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Dendrite-like Process Formation and Cytoskeletal Remodeling Regulated by δ-Catenin expression
Kim, Kwonseop,Sirota, Anna,Chen, Yan-hua,Jones, Shiloh B.,Dudek, Ronald,Lanford, George W.,Thakore, Chittam,Lu, Qun 전남대학교 약품개발연구소 2002 약품개발연구지 Vol.11 No.-
Actin- and microtubule-mediated changes in cell shape are essential for many cellular activities. However, the molecular mechanisms underlying the interplay between the two are complex and remain obscure. Here we show that the expression of δ-catenin (or NPRAP/Neurojungin), a member of p120^ctm subfamily of armadillo proteins can induce the branching of dendrite-like processes in 3T3 cells and enhance dendritic morphogenesis in primary hippocampal neurons. This induction of branching phenotype involves initially the disruption of filamentous actin, and requires the growth of microtubules. The carboxyl-terminal truncation mutant of δ-catenin can cluster and redistribute the full-length protein, and dominantly inhibit its branching effect. δ-Catenin forms protein complexes and can bind directly to actin in vitro. The carboxyl-terminal truncation of δ-catenin does not interfere with its actin-binding capability; therefore the actin interaction alone is not sufficient for the induction of dendrite-like processes. When δ-catenin-transformed cells establish elaborate dendrite-like branches, the main cellular processes become stabilized and resist the disruption od both actin filaments and microscopy and time-lapse recording analyses. We suggest that δ-catenin can effect a biphasic cytoskeletal remodeling event which differentially regulates actin and microtubules and promotes cellular morphogenesis.
Heavy metal assessment of marine sediment in selected coastal districts of the Western Region, Ghana
Kuranchie-Mensah, Harriet,Osei, Juliet,Atiemo, Sampson M.,Nyarko, Benjamin J.B.,Osae, Shiloh K.,Laar, Cynthia,Ackah, Michael,Buah-Kwofie, Archibold,Blankson-Arthur, Sara,Adeti, Prince J. Techno-Press 2013 Advances in environmental research Vol.2 No.2
A preliminary investigation to establish the status of contamination of trace metals in the Western coast of Ghana was conducted prior to the commercial production of crude oil in the area. The study revealed the presence of heavy metals such as Pb (4.00-79.64 mg/kg), As (8.81-236 mg/kg), Cu (12.86-108.06 mg/kg), V (28.07-953.32 mg/kg), Zn (7.08-264.25 mg/kg), Cr (101.69-1366.62 mg/kg), Ni (42.41-451.43 mg/kg), Mn (16.77-1890.45mg/kg), Br (7.66-142.78 mg/kg), Ti (542.03-19960 mg/kg) and Fe (7472.88-97120 mg/kg) at six sites sampled along the coast. With the exception of Ti and Fe which showed no variation in metal concentration, the rest of the metals varied significantly among the sampled locations. Potential ecological risk of metals particularly of Co, As and Br which exhibited extreme enrichment of the sediments indicates considerable metal pollution in the studied areas. The degree of contamination is of particular concern especially to benthic biota that inhabit this environment for survival.