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      • 창지투선도구와 북한나선특별시간 경제협력

        림금숙(Lin, jin―shu) 국제지역연구학회 2012 국제지역학논총 Vol.5 No.2

        본 연구에서는 창지투(?吉?)선도구와 북한의 나선특별시 간의 경제 협력의 배경과 추진현황 및 제약 요인에 관하여 토의하려고 한다. 창지투 선도구와 북한의 나선특별시 간의 경제협력은 지린성의 “항구를 빌어 바다로 나가는 전략”을 실현하는 관건이며, 북한이 나선특별시의 개발 및 개방을 통해 경제 회생의 돌파구를 마련하는데 중요한 계기가 될 것이며, 두만강지역 국제자유무역지대 건설에 중대한 의의를 지니고 있다. 창지투선도구와 북한의 나선특별시간 경제협력의 중점 과제로는 북한의 나진항을 통하여 중국의 동북지역과 남방지역을 잇는 다국적 운송통로와 몽골, 러시아, 중국, 한국, 일본 더 나아가 미주지역을 잇는 동북아지역 물류운송 통로의 구축; 자원개발과 수출가공을 중심으로 한 산업협력; 두만강지역의 다국적 관광협력; 두만강지역 국제자유무역 지대의 건설 등이다. 현재 창지투선도구와 나선특별시간 경제협력은 사회기초 시설 투자에 필요한 자금 조달, 북한 경내 도로, 철도, 항만 등 기초 시설 건설자금의 마련, 두만강지역 국제물류 통로의 원활한 운영에 소요되는 물류집산지의 건설, 산업단지 건설에 필요한 기업유치, 다국적 관광업의 활성화에 필요한 개방정책 등 여러 가지 문제에 직면하고 있다. 두만강지역 다국적 개발 협력을 제약하는 주요 요인들로는 두만강 지역개발 이익을 둘러싼 주변국의 이해관계; 막대한 자금 수요에 비하여 외자유치의 미비; 북한의 열악한 인프라 환경과 체제개혁의 지연; 북한의 “핵개발”로 인한 동북아 지역의 복잡한 정치, 외교적 환경 등이다. 창지투선도구와 북한의 나선특별시간 경제 협력을 진일보 추진하려면 북?중 두 나라 정부가 이 지역에 대한 특수한 정책을 실시하는 동시에 공동개발에 필요한 자금 지원의 확대와 아시아은행 등 국제 금융기구의 공적자금 활용이 필요하다. 북한 정부는 당초 중국의 심천특구 건설 경험들을 적극 수용하여 북한 실정에 알맞은 특구건설 대안을 모색하는 것 역시 중요한 과제이다. 나진항과 부산항을 연결하는 물류운송 루트의 구축은 한국이 동북아 물류중심 국가로 부상할 수 있는 중요한 계기가 될 것이다. 따라서 한국은 단순히 관망하거나 북한이 중국의 영향권에 편입되는 것을 우려하는 자세에서 벗어나 적극적으로 두만강지역 개발 협력에 참여해야 할 것이다. The economic and trade cooperation between Changchun?Jilin?Tumen Pilot Zone and the city of Luoxian in DPRK is the need for the realization of the strategic target of the Changchun?Jilin?Tumen Pilot Zone, the promotion of the opening up of the city of Luoxian in DPRK, and the promotion of the economic and trade cooperation in countries in Tumen River area. In the process of Promoting economic and trade cooperation between Changchun?Jilin?Tumen Pilot Zone and the city of Luoxian in DPRK, The construction of the logistic corridor is the focus, International tourism cooperation is an important carrier of bilateral economic and trade cooperation, while the manufacturing industry cooperation which is mainly about processing trade is the direction of the development of bilateral economic and trade cooperation. Hence, Corridor construction has to be focused to accelerate international tourism and industrial cooperation, Promoting economic and trade cooperation between Changchun?Jilin?Tumen Pilot Zone and the city of Luoxian in DPRK in a smooth and orderly manner.

