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( Ilia Polishchuk ),( Ahmed Algedafi ),( Jorge Shmuel Delgado ),( Dov Gefel ),( Galina Novokhatko ),( Olga Grisko ),( Shirly Hever ),( Alice Hochberg ),( Eli Ben Valid ),( Mariana Zamir ),( Levi Doron 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Gallstones and alcohol are the most important worldwide etiologic causes of acute pancreatitis. In Israel, we lack critical information regarding the etiology of acute pancreatitis. Objectives: to delineate the prevalence, the main causes, rate of recurrence of acute pancreatitis in southern Israel. Methods: We performed a retrospective cohort study, including the review of all medical charts of hospitalized patients diagnosed with acute pancreatitis between the years 2000-12. Results: 600 patients with “acute pancreatitis” were recorded (1.4:1000 admissions). 42% of patients were admitted to the general surgery department, and 50.9% to internal medicine wards. The main causes for acute pancreatitis were cholelithiasis (41.5%), alcohol (8.8%) and drugs (8.3%). Disothiazide was the most common drug associated with pancreatitis followed by Sitagliptin, Angiotensin Converting Enzyme inhibitors and simvastatin. 33.6% of cases were of undetermined etiology. Recurrence was noted in 33.8% of patients (alcohol OR 3.7%, hypertrigliceridemia OR 1.8) with noimplications on mortality. Conclusions: Biliary pancreatitis is still the main cause of pancreatitis in Israel and is a much more common etiology than alcohol. Drug-induced pancreatitis is a common etiology, with Thiazide being the most common drug associated with pancreatitis followed by ACE-Inhibitors sitagliptin and simvastatin. Sitagliptin was found to be a significant cause for acute pancreatitis (OR 1:5). A third of the cases of acute pancreatitis are idiopathic. Recurrence appears at least in a third of the patients.
Salim Lahmiri,Debra Ann Dawson,Amir Shmuel 대한의용생체공학회 2018 Biomedical Engineering Letters (BMEL) Vol.8 No.1
Parkinson’s disease (PD) is a widespreaddegenerative syndrome that affects the nervous system. Itsearly appearing symptoms include tremor, rigidity, andvocal impairment (dysphonia). Consequently, speechindicators are important in the identification of PD basedon dysphonic signs. In this regard, computer-aided-diagnosissystems based on machine learning can be useful inassisting clinicians in identifying PD patients. In this work,we evaluate the performance of machine learning basedtechniques for PD diagnosis based on dysphonia symptoms. Several machine learning techniques were consideredand trained with a set of twenty-two voice disordermeasurements to classify healthy and PD patients. Thesemachine learning methods included linear discriminantanalysis (LDA), k nearest-neighbors (k-NN), naı¨ve Bayes(NB), regression trees (RT), radial basis function neuralnetworks (RBFNN), support vector machine (SVM), andMahalanobis distance classifier. We evaluated the performanceof these methods by means of a tenfold cross validationprotocol. Experimental results show that the SVMclassifier achieved higher average performance than allother classifiers in terms of overall accuracy, G-mean, andarea under the curve of the receiver operating characteristicplot. The SVM classifier achieved higher performancemeasures than the majority of the other classifiers also interms of sensitivity, specificity, and F-measure statistics. The LDA, k-NN and RT achieved the highest averageprecision. The RBFNN method yielded the highestF-measure.; however, it performed poorly in terms of otherperformance metrics. Finally, t tests were performed toevaluate statistical significance of the results, confirmingthat the SVM outperformed most of the other classifiers onthe majority of performance measures. SVM is a promisingmethod for identifying PD patients based on classificationof dysphonia measurements.
