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Shi, Liang,Seo, Hyo Jin Optical Society of America 2011 Optics express Vol.19 No.8
<P>The single-phased K<sub>2</sub>Y<sub>1-x</sub>Eu<sub>x</sub>Zr(PO<sub>4</sub>)<sub>3</sub> (x = 0~1) phosphors were prepared by solid-state reaction. The greenish-blue Zr<sup>4+</sup>-emission due to the Zr<sup>4+</sup>-O<sup>2-</sup> charge transfer transition is observed in the K<sub>2</sub>YZr(PO<sub>4</sub>)<sub>3</sub> (x = 0) phosphor under UV excitation. Together with the Zr<sup>4+</sup>-emission, the red emission of Eu<sup>3+</sup> is progressively developed by replacement of Y<sup>3+</sup> to Eu<sup>3+</sup> over the full Eu-content (x = 0~1) in K<sub>2</sub>Y<sub>1-x</sub>Eu<sub>x</sub>Zr(PO<sub>4</sub>)<sub>3</sub>. The emission color varies from greenish-blue to whitish with increasing Eu<sup>3+</sup>-content and the white-light emission is realized in single-phased phosphor of K<sub>2</sub>EuZr(PO<sub>4</sub>)<sub>3</sub> (x = 1) by combining the Zr<sup>4+</sup>-emission and the Eu<sup>3+</sup>-emission.</P>
Shi, Liang,Wu, Li-Li,Yang, Jian-Rong,Chen, Xiao-Fei,Zhang, Yi,Chen, Zeng-Qiang,Liu, Cun-Li,Chi, Sheng-Ying,Zheng, Jia-Ying,Huang, Hai-Xia,Yu, Fu-Jun,Lin, Xiang-Yang Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.7
Background: Recently, peroxiredoxin3 (PRDX3) was identified as a novel molecular marker for the progression of hepatocellular carcinoma (HCC). However, its potential clinical application as a serum marker for the early diagnosis and prognosis of HCC has not been investigated. Methods: PRDX3, alpha-fetaprotein (AFP), and other biochemical parameters were measured in serum samples from 297 Chinese patients, including 96 with HCC, 98 with liver cirrhosis (LC), and 103 healthy controls (HCs). Correlations between serum PRDX3 expression and clinicopathological variables and the relationship between serum PRDX3 expression and prognosis were analyzed. Results: Serum PRDX3 was significantly higher in HCC patients than in the LC and HC groups. The sensitivity and specificity of serum PRDX3 for the diagnosis of HCC were 85.9% and 75.3%, respectively, at a cutoff of 153.26 ng/mL, and the area under the curve was 0.865. Moreover, serum PRDX3 expression was strongly associated with AFP level, tumor diameter, TNM stage, and portal vein invasion. Kaplan-Meier curve analysis revealed that HCC patients with high serum PRDX3 expression had a shorter median survival time than those with low PRDX3 expression. Moreover, serum PRDX3 expression was an independent risk factor for overall survival. The inverse correlation between serum PRDX3 and patient survival remained significant in patients with early-stage HCC and in those with normal serum AFP levels. Conclusions: Serum PRDX3 can be used as a noninvasive biomarker for the diagnosis and/or prognosis of HCC.
Shi, Liang,Chen, Zhan-Guo,Wu, Li-li,Zheng, Jian-Jian,Yang, Jian-Rong,Chen, Xiao-Fei,Chen, Zeng-Qiang,Liu, Cun-Li,Chi, Sheng-Ying,Zheng, Jia-Ying,Huang, Hai-Xia,Lin, Xiang-Yang,Zheng, Fang Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.23
Many chemotherapeutic agents have been successfully used to treat hepatocellular carcinoma (HCC); however, the development of chemoresistance in liver cancer cells usually results in a relapse and worsening of prognosis. It has been demonstrated that DNA methylation and histone modification play crucial roles in chemotherapy resistance. Currently, extensive research has shown that there is another potential mechanism of gene expression control, which is mediated through the function of short noncoding RNAs, especially for microRNAs (miRNAs), but little is known about their roles in cancer cell drug resistance. In present study, by taking advantage of miRNA effects on the resistance of human hepatocellular carcinoma cells line to cisplatin, it has been demonstrated that miR-340 were significantly downregulated whereas Nrf2 was upregulated in HepG2/CDDP (cisplatin) cells, compared with parental HepG2 cells. Bioinformatics analysis and luciferase assays of Nrf2-3'-untranslated region-based reporter constructor indicated that Nrf2 was the direct target gene of miR-340, miR-340 mimics suppressing Nrf2-dependent antioxidant pathway and enhancing the sensitivity of HepG2/CDDP cells to cisplatin. Interestingly, transfection with miR-340 mimics combined with miR-340 inhibitors reactivated the Nrf2 related pathway and restored the resistance of HepG2/CDDP cells to CDDP. Collectively, the results first suggested that lower expression of miR-340 is involved in the development of CDDP resistance in hepatocellular carcinoma cell line, at least partly due to regulating Nrf2-dependent antioxidant pathway.
Practical Swarm Optimization based Fault-Tolerance Algorithm for the Internet of Things
( Shiliang Luo ),( Lianglun Cheng ),( Bin Ren ) 한국인터넷정보학회 2014 KSII Transactions on Internet and Information Syst Vol.8 No.4
The fault-tolerance routing problem is one of the most important issues in the application of the Internet of Things, and has been attracting growing research interests. In order to maintain the communication paths from source sensors to the macronodes, we present a hybrid routing scheme and model, in which alternate paths are created once the previous routing is broken. Then, we propose an improved efficient and intelligent fault-tolerance algorithm (IEIFTA) to provide the fast routing recovery and reconstruct the network topology for path failure in the Internet of Things. In the IEIFTA, mutation direction of the particle is determined by multi-swarm evolution equation, and its diversity is improved by the immune mechanism, which can improve the ability of global search and improve the converging rate of the algorithm. The simulation results indicate that the IEIFTA-based fault-tolerance algorithm outperforms the EARQ algorithm and the SPSOA algorithm due to its ability of fast routing recovery mechanism and prolonging the lifetime of the Internet of Things.
