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Shiv Shankar Kumar,Arindam Dey,A. Murali Krishna 대한토목학회 2020 KSCE JOURNAL OF CIVIL ENGINEERING Vol.24 No.4
The response of saturated soil during earthquakes is governed by many factors such as frequency content, strain, stress, excess pore-water pressure and strength variations within the soil mass. This paper highlights the effect of strains on the stiffness modulus and its degradation at the liquefied condition of cohesionless soil. Cyclic triaxial (CT) tests, in stress-controlled manner, were carried out on saturated sandy soil specimens made at different relative density (Dr = 30% − 90%) and effective stress (σ'c = 50 − 200 kPa). The reconstituted specimens were subjected to regular and irregular stress histories. Representative strong motions with varying PGA were chosen, and the corresponding irregular stress histories were used. Additionally, regular stress histories constituted from different cyclic stress amplitudes were also used. The responses of the saturated specimen were obtained in terms of the excess pore-water pressure generation and strain accumulation with elapsed time. In comparison to the standard frequencyand duration parameters (namely the predominant period and significant durations), it is observed that the responses are more influenced by Arias intensity and specific energy density of the strong motion. Based on the increase in pore-water pressure, reduction in shear modulus and increase in shear strain within the specimens, the complete manifestation of liquefaction is divided in four zones, namely the no liquefaction zone, quasi-liquefaction zone, zone marking the onset of liquefaction and the completely liquefied zone. The criteria for the onset of liquefaction of Brahmaputra sand involving shear strain, peak ground acceleration and cyclic stress ratio are provided.
The Energy Efficient for Wireless Sensor Network Using The Base Station Location
Shiv Raj Baral,Young-Il Song,Kyedong Jung,Jong-Yong Lee 한국인터넷방송통신학회 2015 International Journal of Internet, Broadcasting an Vol.7 No.1
Energy constraints of wireless sensor networks are an important challenge. Data Transmission requires energy. Distance between origin and destination has an important role in energy consumption. In addition, the location of base station has a large impact on energy consumption and a specific method not proposed for it. In addition, a obtain model for location of base station proposed. Also a model for distributed clustering is presented by cluster heads. Eventually, a combination of discussed ideas is proposed to improve the energy consumption. The proposed ideas have been implemented over the LEACH-C protocol. Evaluation results show that the proposed methods have a better performance in energy consumption and lifetime of the network in comparison with similar methods.
Ventx1.1 competes with a transcriptional activator Xcad2 to regulate negatively its own expression
( Shiv Kumar ),( Zobia Umair ),( Vijay Kumar ),( Unjoo Lee ),( Sun-cheol Choi ),( Jaebong Kim ) 생화학분자생물학회(구 한국생화학분자생물학회) 2019 BMB Reports Vol.52 No.6
Dorsoventral patterning of body axis in vertebrate embryo is tightly controlled by a complex regulatory network of transcription factors. Ventx1.1 is known as a transcriptional repressor to inhibit dorsal mesoderm formation and neural differentiation in Xenopus. In an attempt to identify, using chromatin immunoprecipitation (ChIP)-Seq, genome-wide binding pattern of Ventx1.1 in Xenopus gastrulae, we observed that Ventx1.1 associates with its own 5’-flanking sequence. In this study, we present evidence that Ventx1.1 binds a cis-acting Ventx1.1 response element (VRE) in its own promoter, leading to repression of its own transcription. Site-directed mutagenesis of the VRE in the Ventx1.1 promoter significantly abrogated this inhibitory autoregulation of Ventx1.1 transcription. Notably, Ventx1.1 and Xcad2, an activator of Ventx1.1 transcription, competitively co-occupied the VRE in the Ventx1.1 promoter. In support of this, mutation of the VRE down-regulated basal and Xcad2-induced levels of Ventx1.1 promoter activity. In addition, overexpression of Ventx1.1 prevented Xcad2 from binding to the Ventx1.1 promoter, and vice versa. Taken together, these results suggest that Ventx1.1 negatively regulates its own transcription in competition with Xcad2, thereby fine-tuning its own expression levels during dorsoventral patterning of Xenopus early embryo. [BMB Reports 2019; 52(6): 403-408]