      • KCI등재

        Controlled Synthesis of Hydroxyapatite Using a Novel Natural Rosin-Based Surfactant

        Shu-Hui Zhan,Xue-He Jiang,Juan Li,Zhi Meng,Lin-Lin Chen,Chun-Rui Han 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2017 NANO Vol.12 No.8

        Hydroxyapatite (HAP) with multiform morphologies, such as hollow dandelion-like bundles and nanoparticles with a diameter of 50 nm, was prepared using natural rosin-based surfactant dehydroabietyl phosphate diester (DDPD) as phosphorus source, crystal growth control agent, and template simultaneously by a facile hydrothermal method. Samples were obtained and characterized by X-ray powder diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM). Results showed that DDPD and pH value of solution were the key factors for the morphology of HAP. Hollow dandelion-like bundles HAP, containing the Ca-monodehydroabietyl phosphate (PM-Ca) organic metal compounds, were formed at pH=3 without acid-base regulation, and nanoparticles were obtained at pH=12. SEM exhibited that the hollow dandelion-like bundles HAP are of 10 μm (outer) and 1 μm (inner) diameter, respectively. Cell viabilities are above 95% when the cells are co-cultured with all HAP samples at concentrations in the range of 250–1000 μg/ml. It indicated that the prepared HAP with PM-Ca has a good cytocompatibility without apparent toxicity. Finally, the possible formation mechanism of the HAP microstructures was discussed in detail.

      • Behavioral Based Safety Implementation to Improve Industrial Safety in Taiwan Local Industries

        Shu-Chiang Lin,Guanhuah Chen,Ilma Mufidah 대한인간공학회 2014 대한인간공학회 학술대회논문집 Vol.2014 No.5

        Since the 1970s, practicing of Behavior-based safety (BBS) concept among some developed countries has been considered as an effective technique to tackle occupational safety and health issues. BASF, Dow Chemical and Toyota Motor are some big corporations that have been creating their own plans to implement BBS programs. BBS was first introduced to Taiwan’s industries in the past decade. Although many companies from different local industries begin to follow the same paths of implementing BBS programs by either directly use or adapt these big foreign corporations’ plans, the results are not quite as promising as the local companies wished. Because of the plans ineffectiveness, local companies don’t see the need to further promote such plans. This study takes aim at the reasons that may contribute to the ineffectiveness of the BBS programs when they were implemented locally. This study also strives to build a model and strategy that fits for Taiwan’s local industries with means of extensive literature review and through on-site survey of local industries that have implemented the BBS plans. Three local companies, each represents different industry, participated our on-site survey, and a TO-DOIT model was proposed in our research. Specifically, our TO-DOIT model is a revision that is extended from researcher Geller’s DOIT model. The DOIT is an abbreviation of define, observe, intervene, and influence, while our TO-DOIT is to promote the top management support and full participation as foundations for DOIT. Fitful locally, our TO-DOIT model is capable of assisting Taiwan’s local industries to promote safe behavior. A true practice of TO-DOIT model shows that after its implementation in a local company, the injury rate decreased from 39 in 2005 to 20 in 2010, injury frequency rate decreased from 0.75 in 2005 to 0.09 in 2010, and the aggregate damage index decreased from 0.17 in 2005 to 0.04 in 2010. In conclusion, the proposed TO-DOIT model is much more effective and fits better to Taiwan’s local industries in promoting BBS.

      • KCI등재

        Studying the Strain Effect on Silicon Atomic Wires

        Shu-Tong Chang,Shu-Hui Liao,Hsiao-Chun Huang,Chee-Wee Liu,Chung-Yi Lin 한국물리학회 2008 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.53 No.6

        The transport properties of a Si3 atomic wire system, which is formed by a Si3 cluster connected to two lithium electrodes with bias applied, is studied using the simulator Virtual NanoLab that is constructed based on the non-equilibrium Green’s function (NEGF) scheme. We investigated the Si3 atomic wire system under three strain conditions (tensile, compressive and shear). Different trends in the I-V characteristics are observed for the three cases at various applied biases. The transmission spectrum T(E, Vb), as a function of energy and applied biases, are analyzed. The interactions among eigenstates of the molecular projected self-consistent Hamiltonian (MPSH) strongly affect the transport properties of the system.

