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A Study on the Waxing Effectiveness of Sugaring
Shinhwa Kang(Shinhwa Kang),Jiyoung Lee(Jiyoung Lee) J-INSTITUTE 2022 Protection Convergence Vol.7 No.2
Purpose: The pursuit of beauty, which started from ancient times, is a basic human need, and many studies on the attractiveness of appearance are on the rise, and such research on human beauty is an important public value. Recently, interest and demand for waxing are rising, but the level of professional education on waxing is low and the understanding of skin changes and follow-up care after waxing is low, so the need for research on waxing is emerging. The purpose of this study is to find out the difference in skin condition and hair growth rate after Brazilian treatment according to the type of waxing and to present it as basic data, and to contribute to the public value in beauty culture. Method: The subject of this study was a woman in her early 20s who had no experience with waxing, and waxed the bikini area between June and August 2022 using sugar wax and hard wax respectively. For 4 weeks after Brazilian waxing, the skin condition(including ingrown hair, folliculitis, etc.) and hair growth length were compared and analyzed at weekly intervals. The results were analyzed after the mixed study using clinical trials and interview methods. Results: As a result of comparative analysis of the skin condition and the length of the growing hair at weekly intervals after waxing, the condition of the skin showed that ingrown hair and inflammation occurred in the area where the sugar wax was applied, and the hair growth rate was slow. In the area treated with hard waxing, ingrown hair did not occur compared to sugar waxing, and the number of inflammations was significantly lower. The growth rate of cross-section hair was faster than that of sugar waxing, and it was confirmed that the thick-ness of the hair also grew thicker. Conclusion: Sugar waxing had excellent effects on hair removal and hair thickness reduction, such as lower skin dryness, redness, and irritation of pores compared to hard waxing, but follow-up care is expected to be very important. If follow-up care is not performed properly after Brazilian waxing, it is thought that the risk factors for ingrown hair and folliculitis may be high.
벼 흰잎마름병의 신속하고 간편한 진단을 위한 Recombinase Polymerase Amplification 등온증폭법
김신화(Shinhwa Kim),이봉춘(Bong Choon Lee),김현주(Hyun Ju Kim),최수연(Soo Yeon Choi),서수좌(Su Jwa Seo),김상민(Sang-Min Kim) 한국식물병리학회 2020 식물병연구 Vol.26 No.4
Xanthomonas oryzae pv. oryzae는 벼 흰잎마름병을 일으키는 세균이며, 벼 흰잎마름병은 벼 주요 재배지에서 꾸준하게 발생하고 있다. 본 연구에서는 벼흰잎마름병균을 신속하고 간편하게 검출하기 위해 등온증폭법 중 하나인 recombinase polymerase amplification (RPA)를 적용하여 현장진단 등을 위한 유전자기반 진단법을 개발하였다. RPA법은 짧은 시간의 등온 조건에서 유전자 증폭이 가능하다는 장점이 있다. 본 연구에서개발한 벼 흰잎마름병 RPA 진단법은 39oC에서 5분간만 반응하면 목표유전자의 증폭이 이루어지므로 기존 진단법보다 신속하고 간편하며 우리나라에 존재하는 K1–K3a의 4종 레이스에모두 적용가능하며, DNA 추출 없이 식물체 잎의 즙액으로 증폭반응 수행이 가능하며 기존 Taq 기반 PCR보다 약 10배 검출민감도가 높고 고가의 thermal cycler 없이도 항온수조, 발열블록 혹은 체온을 이용한 증폭반응 수행이 가능하다. 벼흰잎마름병은 벼의 농작물재해보험 대상재해 병충해 중의 하나이므로과학적 진단결과가 요구되나, 일선 농촌지도 현장에서는 유전자기반 진단을 위한 장비, 기술 등의 부족으로 분자진단이 어려웠다. 본 연구에서 개발한 벼 흰잎마름병 RPA 진단을 활용한다면 병징 의심부위 마쇄액을 주형으로, 손으로 5분 동안 반응시키는 것만으로도 신속하고 간편하게 벼 흰잎마름병의 목표유전자 증폭산물을 형성하므로 벼 흰잎마름병 진단의 최일선에서 활용할 수 있을 것이다. Rice bacterial leaf blight (BLB) by Xanthomonas oryzae pv. oryzae (Xoo) is considered to be one of the major rice diseases steadily occurring around the rice-producing countries. In this study, we developed a recombinase polymerase amplification (RPA) assay for the rapid, convenient and specific diagnosis of Xoo by targeting Xoo-specific transposase A gene. As the target gene can be amplified in 10 min without DNA extraction process and special equipment for temperature control, RPA for BLB can be useful and practical component for on-site diagnosis.