( Yuval Kesary ),( Vivek Singh ),( Tal Frenkel ),( Rutenberg ),( Arie Greenberg ),( Shmuel Dekel ),( Ran Schwarzkopf ),( Nimrod Snir ) 대한슬관절학회 2021 대한슬관절학회지 Vol.33 No.-
Purpose: Patellofemoral pain syndrome (PFPS) is a common pathology usually presenting with anterior or retropatellar pain. It is associated with a relative imbalance between the vastus medialis oblique (VMO) and the vastus lateralis (VL) muscles. This can lead to considerable morbidity and reduced quality of life (QOL). This study aims to assess the long-term functional outcome of PFPS treated with VL muscle botulinum toxin A (BoNT-A) injection. Materials and methods: A retrospective review was performed on 26 consecutive patients (31 knees) with a mean age of 50.1 years (± 19.7 years) who were treated with BoNT-A injections to the VL muscle followed by physiotherapy between 2008 and 2015. Pre- and post-treatment pain levels (numerical rating scale, NRS), QOL (SF-6D), and functional scores (Kujala and Lysholm questionnaires) were measured. Demographics, physical therapy compliance, previous surgeries, perioperative complications, and patient satisfaction levels were collected. Results: The mean follow-up time was 58.8 ± 36.4 months. There were significant improvements in all the examined domains. The average pain score (NRS) decreased from 7.6 to 3.2 (P < 0.01), and the Kujala, Lysholm, and SF-6D scores improved from 58.9 to 82.7 (P < 0.001), 56.2 to 83.2 (P < 0.001), and 0.6 to 0.8 (P < 0.001), respectively. Similar delta improvement was achieved irrespective of gender, age, compliance to post-treatment physical therapy, or coexisting osteoarthritis. Patients who presented with a worse pre-treatment clinical status achieved greater improvement. Prior to BoNT-A intervention, 16 patients (18 knees) were scheduled for surgery, of whom 12 (75%, 13 knees) did not require further surgical intervention at the last follow-up. Conclusions: A single intervention of BoNT-A injections to the VL muscle combined with physiotherapy is beneficial for the treatment of patients with persistent PFPS. Level III evidence: Retrospective cohort study.
Keren-Lee Rozenfeld,Lior Lupu,Ilan Merdler,Samuel Morgan,Shmuel Banai,Yacov Shacham 대한노인병학회 2022 Annals of geriatric medicine and research Vol.26 No.4
Background: Primary percutaneous coronary intervention (PCI) is the preferred treatment strategy for patients with ST-elevation myocardial infarction (STEMI); however, its efficacy remains unclear in very older adult patients with STEMI. Methods: This retrospective single-center observational study included 530 patients aged >75 years admitted to Tel Aviv Sourasky Medical Center with a diagnosis of acute STEMI. Primary PCI was performed for patients with symptoms ≤12 hours in duration, while the other patients were conservatively treated. We evaluated 30-day mortality and complications occurring during hospitalization based on data from patient records. Results: Among the study patients, only 28/530 (5%) were conservatively treated. In-hospital complications, including the use of inotropes or intra-aortic balloon counterpulsation and the need for mechanical ventilation, did not differ significantly between the groups. The only parameter that showed a trend toward significance was the incidence of heart failure during hospitalization (p=0.042). The risk for 30-day mortality was substantially higher in the conservative treatment group than in the invasive treatment group (27% vs. 10%; p = 0.02). Conclusion: Our data suggested that despite concerns regarding the safety of the primary PCI strategy in the older adult STEMI population, this treatment strategy was associated with a survival benefit.
Orai1 and STIM1 in ER/PM junctions: roles in pancreatic cell function and dysfunction
Son, Aran,Park, Seonghee,Shin, Dong Min,Muallem, Shmuel American Physiological Society 2016 American journal of physiology. Cell physiology Vol.310 No.6
<P>Membrane contact sites (MCS) are critical junctions that form between the endoplasmic reticulum (ER) and membranes of various organelles, including the plasma membrane (PM). Signaling complexes, including mediators of Ca2+ signaling, are assembled within MCS, such as the ER/PM junction. This is most evident in polarized epithelial cells, such as pancreatic cells. Core Ca2+ signaling proteins cluster at the apical pole, the site of inositol 1,4,5-trisphosphate-mediated Ca2+ release and Orai1/transient receptor potential canonical-mediated store-dependent Ca2+ entry. Recent advances have characterized the proteins that tether the membranes at MCS and the role of these proteins in modulating physiological and pathological intracellular signaling. This review discusses recent advances in the characterization of Ca2+ signaling at ER/PM junctions and the relation of these junctions to physiological and pathological Ca2+ signaling in pancreatic acini.</P>