      • KCI등재

        Exploring the Influential Factors of Manufacturers’ Initial Intention in Applying for the Green Mark EcoLabel in Taiwan

        Shu-Chiang Lin,Satria Fadil Persada,Reny Nadlifatin,Hsiang-Yu Tsai,Chih-Hsing Chu 한국정밀공학회 2015 International Journal of Precision Engineering and Vol.2 No.4

        The Green Mark eco-label constitutes an essential program introduced by Taiwan’s Environmental Protection Administration to support environmental protection. In the manufacturing industry, the Green Mark eco-label is intended to enable differentiating between manufacturers that apply green processes and those that do not. This paper presents an assessment model for identifying manufacturers’ initial intention to apply the Green Mark eco-label. The model was derived from the certification process flow. A total of 200 structured questionnaires were distributed to manufacturers in Taiwan, and 172 responses were retrieved. The model was analyzed by applying structural equation modeling, and the correlation of review process and end certification process exhibited the strongest correlation. Improving the document verification stage is highly likely to increase the overall initial intention ofmanufacturers to participate in the Green Mark eco-label program. The overall certification process contributed 16% to the total initial intention of manufacturers to apply the Green Mark eco-label to their products.

      • SCIESCOPUSKCI등재

        The Clinical Observation of Inflammation Theory for Depression: The Initiative of the Formosa Long COVID Multicenter Study (FOCuS)

        Shu-Tsen Liu(Shu-Tsen Liu),Sheng-Che Lin(Sheng-Che Lin),Jane Pei-Chen Chang(Jane Pei-Chen Chang),Kai-Jie Yang(Kai-Jie Yang),Che-Sheng Chu(Che-Sheng Chu),Chia-Chun Yang(Chia-Chun Yang),Chih-Sung Liang( 대한정신약물학회 2023 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.21 No.1

        There is growing evidence that the coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is associated with increased risks of psychiatric sequelae. Depression, anxiety, cognitive impairments, sleep disturbance, and fatigue during and after the acute phase of COVID-19 are prevalent, long-lasting, and exerting negative consequences on well-being and imposing a huge burden on healthcare systems and society. This current review presented timely updates of clinical research findings, particularly focusing on the pathogenetic mechanisms underlying the neuropsychiatric sequelae, and identified potential key targets for developing effective treatment strategies for long COVID. In addition, we introduced the Formosa Long COVID Multicenter Study (FOCuS), which aims to apply the inflammation theory to the pathogenesis and the psychosocial and nutrition treatments of post-COVID depression and anxiety.

      • KCI등재

        Virtual Screening and Testing of GSK-3 Inhibitors Using Human SH-SY5Y Cells Expressing Tau Folding Reporter and Mouse Hippocampal Primary Culture under Tau Cytotoxicity

        Lin Chih-Hsin,Hsieh Yu-Shao,Sun Ying-Chieh,Huang Wun-Han,Chen Shu-Ling,Weng Zheng-Kui,Lin Te-Hsien,Wu Yih-Ru,Chang Kuo-Hsuan,Huang Hei-Jen,Lee Guan-Chiun,Hsieh-Li Hsiu Mei,Lee-Chen Guey-Jen 한국응용약물학회 2023 Biomolecules & Therapeutics(구 응용약물학회지) Vol.31 No.1

