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Shofiqur Rahman,Kouji Umeda,Faustino C. Icatlo, Jr.,이기웅,김성한,최혁준,한복경,박영서,Nguyen Van Sa 한국식품과학회 2013 Food Science and Biotechnology Vol.22 No.6
Infant formula supplemented with hyperimmuneimmunoglobulin Y (IgY) against human rotavirus (HRV)was evaluated in vitro against HRV reassortant clinicalstrains ATCC VR 2273 and ATCC VR 2274. Specific antihumanrotavirus antibody powder (Rotamix IgY) wasprepared. The effectiveness of Rotamix IgY alone and as apre-mixed solution with infant formula was evaluated forneutralizing rotavirus infectivity in MA104 cells. The testinfant formula cross-reacted strongly against differenthuman rotavirus strains with titers of 80-320 using a 50%fluorescent focus (FF) inhibition test. Both rotamix IgYalone and in a pre-mixed solution with infant formulashowed multi-serotypic cross neutralization activities againstthe major rotavirus global serotypes G1, G2, G3, and G4alone and with other human and animal-strains in vitro. Cell-rotavirus adhesion and cell damage arising fromrotavirus infection were significantly inhibited in a dosedependent manner, compared to control IgY supplementedinfant formula.
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Hlaing Myat Thu,Theingi Win Myat,Mo Mo Win,Kyaw Zin Thant,Shofiqur Rahman,Kouji Umeda,Sa Van Nguyen,Faustino C. Icatlo Jr,Kyoko Higo-moriguchi 한국축산식품학회 2017 한국축산식품학회지 Vol.37 No.1
The rotavirus-induced diarrhea of human and animal neonates is a major public health concern worldwide. Until recently, no effective therapy is available to specifically inactivate the rotavirion particles within the gut. Passive immunotherapy by oral administration of chicken egg yolk antibody (IgY) has emerged of late as a fresh alternative strategy to control infectious diseases of the alimentary tract and has been applied in the treatment of diarrhea due to rotavirus infection. The purpose of this concise review is to evaluate evidence on the properties and performance of anti-rotavirus immunoglobulin Y (IgY) for prevention and treatment of rotavirus diarrhea in human and animal neonates. A survey of relevant anti-rotavirus IgY basic studies and clinical trials among neonatal animals (since 1994-2015) and humans (since 1982-2015) have been reviewed and briefly summarized. Our analysis of a number of rotavirus investigations involving animal and human clinical trials revealed that anti-rotavirus IgY significantly reduced the severity of clinical manifestation of diarrhea among IgY-treated subjects relative to a corresponding control or placebo group. The accumulated information as a whole depicts oral IgY to be a safe and efficacious option for treatment of rotavirus diarrhea in neonates. There is however a clear need for more randomized, placebo controlled and double- blind trials with bigger sample size to further solidify and confirm claims of efficacy and safety in controlling diarrhea caused by rotavirus infection especially among human infants with health issues such as low birth weights or compromised immunity in whom it is most needed.
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