최신화(Shinhwa Choi),허남건(Nahmkeon Hur),강신형(Shin Hyound Kang) 대한기계학회 2015 대한기계학회 춘추학술대회 Vol.2015 No.11
This paper conducts a study on design of centrifugal blood pump in ECMO Condition. To obtain accurate simulation result, numerical investigation was performed steady and unsteady simulation. Based on numerical result, the unsteady simulations are more accurate than the steady results. Therefore unsteady simulation is more appropriate for future numerical investigation about Prototype. The maxium head value error occur between design curve with prototype unsteady simulation result. This error is considered loss problem at volute. Future paln study deep into a volute design.
Lee, Sung Bae,Noh, Shinhwa,Yeom, Hye Duck,Kim, Hyunah,Kim, Wonkil,Kim, Yoon Suh,Bae, Hyunsu,Lee, Jun-Ho Kyung Hee Oriental Medicine Research Center, Kyung 2016 Oriental Pharmacy and Experimental Medicine Vol.16 No.4
Alisma Rhizomes is used as a diuretic, hypolipidemic, anti-diabetic and anti-inflammatory agent in traditional East-Asian medicine. In this study, we tested the effect of Alisma Rhizomes on the <TEX>${\alpha}3{\beta}4$</TEX> nicotinic acetylcholine (nACh) receptor channel current in Xenopus oocytes. The acetylcholine-induced inward peak current (<TEX>$I_{ACh}$</TEX>) was measured with the two-electrode voltage-clamp technique. This experiment shows that the <TEX>${\alpha}3{\beta}4$</TEX> nACh receptor cRNA injected into oocytes followed by co-application with Alisma Rhizomes inhibited <TEX>$I_{ACh}$</TEX> in a noncompetitive or voltage insensitive condition. The half maximal inhibitory concentration (<TEX>$IC_{50}$</TEX>) of Alisma Rhizomes was <TEX>$12.5{\pm}3.4{\mu}g/ml$</TEX> and the Vmax was <TEX>$55.4{\pm}4.7$</TEX>. Protostane-type triterpenoids are the main active ingredient of Alisma Rhizomes (Alisol A, Alisol B, Alisol B 23-acetate, Alisol C 23-acetate). The respective IC50 values of Alisol A, Alisol B, Alisol B 23-acetate, and Alisol C 23-acetate were <TEX>$1.7{\pm}0.1$</TEX>, <TEX>$2.8{\pm}0.5$</TEX>, <TEX>$2.6{\pm}0.7$</TEX> and <TEX>$3.5{\pm}0.3{\mu}M$</TEX> in the <TEX>${\alpha}3{\beta}4$</TEX> nACh receptor expressed in Xenopus oocytes. Altogether, our research shows that protostane-type triterpenoids may modulate the <TEX>${\alpha}3{\beta}4$</TEX> nACh receptors expressed in oocytes in a reversible, concentration dependent and non-competitive manner. Furthermore, this modulation of the nACh receptor activity by protostane-type triterpenoids could underlie the pharmaceutics actions of Alisma rhizome.
A Molecular Basis for the Inhibition of Transient Receptor Potential Vanilloid Type 1 by Gomisin A
Lee, Sung Bae,Noh, Shinhwa,Yeom, Hye Duck,Jo, Heejin,Eom, Sanung,Kim, Yoon Suh,Nam, Sangsoo,Bae, Hyunsu,Lee, Jun-Ho Oxford University Press 2017 Evidence-based Complementary and Alternative Medic Vol.2017 No.-
<P> Transient receptor potential (TRP) channel has critical actions as conditional sensors in primary afferent neurons.We studied the regulatory action of gomisin A on TRPV1 channel current in this report. Schisandra chinensis contains bioactive compounds such as the gomisin derivatives and their related compounds. Coapplication with gomisin A inhibited the capsaicin-mediated inward peak current. This inhibitory effect of gomisin A on capsaicin-induced inward current showed concentration-dependence and was reversible. The half maximal inhibitory concentration of gomisin A was 62.7 ± 8.4 μM. In addition, this inhibition occurred in a noncompetition regulation mode and voltage insensitivemanner. Furthermore, molecular docking studies of gomisin A on TRPV1 showed that it interacted predominantly with residues at cavities in the segments 1 and 2 of each subunit. Four potential binding sites for this ligand in the extracellular region at sensor domain of TRPV1 channel were identified. Point mutagenesis studies were undertaken, and gomisin A potency decreased for both the Y453A and N467A mutants.The double mutation of Y453 and N467 significantly attenuated inhibitory effects by gomisin A. In summary, this study revealed the molecular basis for the interaction between TRPV1 and gomisin A and provides a novel potent interaction ligand. </P>