        Glycogen synthase kinase-3β (GSK-3β) is an important serine/threonine kinase that implicates in multiple cellular processes and links with the neurodegenerative diseases including Alzheimer’s disease (AD). In this study, structure-based virtual screening was performed to search database for compounds targeting GSK-3β from Enamine’s screening collection. Of the top-ranked compounds, 7 primary hits underwent a luminescent kinase assay and a cell assay using human neuroblastoma SH-SY5Y cells expressing Tau repeat domain (TauRD) with pro-aggregant mutation ΔK280. In the kinase assay for these 7 compounds, residual GSK-3β activities ranged from 36.1% to 90.0% were detected at the IC50 of SB-216763. In the cell assay, only compounds VB-030 and VB-037 reduced Tau aggregation in SH-SY5Y cells expressing ΔK280 TauRD-DsRed folding reporter. In SH-SY5Y cells expressing ΔK280 TauRD, neither VB-030 nor VB-037 increased expression of GSK-3α Ser21 or GSK-3β Ser9. Among extracellular signal-regulated kinase (ERK), AKT serine/threonine kinase 1 (AKT), mitogen-activated protein kinase 14 (P38) and mitogenactivated protein kinase 8 (JNK) which modulate Tau phosphorylation, VB-037 attenuated active phosphorylation of P38 Thr180/ Tyr182, whereas VB-030 had no effect on the phosphorylation status of ERK, AKT, P38 or JNK. However, both VB-030 and VB-037 reduced endogenous Tau phosphorylation at Ser202, Thr231, Ser396 and Ser404 in neuronally differentiated SH-SY5Y expressing ΔK280 TauRD. In addition, VB-030 and VB-037 further improved neuronal survival and/or neurite length and branch in mouse hippocampal primary culture under Tau cytotoxicity. Overall, through inhibiting GSK-3β kinase activity and/or p-P38 (Thr180/Tyr182), both compounds may serve as promising candidates to reduce Tau aggregation/cytotoxicity for AD treatment.

      • KCI등재

        Impact of Stress Engineering on the Electron Mobility and the Balistic Current for Strained Si NMOSFETs

        Shu-Tong Chang,Shu-Hui Liao,Wei-Ching Wang,Chung-Yi Lin,Jun-Wei Fan 한국물리학회 2008 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.53 No.2

        The physical mechanisms of electron mobility and balistic drain curent enhancement by stress are investigated. From modified higher-order k·p band calculations, the stress-induced split of the conduction band edge and the effective mass change are quantitatively evaluated. It was experimentaly and theoreticaly demonstrated that the energy surface of 2-fold valeys in Si NMOSFETs on a (001) wafers is especially warped due to a uniaxial [110] stress, resulting in a lighter transverse effective mass of the 2-fold valleys parallel to the stress. The physical reasons for the warped subband structure and the abnormal mobility enhancement caused by the uniaxial stres are investigated. The rates of variation of the experimental electron mobility in NMOSFETs on wafers with (01) orientations undera <110> uniaxial stress as a function of the channel direction is theoretically studied. The limits of electron mobility enhancement and the effectiveness of stress enginering in enhancing the balistic drain current of NMOSFETs are also discussed.

      • Fragrant Bamboo: The Constructivist Inquiry-based Science Project Curriculum Implementing Place-based Education for Preschool Children in Taiwan Tayal Indigenous Tribe

        Shu-Chen Chien,Chao-Ti Hsiung,Shu-Fang Chen,Chun-Pin Lin 환태평양유아교육연구학회 2010 Asia-Pacific journal of research in early childhoo Vol.4 No.2

        The collaborative teaching research was conducted in northern Taiwan’s Tayal indigenous tribe to practice a constructivist inquiry-based science project curriculum implementing place-based education for kindergarten children. Research participants included 2 classroom teachers and 15 young children. Entering the natural tribal context, the researcher collected data through field observations, interviews, and other documentation. Qualitative method was adopted to analyze research data. A bamboo project was implemented relating to children’s life experiences. Research findings reveal: (1) teachers and children managed to co-construct a science project curriculum based on local resources and Tayal traditional knowledge (2) children developed basic scientific concepts and knowledge about natural plants through the inquiry-based project curriculum and (3) teachers regarded their roles as being colearners with children and realized the importance of children’s active involvement in the constructivist inquiry-based teaching. The result can help to improve science teaching/learning for indigenous children by utilizing environmental resources as well as traditional knowledge in future education.

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