양격산화탕(凉膈散火湯)의 항염증(抗炎症) 효과에 대한 연구

탁미진,탁명림,강경화,고우신,윤화정,Tak, Mi-Jin,Tark, Myoung-Rim,Kang, Kyoung-Hwa,Ko, Woo-Shin,Yoon, Hwa-Jung 대한한방안이비인후피부과학회 2010 한방안이비인후피부과학회지 Vol.23 No.1

Objective: Yang Geouk San Hwa - Tang (YGSHT) has been widely used in Sasang Constitutional Medicine of Korea for treatment of acute inflammatory symptom, such as palatine tonsillitis, polydipsia, headache, papule, pimple however, the mechanism of its anti-inflammatory activity has not been clarified. In this study, therefore, we investigated the mechanism of the inhibitory effect of YGSHT on LPS-induced inflammation. Materials and methods: The effect of YGSHT was analyzed by ELISA, RT-PCR and Western blotting in LPS-stimulated RAW264.7 cells. Results: We found that YGSHT suppressed not only the production of pre-inflammatory cytokines (IL-$1{\beta}$ and TNF-$\alpha$), the generation of nitric oxide (NO) and prostaglandin E (PGE)2, but also the mRNA expression of pre-inflammatory cytokines, inducible nitric oxide synthase (iNOS), and cyclooxygenase (COX)-2. Furthermore, YGSHT was shown to inhibit the phosphorylation of ERK1/2 and JNK1/2 and the activation and translocation of NF-kB from cytosol to nuclear in LPS-stimulated RAW264.7 cells. Conclusions: These results suggest that YGSHT exerts an anti-inflammatory effect through the regulation of the ERK1/2 and JNK1/2 pathway and NF-kB pathway, thereby decreasing production of pre-inflammatory cytokines, NO, and PGE2.

노인의 기능저하예방을 위한 표준운동프로그램 개발 및 효과검증 연구

원영신(Won young Shin),도기현(Do ki hyun),홍미화(Hong Mi Hwa),조은영(Cho Eun Young),정문미(Jung Moon Mi) 글로벌시니어건강증진개발원 2012 글로벌시니어건강증진개발원 논문집 Vol.2 No.1

본 연구의 목적은 일상생활 속에서도 누구나 쉽고 편하게 따라 할 수 있는 노인의 신체기능 저하예방 및 개선에 적합한 표준운동프로그램을 개발한 후, 그 효과를 검증하는 것이다. 연구대상은 서울시 마포구 화신경로당에 등록되어 있고, 본 프로그램에 참여한 총 36명(남성노인 10명, 여성노인 26명)의 노인으로 선정하였으며, 평균연령은 77세이다. 프로그램은 2011년 8월 19일부터 10월 18일까지 총 3개월 동안 주 2회씩 12주간, 총 18회를 실시하였으며, 안무가 1명과 보조연구원 1명이 프로그램을 진행하였다. 조사도구는 설문지로 SFT(Senior Fitness Test)를 사용하였으며, 노인 체력 테스트로 본 프로그램의 효과분석을 실시하였고 세부적으로는 상·하체 유연성, 상·하체 근력, 평형성, 민첩성 에 관한 테스트를 실시하였다. 사후검사는 프로그램 18회를 모두 진행하고 10월 18일 프로그램이 종료된 후, 사전검사와 동일한 방법으로 실시하였다. 자료처리는 SPSS Windows 15.0 version 을 이용하여 빈도분석, 대응표본 t-test를 실시하였으며, 그 결과는 다음과 같다. 첫째, 참여노인의 체력 요인에 대한 차이분석 결과, 평형성을 제외한 하체유연성, 상체유연성, 하체근력, 상체근력, 평형성, 민첩성 모든 요인에서 통계적으로 유의하게 증가하였다. 둘째, 참여노인의 신체구성비에 대한 차이 분석 결과, 체지방율과 BMI는 통계적으로 유의하게 감소하였고, 기초대사량과 근육량은 유의하게 증가하였다. 또한 체지방량은 감소하여 프로그램에 따른 긍정적인 효과가 검증되었다. The purpose of this study was to verify the effect of poor physical function of the elderly in everyday life that anyone can easily and comfortably suitable for the prevention and improvement to develop a standard exercise program after. Distribution of Hwa-Sin-dong, Mapo-gu, Seoul incarnation is registered in the senior center, was selected and a total of 36 patients (10 patients, elderly men and elderly women, n = 26) participated in this program for the elderly, the age range from 61 years to 91-year-old and the average age 77-year-old. Program for three months from August 19, 2011 10 18 in 12 weeks, a total of 18 times, twice a week was conducted by research assistant choreographer with 1 program. Research tool, a detailed questionnaire to the elderly as a fitness test this program was carried out to analyze the effects of SFT (Senior Fitness Test), the upper and lower body flexibility (right, left), upper and lower body strength, balance (right, left), agility test was conducted. Post-inspection program 18 times in the same way as the pre-test and after the program ends Oct. 18, and all proceeds were conducted. Data processing were analyzed using SPSS Windows 15.0 version to the corresponding sample t-test was conducted, and the results are as follows. First, the analysis for differences in participation in physical factors of the elderly, lower body flexibility, balance, except for lower body strength, upper body flexibility, upper body strength, balance, and agility in all factors statistically significantly increased. Second, the difference analysis results for the participation of the elderly in the Composition of the body, was a statistically significant reduction in the percentage of body fat and BMI, basal metabolic rate, muscle mass increased significantly increased. Also reduced body fat, according to the program has a positive effect was verified.

