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Risk Assessments of Floods Caused by Volcanic Eruptions of the Changbai Volcano and Countermeasures
( Shengwu Qin ),( Shuangshuang Qiao ) 대한지질공학회 2019 대한지질공학회 학술발표회논문집 Vol.2019 No.2
The active Changbai volcano (SE China) and the 2.04 km3 volume of water in the large caldera lake will cause serious economic losses and many human casualties in the event of an eruption. It is of great significance to evaluate the flood risk from the two aspects of flood hazards and vulnerability using a geographic information system (GIS). In this paper, based on the hydrological analysis function of ArcGIS (10.2, Esri, California, USA, 2013) and the topographic data at the bottom of Tianchi Lake, the relationship between the volume of overflow water and the increase in the lake surface height was calculated. The inundation maps under the four scenarios with the surface of the Tianchi Lake uplifted by 100, 165, 225, and 285 m were simulated by the MIKE21 hydraulic model. The simulation results were combined with six factors, the distance to power stations, the distance to roads, the population density, buildings, eco-environment, and the distance to tourist sites, to assess the risk of floods from the overflow of the caldera lake. Flood risk maps can provide a basis for disaster prevention and mitigation in the area of Changbai Mountain and have practical significance for social stability and sustainable economic development.
Lu Yan,Huiyuan Wang,Yifan Jiang,Jinhua Liu,Zhao Wang,Yongxin Yang,Shengwu Huang,Yongzhuo Huang 한국고분자학회 2013 Macromolecular Research Vol.21 No.4
Macromolecular drugs become an essential part in neuroprotective treatment. However, the nature of ineffective delivery crossing the blood brain barrier (BBB) renders those macromolecules undruggable for clinical practice. Recently, brain target via intranasal delivery have provided a promising solution to circumventing the BBB. Despite the direct route from nose to brain (i.e. olfactory pathway), there still are big challenges for large compounds like proteins to overcome the multiple delivery barriers such as nasal mucosa penetration, intracellular transport along the olfactory neuron, and diffusion across the heterogeneous brain compartments. Herein presented is an intranasal strategy mediated by cell-penetrating peptide modified poly(lactic-co-glycolic acid) (PLGA) nanoparticles for the delivery of insulin to the brain, a potent therapeutic against Alzheimer’s disease. The results revealed that the cell-penetrating peptide can potentially deliver insulin into brain via the nasal route, showing a total brain delivery efficiency of 6%. It could serve as a potential treatment for neurodegenerative diseases.