinases, in OA. The aim of this study was todetermine whether miR-455-3p can regulate cartilage degeneration in OA by targeting PAK2. MiR-455-3p knockoutmice showed significant degeneration of the knee cartilage. MiR-455-3p expression increased and PAK2 expressiondecreased in the late stage of human adipose-derived stem cell (hADSC) chondrogenesis and in chondrocytesaffected by OA. Furthermore, in both miR-455-3p-overexpressing chondrocytes and PAK2-suppressing chondrocytes,cartilage-specific genes were upregulated, and hypertrophy-related genes were downregulated. A luciferase reporterassay confirmed that miR-455-3p regulates PAK2 expression by directly targeting the 3′-untranslated regions (3′UTRs)of PAK2 mRNA. IPA-3, a PAK inhibitor, inhibited cartilage degeneration due to OA. Moreover, suppressing PAK2promoted R-Smad activation in the TGF/Smad signaling pathway in chondrocytes. Altogether, our results suggest thatmiR-455-3p promotes TGF-β/Smad signaling in chondrocytes and inhibits cartilage degeneration by directlysuppressing PAK2. These results thus indicate that miR-455-3p and PAK2 are novel potential therapeutic agents andtargets, respectively, for the treatment of OA.
Kocuria halotolerans sp. nov., an actinobacterium isolated from a saline soil in China.
Tang, Shu-Kun,Wang, Yun,Lou, Kai,Mao, Pei-Hong,Xu, Li-Hua,Jiang, Cheng-Lin,Kim, Chang-Jin,Li, Wen-Jun Society for General Microbiology 2009 International journal of systematic and evolutiona Vol.59 No.6
<P>A Gram-positive actinobacterium, designated strain YIM 90716(T), was isolated from a saline soil sample collected from Ganjiahu Suosuo Forest National Nature Reserve in Xinjiang Province, north-west China. The new isolate contained lysine, glutamic acid and alanine with peptidoglycan type Lys-Ala(3) (variation A3alpha). The major phospholipids were phosphatidylglycerol and diphosphatidylglycerol. The predominant menaqinone was MK-7(H(2)). The major fatty acids were anteiso-C(15 : 0), iso-C(16 : 0) and anteiso-C(17 : 0). The DNA G+C content of strain YIM 90716(T) was 68.0 mol%. Chemotaxonomic properties supported the affiliation of strain YIM 90716(T) to the genus Kocuria. Phylogenetic analysis based on 16S rRNA gene sequences revealed that the organism was related most closely to Kocuria kristinae DSM 20032(T) (96.8 % similarity) and showed lower levels of 16S rRNA gene similarity (<96.5 %) with the type strains of other species of the genus Kocuria. The results of fatty acid analysis and physiological and biochemical tests allowed the genotypic and phenotypic differentiation of strain YIM 90716(T) from its closest relatives. On the basis of data from the present polyphasic study, strain YIM 90716(T) is considered to represent a novel species of the genus Kocuria, for which the name Kocuria halotolerans sp. nov. is proposed. The type strain is YIM 90716(T) (=DSM 18442(T)=KCTC 19172(T)=CCTCC AB 206069(T)).</P>
Nie, Shu-Ping,Chen, Hui,Zhuang, Mao-Qiang,Lu, Ming Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.16
Objectives: Several preclinical and observational studies have shown that anti-diabetic medications (ADMs) may modify the risk of lung cancer. We performed a systematic review and meta-analysis evaluating the effect of metformin, sulfonylureas (SUs), thiazolidinediones (TZDs), and insulin on the risk of lung cancer in patients with diabetes mellitus (DM). Materials and Methods: We conducted a systematic search of Pubmed and Web of Science, up to August 20, 2013. We also searched the Conference Proceedings Citation Index (CPCI) and China National Knowledge Infrastructure (CNKI) for abstracts from major meetings. Fixed or random effect pooled measures were selected based on heterogeneity among studies, which was evaluated using Q test and the I2 of Higgins and Thompson. Meta-regression was used to explore the sources of between-study heterogeneity. Publication bias was analyzed by Begg's funnel plot and Egger's regression test. Associations were assessed by odds ratios (ORs) with 95% confidence intervals (CIs). Results: A total of 15 studies (11 cohort, 4 case-control) were included in this meta-analysis. In observational studies no significant association between metformin (n=11 studies; adjusted OR=0.99, 95%CI: 0.87-1.12), SUs (n=5 studies; adjusted OR=0.98, 95%CI: 0.79-1.22), or TZDs (n=7 studies; adjusted OR=0.92, 95%CI: 0.75-1.13), insulin (n=6 studies; adjusted OR=1.13, 95%CI: 0.79-1.62) use and risk of developing lung cancer was noted. There was considerable inherent heterogeneity between studies not explained by study design, setting, or location. Conclusions: Meta-analysis of existing studies does not support a protective or harmful association between ADMs use and risk of lung cancer in patients with DM. There was considerable heterogeneity across studies, and future, well-designed, prospective studies would be required for better understanding of any association.
( Xiao Mao Xiong ),( Yuan Liang Hu ),( Nan Feng Yan ),( Ying Na Huang ),( Nan Peng ),( Yun Xiang Liang ),( Shu Miao Zhao ) 한국미생물 · 생명공학회 2014 Journal of microbiology and biotechnology Vol.24 No.8
A systematic investigation was performed on the bacterial, Bacillus, fungal, and yeast communities of the three types of Daqu (mechanically prepared, manually prepared, and mixed prepared) used in Baiyunbian Company by reconditioning PCR-denaturing gradient gel electrophoresis (PCR-DGGE). The DGGE results showed that the microbes in the three types of Daqu were mainly thermotolerant and thermophilic microbes, and the most dominant bacterial species were Bacillus and Virgibacillus, followed by Lactobacillus and Trichococcus. Furthermore, the dominant fungi were found to be molds, such as Rasamsonia, Penicillium, Aspergillus, and Monascus, and the dominant yeasts were Saccharomyces cerevisiae, Saccharomycopsis fibuligera, Pichia anomala, and Debaryomyces hansenii. In general, the three types of Daqu showed slight differences in microbial communities, and the Shannon indexes (H`) of the manually prepared and mechanically prepared Daqu were similar. The results suggest that mechanically prepared Daqu can replace manually prepared Daqu in liquor production, and this research provides useful information for liquor production and process improvement.
Chen, Shu-Dong,Song, Mao-Min,Zhong, Zhi-Qiang,Li, Na,Wang, Pi-Lin,Cheng, Shi,Bai, Ri-Xing,Yuan, Hui-Sheng Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.3
Radixin, encoded by a gene on chromosome 11, plays important roles in cell motility, invasion and tumor progression. However, its function in pancreatic cancer remains elusive. In this study, radixin gene expression was suppressed with a lentivirus-mediated short-hairpin RNA (shRNA) method. We found that radixin shRNA caused down-regulation of radixin in PANC-1 cells, associated with inhibition of pancreatic cancer cell proliferation, survival, adhesion and invasive potential in vitro. When radixin-silenced cells were implanted in nude mice, tumor growth and microvessel density were significantly inhibited as compared to blank control cells or nonsense shRNA control cells. Thrombospondin-1 (TSP-1) and E-cadherin were up-regulated in radixin-silenced PANC-1 cells. Our results suggest that radixin might play a critical role in pancreatic cancer progression, possibly through invvolvement of down-regulation of TSP-1 and E-cadherin expression.