근력평가의 척도인 1RM과 MVC의 상관관계

신화경,이상헌,태기식 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.14 No.1

노모를 부양하는 재미교포 자녀와 노모간의 상호지원교환, 지원교환에 대한 평가가 관계의 질에 미치는 영향

신화용 한국가족관계학회 2004 한국가족관계학회지 Vol.9 No.3

This research examined the intergenerational support exchanges between aged mothers(in-law) and caregiving daughters(in-law), and their influences on the relationship quality of mothers(in-law) and daughters(in-law). The data for the study were collected from 158 pairs of caregiving daughters(in-law) and mothers(in-law) living in 4 major cities in the U. S. A. The amount of support that mothers(in-law) provided to their daughters(in-law) was smaller than that mothers(in-law) received from their daughters(in-law). With respect to the evaluation of support exchanges, daughters(in-law) perceived that mothers(in-law) are more benefitted from their exchanges, while mothers(in-law) perceived their exchanges as fair and equivalent. Mothers(in-law) experienced a higher relationship quality when they received more support from their children and when they provided more support to their children. For children, relationship quality was affected by their family position(daughter vs. daughter-in-law), provision of support to their parents, and mothers' perceptions of receiving support.

국소 팽창 마취법을 이용한 하지정맥류의 수술법

신화균 순천향의학연구소 2005 Journal of Soonchunhyang Medical Science Vol.11 No.1

Background : To determine the efficacy and safety of operation of varicose veins using a tumescent anesthetic technique. Patients & Methods : 58 consecutive patients underwent 86 surgical procedure, including high ligations and stripping of the greater saphenous vein. There were 36 women and 22 men. All patients were operated under local anesthesia. Results : The operations were easily performed under tumescent anesthetic technique without major complications. 58 patients(36/62.1% female, 22/37.9% male, aged 20-70 years) had varicose vein. Average age at the time of operation was 48.3 years(range, 20 to 70 years). There were 49 unilateral procedures and 9 bilateral operations. Operative time ranged from 24 to 64 minutes (average 38.2 minutes) in the unilateral procedure. The number of incisions per limb averaged 2.7(range, 2 to 5). Conclusion : Varicose vein removal using the tumescent technique for local anesthesia is a safe and efficient procedure.

주거 공간 개조에 관한 사례 분석 연구

신화경,안진희 상명대학교 자연과학연구소 2002 自然科學硏究 Vol.9 No.-

주거 공간의 개조는 삶의 질을 보다 향상시키고자 하는 필요에서 거주자 고유의 개성을 인정하는 생활을 담아 내기 위한 수단으로 시행되고 있다. 개조의 필요성에 대한 홍보가 점차 증가하고 있으며 개조에 관한 시민 의식과 관심이 고조되는 현 시점에서 본 연구는 주거 공간 개조 사례를 통해 주거 공간 개조 특성을 파악하여 향후 거주 공간 계획에 필요한 자료를 제시하고자 한다. 주거 공간은 개인 공간, 공동 공간, 위생 공간, 가사 작업 공간, 기타 공간으로 구분하고 각 공간별로 새로 만들어진 공간, 기존 공간의 분리, 공간의 확장, 위치 변경 등의 내용으로 개조 특성을 파악하였다. 분석 결과, 주거 공간 중 개인 공간의 개조가 가장 많이 나타났으며, 다음으로는 가사 작업 공간에서의 개조가 많이 나타났다. 개조 내용으로는 공간의 확장이 가장 많이 나타났으며, 다음으로는 위치 변경이 많이 나타났다.

각화낭성치성종양의 재발과 연관된 p53, Ki-67, PCNA 및 cytokeratin 17, cytokeratin 18의 발현

신상훈,성화식,이승환 부산대학교 병원 암연구소 2008 부산대병원학술지 Vol.- No.24

The keratocystic odontogenic tumor(OKC) represents approximately 11% of odontogenic cysts and is decided by microscopic and histopathologic determinant rather than by clinical apprearance. The OKC is noted for its capacity to recur after treatment. In this study, p53, Ki-67, PCNA and cytokeratin 17, cytokeratin 18 expression of OKC in relation to non-recurrenct lesion and recurrent lesion after cyst enucleation were examinated. The p53, Ki-67, PCNA and cytokeratin 17, cytokeratin 18 antibody staining were used. The obtained results were as follows. In proliferating rate of non-recurrent OKCs and recurrent OKCs using p53, Ki-67 and PCNA staing, there was not significant difference. In cytokeratin 17 staining, strong positive reaction was showed in all layers of recurrent OKCs rather than non-recurrent OKCs. In cytokeratin 18 staining, negative or weakly positive reaction was showed in recurrent OKCs rather than non-recurrent OKCs. In summary, it was suggested that the recurrence of OKCs was not related to proliferating rate of epithelium and the prognosis of the recurrence of OKCs is helped using cytokeratin 17 and cytokeratin 18.

