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Shin, J.I.,Lim, H.Y.,Kim, H.W.,Seung, B.J.,Ju, J.H.,Sur, J.H. ACADEMIC PR 2016 JOURNAL OF COMPARATIVE PATHOLOGY Vol.155 No.1
<P>This study was designed to investigate the role of obesity in canine malignant mammary tumours (CMMTs), by assessing aromatase expression and the regulatory roles of immune mediators such as cyclo-oxygenase-2 (COX2), prostaglandin E-2 (PGE(2)), nuclear factor kappa beta (NF-kappa B), hypoxia inducible factor-1 alpha (HIF-1 alpha cc) and adipokines (i.e. leptin) in lean, optimal body weight, overweight and obese animals. Clinicopathological data, including the breed, body weight, body condition score and age and neutering status, were collected, together with histopathological characteristics (i.e. histological types, grading and lymphatic invasion). To determine the expression of each factor, immunohistochemistry was conducted with 60 samples of malignant CMMTs. CMMTs from overweight and obese animals had significantly elevated levels of PGE(2), and aromatase expression correlated significantly with PGE(2), NF-kappa B and leptin expression. However, no significant difference was observed in terms of histopathological characteristics. The results suggest that PGE(2), a known obesity-related immune mediator, could be upregulated in CMMTs from overweight and obese animals. In addition, PGE(2), NF-kappa B and leptin influenced the expression of aromatase, as observed in women. (C) 2016 Elsevier Ltd. All rights reserved.</P>
Shin, Ji‐,Ae,Kim, Jae‐,Jin,Choi, Eun‐,Sun,Shim, Jung‐,Hyun,Ryu, Mi Heon,Kwon, Ki Han,Park, Hee‐,Min,Seo, Jin‐,Young,Lee, Soo‐,Yeon,Lim, Do‐,Won,Cho, Nam Wiley Subscription Services, Inc., A Wiley Company 2013 Head & neck Vol.35 No.7
<P><B>Abstract</B></P><P><B>Background</B></P><P>The aims of this study were to evaluate the apoptotic activities and molecular mechanisms of methanol extracts of <I>Dianthus chinensis</I> (MEDC) and <I>Acalypha australis</I> L. (MEAL) in human oral cancer cells.</P><P><B>Methods</B></P><P>The apoptotic effects and related molecular mechanisms of MEDC and MEAL on oral cancer cells were evaluated using MTS assay, DAPI staining, immunostaining, Western blotting, and reverse transcriptase–polymerase chain reaction.</P><P><B>Results</B></P><P>Sp1 was overexpressed in oral tumor tissues compared with normal oral mucosa. Downregulation of Sp1 inhibited the growth of SCC‐15 and YD‐15 oral cancer cells. MEDC and MEAL inhibited cell growth and induced apoptosis in both cell lines by decreasing the expression of Sp1. In addition, treatment of cells with MEDC and MEAL decreased Mcl‐1 expression, which is a downstream target of Sp1.</P><P><B>Conclusion</B></P><P>Our results indicate that MEDC and MEAL are bioactive natural products that can potentially induce apoptosis of tumor cells that overexpress the Sp1 protein. © 2012 Wiley Periodicals, Inc. Head Neck, 2013</P>
Shin, J.I.,Song, K.S.,Kim, H.,Cho, N.H.,Kim, J.,Kim, H.S.,Lee, J.S. Blackwell Publishing Ltd 2011 British journal of dermatology Vol.164 No.6
<P><B>Summary</B></P><P><B>Background </B> Because inflammatory cytokines are known to be potent inducers of matrix metalloproteinases (MMPs), and MMPs themselves can promote inflammation, we speculated that MMP activation might be involved in the pathogenesis of Henoch–Schönlein purpura (HSP) vasculitis.</P><P><B>Objectives </B> To investigate the gene expression profile of all known MMPs and tissue inhibitors of metalloproteinases (TIMPs) in children with HSP and to examine the role, if any, of MMPs in the pathogenesis of HSP.</P><P><B>Methods </B> Peripheral blood samples were obtained from 10 patients with HSP (nine were in the acute stage, one had HSP nephritis) and four healthy controls. Peripheral blood samples were also taken from the nine patients with HSP when they reached the convalescent stage of the disease. From these samples, total RNA was purified and gene expressions were measured using real‐time polymerase chain reaction.