Stress Evolution Law and Failure Characteristics of Mining Floor Rock Mass above Confined Water
Shiliang Liu,Weitao Liu,Jianjun Shen 대한토목학회 2017 KSCE Journal of Civil Engineering Vol.21 No.7
The discussion of stress evolution law and failure characteristics of rock mass in mining floor above confined water is the key to control the floor water inrush in deep mining. Based on analyzing the strike support pressure of working face, the mechanical model of coal floor above the confined water was established. Then, vertical, horizontal and shear stress distribution maps and the failure range morphological map of mining floor were calculated based on data processing software Origin. Then, with the similar simulation test bed for water inrush from coal seam floor, the fluid solid coupling simulation material was selected, and the stress evolution law and failure characteristics of coal seam mining floor were improved. The results showed that the vertical stress contour is a “semi-elliptical” shape distribution and the greater the floor depth, the smaller the affected degree, but the influenced range increased. The higher shear stress zone occurred in the vicinity of working face coal wall. The failure range morphological map of mining floor was approximately a spoon shape and maximum failure depth was 14.0 m based on the mechanical theory. The maximum failure depth of the floor was 13.4 m based on the similar simulation experiment. So, the experimental results are in agreement with the theoretical results. The results in this paper can provide theory basis for safety mining above confined water.
Practical Swarm Optimization based Fault-Tolerance Algorithm for the Internet of Things
( Shiliang Luo ),( Lianglun Cheng ),( Bin Ren ) 한국인터넷정보학회 2014 KSII Transactions on Internet and Information Syst Vol.8 No.3
The fault-tolerance routing problem is one of the most important issues in the application of the Internet of Things, and has been attracting growing research interests. In order to maintain the communication paths from source sensors to the macronodes, we present a hybrid routing scheme and model, in which alternate paths are created once the previous routing is broken. Then, we propose an improved efficient and intelligent fault-tolerance algorithm (IEIFTA) to provide the fast routing recovery and reconstruct the network topology for path failure in the Internet of Things. In the IEIFTA, mutation direction of the particle is determined by multi-swarm evolution equation, and its diversity is improved by the immune mechanism, which can improve the ability of global search and improve the converging rate of the algorithm. The simulation results indicate that the IEIFTA-based fault-tolerance algorithm outperforms the EARQ algorithm and the SPSOA algorithm due to its ability of fast routing recovery mechanism and prolonging the lifetime of the Internet of Things.
Shiliang Wang,Hua Zhong,Meijuan Lu,Guohua Song,Xiaomei Zhang,Min Lin,Shengliang Yang,Mincai Qian 대한신경정신의학회 2018 PSYCHIATRY INVESTIGATION Vol.15 No.8
Objective_The pathogenesis of depression is not fully understood yet, but studies have suggested higher circulating C reactive protein (CRP) level might relate to depression occurrence. However, due to high variability of patients’ individual condition, the results to date are inconsistent. Considering CRP single-nucleotide polymorphisms (SNPs) could also regulate plasma CRP levels, in the present study, we hypothesized that inherited CRP allelic variations may co-vary with depressive symptomatology. Methods_We recruited 60 depression patients with family depression history and 60 healthy control volunteers into this project. We detected circulation CRP level as well as genome CRP SNPs from participants of this project. Results_We have found a significantly higher circulating CRP level in patients with a positive family history. Furthermore, we also identified some certain inherited CRP SNPs (A allele in rs1417938 and C allele in rs1205) could up regulate serum CRP level and distributed more in depression patients with family history. Conclusion_Our finding may raise new evidence that genetically increased serum CRP level through SNPs variation is likely to induce family inherited depression.
Simulation Study on Removal Mechanism of Si3N4 Ceramic in Rotary Ultrasonic Grinding
Shiliang Wei,Tao Zhang,Hengju Wei,Wei Wang,Haiyang Wang,Youdi Liu 한국정밀공학회 2023 International Journal of Precision Engineering and Vol.24 No.6
Hot-pressed Si3N4 ceramic is a kind of high-performance ceramic material, which is widely used in national defense, aerospace, and other professional fields. Aiming at the problem of poor surface quality of Si3N4 ceramic material, the paper carried out a simulation study on the removal mechanism of Si3N4 ceramic by rotary ultrasonic grinding. The study provides a theoretical basis for improving the surface quality and processing efficiency of hot-pressed Si3N4 ceramics. Combined with dynamic simulation software to complete single abrasive and double abrasive rotary ultrasonic grinding simulation. Material removal and surface crack propagation in single and double abrasive grains rotary ultrasonic grinding of Si3N4 ceramic were analyzed by crack propagation theory. The grinding force of Si3N4 ceramics with different ultrasonic amplitude and grinding depth and the local stress change at the time of crack generation with different ultrasonic amplitude were compared and analyzed. Complete single abrasive and double abrasive rotary ultrasonic scratch test. The grinding force and surface crack generation obtained by rotary ultrasonic scratch test and rotary ultrasonic grinding simulation were analyzed. The maximum error of the simulation results of single-grain and double-grain rotary ultrasonic grinding is 12.8% and 14.7% respectively. The surface crack of the scratch test workpiece is consistent with the simulation results.