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Identification of Loop Nucleotide Polymorphisms Affecting MicroRNA Processing and Function
Xiaoxing Xiong,Shengmei Zhu,Xianhui Kang,Yueying Zheng,Sibiao Yue 한국분자세포생물학회 2013 Molecules and cells Vol.36 No.6
MicroRNAs are short 21-22 nucleotide single strand RNAs that are involved in post-transcriptional regulation of gene expression. Most microRNAs are first transcribed as long primary microRNAs and then undergo a two step-wise sequential processing to yield single-stranded mature microRNAs. It has been suggested that the loop region of primary microRNAs plays an important role in regulating microRNA biogenesis and target recognition. However, despite the fact that several single nucleotide polymorphisms have been identified in mature microRNA sequences and are related to human diseases, it remains unclear whether and how the single nucleotide polymorphisms in the loop regions of primary microRNAs would affect the biogenesis and function of microRNAs. Herein, we provide evidence that primary microRNAs loop nucleo-tides control the accuracy and efficiency of microRNA processing. Accordingly, we identified 32 single nucleotide polymorphisms in the loop regions of human primary microRNAs using bioinformatics, and further validated three loss-of-function and one gain-of-function single nucleotide polymorphisms using dual-luciferase assays. Thus, these results reveal a critical regulatory role encoded in the loop nucleotides of primary microRNAs for microRNA processing and function.
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A Symmetric Lookup-based Secure P2P Routing Algorithm
( Bingqing Luo ),( Yiai Jin ),( Shengmei Luo ),( Zhixin Sun ) 한국인터넷정보학회 2016 KSII Transactions on Internet and Information Syst Vol.10 No.5
To prevent structured peer to peer (P2P) overlay networksfrom being attacked by malicious nodes, a symmetric lookup-based routing algorithm referred to as Symmetric-Chord is proposed in this paper. The proposed algorithm determines the precision of routing lookup by constructing multiple paths to the destination. The selective routing algorithm is used to acquire information on the neighbors of the root. Authenticity of the root is validated via consistency shown between the information ascertained from the neighbors and information from the yet-to-be-verified root, resulting in greater efficiency of resource lookup. Simulation results demonstrate that Symmetric-Chordhas the capability of detecting malicious nodes both accurately and efficiently, so as to identify which root holds the correct key, and provides an effective approach to the routing security for the P2P overlay network.
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Optimization of Energy Consumption in the Mobile Cloud Systems
( Pan Su ),( Wang Shengping ),( Zhou Weiwei ),( Liu Shengmei ) 한국인터넷정보학회 2016 KSII Transactions on Internet and Information Syst Vol.10 No.9
We investigate the optimization of energy consumption in Mobile Cloud environment in this paper. In order to optimize the energy consumed by the CPUs in mobile devices, we put forward using the asymptotic time complexity (ATC) method to distinguish the computational complexities of the applications when they are executed in mobile devices. We propose a multi-scale scheme to quantize the channel gain and provide an improved dynamic transmission scheduling algorithm when offloading the applications to the cloud center, which has been proved to be helpful for reducing the mobile devices energy consumption. We give the energy estimation methods in both mobile execution model and cloud execution model. The numerical results suggest that energy consumed by the mobile devices can be remarkably saved with our proposed multi-scale scheme. Moreover, the results can be used as a guideline for the mobile devices to choose whether executing the application locally or offloading it to the cloud center.
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Massive MIMO TWO-Hop Relay Systems Over Rician Fading Channels
( Jian Cao ),( Shujuan Yu ),( Jie Yang ),( Yun Zhang ),( Shengmei Zhao ) 한국인터넷정보학회 2019 KSII Transactions on Internet and Information Syst Vol.13 No.11
With the advent of the fifth-generation (5G) era, Massive multiple-input multiple-output (MIMO) relay systems have experienced the rapid development. Recently, the performance analysis models of Massive MIMO relay systems have been proposed, which are mostly based on Rayleigh fading channels. In order to create a more suitable model for 5G Internet of Things scenarios, our study is based on the Rician fading channels, where line-of-sight (LOS) path exists in the channels. In this paper, we assume the channel state information (CSI) is perfect. In this case, we use statistical information to derive the analytical exact closed-form expression for the achievable sum rate of the uplink for the Massive MIMO two-hop relay system over Rician fading channels. Moreover, considering the different communication scenarios, we derive the analytical exact closed-form expression for the achievable sum rates of the uplink for other three scenarios. Finally, based on these expressions, we make simulations and analyze the performance under different transmit powers and Rician-factors, which provides a theoretical basis and reference for further research.
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