</P><P><B>Results </B> MMP‐8 expression was decreased in patients with arthralgia (<I>P </I>=<I> </I>0·038), and MMP‐3 (<I>P </I>=<I> </I>0·03) and TIMP‐4 expressions (<I>P </I>=<I> </I>0·016) were elevated in HSP patients with nephritis. Soft tissue oedema was associated with decreased expressions of MMP‐26 (<I>P </I>=<I> </I>0·038) and MMP‐28 (<I>P </I>=<I> </I>0·038). MMP‐1, MMP‐8, MMP‐9, MMP‐10, MMP‐13, MMP‐16 and MMP‐26 levels were significantly higher in patients in the acute stage of HSP than in normal controls (<I>P </I><<I> </I>0·05). MMP‐9 (<I>P </I>=<I> </I>0·097) and MMP‐19 (<I>P </I>=<I> </I>0·054) levels decreased to borderline significance in patients in the convalescent stage compared with those in the acute stage. The duration of steroid administration was negatively correlated with MMP‐1, MMP‐2, MMP‐7, MMP‐10, MMP‐12, MMP‐19, MMP‐23 and TIMP‐1 levels (<I>P </I><<I> </I>0·05), suggesting a suppressive effect of steroids on the expressions of MMPs and TIMPs.</P><P><B>Conclusions </B> This is the first study to describe the expression profile of all known MMPs and TIMPs in children with HSP, and our results suggested that abnormal levels of MMP and TIMP activity may have a role in the pathogenesis of HSP.</P>
Shinji Yoshii,Marina Kubo,Mio Matsumoto,Takefumi Kikuchi,Yasunari Takakuwa 대한소화기내시경학회 2020 Clinical Endoscopy Vol.53 No.2
Background/Aims: A multifunctional snare SOUTEN has a sharp tip at the top of the snare loop that enables incision of the mucosa,dissection of the submucosal layer, and snaring of lesion. This study assessed the effcacy and safety of complete endoscopic resection ofcolorectal neoplasia using SOUTEN. Methods: We analyzed the rates of gross en bloc resection and complete resections of 108 consecutive tumors from 69 patientsresected by precutting endoscopic mucosal resection (precutting), hybrid endoscopic submucosal dissection (hybrid), or conventionalendoscopic submucosal dissection (conventional) using SOUTEN. Results: Out of the 108 tumors, 50 were resected by precutting, 27 were resected by hybrid after attempting precutting, and theremaining 31 were resected by conventional after attempting precutting and hybrid resections. The median tumor sizes were 14.5 mmfor precutting, 16.4 mm for hybrid, and 21.1 mm for conventional. The success rate of gross en bloc resection and histological completeresection were 100% and 94.0% for precutting, 96.4% and 96.4% for hybrid, and 100% and 100% for conventional method, respectively. No procedure-related complication occurred. Conclusions: By using SOUTEN, precutting and hybrid were successfully performed on 10–30 mm tumors with a shorter proceduretime than conventional without major complications.
A Proposal for Prototype-Free Production Preparation Processes Utilizing 3DCG Animations
Shinji Shinoda,Kazuhiro Shimozawa,Akira Niwa,Takeshi Kawase,Toshiyuki Matsumoto,Tadahiro Mizumachi 대한산업공학회 2009 Industrial Engineeering & Management Systems Vol.8 No.2
As the use of 3DCAD data became widespread in designing products in manufacturing, attempts have been made to shorten lead time and reduce cost of production preparation utilizing 3DCAD data for launching assembly lines. In order to create assembly plans not only efficient but easy for operators to operate (‘easy-tooperate’), this study presents approaches, methods, and systems for creating 3DCGAs (3 Dimensional Computer Graphic Animations) which automatically utilize a prototype-free production preparation methodology. Characteristics of this study include that it proposes the methodology for creating assembly operation 3DCGAs automatically, for all the possible assembly operations corresponding each of the possible assembly sequences first. Using the created 3DCGAs, the study next considers assembly methods by evaluating how easy or ‘operator friendly’ they are in implementing, and devises tools or jigs to be used, and plans efficient assembly line organization. The concept of the methodology was formed by focusing on the value-adding assembly steps at which parts turn into products directly. The study also validates the effectiveness of the presented methodology by employing the methods used in actual production preparation process in businesses, and proves that an efficient assembly line can be organized in a shorter period of time utilizing the developed system and by preparing easy-to-operate and efficient plans in 3DCGAs at the design stage.