Predictors of steroid non-response and new approaches in severe alcoholic hepatitis
Shiv Kumar Sarin,Shvetank Sharma 대한간학회 2020 Clinical and Molecular Hepatology(대한간학회지) Vol.26 No.4
Severe alcoholic hepatitis (SAH) remains a disease with high mortality. Steroid is the main stay and has been shown to give modest 28-day survival benefit in carefully selected patients, but no 90-day survival benefit. Since non-responders have high incidence of infections and increased mortality, it would be worthwhile to identify them before starting steroid therapy. A high and rising bilirubin, urinary acetyl carnitine >2,500 ng/mL, high asiloglycoprotein positive microparticles, and specific features in liver biopsy could predict steroid non-response at baseline. There is an ever-growing need to find new and effective therapies for SAH patients. Besides aggressive nutrition, granulocyte colony stimulating factor, fecal microbiota transplantation, and plasma exchange appear promising therapies and provide a hope for steroid ineligible or steroid non-responsive patients. Suppression of hepatic inflammation, preventing new bacterial or fungal infections, and enhancing liver regeneration will remain the key targets for next generation therapies.
Shiv Bhushan,Santunu Sarangi,Gopi Krishna S.,Abirmoya Santra,Sarvesh Dubey,Pramod Kumar Tiwari 대한전자공학회 2013 Journal of semiconductor technology and science Vol.13 No.4
In this paper, an analytical threshold voltage model is developed for a short-channel double-material-gate (DMG) strained-silicon (s-Si) on silicon-germanium (Si1-x Gex) MOSFET structure. The proposed threshold voltage model is based on the so called virtual-cathode potential formulation. The virtual-cathode potential is taken as minimum channel potential along the transverse direction of the channel and is derived from tow-dimensional (2D) potential distribution of channel region. The (2D) potential distribution of channel region. The 2D channel potential is formulated by solving the 2D Poisson"s equation with suitable boundary conditions in both the strained-Si layer and relaxed Si1-x Gex layer. The effects of a number of device parameters like the Ge mole fraction, Si film thickness and gate-length ratio have been considered on threshold voltage. Further, the drain induced barrier lowering (DIBL) has also been analyzed for gate-length ratio and amount of strain variations. The validity of the present 2D analytical model is verified with ATLAS<SUP>TM</SUP>, a 2D device simulator from Silvaco Inc.
Shiv Kumar,S. A. Khan,Ozair Alam,Rizwan Azim,Atul Khurana,M. Shaquiquzzaman,Nadeem Siddiqui,Waquar Ahsan 대한화학회 2011 Bulletin of the Korean Chemical Society Vol.32 No.7
4-Chlorotetrazolo[1,5-a]quinoxaline (III) was synthesized by azide (2+3) cycloaddition of 2,3-dichloroquinoxaline (II). Compound (III) on further refluxing with hydrazine hydrate furnished 4-hydrazinotetrazolo[1,5-a]quinoxaline (IV). Further refluxing of (IV) with different aromatic aldehydes in methanol yielded corresponding Schiff’s bases V(a-j). Various 4-aminotetrazolo[1,5-a]quinoxaline based azetidinones VII(a-j) were synthesized by stirring the compounds V(a-j), at low temperature, with equimolar mixture of chloroacetylchloride & triethylamine in dry benzene, while 4-aminotetrazolo[1,5-a]quinoxaline based thiazolidinones VIII(a-j) were synthesized by refluxing Schiff’s bases V(a-j) with thioglycolic acid in oil-bath. The structures of all the compounds were confirmed on the basis of ^1H-NMR & FT-IR spectral data. All the newly synthesized compounds were screened for in-vitro antimicrobial activity against E. coli, S. aureus, K. pneumoniae & P. aeruginosa & antifungal activity against C. albicans. Few of them have exhibited the promising activity.