응급실을 내원한 구강악안면외과 안면골 골절 환자의 변화에 대한 비교 연구

신상훈,성화식,강영훈,황대석,김용덕,김욱규,김종렬,정인교 부산대학교 병원 암연구소 2008 부산대병원학술지 Vol.- No.24

Although there have been many clinical studies about the facial trauma in the recent as well as in the past, severity and frequency of facial trauma are reported multifarious. It seemed to be because of variety of social, cultural, and environmental factors, and the view point of investigators. In this study, we investigated about the patients visiting emergency room during recent 4 years(2004-2007), and compared with retrospective study during former 10 years(1992-1996, 1999-2003) in Dept. OMS Pusan National University Hospital. We assessed the cause, type, demographic, etc, and analyzed alterations of facial bone fractures during past 3 periods. The results were as follows. The total number of patients was increased. 429 patients treated for maxillofacial fractures between January 1992 and December 1996, 466 patients treated between January 1992 and December 1996 and 764 patients treated between January 2004 and December 2007. The male-to-female ratio were 4.6:1, 3.9:1, and 4.16:1, respectively. Patient in the age groups of 10-19 years and 20-29 years increased in the latter two periods. Assaults and falls are decreased gradually, but slip down s are increased. Traffic accidents are still major cause of facial trauma. The mandibular fractures showed the highest incidence thorought three periods. Symphysis fractures of mandible was increased and condyle fractures of mandible was drecreased in the third period.

12주 근력강화훈련 동안 표면근전도 신호의 특성

신화경,조상현,차광석 한국전문물리치료학회 2003 한국전문물리치료학회지 Vol.10 No.1

Ⅰ. 서론 Ⅱ. 연구방법 1. 연구대상 2. 실험설계 3. 근력강화훈련 4. 최대 근력의 평가 5. 표면근전도 신호 수집 가. 장비 설정 나. 표면근전도 신호 수집 6. 신호 처리 가. 주파수 스펙트럼 분석 나. 적분EMG 7. 통계분석 가. 정규화 나. 통계분석 Ⅲ. 결과 1. 근육 둘레의 변화 2. 적분EMG와 근수축력의 변화 가. 등척성 운동 나. 등장성 운동 다. 12주 동안 근력과 적분EMG의 변화 3. 초기중앙주파수의 변화 4. 피로지수의 변화 5. 회귀직선 기울기의 변화 Ⅳ. 고찰 Ⅴ. 결론 This study tested whether repeated measurement of median frequency (MDF)-related variables could express the muscle power changes during a 12-week DeLome strengthening program, by using consecutive overlapping FFT (Fast Fourier transformation) and integrated EMG (IEMG) from surface EMG data for isometric and isotonic exercise. To evaluate the effect of training, the following were recorded every 3 weeks for the elbow flexors and knee extensors of 5 healthy male volunteers: MVC, 1RM, limb circumference, and surface EMG during isometric MVC or isotonic contraction at 10RM load. From the EMG data, IEMG and variables from a regression analysis between MDF and time were obtained. MVC, 1RM, IEMG, and initial MDF increased linearly over the training period. The fatigue index and slope of the regression line increased temporarily until the 6th week and decreased thereafter. From these results, there appeared to be enhanced neural recruitment of fast twitch fibers in the first 6 weeks and continued enhancement in the recruitment and hypertrophy of fast twitch fibers, which led to increased fatigue resistance, over the last 6 weeks. Accordingly, the MDF and IEMG analysis technique could demonstrate the effect of the program detected significant changes in both isometric and isotonic contractions. EMG analysis methods can be used to estimate the electrophysiological and histological changes in skeletal muscles during a strengthening program.

중학교 남녀학생별 가정교과에 대한 인식 및 학습효과 : 경남지역을 중심으로

신동순,김상희,오화자,정효숙,정혜경 한국 가정과 교육 학회 1997 한국가정과교육학회지 Vol.9 No.1

The aims of this research study is to clear the differences of the learning effects and the cognition of Home Economics by sex in the middle school and to collect the future-oriented educational datas, after implementing the 6th education curriculum. The results of the study are as follows ; 1. Most of students had the cognition that Home Economics is a subject matter of a needful knowledge and skill for the family life, half students a cultural subject matter for the modern life. The former was supported by female students, the latter by male students. 2. Most of students were interested in actual training fields of cooking and hand-sewing, had a strong interest about a field of physical and social-psychological growth. The differences by sex were statistically significant in these fields. 3. Most of students had positive responses in the learning effects of Home Economics. The most useful field was cooking and the worst was the structure and method of sewing machine. 4. The shortage and the dissatisfaction in the learning of Home Economics were lacking of the actual training hours, the old-fashioned teaching methods and the shortage of teaching materials etc.