Shinji Hiyama,Toshie Sugiyama,Seiji Kusuhara,Takashi Uchida 대한수의학회 2012 JOURNAL OF VETERINARY SCIENCE Vol.13 No.3
The temporal expression of estrogen receptor (ER)α and ERβ mRNA was examined in male Japanese quails. Femurs of quails receiving 17βestradiol underwent RTPCR and histochemical analysis 1 to 15 days after treatment. Untreated quails were used as controls (day 0). Between days 0 and 5, cells lining the bone endosteal surface differentiated into osteoblasts, which in turn formed medullary bone. Expression of ERα was already observed on day 0 and increased slightly during bone formation whereas ERβ was hardly detected throughout this process. After osteoclasts appeared on the medullary bone surface, this type of bone disappeared from the bone marrow cavity (days 7∼15). ERα expression simultaneously decreased slightly and ERβ levels remained very low. These results suggest that estrogen activity mediated by ERα not only affects medullary bone formation but also bone resorption.
( Shinji Ishii ),( Suguru Fukahori ),( Kimio Asagiri ),( Yoshiaki Tanaka ),( Nobuyuki Saikusa ),( Naoki Hashizume ),( Motomu Yoshida ),( Daisuke Masui ),( Naoko Komatsuzaki ),( Naruki Higashidate ),( 대한소화기기능성질환·운동학회(구 대한소화관운동학회) 2017 Journal of Neurogastroenterology and Motility (JNM Vol.23 No.4
Background/Aims The aim of this study is to investigate the degree of delayed gastric emptying (DGE) and evaluate how the severity of DGE affects gastroesophageal reflux disease (GERD) in neurologically impaired (NI) patients utilizing 24-hour multichannel intraluminal impedance pH measurements (pH/MII) and <sup>13</sup>C-acetate breath test (<sup>13</sup>C-ABT) analyses. Methods <sup>13</sup>C-ABT and pH/MII were conducted in 26 NI patients who were referred to our institution due to suspected GERD. At first, correlation analyses were performed to investigate the correlation between the <sup>13</sup>C-ABT parameters and the clinical or pH/MII parameters. Thereafter, all patients were divided into 2 groups (DGE and severe DGE [SDGE] group) according to each cut off half emptying time (t<sub>1/2</sub>, 90-170 minutes). Each pH/MII parameter was compared between the 2 groups in each set-up cutoff t<sub>1/2</sub>. Results The mean t<sub>1/2</sub> of all patients was 215.5 ± 237.2 minutes and the t<sub>1/2</sub> of 24 (92.3%) patients were > 100 minutes. Significant moderate positive correlations were observed between both t1/2 and lag phase time and the non-acid reflux related parameters. Furthermore, the patients in the SDGE group demonstrated higher non-acid reflux related parameters than those of the DGE groups when the cutoff was t<sub>1/2</sub> ≥ 140 minutes. Conclusion The present study demonstrated that GE with t<sub>1/2</sub> ≥ 140 minutes was related to an increase of non-acid exposure reaching up to the proximal esophagus in NI patients, and indicating that NI patients with SDGE might have a high risk of non-acid GERD. (J Neurogastroenterol Motil 2017;23:533-540)
( Shinji Okabayashi ),( Taku Kobayashi ),( Tomohisa Sujino ),( Ryo Ozaki ),( Satoko Umeda ),( Takahiko Toyonaga ),( Eiko Saito ),( Masaru Nakano ),( Maria Carla Tablante ),( Shojiroh Morinaga ),( Tosh 대한장연구학회 2017 Intestinal Research Vol.15 No.4
Extracolonic involvement of the gastrointestinal tract is extremely uncommon in ulcerative colitis (UC) and rarely found in the upper gastrointestinal tract or in postoperative cases since it typically responds to steroids. Here we report a case of UC complicated by extensive ileal inflammation that was refractory to steroids. A 20-year-old man was diagnosed with UC of typical pancolitis without ileal involvement and started treatment with pH-dependent mesalazine and oral prednisolone. Although his symptoms transiently resolved, the condition flared when the steroid dose was tapered down. Computed tomography revealed marked thickening of the ileal wall, and capsule endoscopy and balloon-assisted enteroscopy found diffuse mucosal inflammation with ulcers in the ileum. On the contrary, the inflammation in the colon and rectum was improving. Since the response to the second steroid course was inadequate, treatment with adalimumab and 6-mercaptopurine was initiated and finally achieved clinical and endoscopic remission. The investigation of small intestinal lesions is necessary in patients with UC whose clinical deterioration cannot be explained by colonic lesions. (Intest Res 2017;15:535-539)